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【结 构 式】 
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【分子编号】29096 【品名】Chloro(trimethyl)silane; Trimethylsilyl chloride; Trimethylchlorosilane 【CA登记号】75-77-4 |
【 分 子 式 】C3H9ClSi 【 分 子 量 】108.64266 【元素组成】C 33.17% H 8.35% Cl 32.63% Si 25.85% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(II)The silylation of 4-acetoxy-2-pyrrolidone (I) with trimethylchlorosilane (II) by means of triethyl amine in THF gives the corresponding N-trimethylsilyl derivative (III), which is condensed with 4-methoxybenzoyl chloride (IV) by means of NaHCO3 in THF yielding 1-(4-methoxybenzoyl)pyrrolin-2-one (V). Finally, this compound is reduced with H2 over Pd/C in ethyl acetate.
| 【1】 Kyburz, E.; Aschwanden, W. (F. Hoffmann-La Roche AG); 1-(p-Methoxy-p-hydroxy, and p-benzyloxybenzoyl)-2-pyrrolidinones. DD 141828; EP 0005143; EP 0044088; ES 477587; ES 483756; JP 54117468 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 29095 | 4-Acetoxy-2-pyrrolidone; 5-Oxo-3-pyrrolidinyl acetate | C6H9NO3 | 详情 | 详情 | |
| (II) | 29096 | Chloro(trimethyl)silane; Trimethylsilyl chloride; Trimethylchlorosilane | 75-77-4 | C3H9ClSi | 详情 | 详情 |
| (III) | 29097 | 5-oxo-1-(trimethylsilyl)-3-pyrrolidinyl acetate | C9H17NO3Si | 详情 | 详情 | |
| (IV) | 22671 | 4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride | 100-07-2 | C8H7ClO2 | 详情 | 详情 |
| (V) | 29098 | 1-(4-methoxybenzoyl)-1,5-dihydro-2H-pyrrol-2-one | C12H11NO3 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(I)
| 【1】 Zan LB, Yang YY, Liu NJ, et al. 2007. Synthesis of N-[[3-(trimethylsilyl) phenyl] methyl]guanidine as precursor for carrier-free [3-(iodo-125I) phenyl] guanidine. Yuanzineng Kexue Jishu, 4(6):689～693. |
| 【2】 Amarteya JK, A1-Jammaza I, Lambrecht RM. 2001. An efficient batch preparation of high specific activity [123I] and [124I] mIBG. Applied Radiation and Isotop, 54(5): 711～714. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 29096 | Chloro(trimethyl)silane; Trimethylsilyl chloride; Trimethylchlorosilane | 75-77-4 | C3H9ClSi | 详情 | 详情 |
| (II) | 67158 | 3-Bromotoluene;1-Bromo-3-methylbenzene | 591-17-3 | C7H7Br | 详情 | 详情 |
| (III) | 67159 | trimethyl(m-tolyl)silane | C10H16Si | 详情 | 详情 | |
| (IV) | 67160 | 1-bromopyrrolidine-2,5-dione | 128-08-5 | C4H4BrNO2 | 详情 | 详情 |
| (V) | 67161 | (3-(bromomethyl)phenyl)trimethylsilane | C10H15BrSi | 详情 | 详情 | |
| (VI) | 12376 | Phthalimide; 1H-Isoindole-1,3(2H)-dione; Isoindole-1,3-dione;Phthalic dicarboximide;Phenylimide;Isoindole-1,3-dione | 85-41-6 | C8H5NO2 | 详情 | 详情 |
| (VII) | 67162 | 2-(3-(trimethylsilyl)benzyl)isoindoline-1,3-dione | C18H19NO2Si | 详情 | 详情 | |
| (VIII) | 67163 | (3-(trimethylsilyl)phenyl)methanamine | C10H17NSi | 详情 | 详情 | |
| (IX) | 67164 | 1-(3-(trimethylsilyl)benzyl)guanidine | C11H19N3Si | 详情 | 详情 | |
| (X) | 41075 | N-(3-iodobenzyl)guanidine | 80663-95-2 | C8H10IN3 | 详情 | 详情 |
Extended Information