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【结 构 式】

【分子编号】46050

【品名】[2-(acetoxy)-1-(chloromethyl)ethoxy]methyl acetate

【CA登记号】

【 分 子 式 】C8H13ClO5

【 分 子 量 】224.64092

【元素组成】C 42.77% H 5.83% Cl 15.78% O 35.61%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

The reaction of 4-(chloromethyl)-1,3-dioxolane (I) with Ac2O, HOAc and ZnCl2 gives the diacetoxy compound (II), which is treated with KOAc to yield the triacetoxy compound (III). The condensation of (III) with diacetyl guanine (IV) by means of ethylsulfonic acid affords the triacetyl ganciclovir (V), which is finally deacetylated with methylamine in methanol.

1 Gao, H.; Mitra, A.K.; Synthesis of acyclovir, ganciclovir and their prodrugs: A review. Synthesis 2000, 3, 329.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 46049 4-(chloromethyl)-1,3-dioxolane C4H7ClO2 详情 详情
(II) 46050 [2-(acetoxy)-1-(chloromethyl)ethoxy]methyl acetate C8H13ClO5 详情 详情
(III) 46051 3-(acetoxy)-2-(2-oxopropoxy)propyl acetate C10H16O6 详情 详情
(IV) 29151 5H-dibenzo[a,d]cyclohepten-5-one; Dibenzosuberenone 2222-33-5 C15H10O 详情 详情
(V) 29170 2-[[2-(acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl]methoxy]-3-(acetoxy)propyl acetate C15H19N5O7 详情 详情
Extended Information