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【结 构 式】 
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【分子编号】14735 【品名】6-[chloro(4-chlorophenyl)methyl]-1-methyl-1H-1,2,3-benzotriazole 【CA登记号】 |
【 分 子 式 】C14H11Cl2N3 【 分 子 量 】292.16696 【元素组成】C 57.55% H 3.79% Cl 24.27% N 14.38% |
合成路线1
该中间体在本合成路线中的序号：(IX)The reaction of 3-chloro-4-nitrobenzoic acid (I) with methylamine gives 3-(methylamino)-4-nitrobenzoic acid (II), which is hydrogenated in the presence of Raney Nickel to yield 4-amino-3-(methylamino)benzoic acid (III). Treatment of compound (III) with sodium nitrite affords 1-methyl-1H-benzotriazole-6-carboxylic acid (IV), which is reduced with lithium aluminum hydride in THF to give 6-(hydroxymethyl)-1-methyl-1H-benzotriazole (V). Oxidation of (V) with potassium permanganate in dichloroethane yields 1-methyl-1H-benzotriazole-6-carboxaldehyde (VI), which on treatment with the Grignard reagent derived from 1-bromo-4-chlorobenzene (VII) gives 6-(4-chloro-alpha-hydroxybenzyl)-1-methyl-1H-benzotriazole (VIII). Treatment of compound (VIII) with thionyl chloride in THF yields 6-(alpha,4-dichlorobenzyl)-1-methyl-1H-benzotriazole (IX), which is finally condensed with 1,2,4-triazole (X) and sodium hydride in DMF.
| 【1】 Raeymaekers, A.H.M.; Freyne, E.J.E.; Van Gelder, J.L.H.; Vener, M.G. (Janssen Pharmaceutica NV); (1H-Arol-1-ylmethyl)substd. Benzotriazole derivatives. AU 8816537; EP 0293978; JP 1988316775 . |
| 【2】 Graul, A.; Prous, J.; Castaner, J.; Vorozole. Drugs Fut 1994, 19, 5, 457. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14727 | 3-chloro-4-nitrobenzoic acid | C7H4ClNO4 | 详情 | 详情 | |
| (II) | 14728 | 3-(methylamino)-4-nitrobenzoic acid | C8H8N2O4 | 详情 | 详情 | |
| (III) | 14729 | 4-amino-3-(methylamino)benzoic acid | C8H10N2O2 | 详情 | 详情 | |
| (IV) | 14730 | 1-methyl-1H-1,2,3-benzotriazole-6-carboxylic acid | C8H7N3O2 | 详情 | 详情 | |
| (V) | 14731 | (1-methyl-1H-1,2,3-benzotriazol-6-yl)methanol | C8H9N3O | 详情 | 详情 | |
| (VI) | 14732 | 1-methyl-1H-1,2,3-benzotriazole-6-carbaldehyde | C8H7N3O | 详情 | 详情 | |
| (VII) | 14733 | 4-Bromochlorobenzene; 1-bromo-4-chlorobenzene | 106-39-8 | C6H4BrCl | 详情 | 详情 |
| (VIII) | 14734 | (4-chlorophenyl)(1-methyl-1H-1,2,3-benzotriazol-6-yl)methanol | C14H12ClN3O | 详情 | 详情 | |
| (IX) | 14735 | 6-[chloro(4-chlorophenyl)methyl]-1-methyl-1H-1,2,3-benzotriazole | C14H11Cl2N3 | 详情 | 详情 | |
| (X) | 13135 | 1H-1,2,4-Triazole; 1,2,4-Triazole | 288-88-0 | C2H3N3 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(VI)A scaleable process to produce vorozole has been reported: The reaction of 2,4-dichloronitrobenzene (I) with methylamine gives 5-chloro-N-methyl-2-nitroaniline (II), which is condensed with 4-chlorobenzonitrile (III) and oxidized with air to yield 4'-chloro-3-(methylamino)-4-nitrobenzophenone (IV). The hydrogenation of compound (IV), followed by cyclization by means of nitrous acid and reduction of the carbonyl group with NaBH4 affords the benzotriazole (V). Reaction of the OH group of (V) with SOCl2 provides the corresponding chloro derivative (VI), which is treated with acetohydrazide (VII) to give the racemic hydrazine derivative (VIII). Optical resolution of (VIII) by chiral chromatography yields the (S)-isomer (IX), which is finally cyclized with formamidine to afford vorozole.
| 【1】 De Knaep, A.G.M.; Vandendriessche, A.M.J.; Daemen, D.J.E.; et al.; Development summary towards a manufacturable process for R 83842 [(S)-6-[(4-chlorophenyl) (1H-1,2,4-triazol-1-yl)methyl]-1-methyl-1H-benzotriazole]. Org Process Res Dev 2000, 4, 3, 162. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 21787 | 2,4-dichloro-1-nitrobenzene | 611-06-3 | C6H3Cl2NO2 | 详情 | 详情 |
| (II) | 46715 | 5-chloro-N-methyl-2-nitroaniline; N-(5-chloro-2-nitrophenyl)-N-methylamine | 35966-84-8 | C7H7ClN2O2 | 详情 | 详情 |
| (III) | 27360 | 4-chlorobenzonitrile | 623-03-0 | C7H4ClN | 详情 | 详情 |
| (IV) | 46716 | (4-chlorophenyl)[3-(methylamino)-4-nitrophenyl]methanone | C14H11ClN2O3 | 详情 | 详情 | |
| (V) | 14734 | (4-chlorophenyl)(1-methyl-1H-1,2,3-benzotriazol-6-yl)methanol | C14H12ClN3O | 详情 | 详情 | |
| (VI) | 14735 | 6-[chloro(4-chlorophenyl)methyl]-1-methyl-1H-1,2,3-benzotriazole | C14H11Cl2N3 | 详情 | 详情 | |
| (VII) | 29262 | acetohydrazide | 1068-57-1 | C2H6N2O | 详情 | 详情 |
| (VIII) | 46717 | 6-[(4-chlorophenyl)(hydrazino)methyl]-1-methyl-1H-1,2,3-benzotriazole | C14H14ClN5 | 详情 | 详情 | |
| (IX) | 46718 | 6-[(S)-(4-chlorophenyl)(hydrazino)methyl]-1-methyl-1H-1,2,3-benzotriazole | C14H14ClN5 | 详情 | 详情 | |
| (X) | 15369 | Iminoformamide; Methanimidamide | 463-52-5 | CH4N2 | 详情 | 详情 |