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【结 构 式】 
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【分子编号】12285 【品名】4-(Acetamido)benzoyl chloride 【CA登记号】 |
【 分 子 式 】C9H8ClNO2 【 分 子 量 】197.62076 【元素组成】C 54.7% H 4.08% Cl 17.94% N 7.09% O 16.19% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The reaction of 4-(acetamido)benzoic acid (I) with oxalyl chloride in DMF gives 4-(acetamido)benzoyl chloride (II), which is condensed with 2-nitroaniline (III) by means of pyridine in ethyl acetate yielding 4-(acetamido)-N-(2-nitrophenyl)benzamide (IV). Finally, the nitro group of (IV) is reduced with H2 over Pd/C in THF.
| 【1】 (Godecke AG); Novel N-(2'Aminophenyl)-benzamide derivs. And pharmaceutical compsns. containing them. AT 388913 . |
| 【2】 Graul, A.; Leeson, P.; Castaner, J.; CI-994. Drugs Fut 1997, 22, 11, 1201. |
| 【3】 Weiershausen, U.; Satzinger, G.; Vollmer, K.-O.; Herrmann, W. (Gödecke AG); N-(2'-Aminophenyl)-benzamide derivs., process for their preparation and their use in the treatment of neoplastic diseases. AU 8771790; DE 3613571; DE 3625359; EP 0242851; JP 1988115852; US 5137918 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12284 | 4-(Acetamido)benzoic acid; p-Acetamidobenzoic acid | 556-08-1 | C9H9NO3 | 详情 | 详情 |
| (II) | 12285 | 4-(Acetamido)benzoyl chloride | C9H8ClNO2 | 详情 | 详情 | |
| (III) | 11608 | o-Nitroaniline; 2-Nitroaniline; 2-Nitrophenylamine | 88-74-4 | C6H6N2O2 | 详情 | 详情 |
| (IV) | 12287 | 4-(Acetamido)-N-(2-nitrophenyl)benzamide | C15H13N3O4 | 详情 | 详情 |
Extended Information