5H-dibenzo[a,d]cyclohepten-5-one; Dibenzosuberenone -Drug Synthesis Database

【结构式】

【分子编号】29151

【品名】5H-dibenzo[a,d]cyclohepten-5-one; Dibenzosuberenone

【CA登记号】2222-33-5

【分子式】C₁₅H₁₀O

【分子量】206.2438

【元素组成】C 87.36% H 4.89% O 7.76%

与该中间体有关的原料药合成路线共 10 条

合成路线1 合成路线2 合成路线3 合成路线4 合成路线5 合成路线6 合成路线7 合成路线8 合成路线9 合成路线10

合成路线1

该中间体在本合成路线中的序号：(I)

The Wittig condensation of triethyl phosphonoacetate (II) with 5H-dibenzo[a,d]cyclohepten-5-one (I) by means of NaH in DMSO gives the ethyl (III), which is finally hydrolyzed with KOH in refluxing ethanol.

参考文献中间体

合成目标

【1】 Bergmann, E.D.; Solomonovici, A.; Fulvenes and thermochromic ethylenes. 57. Wittig-Homer reaction with fulvene ketones and related ketones. Synthesis 1970, 2, 4, 183-189.
【2】 Wolf, M. (American Home Products Corp.); Method for treating inflammation. EP 0035903; GB 2071098; JP 82500244; US 4267192 .
【3】 Serradell, M.N.; Castaner, J.; Arrigoni-Martelli, E.; WY-41770. Drugs Fut 1985, 10, 4, 309.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	29151	5H-dibenzo[a,d]cyclohepten-5-one; Dibenzosuberenone	2222-33-5	C₁₅H₁₀O	详情	详情
(II)	10019	Ethyl 2-(diethoxyphosphoryl)acetate; Triethyl phosphonoacetate	867-13-0	C₈H₁₇O₅P	详情	详情
(III)	29152	ethyl 2-(5H-dibenzo[a,d]cyclohepten-5-ylidene)acetate		C₁₉H₁₆O₂	详情	详情

合成路线2

该中间体在本合成路线中的序号：(IV)

The reaction of 4-(chloromethyl)-1,3-dioxolane (I) with Ac2O, HOAc and ZnCl2 gives the diacetoxy compound (II), which is treated with KOAc to yield the triacetoxy compound (III). The condensation of (III) with diacetyl guanine (IV) by means of ethylsulfonic acid affords the triacetyl ganciclovir (V), which is finally deacetylated with methylamine in methanol.

参考文献中间体

合成目标

【1】 Gao, H.; Mitra, A.K.; Synthesis of acyclovir, ganciclovir and their prodrugs: A review. Synthesis 2000, 3, 329.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	46049	4-(chloromethyl)-1,3-dioxolane		C₄H₇ClO₂	详情	详情
(II)	46050	[2-(acetoxy)-1-(chloromethyl)ethoxy]methyl acetate		C₈H₁₃ClO₅	详情	详情
(III)	46051	3-(acetoxy)-2-(2-oxopropoxy)propyl acetate		C₁₀H₁₆O₆	详情	详情
(IV)	29151	5H-dibenzo[a,d]cyclohepten-5-one; Dibenzosuberenone	2222-33-5	C₁₅H₁₀O	详情	详情
(V)	29170	2-[[2-(acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl]methoxy]-3-(acetoxy)propyl acetate		C₁₅H₁₉N₅O₇	详情	详情

合成路线3

该中间体在本合成路线中的序号：(VII)

The reaction of 5H-dibenzo[a,d]cyclohepten-5-one (VII) with NH3 and TiCl4 in toluene gives 5H-dibenzo[a,d]cycloheptene-5-imine (VIII), which is tosylated with p-toluenesulfonyl chloride in pyridine to yield 5-(p-toluenesulfonimino)-5H-dibenzo[a,d]cycloheptene (IX). The methylation of (IX) with methyllithium in dry THF affords 5-methyl-5-(p-toluenesulfonimido)-5H-dibenzo[a,d]cycloheptene (X), which is internally cyclized by means of KOH in diglyme at 170 C giving 5-methyl-N-(p-toluenesulfonyl)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5,10-imine (XI). Finally, this compound is hydrolyzed with aqueous HCl in refluxing AcOH.

参考文献中间体

合成目标

【1】 Shepard, K.L.; Brenner, D.G.; EP 0019866 .
【2】 Thorpe, P.J.; Castaner, J.; Serradell, M.N.; Blancafort, P.; MK-801. Drugs Fut 1983, 8, 2, 120.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(VII)	29151	5H-dibenzo[a,d]cyclohepten-5-one; Dibenzosuberenone	2222-33-5	C₁₅H₁₀O	详情	详情
(VIII)	35932	5H-dibenzo[a,d]cyclohepten-5-imine		C₁₅H₁₁N	详情	详情
(IX)	35933	N-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-4-methylbenzenesulfonamide		C₂₂H₁₇NO₂S	详情	详情
(X)	35934	4-methyl-N-(5-methyl-5H-dibenzo[a,d]cyclohepten-5-yl)benzenesulfonamide		C₂₃H₂₁NO₂S	详情	详情
(XI)	35935	1-methyl-16-[(4-methylphenyl)sulfonyl]-16-azatetracyclo[7.6.1.0(2,7).0(10,15)]hexadeca-2,4,6,10,12,14-hexaene		C₂₃H₂₁NO₂S	详情	详情

合成路线4

该中间体在本合成路线中的序号：(I)

Condensation of dibenzosuberenone (I) with sodium 2-chloro-2,2-difluoroacetate (II) in diglyme at 165 C gives 10,11-(difluoromethano)benzosuberone (III), which is reduced with NaBH4 in THF/methanol to yield the corresponding syn-alcohol (IV). Reaction of alcohol (IV) with hot SOCl2 affords a mixture of the syn- and anti-chloro derivatives (V). This mixture (V) is treated with 1-for-mylpiperazine (VI) in refluxing acetonitrile to provide a mixture of syn- and anti-4-[10,11-(difluoromethano)dibenzosuber-5-yl]piperazine-1-carbaldehyde (VI), which is separated by chromatography. The desired anti-isomer (VII) is then treated with KOH in refluxing ethanol/water to give the piperazine derivative (VIII), which is finally condensed with 5-[2(R),3-epoxypropoxy]quinoline (IX) in refluxing isopranol. 5-[2(R),3-Epoxypropoxy]quinoline (IX) is obtained by reaction of 5-hydroxyquinoline (X) with (R)-glycidyl tosylate (XI) by means of NaH in DMF.

参考文献中间体

合成目标

【1】 Sorbera, L.A.; Castaner, J.; Silvestre, J.S.; Bayes, M.; Zosuquidar Trihydrochloride.. Drugs Fut 2003, 28, 2, 125-136.
【2】 Knaus, E.E.; Vo, D.; Wolowyk, M.W.; Synthesis and cardioselective beta-adrenergic antagonist activity of quinolyloxypropanolamines. Drug Des Discov 1992, 9, 1, 69.
【3】 Bruno, N.A.; Nelson, J.T.; Wu, H.; Muehldorf, A.V.; Makra, F.; Cheung, P.; Slate, D.L.; Zutshi, N.; Casey, S.M.; Pfister, J.R.; Methanodibenzosuberylpiperazines as potent multidrug resistance reversal agents. Bioorg Med Chem Lett 1995, 5, 21, 2473.
【4】 Pfister, J.R.; Slate, D.L. (Syntex (USA) LLC); 10,11-Methanodibenzosuberane derivs. used as chemosensitizing agents. EP 0695293; EP 0866063; JP 1996509223; WO 9424107 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	29151	5H-dibenzo[a,d]cyclohepten-5-one; Dibenzosuberenone	2222-33-5	C₁₅H₁₀O	详情	详情
(II)	59522	sodium 2-chloro-2,2-difluoroacetate		C₂ClF₂NaO₂	详情	详情
(III)	56203	1,1-difluoro-1a,10b-dihydrodibenzo[a,e]cyclopropa[c]cyclohepten-6(1H)-one		C₁₆H₁₀F₂O	详情	详情
(IV)	56204	(1aR,10bS)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-ol		C₁₆H₁₂F₂O	详情	详情
(V)	56205	6-chloro-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cycloheptene		C₁₆H₁₁ClF₂	详情	详情
(VI)	23801	1-piperazinecarbaldehyde; N-Formylpiperazine	7755-92-2	C₅H₁₀N₂O	详情	详情
(VII)	56206	4-[(1aR,10bS)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-1-piperazinecarbaldehyde		C₂₁H₂₀F₂N₂O	详情	详情
(VIII)	56207	1-[(1aR,10bS)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]piperazine		C₂₀H₂₀F₂N₂	详情	详情
(IX)	56211	(2R)oxiranylmethyl 5-quinolinyl ether; 5-[(2R)oxiranylmethoxy]quinoline		C₁₂H₁₁NO₂	详情	详情
(X)	23805	5-quinolinol	578-67-6	C₉H₇NO	详情	详情
(XI)	16242	(2R)oxiranylmethyl 4-methylbenzenesulfonate; (2R)-(-)-Glycidyl tosylate	113826-06-5	C₁₀H₁₂O₄S	详情	详情

合成路线5

该中间体在本合成路线中的序号：(I)

The starting product dibenzo[a,d]cyclohepta-1,4,6-triene-5-one (I) is prepared by condensation of phthalic anhydride (X) with phenylacetic acid (XI) by means of sodium acetate at 240 C that gives benzalphthalide (XII). This compound is reduced with red phosphorus in refluxing aqueous HI yielding 2-(2-phenylethyl)benzoic acid (XIII), which is then cyclized with polyphosphoric acid at 175 C afforing dibenzo[a,d]cyclohepta-1,4-diene-5-one (XIV). The ketone (XIV) is brominated with NBS in CCl4 to the bromo ketone (XV) and finally dehydrobrominated with triethylamine.

参考文献中间体

合成目标

【1】 Roberts, P.J.; Castañer, J.; Cyclobenzaprine. Drugs Fut 1977, 2, 5, 299.
【2】 Vilani, F.J. (Schering Corp.); 5-(3'-Dimethylamino-2'-methylpropyl)dibenzocycloheptenes. US 3409640 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	29151	5H-dibenzo[a,d]cyclohepten-5-one; Dibenzosuberenone	2222-33-5	C₁₅H₁₀O	详情	详情
(X)	11900	2-Benzofuran-1,3-dione;1,2-Benzenedicarboxylic Anhydride;1,2-BENZENE DICARBOXYLIC ACID ANHYDRIDE;1,2-BENZENEDICARBONIC ACID, ANHYDRIDE;1,3-DIOXOPHTHALAN;1,3-ISOBENZOFURANDIONE;o-phthalic anhydride; Phthalic anhydride	85-44-9	C₈H₄O₃	详情	详情
(XI)	16148	Benzeneacetic acid; 2-Phenylacetic acid; Phenyl Acetic Acid	103-82-2	C₈H₈O₂	详情	详情
(XII)	40121	3-[(Z)-benzylidene]-2-benzofuran-1-one; Benzalphthalide; 3-[(Z)-benzylene]-1-isobenzofuranone; Benzylidenephthalide; 3-[(Z)-benzylene]-1(3H)-isobenzofuranone; 3-(Z)-Benzylidenephthalide	575-61-1	C₁₅H₁₀O₂	详情	详情
(XIII)	40122	2-phenethylbenzoic acid	4890-85-1	C₁₅H₁₄O₂	详情	详情
(XIV)	40123	10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one; Dibenzosuberone	1210-35-1	C₁₅H₁₂O	详情	详情
(XV)	40124	10-bromo-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one		C₁₅H₁₁BrO	详情	详情

合成路线6

该中间体在本合成路线中的序号：(I)

The Grignard reaction of dibenzo[a,d]cyclohepta-1,4,6-triene-5-one (I) with allyl magnesium bromide (A) in ethyl ether gives 5-hydroxy-5-allyldibenzo[a,d]cyclohepta-1,4,6-triene (II), which is dehydrated with acetic anhydride and acetyl chloride at 90 C yielding 5-propenylidenedibenzo[a,d]cyclohepta-1,4,6-triene (III). Finally, this compound is treated with phenylmagnesium bromide and dimethylamine (B) at 80 C.

参考文献中间体

合成目标

【1】 Roberts, P.J.; Castañer, J.; Cyclobenzaprine. Drugs Fut 1977, 2, 5, 299.
【2】 Schmitt, G. (F. Hoffmann-La Roche AG); A process for the manufacture of tricyclic amines. BE 0636000; CH 385191; DE 1468006; FR 1366413; GB 990105 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(A)	10386	Allyl(bromo)magnesium	1730-25-2	C₃H₅BrMg	详情	详情
(B)	19443	N-methylmethanamine; N,N-dimethylamine	124-40-3	C₂H₇N	详情	详情
(I)	29151	5H-dibenzo[a,d]cyclohepten-5-one; Dibenzosuberenone	2222-33-5	C₁₅H₁₀O	详情	详情
(II)	40125	5-allyl-5H-dibenzo[a,d]cyclohepten-5-ol		C₁₈H₁₆O	详情	详情
(III)	40126	5-(2-propenylidene)-5H-dibenzo[a,d]cycloheptene		C₁₈H₁₄	详情	详情

合成路线7

该中间体在本合成路线中的序号：(I)

The Grignard reaction of dibenzo[a,d]cyclohepta-1,4,6-triene-5-one (I) with dimethylaminopropyl magnesium (C) chloride in ethyl ether gives 5-hydroxy-5-(3-dimethylaminopropyl)dibenzo[a,d]cyclohepta-1,4,6-triene (IV), which is then treated with HCl in refluxing acetic acid. Alternatively, it can also be obtained by methylation of 5-(3-methylaminopropylidene)dibenzo[a,d]cyclohepta-1,4,6-triene (IX) with formic acid and formaldehyde at 100 C.

参考文献中间体

合成目标

【1】 Protiva, M.; Vera, S.; CZ 136585 .
【2】 Roberts, P.J.; Castañer, J.; Cyclobenzaprine. Drugs Fut 1977, 2, 5, 299.
【3】 Vilani, F.J. (Schering Corp.); 5-(3'-Dimethylamino-2'-methylpropyl)dibenzocycloheptenes. US 3409640 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	29151	5H-dibenzo[a,d]cyclohepten-5-one; Dibenzosuberenone	2222-33-5	C₁₅H₁₀O	详情	详情
(IV)	40127	5-[3-(dimethylamino)propyl]-5H-dibenzo[a,d]cyclohepten-5-ol	18029-54-4	C₂₀H₂₃NO	详情	详情
(IX)	40128	N-[3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)propyl]-N-methylamine; 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine		C₁₉H₁₉N	详情	详情
(C)	37604	bromo[3-(dimethylamino)propyl]magnesium	120615-47-6	C₅H₁₂BrMgN	详情	详情

合成路线8

该中间体在本合成路线中的序号：(I)

The Grignard reaction of dibenzo[a,d]cyclohepta-1,4,6-triene-5-one (I) with cyclopropyl magnesium bromide (D) in THF gives 5-hydroxy-5-cyclopropyldibenzo[a,d]cyclohepta-1,4,6-triene (V), which is then treated with HBr in acetic acid to yield 5-(3-bromopropylidene)dibenzo[a,d]cyclohepta-1,4,6-triene (VI). Finally, (VI) is treated with dimethylamine (B) in benzene at 95 C. The hydroxycompound (V), obtained as before, is treated with HClO4 in dioxane to yield 5-(3-hydroxypropylidene)dibenzo[a,d]cyclohepta-1,4,6-triene (VII), which is then treated with p-toluenesulfonyl chloride in pyridine to afford the tosyl derivate (VIII). Finally, (VIII) is treated with dimethylamine (B) in benzene at 100 C.

参考文献中间体

合成目标

【1】 Roberts, P.J.; Castañer, J.; Cyclobenzaprine. Drugs Fut 1977, 2, 5, 299.
【2】 Hoffsommer, R.D. Jr.; et al.; Nouveaux derives de dibenzocycloheptenes et leur preparation. BE 0631012 .
【3】 Wendler, N.L.; Dibenzocycloheptenes. BE 0633316 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(D)	12450	Bromo(cyclopropyl)magnesium;cyclopropylmagnesium bromide;cyclopropylmagnesiumbromide	23719-80-4	C₃H₅BrMg	详情	详情
(B)	19443	N-methylmethanamine; N,N-dimethylamine	124-40-3	C₂H₇N	详情	详情
(I)	29151	5H-dibenzo[a,d]cyclohepten-5-one; Dibenzosuberenone	2222-33-5	C₁₅H₁₀O	详情	详情
(V)	40129	5-cyclopropyl-5H-dibenzo[a,d]cyclohepten-5-ol		C₁₈H₁₆O	详情	详情
(VI)	40130	5-(3-bromopropylidene)-5H-dibenzo[a,d]cycloheptene		C₁₈H₁₅Br	详情	详情
(VII)	40131	3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propanol		C₁₈H₁₆O	详情	详情
(VIII)	40132	3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)propyl 4-methylbenzenesulfonate		C₂₅H₂₂O₃S	详情	详情

合成路线9

该中间体在本合成路线中的序号：(II)

Regioselective lithiation of the tris-O-silylated uridine (I) with sec-butyllithium in the presence of TMEDA, followed by addition to dibenzosuberenone (II) afforded the 5-(dibenzocycloheptenyl)uridine derivative (III). Subsequent reduction of the tertiary alcohol of (III) with triethylsilane in the presence of boron trifluoride, followed by re silylation with tert-butyldimethylsilyl chloride furnished (IV). The 4-thiouridine derivative (V) was then obtained by thionation of (IV) with phosphorus pentasulfide in refluxing pyridine. Removal of the O-silyl protecting groups of (V) was effected by treatment with HF-pyridine, yielding (VI). Phosphorylation of the primary hydroxyl of (VI) with phosphoryl chloride in the presence of 1,8-bis-(dimethylamino)naphthalene in trimethyl phosphate, followed by condensation with dichloromethylenebisphosphonic acid gave rise to the target triphosphate analogue, which was finally converted to the corresponding tetrasodium salt by passage through a cation-exchange resin.

参考文献中间体

合成目标

【1】 Kindon, N.; Jewel, R.; Johnson, T.; McInally, J.; Meghani, P.; Thom, S.; SAR leading to the discovery of AR-C 85095MX, a potent and selective P2Y2 antagonist. 11th RSC-SCI Med Chem Symp (Sept 9 2001, Cambridge) 2001, Abst P8.
【2】 Meghani, P.; Kindon, N.; Thom, S. (AstraZeneca AB; AstraZeneca plc); Novel phosphate cpds. and their use as medicaments. WO 9845309 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
	22305	dichloro(phosphono)methylphosphonic acid		CH₄Cl₂O₆P₂	详情	详情
(I)	60690	1-[(2R,3R,4R,5R)-3,4-bis{[tert-butyl(dimethyl)silyl]oxy}-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione		C₂₇H₅₄N₂O₆Si₃	详情	详情
(II)	29151	5H-dibenzo[a,d]cyclohepten-5-one; Dibenzosuberenone	2222-33-5	C₁₅H₁₀O	详情	详情
(III)	60691	1-[(2R,3R,4R,5R)-3,4-bis{[tert-butyl(dimethyl)silyl]oxy}-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)tetrahydro-2-furanyl]-5-(5-hydroxy-5H-dibenzo[a,d]cyclohepten-5-yl)-2,4(1H,3H)-pyrimidinedione		C₄₂H₆₄N₂O₇Si₃	详情	详情
(IV)	60692	1-[(2R,3R,4R,5R)-3,4-bis{[tert-butyl(dimethyl)silyl]oxy}-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)tetrahydro-2-furanyl]-5-(5H-dibenzo[a,d]cyclohepten-5-yl)-2,4(1H,3H)-pyrimidinedione		C₄₂H₆₄N₂O₆Si₃	详情	详情
(V)	60693	1-[(2R,3R,4R,5R)-3,4-bis{[tert-butyl(dimethyl)silyl]oxy}-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)tetrahydro-2-furanyl]-5-(5H-dibenzo[a,d]cyclohepten-5-yl)-4-thioxo-3,4-dihydro-2(1H)-pyrimidinone		C₄₂H₆₄N₂O₅SSi₃	详情	详情
(VI)	60694	5-(5H-dibenzo[a,d]cyclohepten-5-yl)-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-4-thioxo-3,4-dihydro-2(1H)-pyrimidinone		C₂₄H₂₂N₂O₅S	详情	详情

合成路线10

该中间体在本合成路线中的序号：(I)

Reduction of dibenzosuberenone (I) with in situ generated AlH3 affords dibenzocycloheptene (II). Subsequent epoxidation of (II) employing m-chloroperbenzoic acid gives the dibenzocycloheptaoxirane (III) (1). Epoxide ring opening in (III) with allylmagnesium bromide produces the trans alcohol (IV). Bromination of the double bond of (IV) with pyridinium tribromide leads to the trans-fused tetrahydrofuran derivative (V) as a mixture of 4 diastereoisomers. Then, substitution of the bromide ion of (V) with dimethylamine, followed by chromatographic separation of the isomers provides the target compound.

参考文献中间体

合成目标

【1】 Alonso, J.M.; Andres, J.I.; Cid, J.M.; et al.; Synthesis of 2-aminomethyl-3,3a,8,12b-tetrahydro-2H-dibenzocyclohepta[1,2-b]furan derivatives as potential anxiolytic agents. Drugs Fut 2002, 27, Suppl. A.
【2】 Gil-Lopetegui, P.; Fernandez-Gadea, F.J.; Meert, T.F. (Janssen Pharmaceutica NV); Substd. tetracyclic tetrahydrofuran derivs.. EP 0892793; JP 2000508327; WO 9738991 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	29151	5H-dibenzo[a,d]cyclohepten-5-one; Dibenzosuberenone	2222-33-5	C₁₅H₁₀O	详情	详情
(II)	58423	5H-dibenzo[a,d]cycloheptene		C₁₅H₁₂	详情	详情
(III)	58424	6,10b-dihydro-1aH-dibenzo[3,4:6,7]cyclohepta[1,2-b]oxirene		C₁₅H₁₂O	详情	详情
(IV)	58425	(10S,11R)-11-allyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol		C₁₈H₁₈O	详情	详情
(V)	58426	(3aR,12bS)-2-(bromomethyl)-3,3a,8,12b-tetrahydro-2H-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan		C₁₈H₁₇BrO	详情	详情

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