ethyl 2-(5H-dibenzo[a,d]cyclohepten-5-ylidene)acetate -Drug Synthesis Database

【结构式】

【分子编号】29152

【品名】ethyl 2-(5H-dibenzo[a,d]cyclohepten-5-ylidene)acetate

【CA登记号】

【分子式】C₁₉H₁₆O₂

【分子量】276.33484

【元素组成】C 82.58% H 5.84% O 11.58%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The Wittig condensation of triethyl phosphonoacetate (II) with 5H-dibenzo[a,d]cyclohepten-5-one (I) by means of NaH in DMSO gives the ethyl (III), which is finally hydrolyzed with KOH in refluxing ethanol.

参考文献中间体

合成目标

【1】 Bergmann, E.D.; Solomonovici, A.; Fulvenes and thermochromic ethylenes. 57. Wittig-Homer reaction with fulvene ketones and related ketones. Synthesis 1970, 2, 4, 183-189.
【2】 Wolf, M. (American Home Products Corp.); Method for treating inflammation. EP 0035903; GB 2071098; JP 82500244; US 4267192 .
【3】 Serradell, M.N.; Castaner, J.; Arrigoni-Martelli, E.; WY-41770. Drugs Fut 1985, 10, 4, 309.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	29151	5H-dibenzo[a,d]cyclohepten-5-one; Dibenzosuberenone	2222-33-5	C₁₅H₁₀O	详情	详情
(II)	10019	Ethyl 2-(diethoxyphosphoryl)acetate; Triethyl phosphonoacetate	867-13-0	C₈H₁₇O₅P	详情	详情
(III)	29152	ethyl 2-(5H-dibenzo[a,d]cyclohepten-5-ylidene)acetate		C₁₉H₁₆O₂	详情	详情

Extended Information