合成路线1
该中间体在本合成路线中的序号:
(IV) The silylation of 4-acetoxy-2-pyrrolidone (I) with trimethylchlorosilane (II) by means of triethyl amine in THF gives the corresponding N-trimethylsilyl derivative (III), which is condensed with 4-methoxybenzoyl chloride (IV) by means of NaHCO3 in THF yielding 1-(4-methoxybenzoyl)pyrrolin-2-one (V). Finally, this compound is reduced with H2 over Pd/C in ethyl acetate.
![](http://zy.yaozh.com/wmf/sch/09/09001501a.jpg)
中间体序号 |
中间体编号 |
品名 |
CAS号 |
分子式 |
供应商 |
用于合成 |
(I) |
29095 |
4-Acetoxy-2-pyrrolidone; 5-Oxo-3-pyrrolidinyl acetate
|
|
C6H9NO3 |
详情 |
详情
|
(II) |
29096 |
Chloro(trimethyl)silane; Trimethylsilyl chloride; Trimethylchlorosilane
|
75-77-4 |
C3H9ClSi |
详情 | 详情
|
(III) |
29097 |
5-oxo-1-(trimethylsilyl)-3-pyrrolidinyl acetate
|
|
C9H17NO3Si |
详情 |
详情
|
(IV) |
22671 |
4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride
|
100-07-2 |
C8H7ClO2 |
详情 | 详情
|
(V) |
29098 |
1-(4-methoxybenzoyl)-1,5-dihydro-2H-pyrrol-2-one
|
|
C12H11NO3 |
详情 |
详情
|
合成路线2
该中间体在本合成路线中的序号:
(IV) The condensation of 4-aminobutyric acid (VI) with acid chloride (IV) by means of NaOH in water gives 4-(4-methoxybenzoylamino)butyric acid (VII), which is then cyclized by means of P2O5 in phosphoric acid.
![](http://zy.yaozh.com/wmf/sch/09/09001502a.jpg)
中间体序号 |
中间体编号 |
品名 |
CAS号 |
分子式 |
供应商 |
用于合成 |
(IV) |
22671 |
4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride
|
100-07-2 |
C8H7ClO2 |
详情 | 详情
|
(VI) |
13620 |
4-Amino-n-butyric acid; 4-Aminobutyric acid;Piperidinic acid;Piperidic acid |
56-12-2 |
C4H9NO2 |
详情 | 详情
|
(VII) |
29099 |
4-[(4-methoxybenzoyl)amino]butyric acid
|
|
C12H15NO4 |
详情 |
详情
|
合成路线3
该中间体在本合成路线中的序号:
(II) By reaction of 2-pyrrolidinone (I) with p-methoxybenzoyl chloride (II) by means of triethylamine in ether or sodium hydride in DMF.
![](http://zy.yaozh.com/wmf/sch/09/09001503a.jpg)
【1】
Kyburz, E.; Aschwanden, W.; 1-(P-Methoxy, p-hydroxy and p-benzyloxybenzoyl)-2-pyrrolidinones. EP 0005143; JP 54117468; US 4369139 .
|
【2】
Blancafort, P.; Serradell, M.N.; Mealy, N.E.; Leeson, P.A.; Castaner, J.; Aniracetam. Drugs Fut 1981, 6, 3, 127.
|
中间体序号 |
中间体编号 |
品名 |
CAS号 |
分子式 |
供应商 |
用于合成 |
(I) |
27397 |
2-Pyrrolidinone
|
616-45-5 |
C4H7NO |
详情 | 详情
|
(II) |
22671 |
4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride
|
100-07-2 |
C8H7ClO2 |
详情 | 详情
|
合成路线4
该中间体在本合成路线中的序号:
(II) A new method for the synthesis of encainide has been reported:
The acylation of methyl anthranilate (I) with 4-anisoyl chloride (II) by means of NaOH in methylene chloride gives methyl N-(p-anisoyl)anthranilate (III), which is condensed with 2-picoline (IV) by means of n-butyllithium in THF yielding 2-(2-pyridylacetyl)-p-anisanilide (V). Finally, this compound is reduced with H2 over Pt/C then with Pd/C, treated with formaldehyde and reduced again with H2 over Pt/C.
![](http://zy.yaozh.com/wmf/sch/09/09003001a.jpg)
中间体序号 |
中间体编号 |
品名 |
CAS号 |
分子式 |
供应商 |
用于合成 |
(I) |
11161 |
methyl 2-aminobenzoate; Methyl anthranilate
|
134-20-3 |
C8H9NO2 |
详情 | 详情
|
(II) |
22671 |
4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride
|
100-07-2 |
C8H7ClO2 |
详情 | 详情
|
(III) |
29100 |
methyl 2-[(4-methoxybenzoyl)amino]benzoate
|
|
C16H15NO4 |
详情 |
详情
|
(IV) |
17590 |
2-methylpyridine; 2-picoline
|
109-06-8 |
C6H7N |
详情 | 详情
|
(V) |
29101 |
4-methoxy-N-[2-[2-(2-pyridinyl)acetyl]phenyl]benzamide
|
|
C21H18N2O3 |
详情 |
详情
|
合成路线5
该中间体在本合成路线中的序号:
(A) The condensation of 2-methylpyridine (I) with 2-nitrobenzaldehyde (II) in acetic anhydride gives 2-(2-nitrostyryl)pyridine (III), which is quaternized with methyl iodide in refluxing acetone yielding 2-(2-nitrostyryl)-1-methylpyridinium iodide (IV) . The reduction of (IV) with H2 over PtO2 in ethanol affords 2-(2-aminophenethyl)-1-methylpiperidine (V), which is then acylated with 4-methoxybenzoyl chloride (A) in pyridine.
![](http://zy.yaozh.com/wmf/sch/09/09003002a.jpg)
【1】
Dykstra, S.J.; Minielli, J.L.; Substituted piperidines and a process for the preparation thereof. BE 0779951; CA 961038; CH 578529; DE 2210154; FR 2128584; GB 1346261; NL 161443C; NL 7202614 .
|
【2】
Kendrick, W.D.; Ferguson, H.C.; acid and quimidine analogs. 2-(o-Acylaminophenethyl)piperidines. J Med Chem 1973, 16, 9, 1015.
|
【3】
Castaner, J.; MJ 9067. Drugs Fut 1977, 2, 3, 176.
|
中间体序号 |
中间体编号 |
品名 |
CAS号 |
分子式 |
供应商 |
用于合成 |
(A) |
22671 |
4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride
|
100-07-2 |
C8H7ClO2 |
详情 | 详情
|
(I) |
17590 |
2-methylpyridine; 2-picoline
|
109-06-8 |
C6H7N |
详情 | 详情
|
(II) |
11370 |
2-Nitrobenzaldehyde
|
552-89-6 |
C7H5NO3 |
详情 | 详情
|
(III) |
40197 |
2-[(E)-2-(2-nitrophenyl)ethenyl]pyridine
|
|
C13H10N2O2 |
详情 |
详情
|
(IV) |
40198 |
1-methyl-2-[(E)-2-(2-nitrophenyl)ethenyl]pyridinium iodide
|
|
C14H13IN2O2 |
详情 |
详情
|
(V) |
40199 |
2-[2-(1-methyl-2-piperidinyl)ethyl]phenylamine; 2-[2-(1-methyl-2-piperidinyl)ethyl]aniline
|
|
C14H22N2 |
详情 |
详情
|
合成路线6
该中间体在本合成路线中的序号:
(A) Nevadensin can be synthesized starting from methyl 2,6-dimethoxyphenyl acetate (I). This compound is nitrated and then hydrogenated, giving methyl 3,5-diamino-2,6-dimethoxyphenyl acetate (III). Treatment of the latter compound with stannous chloride-hydrochloric acid gives dimethoxyphloroglucinol (IV). Introduction of an acetyl group followed by interaction with p-methoxybenzoyl chloride (A) gives 4-acetyl-2,6-dimethoxyphloroglucinyl tri(p-methoxy) benzoate (VI). The latter compound, after being rearranged, is cyclized into 5,7-di(p-methoxy)benzoylnevadensin (VIII). Nevadensin can readily be obtained by the hydrolysis of the compound (VIII).
![](http://zy.yaozh.com/wmf/sch/09/09017401a.jpg)
【1】
Feng, S.; Xu, Y.; Fan, G.; Studies on the antituberculosis principles from Lysionotus pauciflora Maxim. I. Isolation and identification of nevadensin. Acta Pharm Sin 1979, 14, 7, 447-448.
|
【2】
Su, C.; Han, G.; Zhang, Y.; Determination of nevadensin in biological specimens and its pharmacokinetic study. Chin Pharm Bull 1981, 2, 3, 182-185.
|
【3】
Ru-yun, J.; Nevadensin. Drugs Fut 1984, 9, 4, 271.
|
中间体序号 |
中间体编号 |
品名 |
CAS号 |
分子式 |
供应商 |
用于合成 |
(A) |
22671 |
4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride
|
100-07-2 |
C8H7ClO2 |
详情 | 详情
|
(I) |
34188 |
2,6-dimethoxyphenyl acetate
|
|
C10H12O4 |
详情 |
详情
|
(II) |
34189 |
2,6-dimethoxy-3,5-dinitrophenyl acetate
|
|
C10H10N2O8 |
详情 |
详情
|
(III) |
34190 |
3,5-diamino-2,6-dimethoxyphenyl acetate
|
|
C10H14N2O4 |
详情 |
详情
|
(IV) |
34191 |
2,4-dimethoxy-1,3,5-benzenetriol
|
|
C8H10O5 |
详情 |
详情
|
(V) |
34192 |
1-(2,4,6-trihydroxy-3,5-dimethoxyphenyl)-1-ethanone
|
|
C10H12O6 |
详情 |
详情
|
(VI) |
34193 |
2-acetyl-4,6-dimethoxy-3,5-bis[(4-methoxybenzoyl)oxy]phenyl 4-methoxybenzoate
|
|
C34H30O12 |
详情 |
详情
|
(VII) |
34194 |
3-hydroxy-2,6-dimethoxy-5-[(4-methoxybenzoyl)oxy]-4-[3-(4-methoxyphenyl)-3-oxopropanoyl]phenyl 4-methoxybenzoate
|
|
C34H30O12 |
详情 |
详情
|
(VIII) |
34195 |
6,8-dimethoxy-5-[(4-methoxybenzoyl)oxy]-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-yl 4-methoxybenzoate
|
|
C34H28O11 |
详情 |
详情
|
合成路线7
该中间体在本合成路线中的序号:
(IX) The esterification of bromoacetic acid (I) with benzyl alcohol (II) gives the corresponding ester (III), which by reaction with triphenylphosphine (IV) in hot toluene yields the phosphonium bromide (V). The reaction of (V) with NaOH in water-dichloromethane affords benzyl(triphenylphosphoranylidene) acetate (VI), which is submitted to a Wittig condensation with 5-(hydroxymethyl)-2-pyrrolidone (VII) in the presence of Dess-Martin periodinane (DMPI) giving benzyl 3-(5-oxo-2-pyrrolidinyl)-2(E) propenoate (VIII). The acylation of (VIII) with 4-methoxybenzoyl chloride (IX) by means of triethylamine in hot toluene yields the corresponding amide (X), which is finally hydrogenated and deprotected with H2 over Pd/C in THF.
![](http://zy.yaozh.com/wmf/sch/10/10054901a.jpg)
【1】
Huang, C.C.; Synthesis of carbon-14 labeled 1-(4-methoxybenzoyl. J Label Compd Radiopharm 1987, 24, 6, 675.
|
中间体序号 |
中间体编号 |
品名 |
CAS号 |
分子式 |
供应商 |
用于合成 |
(I) |
23660 |
2-Bromoacetic acid
|
79-08-3 |
C2H3BrO2 |
详情 | 详情
|
(II) |
18710 |
Benzyl alcohol; Phenylmethanol
|
100-51-6 |
C7H8O |
详情 | 详情
|
(III) |
12869 |
benzyl 2-bromoacetate
|
5437-45-6 |
C9H9BrO2 |
详情 | 详情
|
(IV) |
12437 |
Triphenylphosphine; Triphenyl phosphine
|
603-35-0 |
C18H15P |
详情 | 详情
|
(V) |
22667 |
[2-(benzyloxy)-2-oxoethyl](triphenyl)phosphonium bromide
|
|
C27H24BrO2P |
详情 |
详情
|
(VI) |
22668 |
benzyl 2-(triphenylphosphoranylidene)acetate
|
|
C27H23O2P |
详情 |
详情
|
(VII) |
10079 |
5-(Hydroxymethyl)-2-pyrrolidinone
|
62400-75-3 |
C5H9NO2 |
详情 | 详情
|
(VIII) |
22670 |
benzyl (E)-3-(5-oxo-2-pyrrolidinyl)-2-propenoate
|
|
C14H15NO3 |
详情 |
详情
|
(IX) |
22671 |
4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride
|
100-07-2 |
C8H7ClO2 |
详情 | 详情
|
(X) |
22672 |
benzyl (E)-3-[1-(4-methoxybenzoyl)-5-oxo-2-pyrrolidinyl]-2-propenoate
|
|
C22H21NO5 |
详情 |
详情
|
合成路线8
该中间体在本合成路线中的序号:
(IV) The partial hydrolysis of perhydropyrrolizine-3,5-dione (I) in the presence of benzyl alcohol (II) by means of aqueous concentrated HCl at 98 C gives benzyl 5-oxopyrrolidine-2-propenoate (III), which is condensed with 4-methoxybenzoyl chloride (IV) by means of triethylamine in hot THF to afford benzyl 1-(4-methoxybenzoyl)-5-oxopyrrolidine-3-propanoate (V). Finally, this compound ls debenzylated by hydrogenolysis with H2 over Pd/C in THF.
![](http://zy.yaozh.com/wmf/sch/10/10054902a.jpg)
【1】
(Pfizer Inc.); 1-Aroyl-5-oxo-2-pyrrolidinepropanoic acid derivs.. EP 0110575; ES 8600238 .
|
【2】
Castaner, J.; Serradell, M.N.; CI-933. Drugs Fut 1985, 10, 12, 972.
|
中间体序号 |
中间体编号 |
品名 |
CAS号 |
分子式 |
供应商 |
用于合成 |
(I) |
29829 |
dihydro-1H-pyrrolizine-3,5(2H,6H)-dione
|
|
C7H9NO2 |
详情 |
详情
|
(II) |
18710 |
Benzyl alcohol; Phenylmethanol
|
100-51-6 |
C7H8O |
详情 | 详情
|
(III) |
29830 |
benzyl 3-(5-oxo-2-pyrrolidinyl)propanoate
|
|
C14H17NO3 |
详情 |
详情
|
(IV) |
22671 |
4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride
|
100-07-2 |
C8H7ClO2 |
详情 | 详情
|
(V) |
29831 |
benzyl 3-[1-(4-methoxybenzoyl)-5-oxo-2-pyrrolidinyl]propanoate
|
|
C22H23NO5 |
详情 |
详情
|
合成路线9
该中间体在本合成路线中的序号:
(IV) This compound can be obtained by two related ways:
1) The condensation of 2-methylindole (I) with 2-morpholinoethyl chloride (II) by means of KOH in hot DMSO gives 1-(2-morpholinoethyl)-2-methylindole (III), which is then submitted to a Friedel-Craft's reaction with 4-methoxybenzoyl chloride (IV) by means of AlCl3 in dichloromethane or ethylene dichloride.
2) The condensation of indole (I) with acyl chloride (IV) by means of methylmagnesium bromide in anhydrous ethyl ether gives 2-methyl-3-(4-methoxy benzoyl)indole (V), which is then condensed with morpholine (II) by means of K2CO3 in DMF.
![](http://zy.yaozh.com/wmf/sch/11/11902701a.jpg)
中间体序号 |
中间体编号 |
品名 |
CAS号 |
分子式 |
供应商 |
用于合成 |
(I) |
28747 |
2-methyl-1H-indole
|
95-20-5 |
C9H9N |
详情 | 详情
|
(II) |
27355 |
4-(2-chloroethyl)morpholine
|
3647-69-6 |
C6H12ClNO |
详情 | 详情
|
(III) |
28748 |
4-[2-(2-methyl-1H-inden-1-yl)ethyl]morpholine
|
|
C16H21NO |
详情 |
详情
|
(IV) |
22671 |
4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride
|
100-07-2 |
C8H7ClO2 |
详情 | 详情
|
(V) |
28749 |
(4-methoxyphenyl)(2-methyl-1H-indol-3-yl)methanone
|
|
C17H15NO2 |
详情 |
详情
|
合成路线10
该中间体在本合成路线中的序号:
(A) Friedel-Crafts acylation of 2,3-dichlorophenetole with 4-methoxybenzoyl chloride gives the substituted benzophenone (I). Selective cleavage of the ethyl ether in (I) with AlCl3 produces phenol (II). Alkylation of (II) with ethyl bromoacetate is followed by heating with 48% HBr to give the phenoxyacetic acid derivative (III). Amidomethylation of (III) using the Tscherniac-Einhorn procedure gives (IV), which affords A-49816 after hydrolysis with HCl/EtOH.
![](http://zy.yaozh.com/wmf/sch/14/14514101a.jpg)
【1】
Plattner, J.J.; Horrom, B.W.; Dodge, P.W.; Ours, C.W.; Lee, C.-M.; Pernet, A.G.; El Masry, S.E.; Smital, J.R.; Bunnell, P.R.; [(Aminomethyl)aryloxy]acetic acid esters. A new cl. J Med Chem 1984, 27, 1579.
|
【2】
Luther, R.R.; Plattner, J.J.; A-49816. Drugs Fut 1988, 13, 12, 1039.
|
中间体序号 |
中间体编号 |
品名 |
CAS号 |
分子式 |
供应商 |
用于合成 |
(A) |
22671 |
4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride
|
100-07-2 |
C8H7ClO2 |
详情 | 详情
|
(B) |
23019 |
1,2-dichloro-3-ethoxybenzene; 2,3-dichlorophenyl ethyl ether
|
|
C8H8Cl2O |
详情 |
详情
|
(I) |
23021 |
(2,3-dichloro-4-ethoxyphenyl)(4-methoxyphenyl)methanone
|
|
C16H14Cl2O3 |
详情 |
详情
|
(II) |
23022 |
(2,3-dichloro-4-hydroxyphenyl)(4-methoxyphenyl)methanone
|
|
C14H10Cl2O3 |
详情 |
详情
|
(III) |
23023 |
2-[2,3-dichloro-4-(4-hydroxybenzoyl)phenoxy]acetic acid
|
|
C15H10Cl2O5 |
详情 |
详情
|
(IV) |
23024 |
2-[2,3-dichloro-4-(3-[[(2-chloroacetyl)amino]methyl]-4-hydroxybenzoyl)phenoxy]acetic acid
|
|
C18H14Cl3NO6 |
详情 |
详情
|
(C) |
23020 |
2-chloro-N-(hydroxymethyl)acetamide
|
2832-19-1 |
C3H6ClNO2 |
详情 | 详情
|
合成路线11
该中间体在本合成路线中的序号:
(V) Treatment of 2-hydroxy-5-nitrobenzyl bromide (I) with triphenylphosphine in refluxing chloroform provides phosphonium bromide derivative (II), which is converted into 2-butyl-5-nitro benzofuran (IV) by first reaction with pentanoyl chloride (III) in refluxing chloroform in the presence of pyridine, followed by treatment with Et3N in refluxing toluene. Acylation of (IV) with anisoyl chloride (V) by means of tin tetrachloride in dichloroethane furnishes 2-butyl-3-(4-methoxy benzoyl)-5-nitro benzofuran (VI), whose methoxy group is then converted into an hydroxy group by treatment with aluminum chloride in refluxing dichloroethane, yielding hydroxy benzoyl derivative (VII). Condensation of (VII) with N,N-dibutyl-N-(3-chloropropyl)amine (VIII) by means of K2CO3 in refluxing butanone affords compound (IX), which is then hydrogenated over PtO2 in EtOH to give amino derivative (X). Finally, the target product is obtained by reaction of (X) with methanesulfonyl chloride and Et3N in dichloroethane and hydrochloride salt formation with HCl in AcOEt/ethyl ether.
![](http://zy.yaozh.com/wmf/sch/19/19176901a.jpg)
【1】
Gubin, J.; Lucchetti, J.; Inion, H.; Chatelain, P.; Rosseels, G.; Kilenyi, S. (Sanofi-Synthélabo); Benzofuran derivs., benzothiophenes, indoles or indolizines, process for production and compsns. containing them. EP 0471609; FR 2665444; JP 1992316554; US 5223510 . |
中间体序号 |
中间体编号 |
品名 |
CAS号 |
分子式 |
供应商 |
用于合成 |
(I) |
50821 |
alpha-Bromo-4-nitro-o-cresol; Koshland's reagent; 2-Hydroxy-5-nitrobenzyl bromide
|
772-33-8 |
C7H6BrNO3 |
详情 | 详情
|
(II) |
50822 |
(2-hydroxy-5-nitrobenzyl)(triphenyl)phosphonium bromide
|
|
C25H21BrNO3P |
详情 |
详情
|
(III) |
15116 |
pentanoyl chloride; valeryl chloride
|
638-29-9 |
C5H9ClO |
详情 | 详情
|
(IV) |
50823 |
2-butyl-5-nitro-1-benzofuran
|
|
C12H13NO3 |
详情 |
详情
|
(V) |
22671 |
4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride
|
100-07-2 |
C8H7ClO2 |
详情 | 详情
|
(VI) |
50824 |
(2-butyl-5-nitro-1-benzofuran-3-yl)(4-methoxyphenyl)methanone
|
|
C20H19NO5 |
详情 |
详情
|
(VII) |
50825 |
(2-butyl-5-nitro-1-benzofuran-3-yl)(4-hydroxyphenyl)methanone
|
|
C19H17NO5 |
详情 |
详情
|
(VIII) |
50826 |
N,N-dibutyl-N-(3-chloropropyl)amine; N-butyl-N-(3-chloropropyl)-1-butanamine
|
36421-15-5 |
C11H24ClN |
详情 | 详情
|
(IX) |
50827 |
(2-butyl-5-nitro-1-benzofuran-3-yl)[4-[3-(dibutylamino)propoxy]phenyl]methanone
|
|
C30H40N2O5 |
详情 |
详情
|
(X) |
50828 |
(5-amino-2-butyl-1-benzofuran-3-yl)[4-[3-(dibutylamino)propoxy]phenyl]methanone
|
|
C30H42N2O3 |
详情 |
详情
|
合成路线12
该中间体在本合成路线中的序号:
(III) Removal of the N-(benzyloxycarbonyl) group from the protected dipeptide (I) by catalytic hydrogenolysis provided the dipeptide Val-Pro-O-t-Bu (II), which was N-acylated with anisoyl chloride (III) to afford anisoyl dipeptide (IV). The tert-butyl ester group of (IV) was then cleaved using trifluoroacetic acid to afford (VI). Alternatively, the intermediate (VI) could be obtained from unprotected Val-Pro-OH (V) by treatment with trimethylsilyl chloride and subsequent acylation of the silyl ester with acid chloride (III). The anisoyl dipeptide (VI) was further condensed with racemic threo-aminoalcohol (VII), either in the presence of EDC and HOBt or via conversion to the mixed anhydride with isobutyl chloroformate, to furnish the corresponding peptide amide (VIII) as a diastereomeric mixture. Subsequent oxidation of the alcohol group of (VIII) to the trifluoromethyl ketone (IX) was carried out using a modified Pfitzner-Moffat procedure in the presence of DMSO, EDC and dichloroacetic acid or with KMnO4 in basic medium. The desired S,S,S-isomer was isolated from the epimeric mixture after repeated crystallizations.
![](http://zy.yaozh.com/wmf/sch/22/22783101a.jpg)
【1】
Bohnert, C.M.; Bernstein, P.R.; Veale, C.A.; et al.; Orally active trifluoromethyl ketone inhibitors of. J Med Chem 1997, 40, 20, 3173.
|
【2】
Pegg, S.J.; Sependa, G.J.; Davies, E.P.; Veale, C.A. (AstraZeneca plc); Diastereomeric pure trifluoromethyl ketone peptide. EP 0743953; JP 1997508902; US 5739157; US 6037363; WO 9521855 .
|
中间体序号 |
中间体编号 |
品名 |
CAS号 |
分子式 |
供应商 |
用于合成 |
(I) |
22770 |
tert-butyl (2S)-1-((2S)-2-[[(benzyloxy)carbonyl]amino]-3-methylbutanoyl)-2-pyrrolidinecarboxylate
|
|
C22H32N2O5 |
详情 |
详情
|
(II) |
22771 |
tert-butyl (2S)-1-[(2S)-2-amino-3-methylbutanoyl]-2-pyrrolidinecarboxylate
|
|
C14H26N2O3 |
详情 |
详情
|
(III) |
22671 |
4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride
|
100-07-2 |
C8H7ClO2 |
详情 | 详情
|
(IV) |
22773 |
tert-butyl (2S)-1-[(2S)-2-[(4-methoxybenzoyl)amino]-3-methylbutanoyl]-2-pyrrolidinecarboxylate
|
|
C22H32N2O5 |
详情 |
详情
|
(V) |
22774 |
(2S)-1-[(2S)-2-amino-3-methylbutanoyl]-2-pyrrolidinecarboxylic acid
|
|
C10H18N2O3 |
详情 |
详情
|
(VI) |
22775 |
(2S)-1-[(2S)-2-[(4-methoxybenzoyl)amino]-3-methylbutanoyl]-2-pyrrolidinecarboxylic acid
|
|
C18H24N2O5 |
详情 |
详情
|
(VII) |
22776 |
(2R,3S)-3-amino-1,1,1-trifluoro-4-methyl-2-pentanol
|
|
C6H12F3NO |
详情 |
详情
|
(VIII) |
22777 |
(2S)-1-[(2S)-2-[(4-methoxybenzoyl)amino]-3-methylbutanoyl]-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)-2-pyrrolidinecarboxamide
|
|
C24H34F3N3O5 |
详情 |
详情
|
(IX) |
22778 |
(2S)-1-[(2S)-2-[(4-methoxybenzoyl)amino]-3-methylbutanoyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)-2-pyrrolidinecarboxamide
|
|
C24H32F3N3O5 |
详情 |
详情
|
合成路线13
该中间体在本合成路线中的序号:
(III) An alternative synthesis has been reported employing pure (2R,3S)-aminoalcohol (XVII). Treatment of isobutyl iodide (X) with sodium nitrite in the presence of urea in DMF afforded 2-methyl-1-nitropropane (XI). Further condensation of fluoral hydrate (XII) with this nitrocompound using K2CO3 provided a diastereomeric mixture of nitroalcohols (XIII). Fractional crystallization from pentane yielded the racemic threo-nitroalcohol (XIV), which was converted to the alredy reported racemic threo-aminoalcohol (VII) by catalytic hydrogenation. This compound (VII) was treated with triphosgene and NaOH to produce oxazolidone (XV). After conversion of (XV) to the corresponding lithium salt with BuLi at -70 C, its condensation with (-)-menthyl chloroformate gave a diastereomeric mixture of carbamates, from which the desired isomer (XVI) was isolated by fractional crystallization from ether/hexane. The chiral auxiliary and the oxazolidone ring were then cleaved by hydrolysis with KOH yielding the (2R,3S)-aminoalcohol (XVII)(1). The coupling of (XVII) with the amino protected dipeptide (XVIII) (obtained by treatment of peptide (I) with trifluoroacetic acid) afforded dipeptide amide (XIX), The N-(benzyloxycarbonyl) protecting group of (XIX) was subsequently removed by catalytic hydrogenation, and the resulting amino compound was condensed with anisoyl chloride (III) to furnish the anisoyl dipeptide (XX). Finally, oxidation of the alcohol group of (XX) using the modified Pfitner-Moffat procedure produced some epimerization of the resulting ketone, the oxidation with KMnO4 in the presence of NaOH yielded the target S,S,S-peptide.
![](http://zy.yaozh.com/wmf/sch/22/22783102a.jpg)
【1】
Bohnert, C.M.; Bernstein, P.R.; Veale, C.A.; et al.; Orally active trifluoromethyl ketone inhibitors of. J Med Chem 1997, 40, 20, 3173.
|
【2】
Pegg, S.J.; Sependa, G.J.; Davies, E.P.; Veale, C.A. (AstraZeneca plc); Diastereomeric pure trifluoromethyl ketone peptide. EP 0743953; JP 1997508902; US 5739157; US 6037363; WO 9521855 .
|
中间体序号 |
中间体编号 |
品名 |
CAS号 |
分子式 |
供应商 |
用于合成 |
(I) |
22770 |
tert-butyl (2S)-1-((2S)-2-[[(benzyloxy)carbonyl]amino]-3-methylbutanoyl)-2-pyrrolidinecarboxylate
|
|
C22H32N2O5 |
详情 |
详情
|
(III) |
22671 |
4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride
|
100-07-2 |
C8H7ClO2 |
详情 | 详情
|
(VII) |
22776 |
(2R,3S)-3-amino-1,1,1-trifluoro-4-methyl-2-pentanol
|
|
C6H12F3NO |
详情 |
详情
|
(X) |
18168 |
1-iodo-2-methylpropane
|
513-38-2 |
C4H9I |
详情 | 详情
|
(XI) |
11782 |
2-Methyl-1-nitropropane
|
|
C4H9NO2 |
详情 |
详情
|
(XII) |
22781 |
2,2,2-trifluoro-1,1-ethanediol
|
421-53-4 |
C2H3F3O2 |
详情 | 详情
|
(XIII) |
11783 |
1,1,1-Trifluoro-4-methyl-3-nitro-2-pentanol
|
|
C6H10F3NO3 |
详情 |
详情
|
(XIV) |
22783 |
(2R,3S)-1,1,1-trifluoro-4-methyl-3-nitro-2-pentanol
|
|
C6H10F3NO3 |
详情 |
详情
|
(XV) |
22784 |
(4S,5R)-4-isopropyl-5-(trifluoromethyl)-1,3-oxazolidin-2-one
|
|
C7H10F3NO2 |
详情 |
详情
|
(XVI) |
22785 |
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (4S,5R)-4-isopropyl-2-oxo-5-(trifluoromethyl)-1,3-oxazolidine-3-carboxylate
|
|
C18H28F3NO4 |
详情 |
详情
|
(XVII) |
22776 |
(2R,3S)-3-amino-1,1,1-trifluoro-4-methyl-2-pentanol
|
|
C6H12F3NO |
详情 |
详情
|
(XVIII) |
22787 |
(2S)-1-((2S)-2-[[(benzyloxy)carbonyl]amino]-3-methylbutanoyl)-2-pyrrolidinecarboxylic acid
|
|
C18H24N2O5 |
详情 |
详情
|
(XIX) |
22788 |
benzyl (1S)-2-methyl-1-[[(2S)-2-([[(1S,2R)-3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl]amino]carbonyl)pyrrolidinyl]carbonyl]propylcarbamate
|
|
C24H34F3N3O5 |
详情 |
详情
|
(XX) |
22789 |
(2S)-1-[(2S)-2-[(4-methoxybenzoyl)amino]-3-methylbutanoyl]-N-[(1S,2R)-3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl]-2-pyrrolidinecarboxamide
|
|
C24H34F3N3O5 |
详情 |
详情
|
合成路线14
该中间体在本合成路线中的序号:
(XVI) Synthesis of intermediate monosaccharide (XVIII): The reaction of tetraacetyl-D-xylose (IX) with HBr in HOAc gives the bromoglycoside (X), which by reaction with ethylmercaptane and lutidine yields the thio orthoester (XI). Hydrolysis of (XI) with NaOMe in methanol affords the deacetylated compound (XII), which is protected with Pmb-Cl and NaH to provide the diether (XIII). The cleavage of the cyclic thio orthoester with ZnCl2 in dichloromethane gives the 2-O-acetyl-thioglycoside (XIV), which is hydrolyzed with NaOMe in methanol to yield the alcohol (XV). Esterification of (XV) with 4-methoxybenzoyl chloride (XVI), DMAP and TEA affords the benzoate ester (XVII), which is finally converted into the target acetimidate (XVIII) by reaction with NBS in dichloromethane/water, and then with trichloroacetonitrile and DBU in the same solvent.
![](http://zy.yaozh.com/wmf/sch/24/24877001b.jpg)
【1】
Jin, Z.; Yu, W.; A new strategy for the stereoselective introduction of steroid side chain via alpha-alkoxy vinyl cuprates: Total synthesis of a highly potent antitumor natural product OSW-1. J Am Chem Soc 2001, 123, 14, 3369.
|
中间体序号 |
中间体编号 |
品名 |
CAS号 |
分子式 |
供应商 |
用于合成 |
(IX) |
48943 |
(3R,4S,5R)-2,3,5-tris(acetoxy)tetrahydro-2H-pyran-4-yl acetate
|
|
C13H18O9 |
详情 |
详情
|
(X) |
23761 |
(2R,3R,4S,5R)-3,5-bis(acetoxy)-2-bromotetrahydro-2H-pyran-4-yl acetate
|
|
C11H15BrO7 |
详情 |
详情
|
(XI) |
48944 |
(2S,3aR,6R,7S,7aR)-6-(acetoxy)-2-(ethylsulfanyl)-2-methyltetrahydro-3aH-[1,3]dioxolo[4,5-b]pyran-7-yl acetate
|
|
C13H20O7S |
详情 |
详情
|
(XII) |
48945 |
(2S,3aR,6R,7S,7aR)-2-(ethylsulfanyl)-2-methyltetrahydro-3aH-[1,3]dioxolo[4,5-b]pyran-6,7-diol
|
|
C9H16O5S |
详情 |
详情
|
(XIII) |
48946 |
(2S,3aR,6R,7S,7aR)-2-(ethylsulfanyl)-6-[(4-methoxybenzyl)oxy]-2-methyltetrahydro-3aH-[1,3]dioxolo[4,5-b]pyran-7-yl 4-methoxybenzyl ether; (2S,3aR,6R,7S,7aR)-2-(ethylsulfanyl)-6,7-bis[(4-methoxybenzyl)oxy]-2-methyltetrahydro-3aH-[1,3]dioxolo[4,5-b]pyran |
|
C25H32O7S |
详情 |
详情
|
(XIV) |
48947 |
(2R,3R,4S,5R)-2-(ethylsulfanyl)-4,5-bis[(4-methoxybenzyl)oxy]tetrahydro-2H-pyran-3-yl acetate
|
|
C25H32O7S |
详情 |
详情
|
(XV) |
48948 |
(2S,3R,4R,5R)-2-(ethylsulfanyl)-4,5-bis[(4-methoxybenzyl)oxy]tetrahydro-2H-pyran-3-ol
|
|
C23H30O6S |
详情 |
详情
|
(XVI) |
22671 |
4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride
|
100-07-2 |
C8H7ClO2 |
详情 | 详情
|
(XVII) |
48949 |
(2S,3R,4S,5R)-2-(ethylsulfanyl)-4,5-bis[(4-methoxybenzyl)oxy]tetrahydro-2H-pyran-3-yl 4-methoxybenzoate
|
|
C31H36O8S |
详情 |
详情
|
(XVIII) |
48950 |
(3R,4S,5R)-4,5-bis[(4-methoxybenzyl)oxy]-2-[(2,2,2-trichloroethanimidoyl)oxy]tetrahydro-2H-pyran-3-yl 4-methoxybenzoate
|
|
C31H32Cl3NO9 |
详情 |
详情
|
合成路线15
该中间体在本合成路线中的序号:
(IX) Synthesis of intermediate monosaccharide (XIII): The reaction of D-xylose (VII) with benzyl alcohol and HCl (gas) gives the 1-O-benzyl-D-xylose (VIII), which is regioselectively acylated with 4-methoxybenzoyl chloride (IX) and pyridine to yield 1-O-benzyl-2-O-(4-methoxybenzoyl)-D-xylose (X). The silylation of (X) with Tes-Cl and imidazole in DMF affords the disilylated compound (XI), which is debenzylated by hydrogenation with H2 over Pd/C in ethyl acetate to provide 2-O-(4-methoxybenzoyl)-3,4-O-bis(triethylsilyl)-D-xylose (XII). Finally, this compound is converted into the target trichloroacetimidate (XIII) by reaction with trichloroacetonitrile and DBU in dichloromethane.
![](http://zy.yaozh.com/wmf/sch/24/24877002b.jpg)
【1】
Deng, S.; et al.; First total synthesis of an exceptionally potent antitumor saponin, OSW-1. J Org Chem 1999, 64, 1, 202.
|
中间体序号 |
中间体编号 |
品名 |
CAS号 |
分子式 |
供应商 |
用于合成 |
(VII) |
48970 |
2,3,4,5-Tetrahydroxypentanal; D-xylopyranose; D-(+)-Xylose; D-xylose; D-(+)-Wood Sugar; Xylose; Wood Sugar
|
58-86-6 |
C5H10O5 |
详情 | 详情
|
(VIII) |
48971 |
(3R,4S,5R)-2-(benzyloxy)tetrahydro-2H-pyran-3,4,5-triol
|
|
C12H16O5 |
详情 |
详情
|
(IX) |
22671 |
4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride
|
100-07-2 |
C8H7ClO2 |
详情 | 详情
|
(X) |
48972 |
(3R,4S,5R)-2-(benzyloxy)-4,5-dihydroxytetrahydro-2H-pyran-3-yl 4-methoxybenzoate
|
|
C20H22O7 |
详情 |
详情
|
(XI) |
48973 |
(3R,4R,5R)-2-(benzyloxy)-4,5-bis[(triethylsilyl)oxy]tetrahydro-2H-pyran-3-yl 4-methoxybenzoate
|
|
C32H50O7Si2 |
详情 |
详情
|
(XII) |
48974 |
(3R,4R,5R)-2-hydroxy-4,5-bis[(triethylsilyl)oxy]tetrahydro-2H-pyran-3-yl 4-methoxybenzoate
|
|
C25H44O7Si2 |
详情 |
详情
|
(XIII) |
48975 |
(3R,4R,5R)-2-[(2,2,2-trichloroethanimidoyl)oxy]-4,5-bis[(triethylsilyl)oxy]tetrahydro-2H-pyran-3-yl 4-methoxybenzoate
|
|
C27H44Cl3NO7Si2 |
详情 |
详情
|
合成路线16
该中间体在本合成路线中的序号:
(IV) The cyclization of 2-methylbenzonitrile (I) with pyridine-2-carbonitrile (II) by means of potassium amide in liquid NH3 gives 3-(2-pyridyl)isoquinoline-1-amine (III), which is finally acylated with 4-methoxybenzoyl chloride (IV) by means of butyllithium in THF.
![](http://zy.yaozh.com/wmf/sch/26/26371301a.jpg)
【1】
de Zwart, M.A.H.; van der Goot, H.; de Zwart, H.; Timmerman, H.; Synthesis and copper-dependent antimycoplasmal activity of 1-amino-3-(2-pyridyl)isoquinoline derivatives. 1. Amides. J Med Chem 1988, 31, 4, 716.
|
【2】
van Muijlwijk-Koezen, J.E.; Timmerman, H.; Link, R.; van der Goot, H.; Ijzerman, A.P.; A novel class of adenosine A3 receptor ligands. 2. Structure affinity profile of a series of isoquinoline and quinazoline compounds. J Med Chem 1998, 41, 21, 3994. |
中间体序号 |
中间体编号 |
品名 |
CAS号 |
分子式 |
供应商 |
用于合成 |
(I) |
28606 |
2-methylbenzonitrile
|
529-19-1 |
C8H7N |
详情 | 详情
|
(II) |
28607 |
2-pyridinecarbonitrile
|
100-70-9 |
C6H4N2 |
详情 | 详情
|
(III) |
28608 |
3-(2-pyridinyl)-1-isoquinolinamine
|
|
C14H11N3 |
详情 |
详情
|
(IV) |
22671 |
4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride
|
100-07-2 |
C8H7ClO2 |
详情 | 详情
|
合成路线17
该中间体在本合成路线中的序号:
(VI) Regioselective ring opening of 3-nitrophthalic anhydride (I) with ammonia yielded amide (II), which was subjected to a Hofmann degradation with Br2 and KOH to afford 3-nitroanthranilic acid (III). Esterification of (III) to ster (IV) using MeOH/HCl, followed by reduction of the nitro group by catalytic hydrogenation, gave methyl 2,3-diaminobenzoate (V). Alternatively, diamino ester (V) was prepared by reduction of nitro acid (III), followed by catalytic esterification. Methyl 2,3-diaminobenzoate (V) was then selectively acylated at the 3-amino group with 4-methoxybenzoyl chloride (VI) producing amide (VII), which was cyclized to the benzimidazole (VIII) upon refluxing in HOAc. The corresponding amide (IX) was obtained by reaction of ester (VIII) with liquid ammonia at 100 C in a pressure vessel. Finally, the methyl ether group of (IX) was cleaved to the title phenol by treatment with boron tribromide.
![](http://zy.yaozh.com/wmf/sch/27/27449701a.jpg)
【1】
Wood, M.D.; Taylor, S.G.; Reavill, C.; et al.; Pharmacological actions of a novel, high-affinity, and selective human dopamine D3 receptor antagonist, SB-277011-A. J Pharmacol Exp Ther 2000, 294, 3, 1154.
|
【2】
Griffin, R.J.; Calvert, A.H.; Newell, D.R.; Curtain, J.N.; Golding, B.T. (University of Newcastle upon Tyne); Benzimidazole cpds.. US 6100283 .
|
中间体序号 |
中间体编号 |
品名 |
CAS号 |
分子式 |
供应商 |
用于合成 |
(I) |
46407 |
4-nitro-2-benzofuran-1,3-dione;3-nitrophthalic anhydride |
641-70-3 |
C8H3NO5 |
详情 | 详情
|
(II) |
46408 |
2-(aminocarbonyl)-3-nitrobenzoic acid
|
|
C8H6N2O5 |
详情 |
详情
|
(III) |
46409 |
2-amino-3-nitrobenzoic acid
|
|
C7H6N2O4 |
详情 |
详情
|
(IV) |
46410 |
methyl 2-amino-3-nitrobenzoate
|
|
C8H8N2O4 |
详情 |
详情
|
(V) |
18889 |
methyl 2,3-diaminobenzoate
|
|
C8H10N2O2 |
详情 |
详情
|
(VI) |
22671 |
4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride
|
100-07-2 |
C8H7ClO2 |
详情 | 详情
|
(VII) |
46411 |
methyl 2-amino-3-[(4-methoxybenzoyl)amino]benzoate
|
|
C16H16N2O4 |
详情 |
详情
|
(VIII) |
46412 |
methyl 2-(4-methoxyphenyl)-1H-benzimidazole-4-carboxylate
|
|
C16H14N2O3 |
详情 |
详情
|
(IX) |
46413 |
2-(4-methoxyphenyl)-1H-benzimidazole-4-carboxamide
|
|
C15H13N3O2 |
详情 |
详情
|
合成路线18
该中间体在本合成路线中的序号:
(II) Friedel-Crafts acylation of 2-methylbenzofuran (I) with p-anisoyl chloride (II) in the presence of SnCl4 afforded the benzoyl benzofuran derivative (III). Ketone (III) reduction to the corresponding benzyl benzofuran (IV) was accomplished employing either LiAlH4 or NaBH4 and ZnI2. The methyl ether group of (IV) was then cleaved with melted pyridine hydrochloride to give phenol (V). Aromatic iodination of (V) with either I2/KI or with ICl in morpholine led to the diiodo phenol (VI). This was then alkylated with ethyl bromoacetate (VII) to furnish ester (VIII), which was finally hydrolyzed with NaOH to the target carboxylic acid.
![](http://zy.yaozh.com/wmf/sch/27/27903801a.jpg)
【1】
Singh, B.N.; Malm, J.; Mellin, C.; Li, Y.-L.; Nilsson, S.; Temciuc, M.; Carlsson, B.; Synthesis and preliminary characterization of a novel antiarrhythmic compound (KB130015) with an improved toxicity profile compared with amiodarone. J Med Chem 2002, 45, 3, 623. |
【2】
Norinder, U.; Bajorath, J.; Stearns, J.F. (Karo Bio AB); Receptor ligands. WO 9220331 .
|
中间体序号 |
中间体编号 |
品名 |
CAS号 |
分子式 |
供应商 |
用于合成 |
(I) |
56239 |
2-Methylbenzofuran
|
|
C9H8O |
详情 |
详情
|
(II) |
22671 |
4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride
|
100-07-2 |
C8H7ClO2 |
详情 | 详情
|
(III) |
56240 |
(4-methoxyphenyl)(2-methyl-1-benzofuran-3-yl)methanone
|
|
C17H14O3 |
详情 |
详情
|
(IV) |
56241 |
3-(4-methoxybenzyl)-2-methyl-1-benzofuran; methyl 4-[(2-methyl-1-benzofuran-3-yl)methyl]phenyl ether
|
|
C17H16O2 |
详情 |
详情
|
(V) |
56242 |
4-[(2-methyl-1-benzofuran-3-yl)methyl]phenol
|
|
C16H14O2 |
详情 |
详情
|
(VI) |
56243 |
2,6-diiodo-4-[(2-methyl-1-benzofuran-3-yl)methyl]phenol
|
|
C16H12I2O2 |
详情 |
详情
|
(VII) |
16640 |
Ethyl 2-bromoacetate; Ethyl bromoacetate
|
105-36-2 |
C4H7BrO2 |
详情 | 详情
|
(VIII) |
56244 |
ethyl 2-{2,6-diiodo-4-[(2-methyl-1-benzofuran-3-yl)methyl]phenoxy}acetate
|
|
C20H18I2O4 |
详情 |
详情
|
合成路线19
该中间体在本合成路线中的序号:
(V) Condensation of salicylaldehyde (I) with 2-bromoacetophenone (II) produced benzofuranyl phenyl ketone (III), which was reduced to 2-benzyl benzofuran (IV) under Wolff-Kishner conditions. Subsequent Friedel-Crafts acylation of (IV) with anisoyl chloride (V) employing SnCl4 afforded ketone (VI). Methyl ether cleavage in (VI) with concomitant intramolecular cyclization, followed by dehydration by means of BBr3 gave rise to benzo naphthofuran (VII). This was brominated in AcOH to yield tribromo derivative (VIII). Mitsunobu coupling of (VIII) with (S)-methyl-2-hydroxy-3-phenylpropionate (IX) furnished ether (X). Finally, the methyl ester group of (X) was hydrolyzed with KOH.
![](http://zy.yaozh.com/wmf/sch/27/27999201a.jpg)
【1】
Dietrich, A.; Katz, A.; Sullivan, D.; Wrobel, J.; Sawicki, D.R.; Tio, C.; Li, Z.; Seestaller, L.; Wu, L.; Zhang, Z.-Y.; Sredy, J.; Moxham, C.; PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphto[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes. J Med Chem 1999, 42, 17, 3199-3202. |
【2】
Dietrich, A.J.; Wrobel, J.E.; Li, Z. (American Home Products Corp.); 11-Aryl-benzo[b]naphtho[2,3-d]furans and 11-aryl-benzo[b]naphtho[2,3-d]thiophenes useful in the treatment of insulin resistance and hyperglycemia. WO 9958521 .
|
中间体序号 |
中间体编号 |
品名 |
CAS号 |
分子式 |
供应商 |
用于合成 |
(I) |
21351 |
2-Hydroxybenzaldehyde;Salicylic aldehyde;2-Formylphenol;salicylaldehyde |
90-02-8 |
C7H6O2 |
详情 | 详情
|
(II) |
10315 |
2-Bromo-1-phenyl-ethanone; 2-Bromo-1-phenyl-1-ethanone
|
70-11-1 |
C8H7BrO |
详情 | 详情
|
(III) |
33663 |
1-benzofuran-2-yl(phenyl)methanone
|
|
C15H10O2 |
详情 |
详情
|
(IV) |
33664 |
2-benzyl-1-benzofuran
|
|
C15H12O |
详情 |
详情
|
(V) |
22671 |
4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride
|
100-07-2 |
C8H7ClO2 |
详情 | 详情
|
(VI) |
33665 |
(2-benzyl-1-benzofuran-3-yl)(4-methoxyphenyl)methanone
|
|
C23H18O3 |
详情 |
详情
|
(VII) |
33666 |
4-naphtho[2,3-b][1]benzofuran-11-ylphenol
|
|
C22H14O2 |
详情 |
详情
|
(VIII) |
33667 |
2,6-dibromo-4-(6-bromonaphtho[2,3-b][1]benzofuran-11-yl)phenol
|
|
C22H11Br3O2 |
详情 |
详情
|
(IX) |
13878 |
methyl (2R)-2-hydroxy-3-phenylpropanoate
|
|
C10H12O3 |
详情 |
详情
|
(X) |
33668 |
methyl (2R)-2-[2,6-dibromo-4-(6-bromonaphtho[2,3-b][1]benzofuran-11-yl)phenoxy]-3-phenylpropanoate
|
|
C32H21Br3O4 |
详情 |
详情
|
合成路线20
该中间体在本合成路线中的序号:
(X) Treatment of salicylaldehyde (I) with methyl chloroacetate (II) in DMF in the presence of potassium carbonate provides methyl o-formylphenoxyacetate (III), which is converted into methyl 2-benzofuranecarboxylate (IV) by reaction with DBU in toluene. Reduction of (IV) by means of LiAlH4 in ether yields hydroxy derivative (V), which then reacts with SOCl2 in ether/DMF to furnish chloro derivative (VI). Treatment of (VI) with NaCN in DMSO affords cyano derivative (VII), which is converted into 2-benzofuraneacetic acid (VIII) by treatment with NaOH in boiling water. Esterification of (VIII) by treatment with HCl in refluxing MeOH affords methyl acetate derivative (IX), which is condensed with p-anisoyl chloride (X) by means of SnCl4 in 1,2-dichloroethane to yield compound (XI). Treatment of (XI) with aluminum powder and iodine crystals (to generate AlI3) in refluxing benzene gives acetic acid derivative (XII), which is iodinated with iodine and K2CO3 in H2O to give derivative (XIII). Esterification of (XIII) by means of iPrOH and H2SO4 provides isopropyl acetate derivative (XIV), which is finally converted into the desired product by reaction with diethylaminoethyl chloride (XV) in NaOH and CH2Cl2 in the presence of benzyltriethylammonium chloride.
![](http://zy.yaozh.com/wmf/sch/28/28261701a.jpg)
【1】
Druzgala, P. (ARYx Therapeutics, Inc.); Benzoylbenzofurane derivs. for treatment of cardiac arrhythmia. EP 0703910; JP 1996511546; US 5364880; WO 9429289 .
|
【2】
Druzgala, P. (ARYx Therapeutics, Inc.); Cpd. for treatment of cardiac arrhythmia, synthesis, and methods of use. US 5849788 .
|
【3】
Druzgala, P. (ARYx Therapeutics, Inc.); Cpd. for treatment of cardiac arrhythmia, synthesis, and methods of use. US 6130240 .
|
中间体序号 |
中间体编号 |
品名 |
CAS号 |
分子式 |
供应商 |
用于合成 |
(I) |
21351 |
2-Hydroxybenzaldehyde;Salicylic aldehyde;2-Formylphenol;salicylaldehyde |
90-02-8 |
C7H6O2 |
详情 | 详情
|
(II) |
10257 |
methyl 2-chloroacetate; methyl chloroacetate
|
96-34-4 |
C3H5ClO2 |
详情 | 详情
|
(III) |
49708 |
methyl 2-(2-formylphenoxy)acetate
|
|
C10H10O4 |
详情 |
详情
|
(IV) |
49709 |
methyl 1-benzofuran-2-carboxylate
|
|
C10H8O3 |
详情 |
详情
|
(V) |
38335 |
1-benzofuran-2-ylmethanol
|
|
C9H8O2 |
详情 |
详情
|
(VI) |
49710 |
2-(chloromethyl)-1-benzofuran
|
|
C9H7ClO |
详情 |
详情
|
(VII) |
38336 |
2-(1-benzofuran-2-yl)acetonitrile
|
|
C10H7NO |
详情 |
详情
|
(VIII) |
49711 |
2-(1-benzofuran-2-yl)acetic acid
|
|
C10H8O3 |
详情 |
详情
|
(IX) |
49712 |
methyl 2-(1-benzofuran-2-yl)acetate
|
|
C11H10O3 |
详情 |
详情
|
(X) |
22671 |
4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride
|
100-07-2 |
C8H7ClO2 |
详情 | 详情
|
(XI) |
49713 |
methyl 2-[3-(4-methoxybenzoyl)-1-benzofuran-2-yl]acetate
|
|
C19H16O5 |
详情 |
详情
|
(XII) |
49714 |
2-[3-(4-hydroxybenzoyl)-1-benzofuran-2-yl]acetic acid
|
|
C17H12O5 |
详情 |
详情
|
(XIII) |
49715 |
2-[3-(4-hydroxy-3,5-diiodobenzoyl)-1-benzofuran-2-yl]acetic acid
|
|
C17H10I2O5 |
详情 |
详情
|
(XIV) |
49716 |
isopropyl 2-[3-(4-hydroxy-3,5-diiodobenzoyl)-1-benzofuran-2-yl]acetate
|
|
C20H16I2O5 |
详情 |
详情
|
(XV) |
16194 |
2-chloro-N,N-diethyl-1-ethanamine; N-(2-chloroethyl)-N,N-diethylamine
|
100-35-6 |
C6H14ClN |
详情 | 详情
|
合成路线21
该中间体在本合成路线中的序号:
(VI) Oxidation of 2,3-dimethylfuran (I) under Vilsmeier conditions with POCl3 in DMF affords aldehyde (II), which is then condensed with benzothiophene (III) by means of n-BuLi in THF to provide secondary alcohol (IV). Reduction of (IV) under Nutaitis conditions with NaBH4 and TFA in THF yields methylene congener (V), which is then treated with p-anisoyl chloride (VI) under Friedel-Crafts conditions with SnCl4 in CS2 to give 1-oxa-9-thiacyclopenta[b]fluorene heterocycle (VII). Demethylation of methyl ether (VII) with BBr3 in CH2Cl2 affords phenol (VIII), which is then bis-iodinated with molecular iodine and NaOH in MeOH to yield di-iodo phenol (IX). Compound (IX) is then condensed with (S)-2-hydroxy-3-phenylpropionic acid (X) under Mitsunobu conditions with DEAD and PPh3 in benzene to furnish (R)-2-benzyl-acetic acid derivative (XI), which is finally hydrolyzed by treatment with KOH in H2O/dioxane to provide the desired product.
![](http://zy.yaozh.com/wmf/sch/28/28908701a.jpg)
【1】
Sredy, j.; Seesteller, L.; Li, Z.; Sawicki, D.R.; Wrobel, J.; Sullivan, D.; Synthesis and PTP1B inhibition of novel 4-aryl-1-oxa-9-thiacyclopenta[b]fluorenes. Bioorg Med Chem Lett 2000, 10, 14, 1535.
|
【2】
Li, Z.; Wrobel, J.E. (American Home Products Corp.); 4-Aryl-1-oxa-9-thia-cyclopenta[b]fluorenes. US 6057316 .
|
中间体序号 |
中间体编号 |
品名 |
CAS号 |
分子式 |
供应商 |
用于合成 |
(I) |
48451 |
2,3-Dimethylfuran
|
14920-89-9 |
C6H8O |
详情 | 详情
|
(II) |
48452 |
4,5-Dimethyl-2-furaldehyde; 4,5-Dimethylfurfural
|
|
C7H8O2 |
详情 |
详情
|
(III) |
25578 |
1-benzothiophene
|
95-15-8 |
C8H6S |
详情 | 详情
|
(IV) |
48453 |
1-benzothiophen-2-yl(4,5-dimethyl-2-furyl)methanol
|
|
C15H14O2S |
详情 |
详情
|
(V) |
48454 |
5-(1-benzothiophen-2-ylmethyl)-2,3-dimethylfuran
|
|
C15H14OS |
详情 |
详情
|
(VI) |
22671 |
4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride
|
100-07-2 |
C8H7ClO2 |
详情 | 详情
|
(VII) |
48455 |
4-(2,3-dimethyl[1]benzothieno[3,2-f][1]benzofuran-4-yl)phenyl methyl ether; 4-(4-methoxyphenyl)-2,3-dimethyl[1]benzothieno[3,2-f][1]benzofuran
|
|
C23H18O2S |
详情 |
详情
|
(VIII) |
48456 |
4-(2,3-dimethyl[1]benzothieno[3,2-f][1]benzofuran-4-yl)phenol
|
|
C22H16O2S |
详情 |
详情
|
(IX) |
48457 |
4-(2,3-dimethyl[1]benzothieno[3,2-f][1]benzofuran-4-yl)-2,6-diiodophenol
|
|
C22H14I2O2S |
详情 |
详情
|
(X) |
39252 |
methyl (2S)-2-hydroxy-3-phenylpropanoate
|
|
C10H12O3 |
详情 |
详情
|
(XI) |
48458 |
methyl (2R)-2-[4-(2,3-dimethyl[1]benzothieno[3,2-f][1]benzofuran-4-yl)-2,6-diiodophenoxy]-3-phenylpropanoate
|
|
C32H24I2O4S |
详情 |
详情
|
合成路线22
该中间体在本合成路线中的序号:
(IV) Ring opening of the chiral epoxide (I) with 2-aminoethanol gave the trans-aminoalcohol (II). Subsequent intramolecular cyclization of (II) under Mitsunobu conditions afforded the chromenooxazine tricyclic system (III). The NH group of (III) was then acylated with anisoyl chloride (IV), yielding amide (V). This compound underwent epimerization at the C-10b position upon treatment with NaH to produce the more stable cis-fused isomer (VI). The methyl ether group of (VI) was finally cleaved by treatment with boron tribromide to furnish the corresponding phenol.
![](http://zy.yaozh.com/wmf/sch/30/30068001a.jpg)
【1】
Lin, Y.-C.; Tsai, M.-C.; Chiu, H.-I.; Yu, H.-C.; Cheng, C.-Y.; N-acyl-1,2,3,4a,5,10b-hexahydro-[1]benzopyrano-[3,4-b][1,4]oxazine-9-carbonitriles as bladder-selective potassium channel openers. Bioorg Med Chem 2001, 9, 2, 383.
|
中间体序号 |
中间体编号 |
品名 |
CAS号 |
分子式 |
供应商 |
用于合成 |
(I) |
48196 |
(1aR,7bR)-2,2-dimethyl-1a,7b-dihydro-2H-oxireno[2,3-c]chromene-6-carbonitrile
|
|
C12H11NO2 |
详情 |
详情
|
(II) |
48192 |
(3R,4S)-3-hydroxy-4-[(2-hydroxyethyl)amino]-2,2-dimethyl-3,4-dihydro-2H-chromene-6-carbonitrile
|
|
C14H18N2O3 |
详情 |
详情
|
(III) |
48193 |
(4aR,10bS)-5,5-dimethyl-1,2,3,4a,5,10b-hexahydrochromeno[3,4-b][1,4]oxazine-9-carbonitrile
|
|
C14H16N2O2 |
详情 |
详情
|
(IV) |
22671 |
4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride
|
100-07-2 |
C8H7ClO2 |
详情 | 详情
|
(V) |
48194 |
(4aR,10bS)-1-(4-methoxybenzoyl)-5,5-dimethyl-1,2,3,4a,5,10b-hexahydrochromeno[3,4-b][1,4]oxazine-9-carbonitrile
|
|
C22H22N2O4 |
详情 |
详情
|
(VI) |
48195 |
(4aR,10bR)-1-(4-methoxybenzoyl)-5,5-dimethyl-1,2,3,4a,5,10b-hexahydrochromeno[3,4-b][1,4]oxazine-9-carbonitrile
|
|
C22H22N2O4 |
详情 |
详情
|