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【结 构 式】 
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【分子编号】29095 【品名】4-Acetoxy-2-pyrrolidone; 5-Oxo-3-pyrrolidinyl acetate 【CA登记号】 |
【 分 子 式 】C6H9NO3 【 分 子 量 】143.1424 【元素组成】C 50.35% H 6.34% N 9.79% O 33.53% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The silylation of 4-acetoxy-2-pyrrolidone (I) with trimethylchlorosilane (II) by means of triethyl amine in THF gives the corresponding N-trimethylsilyl derivative (III), which is condensed with 4-methoxybenzoyl chloride (IV) by means of NaHCO3 in THF yielding 1-(4-methoxybenzoyl)pyrrolin-2-one (V). Finally, this compound is reduced with H2 over Pd/C in ethyl acetate.
| 【1】 Kyburz, E.; Aschwanden, W. (F. Hoffmann-La Roche AG); 1-(p-Methoxy-p-hydroxy, and p-benzyloxybenzoyl)-2-pyrrolidinones. DD 141828; EP 0005143; EP 0044088; ES 477587; ES 483756; JP 54117468 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 29095 | 4-Acetoxy-2-pyrrolidone; 5-Oxo-3-pyrrolidinyl acetate | C6H9NO3 | 详情 | 详情 | |
| (II) | 29096 | Chloro(trimethyl)silane; Trimethylsilyl chloride; Trimethylchlorosilane | 75-77-4 | C3H9ClSi | 详情 | 详情 |
| (III) | 29097 | 5-oxo-1-(trimethylsilyl)-3-pyrrolidinyl acetate | C9H17NO3Si | 详情 | 详情 | |
| (IV) | 22671 | 4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride | 100-07-2 | C8H7ClO2 | 详情 | 详情 |
| (V) | 29098 | 1-(4-methoxybenzoyl)-1,5-dihydro-2H-pyrrol-2-one | C12H11NO3 | 详情 | 详情 |
Extended Information