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【结 构 式】 
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【药物名称】Wy-41770 【化学名称】(5H-Dibenzo[a,d]cyclohepten-5-ylidene)acetic acid 【CA登记号】4517-99-1 【 分 子 式 】C17H12O2 【 分 子 量 】248.28399 |
【开发单位】Wyeth Pharmaceuticals (Originator) 【药理作用】Antiarthritic Drugs, IMMUNOMODULATING AGENTS, Immunomodulators, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES |
合成路线1
The Wittig condensation of triethyl phosphonoacetate (II) with 5H-dibenzo[a,d]cyclohepten-5-one (I) by means of NaH in DMSO gives the ethyl (III), which is finally hydrolyzed with KOH in refluxing ethanol.
| 【1】 Bergmann, E.D.; Solomonovici, A.; Fulvenes and thermochromic ethylenes. 57. Wittig-Homer reaction with fulvene ketones and related ketones. Synthesis 1970, 2, 4, 183-189. |
| 【2】 Wolf, M. (American Home Products Corp.); Method for treating inflammation. EP 0035903; GB 2071098; JP 82500244; US 4267192 . |
| 【3】 Serradell, M.N.; Castaner, J.; Arrigoni-Martelli, E.; WY-41770. Drugs Fut 1985, 10, 4, 309. |
Extended Information