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【结 构 式】 
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【分子编号】28606 【品名】2-methylbenzonitrile 【CA登记号】529-19-1 |
【 分 子 式 】C8H7N 【 分 子 量 】117.15032 【元素组成】C 82.02% H 6.02% N 11.96% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The cyclization of 2-methylbenzonitrile (I) with pyridine-2-carbonitrile (II) by means of potassium amide in liquid NH3 gives 3-(2-pyridyl)isoquinoline-1-amine (III), which is finally acylated with 4-methoxybenzoyl chloride (IV) by means of butyllithium in THF.
| 【1】 de Zwart, M.A.H.; van der Goot, H.; de Zwart, H.; Timmerman, H.; Synthesis and copper-dependent antimycoplasmal activity of 1-amino-3-(2-pyridyl)isoquinoline derivatives. 1. Amides. J Med Chem 1988, 31, 4, 716. |
| 【2】 van Muijlwijk-Koezen, J.E.; Timmerman, H.; Link, R.; van der Goot, H.; Ijzerman, A.P.; A novel class of adenosine A3 receptor ligands. 2. Structure affinity profile of a series of isoquinoline and quinazoline compounds. J Med Chem 1998, 41, 21, 3994. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 28606 | 2-methylbenzonitrile | 529-19-1 | C8H7N | 详情 | 详情 |
| (II) | 28607 | 2-pyridinecarbonitrile | 100-70-9 | C6H4N2 | 详情 | 详情 |
| (III) | 28608 | 3-(2-pyridinyl)-1-isoquinolinamine | C14H11N3 | 详情 | 详情 | |
| (IV) | 22671 | 4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride | 100-07-2 | C8H7ClO2 | 详情 | 详情 |
Extended Information