【结 构 式】 |
【药物名称】VUF-8504 【化学名称】4-Methoxy-N-[3-(2-pyridinyl)-1-isoquinolinyl]benzamide 【CA登记号】 【 分 子 式 】C22H17N3O2 【 分 子 量 】355.39969 |
【开发单位】Vrije Universiteit, Amsterdam (NL) 【药理作用】PHARMACOLOGICAL TOOLS |
合成路线1
The cyclization of 2-methylbenzonitrile (I) with pyridine-2-carbonitrile (II) by means of potassium amide in liquid NH3 gives 3-(2-pyridyl)isoquinoline-1-amine (III), which is finally acylated with 4-methoxybenzoyl chloride (IV) by means of butyllithium in THF.
【1】 de Zwart, M.A.H.; van der Goot, H.; de Zwart, H.; Timmerman, H.; Synthesis and copper-dependent antimycoplasmal activity of 1-amino-3-(2-pyridyl)isoquinoline derivatives. 1. Amides. J Med Chem 1988, 31, 4, 716. |
【2】 van Muijlwijk-Koezen, J.E.; Timmerman, H.; Link, R.; van der Goot, H.; Ijzerman, A.P.; A novel class of adenosine A3 receptor ligands. 2. Structure affinity profile of a series of isoquinoline and quinazoline compounds. J Med Chem 1998, 41, 21, 3994. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 28606 | 2-methylbenzonitrile | 529-19-1 | C8H7N | 详情 | 详情 |
(II) | 28607 | 2-pyridinecarbonitrile | 100-70-9 | C6H4N2 | 详情 | 详情 |
(III) | 28608 | 3-(2-pyridinyl)-1-isoquinolinamine | C14H11N3 | 详情 | 详情 | |
(IV) | 22671 | 4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride | 100-07-2 | C8H7ClO2 | 详情 | 详情 |
Extended Information