7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-thione -Drug Synthesis Database

【结构式】

【分子编号】34118

【品名】7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-thione

【CA登记号】

【分子式】C₁₅H₁₀Cl₂N₂S

【分子量】321.22928

【元素组成】C 56.09% H 3.14% Cl 22.07% N 8.72% S 9.98%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

By cyclization of 2-glycylamino-2',5-dichlorobenzenophenone (I) in pyridine to give 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one (II), which was refluxed with P2S5 in pyridine yielding 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-thione (III). Finally, this product was condensed with acetylhydrazide (A) in butanol.

参考文献中间体

合成目标

【1】 Sternbach, L.H.; 1,4-Benzodiazepines. Chemistry and some aspects of the structure activity relationship. Angew Chem 1971, 10, 34-43.
【2】 Hester, J.B. Jr.; 6-Phenyl-4H-S-triazolo[4,3-a][1,4]benzodiazepines. DE 2012190; FR 2034999; GB 1291631; US 3987052 .
【3】 Castaner, J.; Chatterjee, S.S.; Triazolam. Drugs Fut 1976, 1, 8, 393.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(A)	29262	acetohydrazide	1068-57-1	C₂H₆N₂O	详情	详情
(I)	34116	2-amino-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide		C₁₅H₁₂Cl₂N₂O₂	详情	详情
(II)	34117	7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one		C₁₅H₁₀Cl₂N₂O	详情	详情
(III)	34118	7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-thione		C₁₅H₁₀Cl₂N₂S	详情	详情

Extended Information