【结 构 式】 |
【分子编号】34117 【品名】7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one 【CA登记号】 |
【 分 子 式 】C15H10Cl2N2O 【 分 子 量 】305.16268 【元素组成】C 59.04% H 3.3% Cl 23.24% N 9.18% O 5.24% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(II)By cyclization of 2-glycylamino-2',5-dichlorobenzenophenone (I) in pyridine to give 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one (II), which was refluxed with P2S5 in pyridine yielding 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-thione (III). Finally, this product was condensed with acetylhydrazide (A) in butanol.
【1】 Sternbach, L.H.; 1,4-Benzodiazepines. Chemistry and some aspects of the structure activity relationship. Angew Chem 1971, 10, 34-43. |
【2】 Hester, J.B. Jr.; 6-Phenyl-4H-S-triazolo[4,3-a][1,4]benzodiazepines. DE 2012190; FR 2034999; GB 1291631; US 3987052 . |
【3】 Castaner, J.; Chatterjee, S.S.; Triazolam. Drugs Fut 1976, 1, 8, 393. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(A) | 29262 | acetohydrazide | 1068-57-1 | C2H6N2O | 详情 | 详情 |
(I) | 34116 | 2-amino-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide | C15H12Cl2N2O2 | 详情 | 详情 | |
(II) | 34117 | 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one | C15H10Cl2N2O | 详情 | 详情 | |
(III) | 34118 | 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-thione | C15H10Cl2N2S | 详情 | 详情 |
Extended Information