|
【结 构 式】 
|
【分子编号】29101 【品名】4-methoxy-N-[2-[2-(2-pyridinyl)acetyl]phenyl]benzamide 【CA登记号】 |
【 分 子 式 】C21H18N2O3 【 分 子 量 】346.3856 【元素组成】C 72.82% H 5.24% N 8.09% O 13.86% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)A new method for the synthesis of encainide has been reported: The acylation of methyl anthranilate (I) with 4-anisoyl chloride (II) by means of NaOH in methylene chloride gives methyl N-(p-anisoyl)anthranilate (III), which is condensed with 2-picoline (IV) by means of n-butyllithium in THF yielding 2-(2-pyridylacetyl)-p-anisanilide (V). Finally, this compound is reduced with H2 over Pt/C then with Pd/C, treated with formaldehyde and reduced again with H2 over Pt/C.
| 【1】 Madding, G.D. (Bristol-Myers Squibb Co.); Process for production of encainide. JP 58105963; NL 8204775; US 4394507 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11161 | methyl 2-aminobenzoate; Methyl anthranilate | 134-20-3 | C8H9NO2 | 详情 | 详情 |
| (II) | 22671 | 4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride | 100-07-2 | C8H7ClO2 | 详情 | 详情 |
| (III) | 29100 | methyl 2-[(4-methoxybenzoyl)amino]benzoate | C16H15NO4 | 详情 | 详情 | |
| (IV) | 17590 | 2-methylpyridine; 2-picoline | 109-06-8 | C6H7N | 详情 | 详情 |
| (V) | 29101 | 4-methoxy-N-[2-[2-(2-pyridinyl)acetyl]phenyl]benzamide | C21H18N2O3 | 详情 | 详情 |
Extended Information