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【结 构 式】 
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【分子编号】29831 【品名】benzyl 3-[1-(4-methoxybenzoyl)-5-oxo-2-pyrrolidinyl]propanoate 【CA登记号】 |
【 分 子 式 】C22H23NO5 【 分 子 量 】381.42836 【元素组成】C 69.28% H 6.08% N 3.67% O 20.97% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)The partial hydrolysis of perhydropyrrolizine-3,5-dione (I) in the presence of benzyl alcohol (II) by means of aqueous concentrated HCl at 98 C gives benzyl 5-oxopyrrolidine-2-propenoate (III), which is condensed with 4-methoxybenzoyl chloride (IV) by means of triethylamine in hot THF to afford benzyl 1-(4-methoxybenzoyl)-5-oxopyrrolidine-3-propanoate (V). Finally, this compound ls debenzylated by hydrogenolysis with H2 over Pd/C in THF.
| 【1】 (Pfizer Inc.); 1-Aroyl-5-oxo-2-pyrrolidinepropanoic acid derivs.. EP 0110575; ES 8600238 . |
| 【2】 Castaner, J.; Serradell, M.N.; CI-933. Drugs Fut 1985, 10, 12, 972. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 29829 | dihydro-1H-pyrrolizine-3,5(2H,6H)-dione | C7H9NO2 | 详情 | 详情 | |
| (II) | 18710 | Benzyl alcohol; Phenylmethanol | 100-51-6 | C7H8O | 详情 | 详情 |
| (III) | 29830 | benzyl 3-(5-oxo-2-pyrrolidinyl)propanoate | C14H17NO3 | 详情 | 详情 | |
| (IV) | 22671 | 4-Methoxybenzoyl chloride; p-Methoxybenzoyl chloride; 4-Anisoyl chloride | 100-07-2 | C8H7ClO2 | 详情 | 详情 |
| (V) | 29831 | benzyl 3-[1-(4-methoxybenzoyl)-5-oxo-2-pyrrolidinyl]propanoate | C22H23NO5 | 详情 | 详情 |
Extended Information