[2-(acetoxy)-1-(chloromethyl)ethoxy]methyl acetate -Drug Synthesis Database

【结构式】

【分子编号】46050

【品名】[2-(acetoxy)-1-(chloromethyl)ethoxy]methyl acetate

【CA登记号】

【分子式】C₈H₁₃ClO₅

【分子量】224.64092

【元素组成】C 42.77% H 5.83% Cl 15.78% O 35.61%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The reaction of 4-(chloromethyl)-1,3-dioxolane (I) with Ac2O, HOAc and ZnCl2 gives the diacetoxy compound (II), which is treated with KOAc to yield the triacetoxy compound (III). The condensation of (III) with diacetyl guanine (IV) by means of ethylsulfonic acid affords the triacetyl ganciclovir (V), which is finally deacetylated with methylamine in methanol.

参考文献中间体

合成目标

【1】 Gao, H.; Mitra, A.K.; Synthesis of acyclovir, ganciclovir and their prodrugs: A review. Synthesis 2000, 3, 329.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	46049	4-(chloromethyl)-1,3-dioxolane		C₄H₇ClO₂	详情	详情
(II)	46050	[2-(acetoxy)-1-(chloromethyl)ethoxy]methyl acetate		C₈H₁₃ClO₅	详情	详情
(III)	46051	3-(acetoxy)-2-(2-oxopropoxy)propyl acetate		C₁₀H₁₆O₆	详情	详情
(IV)	29151	5H-dibenzo[a,d]cyclohepten-5-one; Dibenzosuberenone	2222-33-5	C₁₅H₁₀O	详情	详情
(V)	29170	2-[[2-(acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl]methoxy]-3-(acetoxy)propyl acetate		C₁₅H₁₉N₅O₇	详情	详情

Extended Information