3-(2-pyridinyl)-1-isoquinolinamine -Drug Synthesis Database

【结构式】

【分子编号】28608

【品名】3-(2-pyridinyl)-1-isoquinolinamine

【CA登记号】

【分子式】C₁₄H₁₁N₃

【分子量】221.26156

【元素组成】C 76% H 5.01% N 18.99%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The cyclization of 2-methylbenzonitrile (I) with pyridine-2-carbonitrile (II) by means of potassium amide in liquid NH3 gives 3-(2-pyridyl)isoquinoline-1-amine (III), which is finally acylated with 4-methoxybenzoyl chloride (IV) by means of butyllithium in THF.

参考文献中间体

合成目标

【1】 de Zwart, M.A.H.; van der Goot, H.; de Zwart, H.; Timmerman, H.; Synthesis and copper-dependent antimycoplasmal activity of 1-amino-3-(2-pyridyl)isoquinoline derivatives. 1. Amides. J Med Chem 1988, 31, 4, 716.
【2】 van Muijlwijk-Koezen, J.E.; Timmerman, H.; Link, R.; van der Goot, H.; Ijzerman, A.P.; A novel class of adenosine A3 receptor ligands. 2. Structure affinity profile of a series of isoquinoline and quinazoline compounds. J Med Chem 1998, 41, 21, 3994.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	28606	2-methylbenzonitrile	529-19-1	C₈H₇N	详情	详情
(II)	28607	2-pyridinecarbonitrile	100-70-9	C₆H₄N₂	详情	详情
(III)	28608	3-(2-pyridinyl)-1-isoquinolinamine		C₁₄H₁₁N₃	详情	详情
(IV)	22671	4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride	100-07-2	C₈H₇ClO₂	详情	详情

Extended Information