|
【结 构 式】 
|
【分子编号】11608 【品名】o-Nitroaniline; 2-Nitroaniline; 2-Nitrophenylamine 【CA登记号】88-74-4 |
【 分 子 式 】C6H6N2O2 【 分 子 量 】138.12592 【元素组成】C 52.17% H 4.38% N 20.28% O 23.17% |
合成路线1
该中间体在本合成路线中的序号：(II)Condensation of 4-nitrobenzoyl chloride (I) with 2-nitrobenzenamine (II) in boiling dioxane yields N-(2-nitrophenyl)-4-nitrobenzamide (III), which is catalytically reduced by H2 over Pd/C in dimethylfomamide.
| 【1】 Herrmann, M.; Satzinger, G.; Fritschi, E.; Weierhausen, U. (Godecke AG); N-Phenylbenzamide derivs.. EP 0116967; US 4816485 . |
| 【2】 Satzinger, G.; Weiershausen, U.; Dinaline. Drugs Fut 1986, 11, 10, 833. |
合成路线2
该中间体在本合成路线中的序号：(III)Tirapazamine can be obtained by several related ways: 1) By condensation of benzofurazan (I) with cyanamide disodium salt (II) in hot methanol/water. 2) The condensation of 2-nitroaniline (III) with cyanamide (IV) by heating at 100 C gives 3-amino-1,2,4-bezotriazine 1-oxide (V), which is then oxidized with 30% aqueous H2O2 in hot acetic acid. 3) The reaction of 3-hydroxy-1,2,4-benzotriazine 1-oxide (VI) with refluxing POCl3 and dimethylaniline gives 3-chloro-1,2,4-benzotriazine 1-oxide (VII), which by reaction with dry ammonia in ethanol is converted into the corresponding amino derivative (V), already obtained.
| 【1】 Schofield, K.; Robbins, R.F.; Polyazabicyclic compounds. Part II. Further derivatives of benzo-1:2:4-triazine. J Chem Soc 1957, 3186. |
| 【2】 Tennant, G.; Mason, J.C.; Heterocyclic N-oxides. Part VI. Synthesis and nuclear magnetic resonance spectra of 3-aminobenzo-1,2,4-triazines and their mono- and di-N-oxides. J Chem Soc B 1970, 911. |
| 【3】 Robinson, C.; Castaner, J.; Tirapazamine. Drugs Fut 1995, 20, 3, 256. |
| 【4】 Ley, K.; Seng, F.; Metzer, K.G. (Bayer AG); 3-Amino-1,2,4-benzotriazine-1,4-di-N-oxides and processes for their preparation. US 3868371; US 3980779; US 4001410 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11607 | 2,1,3-benzoxadiazole 1-oxide; 2,1,3-benzoxadiazol-1-ium-1-olate | 480-96-6 | C6H4N2O2 | 详情 | 详情 |
| (II) | 63311 | 2-chloro-1-ethoxyethyl ethyl ether; 2-chloro-1,1-diethoxyethane | C6H13ClO2 | 详情 | 详情 | |
| (III) | 11608 | o-Nitroaniline; 2-Nitroaniline; 2-Nitrophenylamine | 88-74-4 | C6H6N2O2 | 详情 | 详情 |
| (IV) | 19648 | Cyanamide | 420-04-2 | CH2N2 | 详情 | 详情 |
| (V) | 11609 | 3-amino-1,2,4-benzotriazin-1-ium-1-olate; 3-Amino-1,2,4-benzotriazine-1-oxide | 5424-06-6 | C7H6N4O | 详情 | 详情 |
| (VI) | 11610 | 3-hydroxy-1,2,4-benzotriazin-1-ium-1-olate | C7H5N3O2 | 详情 | 详情 | |
| (VII) | 11611 | 3-chloro-1,2,4-benzotriazin-1-ium-1-olate | C7H4ClN3O | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(III)The reaction of 4-(acetamido)benzoic acid (I) with oxalyl chloride in DMF gives 4-(acetamido)benzoyl chloride (II), which is condensed with 2-nitroaniline (III) by means of pyridine in ethyl acetate yielding 4-(acetamido)-N-(2-nitrophenyl)benzamide (IV). Finally, the nitro group of (IV) is reduced with H2 over Pd/C in THF.
| 【1】 (Godecke AG); Novel N-(2'Aminophenyl)-benzamide derivs. And pharmaceutical compsns. containing them. AT 388913 . |
| 【2】 Graul, A.; Leeson, P.; Castaner, J.; CI-994. Drugs Fut 1997, 22, 11, 1201. |
| 【3】 Weiershausen, U.; Satzinger, G.; Vollmer, K.-O.; Herrmann, W. (Gödecke AG); N-(2'-Aminophenyl)-benzamide derivs., process for their preparation and their use in the treatment of neoplastic diseases. AU 8771790; DE 3613571; DE 3625359; EP 0242851; JP 1988115852; US 5137918 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12284 | 4-(Acetamido)benzoic acid; p-Acetamidobenzoic acid | 556-08-1 | C9H9NO3 | 详情 | 详情 |
| (II) | 12285 | 4-(Acetamido)benzoyl chloride | C9H8ClNO2 | 详情 | 详情 | |
| (III) | 11608 | o-Nitroaniline; 2-Nitroaniline; 2-Nitrophenylamine | 88-74-4 | C6H6N2O2 | 详情 | 详情 |
| (IV) | 12287 | 4-(Acetamido)-N-(2-nitrophenyl)benzamide | C15H13N3O4 | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(I)Conjugated addition of 2-nitroaniline (I) to acrylonitrile (II) in the presence of Triton B in dioxane yielded propionitrile (III), which was hydrogenated to the phenylenediamine (IV). Treatment of ethyl cyanoacetate (V) with a cold saturated solution of HCl in absolute ethanol gave ethyl ethoxycarbonylacetimidate hydrochloride (VI). Reaction of this acetimidate (VI) with phenylenediamine (IV) in refluxing ethanol afforded the benzimidazole (VII), which was converted to the diester (VIII) on treatment with ethanolic HCl. Dieckmann condensation of diester (VIII) in the presence of sodium ethoxide furnished the tricyclic ketoester (IX), which was finally condensed with 2,6-difluoroaniline (X) in refluxing xilene to afford the target carboxamide.
| 【1】 Maryanoff, B.E.; et al.; Potential anxiolytic agents. Pyrido[1, 2-a]benzimidazoles: A new structural class of ligands for the benzodiazepine binding site on GABA-A receptors. J Med Chem 1995, 38, 1, 16. |
| 【2】 Maryanoff, B.E.; McComsey, D.F.; Winston, H. (Ortho-McNeil Pharmaceutical, Inc.); 3-Oxo-pyrido(1,2-a)benzimidazole-4-carboxyl and 4-oxo-azepino(1,2-a)benzimidazole-5-carboxyl derivs. useful in treating central nervous system disorders. EP 0656002; WO 9404532 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11608 | o-Nitroaniline; 2-Nitroaniline; 2-Nitrophenylamine | 88-74-4 | C6H6N2O2 | 详情 | 详情 |
| (II) | 10847 | Acrylonitrile | 107-13-1 | C3H3N | 详情 | 详情 |
| (III) | 17926 | 3-(2-nitroanilino)propanenitrile | C9H9N3O2 | 详情 | 详情 | |
| (IV) | 17927 | 3-(2-aminoanilino)propanenitrile | C9H11N3 | 详情 | 详情 | |
| (V) | 11877 | Cyanoacetic acid ethyl ester; Ethyl 2-cyanoacetate; Ethyl cyanoacetate; Ethyl isocyanacetate | 105-56-6 | C5H7NO2 | 详情 | 详情 |
| (VI) | 17929 | ethyl 3-ethoxy-3-iminopropanoate | 2318-25-4 | C7H13NO3 | 详情 | 详情 |
| (VII) | 17930 | ethyl 2-[1-(2-cyanoethyl)-1H-benzimidazol-2-yl]acetate | C14H15N3O2 | 详情 | 详情 | |
| (VIII) | 17931 | ethyl 3-[2-(2-ethoxy-2-oxoethyl)-1H-benzimidazol-1-yl]propanoate | C16H20N2O4 | 详情 | 详情 | |
| (IX) | 17932 | ethyl 3-oxo-1,2,3,5-tetrahydropyrido[1,2-a]benzimidazole-4-carboxylate | C14H14N2O3 | 详情 | 详情 | |
| (X) | 17933 | 2,6-Difluorophenylamine; 2,6-Difluoroaniline | 5509-65-9 | C6H5F2N | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：(I)Treatment of o-nitroaniline (I) with 6-bromo-1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphtalene (II), K2CO3 and CuI in xylene yields diphenylamine derivative (III), which is then N-methylated by means of NaH and MeI in DMF to provide (IV). Reduction of the nitro group of (IV) by hydrogenation over Pd/C in ethanol or by treatment with Fe and HCl in H2O/EtOH affords the corresponding amine derivative (V), which is then condensed with terephthalic acid monomethyl ester chloride (VI) in benzene/pyridine to furnish compound (VII). Cyclization of (VII) by means of polyphosphoric acid (PPA) in CH2Cl2 gives diazepin derivative (VIII), which is finally converted in the target product by first nitration with KNO3 in H2SO4 followed by hydrolysis with NaOH in EtOH.
| 【1】 Ohta, K.; Ebisawa, M.; Umemiya, H.; et al.; Retinoid X receptor-antagonistic diazepinylbenzoic acids. Chem Pharm Bull 1999, 47, 12, 1778. |
| 【2】 Shudo, K. (Nikken Chemicals Co., Ltd.); Cpds. potentiating retinoid. JP 1998059951; US 5929069; US 6121256; WO 9711061 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11608 | o-Nitroaniline; 2-Nitroaniline; 2-Nitrophenylamine | 88-74-4 | C6H6N2O2 | 详情 | 详情 |
| (II) | 43776 | 6-bromo-1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthalene | C14H19Br | 详情 | 详情 | |
| (III) | 43777 | 5,5,8,8-tetramethyl-N-(2-nitrophenyl)-5,6,7,8-tetrahydro-2-naphthalenamine; N-(2-nitrophenyl)-N-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)amine | C20H24N2O2 | 详情 | 详情 | |
| (IV) | 43778 | N-methyl-N-(2-nitrophenyl)-N-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)amine; N,5,5,8,8-pentamethyl-N-(2-nitrophenyl)-5,6,7,8-tetrahydro-2-naphthalenamine | C21H26N2O2 | 详情 | 详情 | |
| (V) | 43779 | N-(2-aminophenyl)-N-methyl-N-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)amine; N(1)-methyl-N(1)-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)-1,2-benzenediamine | C21H28N2 | 详情 | 详情 | |
| (VI) | 25029 | p-Phthalic acid monomethyl ester chloride; Terephthalic acid monomethyl ester chloride; Methyl 4-chlorocarbonylbenzoate | 7377-26-6 | C9H7ClO3 | 详情 | 详情 |
| (VII) | 43780 | methyl 4-([2-[methyl(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)amino]anilino]carbonyl)benzoate | C30H34N2O3 | 详情 | 详情 | |
| (VIII) | 43781 | methyl 4-(5,7,7,10,10-pentamethyl-7,8,9,10-tetrahydro-5H-naphtho[2,3-b][1,5]benzodiazepin-12-yl)benzoate | C30H32N2O2 | 详情 | 详情 |
合成路线6
该中间体在本合成路线中的序号：(VI)The reaction of 4-(aminomethyl)benzoic acid (I) with 3-pyridinylmethanol (II) and CDI by means of DBU and TEA in THF gives the carbamate (III), which is treated with oxalyl chloride in toluene to yield the corresponding acyl chloride (IV). Finally, the condensation of (IV) with 1,2-phenylenediamine (V) by means of imidazole in THF affords the target compound. Alternatively, the condensation of acyl chloride (IV) with 2-nitroaniline (VI) by means of pyridine gives the corresponding amide (VII), which is finally reduced with SnCl2 and ammonium acetate in methanol.
| 【1】 Suzuki, T.; Fukazawa, N.; Ando, T.; Tsuchiya, K.; Synthesis and histone deacetylase inhibitory activity of new benzamide derivatives. J Med Chem 1999, 42, 15, 3001. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 27823 | 4-(aminomethyl)benzoic acid | 56-91-7 | C8H9NO2 | 详情 | 详情 |
| (II) | 15798 | 3-Pyridinemethanol; 3-pyridinylmethanol | 100-55-0 | C6H7NO | 详情 | 详情 |
| (III) | 36524 | 4-([[(3-pyridinylmethoxy)carbonyl]amino]methyl)benzoic acid | C15H14N2O4 | 详情 | 详情 | |
| (IV) | 36525 | 3-pyridinylmethyl 4-(chlorocarbonyl)benzylcarbamate | C15H13ClN2O3 | 详情 | 详情 | |
| (V) | 12824 | 2-Aminophenylamine; o-Phenylenediamine; 1,2-Benzenediamine | 95-54-5 | C6H8N2 | 详情 | 详情 |
| (VI) | 11608 | o-Nitroaniline; 2-Nitroaniline; 2-Nitrophenylamine | 88-74-4 | C6H6N2O2 | 详情 | 详情 |
| (VII) | 36526 | 3-pyridinylmethyl 4-[(2-nitroanilino)carbonyl]benzylcarbamate | C21H18N4O5 | 详情 | 详情 |
合成路线7
该中间体在本合成路线中的序号：(I)The reaction of 2-nitroaniline (I) with cyanamide and HCl at 100 C, followed by a treatment with NaOH at the same temperature gives the benzotriazine N-oxide (II), which is diazotized with NaNO2 and HCl, followed by a treatment with POCl3 and dimethylaniline to yield the chloro derivative (III). The reaction of (III) with tetraethyltin and Pd(PPh3)4 in hot DME affords the ethyl derivative (IV), which is finally oxidized with trifluoroperacetic acid in dichloromethane to provide the target N1, N4-bis oxide compound.
| 【1】 Hay, M.P.; Denny, W.A.; New and versatile syntheses of 3-alkyl- and 3-aryl-1,2,4-benzotriazine 1,4-dioxides: Preparation of the bioreductive cytotoxins SR 4895 and SR 4941. Tetrahedron Lett 2002, 43, 52, 9569. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11608 | o-Nitroaniline; 2-Nitroaniline; 2-Nitrophenylamine | 88-74-4 | C6H6N2O2 | 详情 | 详情 |
| (II) | 11609 | 3-amino-1,2,4-benzotriazin-1-ium-1-olate; 3-Amino-1,2,4-benzotriazine-1-oxide | 5424-06-6 | C7H6N4O | 详情 | 详情 |
| (III) | 11611 | 3-chloro-1,2,4-benzotriazin-1-ium-1-olate | C7H4ClN3O | 详情 | 详情 | |
| (IV) | 62231 | 3-ethyl-1,2,4-benzotriazin-1-ium-1-olate | C9H9N3O | 详情 | 详情 |
合成路线8
该中间体在本合成路线中的序号：(I)The N-arylpyrrole (III) was prepared by the Clauson-Kaas reaction of 2-nitroaniline (I) with 2,5-dimethoxytetrahydrofuran (II) in AcOH under microwave irradiation. Subsequent reduction of the nitro group of (III) using BiCl3 and NaBH4 provided aniline (IV), which was condensed with cinnamoyl chloride (V) in the presence of pyridine to give the corresponding amide (VI). Cyclization of (VI) using POCl3 and pyridine produced the pyrroloquinoxaline (VII), and further Vilsmeier-Haack formylation gave aldehyde (VIII). This was condensed with boiling 3-(dimethylamino)propylamine (IX), and the resulting imine (X) was finally reduced to the target amine with NaBH4 in MeOH. The title compound was finally converted to the trioxalate salt upon treatment with oxalic acid in isopropanol.
| 【1】 Guillon, J.; Rault, S.; Kervran, A.; Renard, P.; Manechez, D.; Pfeiffer, B.; Dallemagne, P.; Synthesis of new pyrrolo[1,2-a]quinoxalines: Potential non-peptide glucagon receptor antagonists. Eur J Med Chem 1998, 33, 4, 293. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 15713 | Oxalic acid | 144-62-7 | C2H2O4 | 详情 | 详情 | |
| (I) | 11608 | o-Nitroaniline; 2-Nitroaniline; 2-Nitrophenylamine | 88-74-4 | C6H6N2O2 | 详情 | 详情 |
| (II) | 12132 | 2,5-Dimethoxytetrahydrofuran; 5-Methoxytetrahydro-2-furanyl methyl ether | 696-59-3 | C6H12O3 | 详情 | 详情 |
| (III) | 31487 | 1-(2-nitrophenyl)-1H-pyrrole | 33265-60-0 | C10H8N2O2 | 详情 | 详情 |
| (IV) | 31488 | 2-(1H-pyrrol-1-yl)aniline; 2-(1H-pyrrol-1-yl)phenylamine | 6025-60-1 | C10H10N2 | 详情 | 详情 |
| (V) | 11303 | (E)-3-Phenyl-2-propenoyl chloride; 3-Phenyl-2-propenoyl chloride | 102-92-1 | C9H7ClO | 详情 | 详情 |
| (VI) | 31489 | (E)-3-phenyl-N-[2-(1H-pyrrol-1-yl)phenyl]-2-propenamide | C19H16N2O | 详情 | 详情 | |
| (VII) | 31490 | 4-[(E)-2-phenylethenyl]pyrrolo[1,2-a]quinoxaline | C19H14N2 | 详情 | 详情 | |
| (VIII) | 31491 | 4-[(E)-2-phenylethenyl]pyrrolo[1,2-a]quinoxaline-1-carbaldehyde | C20H14N2O | 详情 | 详情 | |
| (IX) | 25248 | N-(3-aminopropyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,3-propanediamine | 109-55-7 | C5H14N2 | 详情 | 详情 |
| (X) | 31492 | N-[3-(dimethylamino)propyl]-N-((E)-[4-[(E)-2-phenylethenyl]pyrrolo[1,2-a]quinoxalin-1-yl]methylidene)amine; N(1),N(1)-dimethyl-N(3)-((E)-[4-[(E)-2-phenylethenyl]pyrrolo[1,2-a]quinoxalin-1-yl]methylidene)-1,3-propanediamine | C25H26N4 | 详情 | 详情 |
合成路线9
该中间体在本合成路线中的序号：(I)The precursor benzofurazan boronic acid (V) was prepared as follows. Bromination of o-nitroaniline (I) by means of N-bromosuccinimide in AcOH afforded 4-bromo-2-nitroaniline (II). Treatment of (II) with NaOCl gave rise to the 5 bromobenzofurazan N-oxide (III), which was reduced to (IV) employing triphenylphosphine in boiling xylene. Then, lithiation of (IV), followed by reaction with triethyl borate furnished the target boronic acid (V).
| 【1】 Hersperger, R.; Dawson, J.; Mueller, T.; Synthesis of 4-(8-benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridine-6-yl)-benzoic acid: A potent and selective phosphodiesterase type 4D inhibitor. Bioorg Med Chem Lett 2002, 12, 2, 233. |
| 【2】 Hersperger, R. (Novartis AG); Naphtyridine derivs.. EP 0934320; US 6136821; WO 9818796 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11608 | o-Nitroaniline; 2-Nitroaniline; 2-Nitrophenylamine | 88-74-4 | C6H6N2O2 | 详情 | 详情 |
| (II) | 59796 | 4-bromo-2-nitroaniline; 4-bromo-2-nitrophenylamine | C6H5BrN2O2 | 详情 | 详情 | |
| (III) | 59797 | 6-bromo-2,1,3-benzoxadiazol-1-ium-1-olate | C6H3BrN2O2 | 详情 | 详情 | |
| (IV) | 59798 | 5-bromo-2,1,3-benzoxadiazole | C6H3BrN2O | 详情 | 详情 | |
| (V) | 59799 | 2,1,3-benzoxadiazol-5-ylboronic acid | C6H5BN2O3 | 详情 | 详情 |