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【结 构 式】 
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【分子编号】29262 【品名】acetohydrazide 【CA登记号】1068-57-1 |
【 分 子 式 】C2H6N2O 【 分 子 量 】74.08252 【元素组成】C 32.43% H 8.16% N 37.81% O 21.6% |
合成路线1
该中间体在本合成路线中的序号：(IX)The reaction of 3-trifluoromethylbenzaldehyde (I) with morpholine (II) and potassium cyanide by means of p-toluenesulfonic acid in refluxing THF gives alpha-(3-trifluoromethylphenyl)-4-morpholineacetonitrile (III), which is condensed with ethyl acrylate (IV) by means of KOH in THF yielding gamma-cyano-gamma-(3-trifluoromethylphenyl)-4-morpholinebutyric acid ethyl ester (V). The cyclization of (V) with hydrazine in refluxing ethanol affords 4,5-dihydro-6-(3-trifluoromethylphenyl)-3(2H)-pyridazinone (VI), which is dehydrogenated by treatment with Br2 in hot acetic acid to give 6-(3-trifluoromethylphenyl)-3(2H)-pyridazinone (VII). The reaction of (VII) with POCl3 at 100 C affords 3-chloro-6-(3-trifluoromethylphenyl)pyridazine (VIII), which is finally cyclized with acetylhydrazine (IX) in refluxing n-butanol.
| 【1】 Allen, G.R. Jr.; Hanifin, J.W. Jr.; Moran, D.B.; Albright, J.D.; 6-Phenyl-1,2,4-triazolo{8 4,3-b{9 pyridazine hypotensive agents. US 4112095 . |
| 【2】 Albright, J.D.; et al.; Synthesis and anxiolytic activity of 6-(substituted-phenyl)-1,2,4-triazolo[4,3-b]pyridazines. J Med Chem 1981, 24, 5, 592-600. |
| 【3】 Owen, R.T.; Serradell, M.N.; Blancafort, P.; Castaner, J.; CL-218,872. Drugs Fut 1983, 8, 3, 191. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 35964 | 3-(trifluoromethyl)benzaldehyde | 454-89-7 | C8H5F3O | 详情 | 详情 |
| (II) | 10388 | Morpholine | 110-91-8 | C4H9NO | 详情 | 详情 |
| (III) | 35965 | 2-(4-morpholinyl)-2-[3-(trifluoromethyl)phenyl]acetonitrile | C13H13F3N2O | 详情 | 详情 | |
| (IV) | 10164 | ethyl acrylate | 140-88-5 | C5H8O2 | 详情 | 详情 |
| (V) | 35966 | ethyl 4-cyano-4-(4-morpholinyl)-4-[3-(trifluoromethyl)phenyl]butanoate | C18H21F3N2O3 | 详情 | 详情 | |
| (VI) | 35937 | 3-amino-6-chloro-4-phenyl-3,4-dihydro-4-quinazolinol | C14H12ClN3O | 详情 | 详情 | |
| (VII) | 35968 | 6-[3-(trifluoromethyl)phenyl]-3(2H)-pyridazinone | C11H7F3N2O | 详情 | 详情 | |
| (VIII) | 35969 | 3-chloro-6-[3-(trifluoromethyl)phenyl]pyridazine | C11H6ClF3N2 | 详情 | 详情 | |
| (IX) | 29262 | acetohydrazide | 1068-57-1 | C2H6N2O | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(B)Compound can be prepared in three different related ways: 1) The reaction of 5-(o-clorophenyl)-7-ethyl-3H-thieno[2,3-e]-1,4-diazepine-2-one (I) with P2S5 in pyridine at 80 C gives the corresponding thioketone (II), which by reaction with hydrazine hydrate (A) in methanol yields 2-hydrazino-5-(o-chlorophenyl)-7-ethyl-3H-thieno[2,3-e]-1,4-diazepine (III). Finally, this compound is cyclized with acetic anhydride acetic acid in refluxing benzene. This cyclization can also be carried out with refluxing ethyl orthoacetate (E) and H2SO4, with acetimino ethyl ether (G) in refluxing chloroform, with acetamidine hydrochloride (C) and 2-methylimidazole (D) at 160 C or thioacetamide (F) and H2SO4 at 190 C. 2) The condensation of thioketone (II) with acetohydrazide (B) in refluxing chloroform gives 2-acetylhydrazino-5-(o-chlorophenyl)-7-ethyl-3H-thieno[2,3-e]-1,4-diazepine (IV), which is then cyclized with acetic acid in refluxing benzene or by heating at 205 C. 3) The acetylated compound (IV) can also be obtained by acetylation of (III) with acetic anhydride and triethylamine at room temperature.
| 【1】 Nakanishi, M.; et al.; ZA 7204610 . |
| 【2】 Thorpe, P.J.; Castaner, J.; Etizolam. Drugs Fut 1979, 4, 1, 22. |
| 【3】 Nakanishi, M.; et al.; US 3904641 . |
| 【4】 Tahara, T.; et al.; Syntheses and structure-activity relationship pf 6-aryl-4H-s-triazolo[3,4-c]thieno[2,3-e](1,4)diazepines. Arzneim-Forsch Drug Res 1978, 28, 7, 1153-58. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (G) | 12831 | ethyl ethanimidoate | 1000-84-6 | C4H9NO | 详情 | 详情 |
| (D) | 15670 | 2-Methylimidazole; 2-Methyl-1H-imidazole | 693-98-1 | C4H6N2 | 详情 | 详情 |
| (F) | 19170 | ethanethioamide | 62-55-5 | C2H5NS | 详情 | 详情 |
| (A) | 27344 | hydrazine | 302-01-2 | H4N2 | 详情 | 详情 |
| (B) | 29262 | acetohydrazide | 1068-57-1 | C2H6N2O | 详情 | 详情 |
| (E) | 39465 | 1-ethoxy-1,1-ethanediol | C4H10O3 | 详情 | 详情 | |
| (I) | 39461 | 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-2H-thieno[2,3-e][1,4]diazepin-2-one | C15H13ClN2OS | 详情 | 详情 | |
| (II) | 39462 | 5-(2-chlorophenyl)-7-ethyl-1,3,5a,8a-tetrahydro-2H-thieno[2,3-e][1,4]diazepine-2-thione | C15H15ClN2S2 | 详情 | 详情 | |
| (III) | 39463 | 5-(2-chlorophenyl)-7-ethyl-2-hydrazino-3H-thieno[2,3-e][1,4]diazepine | C15H15ClN4S | 详情 | 详情 | |
| (IV) | 39464 | N'-[5-(2-chlorophenyl)-7-ethyl-3H-thieno[2,3-e][1,4]diazepin-2-yl]acetohydrazide | C17H17ClN4OS | 详情 | 详情 | |
| (C) | 15866 | ethanimidamide | C2H6N2 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(A)By cyclization of 2-glycylamino-2',5-dichlorobenzenophenone (I) in pyridine to give 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one (II), which was refluxed with P2S5 in pyridine yielding 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-thione (III). Finally, this product was condensed with acetylhydrazide (A) in butanol.
| 【1】 Sternbach, L.H.; 1,4-Benzodiazepines. Chemistry and some aspects of the structure activity relationship. Angew Chem 1971, 10, 34-43. |
| 【2】 Hester, J.B. Jr.; 6-Phenyl-4H-S-triazolo[4,3-a][1,4]benzodiazepines. DE 2012190; FR 2034999; GB 1291631; US 3987052 . |
| 【3】 Castaner, J.; Chatterjee, S.S.; Triazolam. Drugs Fut 1976, 1, 8, 393. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 29262 | acetohydrazide | 1068-57-1 | C2H6N2O | 详情 | 详情 |
| (I) | 34116 | 2-amino-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide | C15H12Cl2N2O2 | 详情 | 详情 | |
| (II) | 34117 | 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one | C15H10Cl2N2O | 详情 | 详情 | |
| (III) | 34118 | 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-thione | C15H10Cl2N2S | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(B)The reaction of 7-chloro-5-phenyl-1,3-dihydro-3H-1,4-benzodiazepine-2-thione (VIII) with acetylhydrazine (B) in refluxing anhydrous ethanol gives 7-chloro-5-phenyl-2-(2-acetylhydrazino)-1,3-dihydro-3H-1,4-benzodiazepine (IX), which is cyclized by heating at 250 C.
| 【1】 Hester, J.B. Jr.; 6-Phenyl-4H-S-triazolo[4,3-a][1,4]benzodiazepines. DE 2012190; DE 2065893; ES 376689; FR 2034999; GB 1291631; US 3987052 . |
| 【2】 Castaner, J.; Chatterjee, S.S.; Alprazolam. Drugs Fut 1976, 1, 12, 551. |
合成路线5
该中间体在本合成路线中的序号：(VII)A scaleable process to produce vorozole has been reported: The reaction of 2,4-dichloronitrobenzene (I) with methylamine gives 5-chloro-N-methyl-2-nitroaniline (II), which is condensed with 4-chlorobenzonitrile (III) and oxidized with air to yield 4'-chloro-3-(methylamino)-4-nitrobenzophenone (IV). The hydrogenation of compound (IV), followed by cyclization by means of nitrous acid and reduction of the carbonyl group with NaBH4 affords the benzotriazole (V). Reaction of the OH group of (V) with SOCl2 provides the corresponding chloro derivative (VI), which is treated with acetohydrazide (VII) to give the racemic hydrazine derivative (VIII). Optical resolution of (VIII) by chiral chromatography yields the (S)-isomer (IX), which is finally cyclized with formamidine to afford vorozole.
| 【1】 De Knaep, A.G.M.; Vandendriessche, A.M.J.; Daemen, D.J.E.; et al.; Development summary towards a manufacturable process for R 83842 [(S)-6-[(4-chlorophenyl) (1H-1,2,4-triazol-1-yl)methyl]-1-methyl-1H-benzotriazole]. Org Process Res Dev 2000, 4, 3, 162. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 21787 | 2,4-dichloro-1-nitrobenzene | 611-06-3 | C6H3Cl2NO2 | 详情 | 详情 |
| (II) | 46715 | 5-chloro-N-methyl-2-nitroaniline; N-(5-chloro-2-nitrophenyl)-N-methylamine | 35966-84-8 | C7H7ClN2O2 | 详情 | 详情 |
| (III) | 27360 | 4-chlorobenzonitrile | 623-03-0 | C7H4ClN | 详情 | 详情 |
| (IV) | 46716 | (4-chlorophenyl)[3-(methylamino)-4-nitrophenyl]methanone | C14H11ClN2O3 | 详情 | 详情 | |
| (V) | 14734 | (4-chlorophenyl)(1-methyl-1H-1,2,3-benzotriazol-6-yl)methanol | C14H12ClN3O | 详情 | 详情 | |
| (VI) | 14735 | 6-[chloro(4-chlorophenyl)methyl]-1-methyl-1H-1,2,3-benzotriazole | C14H11Cl2N3 | 详情 | 详情 | |
| (VII) | 29262 | acetohydrazide | 1068-57-1 | C2H6N2O | 详情 | 详情 |
| (VIII) | 46717 | 6-[(4-chlorophenyl)(hydrazino)methyl]-1-methyl-1H-1,2,3-benzotriazole | C14H14ClN5 | 详情 | 详情 | |
| (IX) | 46718 | 6-[(S)-(4-chlorophenyl)(hydrazino)methyl]-1-methyl-1H-1,2,3-benzotriazole | C14H14ClN5 | 详情 | 详情 | |
| (X) | 15369 | Iminoformamide; Methanimidamide | 463-52-5 | CH4N2 | 详情 | 详情 |
合成路线6
该中间体在本合成路线中的序号：(VIII)The reaction of 5-bromo-1,3-benzodioxole (I) with (S)-(-)-propylene oxide (II) by means of sec-butyllithium in THF gives the (S)-isopropanol derivative (IV) (also obtained by stereoselective reduction of 1-(1,3-benzodioxol-5-yl)-2-propanone (III) with Z. rouxii ATCC 14462 in a phosphate buffer). The cyclization of (IV) with 4-nitrobenzaldehyde (V) by means of HCl in hot toluene yields the benzopyran (VI), which is oxidized with air in aqueous NaOH affording the carbinol (VII). The reaction of (VII) with acetohydrazide (VIII) and HCl in refluxing ethanol gives the acetyl hydrazone (IX), which is mesylated at the secondary OH group with methanesulfonyl chloride and TEA in dichloromethane yielding the mesylate (X). The cyclization of (X) by means of NaOH in methanol provides the nitro benzodiazepine (XI), which is finally reduced with potassium formate and Pd/C in ethanol/water.
| 【1】 Andrasi, F.; Talampanel. Drugs Fut 2001, 26, 8, 754. |
| 【2】 Anderson, B.A.; et al.; Application of a practical biocatalytic reduction to an enantioselective synthesis of the 5H-2, 3-benzodiazepine LY300164. J Am Chem Soc 1995, 117, 49, 12358. |
| 【3】 Andrasi, F.; Berzsenyi, P.; Botka, P.; Farkas, S.; Goldschmidt, K.; Hamori, T.; Korosi, J.; Moravcsik, I.; Tarnawa, I. (Gyogyszerkutato Intezet Kft.); N-Acyl-2,3-benzodiazepine derivs., pharmaceutical compsns. containing them and process for preparing same. EP 0492485; JP 1993070463; US 5519019; US 5521174; US 5536832; US 5604223; US 5639751 . |
| 【4】 Varie, D.L.; Hansen, M.M.; Anderson, B.; Vicenzi, J.T.; Zmijewski, M.J. (Eli Lilly and Company); Stereoselective process for producing dihydro-2,3-benzodiazepine derivs.. EP 0699677; US 5665878 . |
| 【5】 Zmijewski, M.J. Jr.; Varie, D.L.; Hansen, M.M.; Vicenzi, J.T.; Anderson, B.A. (Eli Lilly and Company); Physical form of dihidro-2,3-benzodiazepine deriv.. EP 0699676 . |
| 【6】 Hansen, M.M.; Vicenzi, J.T.; Groleau, E.G.; Varie, D.L.; Zmijewski, M.J.; Anderson, B.A. (Eli Lilly and Company); Crystalline form of dihydro-2,3-benzodiazepine deriv.. EP 0699678 . |
| 【7】 Anderson, B.A.; Varie, D.L.; Vicenzi, J.T.; Zmijewski, M.J.; Hansen, M.M. (Eli Lilly and Company); Stereoselective process for producing dihydro-2,3-benzodiazepine derivs.. US 5919954 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10124 | 5-Bromo-1,3-benzodioxole; 4-Bromo-1,2-(methylenedioxy)benzene | 2635-13-4 | C7H5BrO2 | 详情 | 详情 |
| (II) | 29268 | (2S)-2-methyloxirane | 16088-62-3 | C3H6O | 详情 | 详情 |
| (III) | 28466 | 1-(1,3-benzodioxol-5-yl)acetone | 4676-39-5 | C10H10O3 | 详情 | 详情 |
| (IV) | 29259 | (2S)-1-(1,3-benzodioxol-5-yl)-2-propanol | C10H12O3 | 详情 | 详情 | |
| (V) | 18184 | 4-Nitrobenzaldehyde | 555-16-8 | C7H5NO3 | 详情 | 详情 |
| (VI) | 29260 | (7S)-7-methyl-5-(4-nitrophenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isochromene | C17H15NO5 | 详情 | 详情 | |
| (VII) | 29261 | (7S)-7-methyl-5-(4-nitrophenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isochromen-5-ol | C17H15NO6 | 详情 | 详情 | |
| (VIII) | 29262 | acetohydrazide | 1068-57-1 | C2H6N2O | 详情 | 详情 |
| (IX) | 29263 | N'-[(E)-[6-[(2S)-2-hydroxypropyl]-1,3-benzodioxol-5-yl](4-nitrophenyl)methylidene]acetohydrazide | C19H19N3O6 | 详情 | 详情 | |
| (X) | 29264 | N'-[(E)-[6-((2S)-2-[[methyl(dimethylene)-lambda(6)-sulfanyl]oxy]propyl)-1,3-benzodioxol-5-yl](4-nitrophenyl)methylidene]acetohydrazide | C22H25N3O6S | 详情 | 详情 | |
| (XI) | 29265 | 1-[(8R)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-7-yl]-1-ethanone | C19H17N3O5 | 详情 | 详情 |
合成路线7
该中间体在本合成路线中的序号：Treatment of diazepinone (I) with phosphorus pentasulfide in refluxing pyridine affords diazepinethione (II). Subsequent reaction with acetyl hydrazine in refluxing n-butanol gives the intermediate acetylhydrazino compound (III), which on prolonged heating cyclizes to the desired triazolodiazepine.
| 【1】 Hellerbach, J.; Zeller, P.; Binder, D.; Hromatka, O. (F. Hoffmann-La Roche AG); Diazepine derivs.. DE 2405682; GB 1456161; US 4155913 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 29262 | acetohydrazide | 1068-57-1 | C2H6N2O | 详情 | 详情 | |
| (I) | 19204 | 5-phenyl-1,3-dihydro-2H-thieno[2,3-e][1,4]diazepin-2-one | C13H10N2OS | 详情 | 详情 | |
| (II) | 19205 | 5-phenyl-1,3-dihydro-2H-thieno[2,3-e][1,4]diazepine-2-thione | C13H10N2S2 | 详情 | 详情 | |
| (III) | 19206 | N'-(5-phenyl-3H-thieno[2,3-e][1,4]diazepin-2-yl)acetohydrazide | C15H14N4OS | 详情 | 详情 |
合成路线8
该中间体在本合成路线中的序号：(VI)Condensation of L-tyrosine methyl ester (I) with 2-benzoylcylohexanone (II) and subsequent dehydrogenation in refluxing anisole in the presence of Pd/C affords the benzophenone derivative (III), which is converted into carboxylic acid (V) by Mitsunobu reaction with heterocyclic alcohol (IV) by means of PPh3 and DEAD in THF followed by saponification of the resulting methyl ester with LiOH in THF/MeOH (1). Coupling of (V) with acetic acid hydrazide (VI) by means of HOBt/Et3N and EDC.HCl in CH2Cl2 furnishes the diacyl hydrazide (VII), which is finally converted into the desired thiadiazole derivative by treatment with Lawesson's Reagent in refluxing toluene.
| 【1】 N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel serieis of potent antihyperglycemic and antihyperlipidemic agents. J Med Chem 1998, 41, 25, 5020. |
| 【2】 Cobb, J.E.; Shearer, B.G.; Lambert, M.H. III; Milburn, M.V. (Glaxo Group Ltd.); Oxazole PPAR antagonists. WO 0117994 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 21431 | methyl (2S)-2-amino-3-(4-hydroxyphenyl)propanoate | 1080-06-4 | C10H13NO3 | 详情 | 详情 |
| (II) | 21432 | 2-benzoylcyclohexanone | 3580-38-9 | C13H14O2 | 详情 | 详情 |
| (III) | 21434 | methyl (2S)-2-(2-benzoylanilino)-3-(4-hydroxyphenyl)propanoate | C23H21NO4 | 详情 | 详情 | |
| (IV) | 19874 | 2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)-1-ethanol | C12H13NO2 | 详情 | 详情 | |
| (V) | 48285 | (2S)-2-(2-benzoylanilino)-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]propionic acid | C34H30N2O5 | 详情 | 详情 | |
| (VI) | 29262 | acetohydrazide | 1068-57-1 | C2H6N2O | 详情 | 详情 |
| (VII) | 48286 | (2S)-N'-acetyl-2-(2-benzoylanilino)-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]propanohydrazide | C36H34N4O5 | 详情 | 详情 |