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【结 构 式】 
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【分子编号】27251 【品名】4-methoxybenzaldehyde; Anisicaldehyde; p-anisaldehyde 【CA登记号】123-11-5 |
【 分 子 式 】C8H8O2 【 分 子 量 】136.15032 【元素组成】C 70.57% H 5.92% O 23.5% |
合成路线1
该中间体在本合成路线中的序号：(I)The intermediate triphenylphosphonium salt (XXI) has been obtained as follows: The Reformatsky condensation of 4-methoxybenzaldehyde (I) with methyl 2-bromopropionate (II) gives a mixture of the syn and anti hydroxyesters (III) and (IV). The syn isomer (III) was dehydrated by means of MsOH yielding the unsaturated ester (V), which is reduced with LiAlH4 to the unsaturated alcohol (VI). The hydroboration of (VI) affords the diol (rac)-anti-(VII), which is also obtained by direct reduction of the anti-hydroxyester (IV) with LiAlH4. The optical resolution of (rac)-(VII) with lipase Amano P and vinyl acetate affords the chiral monoacetate (2R,3R)-(VIII), which is fully acetylated with Ac2O giving the diacetate (IX). Selective catalytic hydrogenolysis of (IX) with H2 over Pd/C in methanol yields the primary monoacetate (X), which is hydrolyzed with K2CO3 in methanol to affords the primary alcohol (XI). The reaction of (XI) with CBr4 and PPh3 in THF provides the bromide (XII), which by treatment with sodium phenylsulfinate (A) affords the phenylsulfone (XIII). Ozonolysis of (XIII) with O3, followed by oxidation with H2O2 gives the carboxylic acid (XIV), which is methylated with diazomethane to the ester (XV). The reduction of (XV) with LiBH4 in THF yields the alcohol (XVI), which is protected with DHP and PPTS yielding the tetrahydropyranyl ether (XVII). The condensation of sulfone (XVII) with the iodoalkane (XVIII) by means of LDA, followed by treatment with HCl in ethanol affords the intermediate addition compound (XIX), which by elimination of the THP group provides the alcohol (XX). Finally, the reaction of (XX) with CBr4 and PPh3 affords the target intermediate phosphonium salt (XXI).
| 【1】 Nozawa, M.; et al.; Enantioselective synthesis of (2R,4'R,8'R)-alpha-tocopherol (vitamin E) based on enzymatic function. Chem Pharm Bull 2000, 48, 2, 272. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (rac)-(VII) | 40895 | (1R,2R)-1-(4-methoxyphenyl)-2-methyl-1,3-propanediol | C11H16O3 | 详情 | 详情 | |
| (2R,3R)-(VIII) | 40896 | (2R,3R)-3-hydroxy-3-(4-methoxyphenyl)-2-methylpropyl acetate | C13H18O4 | 详情 | 详情 | |
| (A) | 40901 | (phenylsulfonyl)sodium | C6H5NaO2S | 详情 | 详情 | |
| (I) | 27251 | 4-methoxybenzaldehyde; Anisicaldehyde; p-anisaldehyde | 123-11-5 | C8H8O2 | 详情 | 详情 |
| (II) | 34941 | methyl 2-bromopropanoate; 2-bromopropionic acid methyl ester | 5445-17-0 | C4H7BrO2 | 详情 | 详情 |
| (III) | 40891 | methyl (2R,3R)-3-hydroxy-3-(4-methoxyphenyl)-2-methylpropanoate | C12H16O4 | 详情 | 详情 | |
| (IV) | 40892 | methyl (2S,3R)-3-hydroxy-3-(4-methoxyphenyl)-2-methylpropanoate | C12H16O4 | 详情 | 详情 | |
| (V) | 40893 | methyl (E)-3-(4-methoxyphenyl)-2-methyl-2-propenoate | C12H14O3 | 详情 | 详情 | |
| (VI) | 40894 | (E)-3-(4-methoxyphenyl)-2-methyl-2-propen-1-ol | C11H14O2 | 详情 | 详情 | |
| (IX) | 40897 | (1R,2R)-3-(acetoxy)-1-(4-methoxyphenyl)-2-methylpropyl acetate | C15H20O5 | 详情 | 详情 | |
| (X) | 40898 | (2S)-3-(4-methoxyphenyl)-2-methylpropyl acetate | C13H18O3 | 详情 | 详情 | |
| (XI) | 40899 | (2S)-3-(4-methoxyphenyl)-2-methyl-1-propanol | C11H16O2 | 详情 | 详情 | |
| (XII) | 40900 | 1-[(2S)-3-bromo-2-methylpropyl]-4-methoxybenzene; 4-[(2S)-3-bromo-2-methylpropyl]phenyl methyl ether | C11H15BrO | 详情 | 详情 | |
| (XIII) | 40902 | [(2S)-3-(4-methoxyphenyl)-2-methylpropyl](dioxo)phenyl-lambda(6)-sulfane; (2S)-3-(4-methoxyphenyl)-2-methylpropyl phenyl sulfone | C17H20O3S | 详情 | 详情 | |
| (XIV) | 40903 | (3S)-3-methyl-4-(phenylsulfonyl)butyric acid | C11H14O4S | 详情 | 详情 | |
| (XV) | 40904 | methyl (3S)-3-methyl-4-(phenylsulfonyl)butanoate | C12H16O4S | 详情 | 详情 | |
| (XVI) | 40905 | (3S)-3-methyl-4-(phenylsulfonyl)-1-butanol | C11H16O3S | 详情 | 详情 | |
| (XVII) | 40906 | (2S)-2-methyl-5-(tetrahydro-2H-pyran-2-yloxy)pentyl phenyl sulfone; 2-[[(4S)-4-methyl-5-(phenylsulfonyl)pentyl]oxy]tetrahydro-2H-pyran | C17H26O4S | 详情 | 详情 | |
| (XVIII) | 40907 | (3R)-1-iodo-3,7-dimethyloctane | C10H21I | 详情 | 详情 | |
| (XIX) | 40908 | tetrahydro-2H-pyran-2-yl (4R,8R)-4,8,12-trimethyltridecyl ether; 2-[[(4R,8R)-4,8,12-trimethyltridecyl]oxy]tetrahydro-2H-pyran | C21H42O2 | 详情 | 详情 | |
| (XX) | 40909 | (3R,7R)-3,7,11-trimethyl-1-dodecanol | C15H32O | 详情 | 详情 | |
| (XXI) | 40910 | triphenyl[(3R,7R)-3,7,11-trimethyldodecyl]phosphonium bromide | C33H46BrP | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(IV)Reaction of 1-nitroso-2-naphthol (I) with isopropylamine in water gives 2-isopropylamino-1-nitrosonaphthalene (II). After hydrogenation, condensation of the resulting 2-isopropylamino-1,2-naphthalendiamine (III) with p-methoxybenzaldehyde yields the 1,2-dihydro derivative (IV), which is converted to MDL-035 with palladium on carbon. Toluene is used as a solvent throughout the synthesis. The overall yield on a 20-kg scale is 57%.
| 【1】 Toja, E.; Schiatti, P.; Selva, D.; 3-Alkyl-2-aryn-3H-naphth[1,2-d]imidazoles, a novel class of nonacidic antiinflammatory agents. J Med Chem 1984, 27, 5, 610-616. |
| 【2】 Toja, E.; Omodei-Sale, A.; Selva, D. (Lepetit SpA); Antimicrobial 3H-naphto[1,2-d]imidazoles. EP 0012866; JP 8092376; US 4340607; US 4435417 . |
| 【3】 Castaner, J.; Chu, S.S.; Serradell, M.N.; Tomoxiprole. Drugs Fut 1985, 10, 2, 133. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 28935 | 1-nitroso-2-naphthol | 131-91-9 | C10H7NO2 | 详情 | 详情 |
| (II) | 28936 | N-isopropyl-1-nitroso-2-naphthalenamine | C13H14N2O | 详情 | 详情 | |
| (III) | 28937 | N-(1-amino-2-naphthyl)-N-isopropylamine | C13H16N2 | 详情 | 详情 | |
| (IV) | 27251 | 4-methoxybenzaldehyde; Anisicaldehyde; p-anisaldehyde | 123-11-5 | C8H8O2 | 详情 | 详情 |
| (V) | 28938 | 3-isopropyl-2-(4-methoxyphenyl)-2,3-dihydro-1H-naphtho[1,2-d]imidazole | C21H22N2O | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(I)The reaction of p-anisaldehyde (I) with N-isopropyl-1,3-diaminopropane (II) in refluxing toluene gives N-anisylidene-N'-isopropyl-1,3-diaminopropane (III), which is then condensed with 2,6-dimethylphenylisocyanate (IV) in refluxing dichloromethane.
| 【1】 Sulkowski, T.S.; Bergey, J.L.; Mascitti, A.A. (American Home Products Corp.); Urea derivatives, processes for preparing them and compositions containing them. EP 0007184; GB 2025406; JP 80500480; US 4224242 . |
| 【2】 Serradell, M.N.; Castaner, J.; Badia, A.; WY-42362. Drugs Fut 1984, 9, 1, 38. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 27251 | 4-methoxybenzaldehyde; Anisicaldehyde; p-anisaldehyde | 123-11-5 | C8H8O2 | 详情 | 详情 |
| (II) | 29953 | N-(3-aminopropyl)-N-isopropylamine; N(1)-isopropyl-1,3-propanediamine | 3360-16-5 | C6H16N2 | 详情 | 详情 |
| (III) | 29954 | N-isopropyl-N-(3-[[(Z)-(4-methoxyphenyl)methylidene]amino]propyl)amine; N(1)-isopropyl-N(3)-[(Z)-(4-methoxyphenyl)methylidene]-1,3-propanediamine | C14H22N2O | 详情 | 详情 | |
| (IV) | 29955 | 2,6-Dimethylphenyl isocyanate; 2-Isocyanato-1,3-dimethylbenzene | 28556-81-2 | C9H9NO | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(X)In a further process, the racemic trans glycidic ester (XII), prepared by Darzen's condensation between anisaldehyde (X) and methyl chloroacetate (XI), was resolved by enantioselective enzymatic hydrolysis, using several different enzymes and reaction conditions to produce the undesired (2S,3R) acid (XIII), while leaving intact the required (2R,3S)-glycidic ester (XIV) (4-7). Opening of the chiral epoxide (XIV) with 2-aminobenzenethiol (VII) proceeded with retention of the configuration, producing methyl (2S,3S)-2-hydroxy-3-(2-aminophenylsulfanyl)-3-(4-methoxyphenyl)propionate (XV) (8). Alternatively, the (S,S)-amino ester (XV) was obtained by resolution with tartaric acid of the racemic three-adduct resulting from epoxide (XII) and 2-aminobenzenethiol (VII) (9). Cyclization of amino ester (XV) in refluxing xylene in the presence of p-toluenesulfonic acid afforded the target lactam (VIII) (9). The cyclization of (XV) to lactam (VIII) was also accomplished by means of trichloroacetic acid or under basic conditions
| 【1】 Bhushan, L.B.; Jayachandran, B.E.; Bhushan, L.V.; Thottappillil, R. (Council of Scientific and Industrial Research); Process for preparing diltiazem. US 5869697 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VII) | 25182 | 2-aminobenzenethiol | 137-07-5 | C6H7NS | 详情 | 详情 |
| (VIII) | 62436 | (2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one | C16H15NO3S | 详情 | 详情 | |
| (X) | 27251 | 4-methoxybenzaldehyde; Anisicaldehyde; p-anisaldehyde | 123-11-5 | C8H8O2 | 详情 | 详情 |
| (XI) | 10257 | methyl 2-chloroacetate; methyl chloroacetate | 96-34-4 | C3H5ClO2 | 详情 | 详情 |
| (XII) | 11905 | methyl (2R,3S)-3-(4-methoxyphenyl)-2-oxiranecarboxylate | C11H12O4 | 详情 | 详情 | |
| (XIII) | 62438 | (2R,3S)-3-(4-methoxyphenyl)-2-oxiranecarboxylic acid | C10H10O4 | 详情 | 详情 | |
| (XIV) | 62435 | ethyl (2R,3S)-3-(4-methoxyphenyl)-2-oxiranecarboxylate | C12H14O4 | 详情 | 详情 | |
| (XV) | 62439 | methyl (2S,3S)-3-[(2-aminophenyl)sulfanyl]-2-hydroxy-3-(4-methoxyphenyl)propanoate | C17H19NO4S | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：(X)A new enantioselective method for the preparation of glycidic ester (XIV) has been disclosed. Methyl trichloroacetate (XVI) was converted to the dichloroketene silyl acetal (XVII) by treatment with zinc powder and chlorotrimethylsilane. Asymmetric aldol condensation of (XVII) with anisaldehyde (X) in the presence of the chiral oxazaborolidine catalyst (XVIII) at -78 C produced methyl (S)-2,2-dichloro-3-hydroxy-3-(4-methoxyphenyl)propionate (XIX). Reductive mono-dechlorination of (XIX) furnished chlorohydrin (XX), which was then cyclized to glycidic ester (XIV) in the presence of NaOMe
| 【1】 Imashiro, R.; Kuroda, T.; Asymmetric synthesis of methyl (2R,3S)-3-(4-methoxyphenyl) glycidate, a key intermediate of diltiazem, via Mukaiyama aldol reaction. Tetrahedron Lett 2001, 42, 7, 1313. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (X) | 27251 | 4-methoxybenzaldehyde; Anisicaldehyde; p-anisaldehyde | 123-11-5 | C8H8O2 | 详情 | 详情 |
| (XIV) | 62435 | ethyl (2R,3S)-3-(4-methoxyphenyl)-2-oxiranecarboxylate | C12H14O4 | 详情 | 详情 | |
| (XVI) | 62440 | methyl 2,2,2-trichloroacetate | 598-99-2 | C3H3Cl3O2 | 详情 | 详情 |
| (XVII) | 62441 | C4H6Cl2O2 | 详情 | 详情 | ||
| (XVIII) | 62442 | C6H12BNO2 | 详情 | 详情 | ||
| (XIX) | 62443 | methyl (3S)-2,2-dichloro-3-hydroxy-3-(4-methoxyphenyl)propanoate | C11H12Cl2O4 | 详情 | 详情 | |
| (XX) | 62444 | methyl (3S)-2-chloro-3-hydroxy-3-(4-methoxyphenyl)propanoate | C11H13ClO4 | 详情 | 详情 |
合成路线6
该中间体在本合成路线中的序号：(X)Addition of phenylmagnesium bromide to cyclohexene oxide (XXI) in the presence of CuCl gave trans-2-phenylcyclohexanol (XXII), which was further esterified with chloroacetyl chloride to afford 2-phenylcyclohexyl chloroacetate (XXIII). Enantioselective hydrolysis of the racemic ester (XXIII) by means of Pseudomonas fluorescens lipase provided pure (1R,2S)-2-phenylcyclohexanol (XXIV), which was again esterified with chloroacetyl chloride, yielding the chiral ester (XXVI). Darzen's condensation of chloro ester (XXVI) with anisaldehyde (X) led to the chiral glycidic ester (XXVII). Epoxide ring opening in (XXVII) with 2-aminothiophenol (VII) furnished amino ester (XXVIII). Intermediate thiazepinone (VIII) was then obtained by cyclization of (XXVIII) using p-toluenesulfonic acid in refluxing xylene. Alternatively, amino ester (XXVIII) was first hydrolyzed to amino acid (XXIX), which was subsequently cyclized with p-toluenesulfonic acid as above (11). The final cyclization of amino acid (XXIX) to the intermediate thiazepinone (VIII) has also been carried out in the presence of trichloroacetic acid
| 【1】 Plaum, M.J.M.; Boesten, W.H.J.; Process for the preparation of a benzothiazepine. EP 0796853; JP 1998007667; US 5859241 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (+/-)-(XXII) | 51208 | (1R,2S)-2-phenylcyclohexanol | C12H16O | 详情 | 详情 | |
| (+/-)-(XXIII) | 62445 | (1S,2R)-2-phenylcyclohexyl 2-chloroacetate | C14H17ClO2 | 详情 | 详情 | |
| (VII) | 25182 | 2-aminobenzenethiol | 137-07-5 | C6H7NS | 详情 | 详情 |
| (VIII) | 62436 | (2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one | C16H15NO3S | 详情 | 详情 | |
| (X) | 27251 | 4-methoxybenzaldehyde; Anisicaldehyde; p-anisaldehyde | 123-11-5 | C8H8O2 | 详情 | 详情 |
| (XXI) | 17986 | 7-oxabicyclo[4.1.0]heptane; cyclohexene oxide | 286-20-4 | C6H10O | 详情 | 详情 |
| (XXIV) | 10492 | (1S,2R)-(+)-trans-2-Phenyl-1-cyclohexanol; (1S,2R)-2-Phenylcyclohexanol | 2362-61-0 | C12H16O | 详情 | 详情 |
| (XXV) | 62445 | (1S,2R)-2-phenylcyclohexyl 2-chloroacetate | C14H17ClO2 | 详情 | 详情 | |
| (XXVI) | 62445 | (1S,2R)-2-phenylcyclohexyl 2-chloroacetate | C14H17ClO2 | 详情 | 详情 | |
| (XXVII) | 62446 | (1R,2S)-2-phenylcyclohexyl (2R,3S)-3-(4-methoxyphenyl)-2-oxiranecarboxylate | C22H24O4 | 详情 | 详情 | |
| (XXVIII) | 62447 | (1R,2S)-2-phenylcyclohexyl (2S,3S)-3-[(2-aminophenyl)sulfanyl]-2-hydroxy-3-(4-methoxyphenyl)propanoate | C28H31NO4S | 详情 | 详情 | |
| (XXIX) | 62448 | (2S,3S)-3-[(2-aminophenyl)sulfanyl]-2-hydroxy-3-(4-methoxyphenyl)propanoic acid | C16H17NO4S | 详情 | 详情 |
合成路线7
该中间体在本合成路线中的序号：(X)The precursor cis-cinnamate (XXXIX) can be obtained by several synthetic routes. Bromination of ethyl trans-4-methoxycinnamate (I) afforded the dibromo ester (XXXVI), which underwent dehydrohalogenation and hydrolysis to the arylpropiolic acid (XXXVII) upon treatment with ethanolic KOH. Acid (XXXVII) was converted to the corresponding isopropyl ester (XXXVIII) by DCC-mediated coupling with isopropanol. Semihydrogenation of (XXXVIII) in the presence of Lindlar catalyst led to the required cis cinnamate (XXXIX). Alternatively, anisaldehyde (X) was converted to the gem-dibromostyrene (XL) by condensation with CBr4 in the presence of PPh3. Reaction of (XL) with BuLi, followed by addition of isopropyl chloroformate to the resultant lithium acetylide, furnished the arylpropiolate (XXXVIII). In another method to obtain the cis-cinnamate (XXXIX), trans-4-methoxycinnamic acid (XLI) was converted to the isopropyl ester (XLII), which was then photochemically isomerized to the desired cis-cinnamate (XXXIX)
| 【1】 Jacobsen, E.N.; Deng, L.; Furukawa, Y.; Martinez, L.E.; Enantioselective catalytic epoxidation of cinnamate esters. Tetrahedron 1994, 50, 15, 4323. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 62431 | ethyl (E)-3-(4-methoxyphenyl)-2-propenoate | C12H14O3 | 详情 | 详情 | |
| (X) | 27251 | 4-methoxybenzaldehyde; Anisicaldehyde; p-anisaldehyde | 123-11-5 | C8H8O2 | 详情 | 详情 |
| (XXXVI) | 62454 | ethyl 2,3-dibromo-3-(4-methoxyphenyl)propanoate | C12H14Br2O3 | 详情 | 详情 | |
| (XXXVII) | 62455 | 3-(4-methoxyphenyl)-2-propynoic acid | C10H8O3 | 详情 | 详情 | |
| (XXXVIII) | 62457 | isopropyl 3-(4-methoxyphenyl)-2-propynoate | C13H14O3 | 详情 | 详情 | |
| (XXXIX) | 62458 | isopropyl (Z)-3-(4-methoxyphenyl)-2-propenoate | C13H16O3 | 详情 | 详情 | |
| (XL) | 62456 | 1-(2,2-dibromovinyl)-4-methoxybenzene; 4-(2,2-dibromovinyl)phenyl methyl ether | C9H8Br2O | 详情 | 详情 | |
| (XLI) | 42108 | (E)-3-(4-methoxyphenyl)-2-propenoic acid | 830-09-1 | C10H10O3 | 详情 | 详情 |
| (XLII) | 63416 | isopropyl (E)-3-(4-methoxyphenyl)-2-propenoate | C13H16O3 | 详情 | 详情 |
合成路线8
该中间体在本合成路线中的序号：(X)Aldol condensation of anisaldehyde (X) with the lithium enolate of the N-acyl oxazolidinone (XLIX) gave adduct (L). Dehydration of alcohol (L) was accomplished by formation of the corresponding mesylate (LI), which underwent elimination in the presence of DBU, to produce a 4:1 mixture of Z and E olefins. After chromatographic isolation of the major Z isomer (LII), diastereoselective Michael addition using a 1:2 mixture of 2-aminothiophenol (VII) and the corresponding lithium thiophenoxide furnished (LIII) as the major diastereoisomer. Intramolecular cyclization of the amino imide (LIII) to the benzothiazepinone (LIV) was accomplished in the presence of trimethylaluminium in refluxing CH2Cl2. The methoxymethyl group of (LIV) was then removed by treatment with TiCl4, leading to the key precursor the thiazepinone (VIII)
| 【1】 Miyata, O.; Shinada, T.; Ninomiya, I.; Naito, T.; Asymmetric construction of two contiguous stereocenters by diastereoface differentiating addition reaction of thiols to chiral imides: Formal synthesis of (+)-diltiazem. Tetrahedron 1997, 53, 7, 2421. |
| 【2】 Miyata, O.; Shinada, T.; Ninomiya, I.; Naito, T.; Asymmetric induction at two contiguous stereogenic centers by diastereoface differentiating nucleophilic addition reaction. Tetrahedron Lett 1991, 32, 29, 3519. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VII) | 25182 | 2-aminobenzenethiol | 137-07-5 | C6H7NS | 详情 | 详情 |
| (VIII) | 62436 | (2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one | C16H15NO3S | 详情 | 详情 | |
| (X) | 27251 | 4-methoxybenzaldehyde; Anisicaldehyde; p-anisaldehyde | 123-11-5 | C8H8O2 | 详情 | 详情 |
| (XLIX) | 62465 | (4S)-4-isopropyl-3-[2-(methoxymethoxy)acetyl]-1,3-oxazolidin-2-one | C10H17NO5 | 详情 | 详情 | |
| (L) | 62466 | (4S)-3-[3-hydroxy-2-(methoxymethoxy)-3-(4-methoxyphenyl)propanoyl]-4-isopropyl-1,3-oxazolidin-2-one | C18H25NO7 | 详情 | 详情 | |
| (LI) | 62467 | 3-[(4S)-4-isopropyl-2-oxo-1,3-oxazolidin-3-yl]-2-(methoxymethoxy)-1-(4-methoxyphenyl)-3-oxopropyl methanesulfonate | C19H27NO9S | 详情 | 详情 | |
| (LII) | 62468 | (4S)-4-isopropyl-3-[(Z)-2-(methoxymethoxy)-3-(4-methoxyphenyl)-2-propenoyl]-1,3-oxazolidin-2-one | C18H23NO6 | 详情 | 详情 | |
| (LIII) | 62469 | (4S)-3-[(2S,3S)-3-[(2-aminophenyl)sulfanyl]-2-(methoxymethoxy)-3-(4-methoxyphenyl)propanoyl]-4-isopropyl-1,3-oxazolidin-2-one | C24H30N2O6S | 详情 | 详情 | |
| (LIV) | 62470 | (2S,3S)-3-(methoxymethoxy)-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one | C18H19NO4S | 详情 | 详情 |
合成路线9
该中间体在本合成路线中的序号：(VII)Several related procedures utilize racemic intermediates that are resolved in more advanced synthetic steps. The racemic trans-glycidic ester (IX) was prepared by Darzen's condensation between anisaldehyde (VII) and methyl chloroacetate (VIII). Opening of the epoxide group of (IX) with 2-aminothiophenol (X) in hot chlorobenzene in the presence of FeCl3 gave rise to the racemic threo adduct (XI) which, without isolation, was cyclized to the cis-lactam (XII) by addition of methanesulfonic acid and then heating to reflux. Alkylation of the lactam N of (XII) with 2-(dimethylamino)ethyl chloride (II) led to the racemic precursor (XIII). Resolution of (XIII) to provide the (S,S)-isomer (VII) was then accomplished by preferential crystallization of supersaturated solutions of several sulfonate salts of (XIII) upon seeding with the desired enantiomer. Racemic diltiazem (XIV), obtained by acetylation of (XIII), has been resolved via formation of the corresponding diastereoisomeric salts with (S)-naproxen
| 【1】 Gizur, T.; Harsanyi, K.; Fogassy, E.; Studies of the resolution of racemates in the synthesis of diltiazem. J Prakt Chem Chem-Ztg 1994, 336, 7, 628. |
| 【2】 Yamada, S.; Yoshioka, R.; Shibatani, T.; Optical resolution of a 1,5-benzothiazepine derivative,a synthetic intermediate of diltiazem, by preferential crystallization and diastereomeric salt formation. Chem Pharm Bull 1997, 45, 12, 1922. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (II) | 11907 | Dimethylaminoethyl chloride; 2-Dimethylaminoethyl chloride; 2-Chloro-N,N-dimethyl-1-ethanamine; N-(2-Chloroethyl)-N,N-dimethylamine | 107-99-3 | C4H10ClN | 详情 | 详情 |
| (VII) | 27251 | 4-methoxybenzaldehyde; Anisicaldehyde; p-anisaldehyde | 123-11-5 | C8H8O2 | 详情 | 详情 |
| (VII) | 62488 | (2S,3S)-5-[2-(dimethylamino)ethyl]-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one | C20H24N2O3S | 详情 | 详情 | |
| (VIII) | 10257 | methyl 2-chloroacetate; methyl chloroacetate | 96-34-4 | C3H5ClO2 | 详情 | 详情 |
| (IX) | 11905 | methyl (2R,3S)-3-(4-methoxyphenyl)-2-oxiranecarboxylate | C11H12O4 | 详情 | 详情 | |
| (X) | 25182 | 2-aminobenzenethiol | 137-07-5 | C6H7NS | 详情 | 详情 |
| (XI) | 62439 | methyl (2S,3S)-3-[(2-aminophenyl)sulfanyl]-2-hydroxy-3-(4-methoxyphenyl)propanoate | C17H19NO4S | 详情 | 详情 | |
| (XII) | 62436 | (2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one | C16H15NO3S | 详情 | 详情 | |
| (XIII) | 62487 | 5-[2-(dimethylamino)ethyl]-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one | C20H24N2O3S | 详情 | 详情 | |
| (XIV) | 62489 | 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate | C22H26N2O4S | 详情 | 详情 |
合成路线10
该中间体在本合成路线中的序号：(II)Condensation of 2'-fluoroacetophenone (I) with 4-methoxybenzaldehyde (II) under acidic conditions afforded chalcone (III). This was subsequently demethylated with boron tribromide to yield the 4-hydroxy chalcone (IV). Alternatively, chalcone (IV) was also obtained by condensation of 2'-fluoroacetophenone (I) with 4-hydroxybenzaldehyde (V). Reaction of chalcone (IV) with 2-(dimethylamino)ethoxyamine dihydrochloride (VI) produced the corresponding oxime as a mixture of syn target compound and anti (VIII) isomers. The title syn isomer was isolated by fractional extraction at increasing pH values or, alternatively, by recrystallization as the corresponding hemifumarate salt. Optionally, the undesired anti compound (VIII) was isomerized by acidic treatment to produce a 45:55 mixture of target compound and (VIII).
| 【1】 Congy, C.; Labeeuw, B.; Gueule, P.; Rinaldi, M. (Sanofi-Synthelabo); Propenone oxime ethers, method for their preparation and pharmaceutical compsns. containing them. EP 0373998; FR 2639942; JP 1990262552 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 48065 | 1-(2-fluorophenyl)-1-ethanone | 445-27-2 | C8H7FO | 详情 | 详情 |
| (II) | 27251 | 4-methoxybenzaldehyde; Anisicaldehyde; p-anisaldehyde | 123-11-5 | C8H8O2 | 详情 | 详情 |
| (III) | 48066 | (E)-1-(2-fluorophenyl)-3-(4-methoxyphenyl)-2-propen-1-one | C16H13FO2 | 详情 | 详情 | |
| (IV) | 48067 | (E)-1-(2-fluorophenyl)-3-(4-hydroxyphenyl)-2-propen-1-one | C15H11FO2 | 详情 | 详情 | |
| (V) | 13433 | 4-Hydroxybenzaldehyde; p-Hydroxybenzaldehyde | 123-08-0 | C7H6O2 | 详情 | 详情 |
| (VI) | 48068 | 2-(aminooxy)-N,N-dimethyl-1-ethanamine; N-[2-(aminooxy)ethyl]-N,N-dimethylamine | C4H12N2O | 详情 | 详情 | |
| (VIII) | 48069 | (E)-1-(2-fluorophenyl)-3-(4-hydroxyphenyl)-2-propen-1-one O-[2-(dimethylamino)ethyl]oxime | C19H21FN2O2 | 详情 | 详情 |
合成路线11
该中间体在本合成路线中的序号：(II)The condensation of 4-O-benzyl-L-tyrosine methyl ester (I) with 4-methoxybenzaldehyde (II) in methanol gives the imine (III), which is oxidized with MCPBA yielding the oxaziridine (IV). The reaction of (IV) with NH2OH affords the 4-O-benzyl-N-hydroxy-L-tyrosine methyl ester (V), which is condensed with cyclohexane-1,4-dione monobutyleneketal (VI) in ethanol giving the imine oxide (VII). The cyclization of (VII) with ethyl acrylate (VIII) in refluxing toluene yields the spiranic isoxazolidine (IX). The hydrogenolysis of the O-N bond of (IX) with H2 over Pd/C, followed by lactam formation by means of AcOH affords the spiranic hydroxypyrrolidinone (X), which is alkylated at the phenolic OH with 3-methyl-2-butenyl bromide (XI) and Cs2CO3 in hot acetone providing the phenolic ether (XII). The reaction of (XII) with tosyl chloride, TEA and DMAP gives the tosylate (XIII), which is treated with sodium azide in DMF to affords the azide (XIV). The reduction of (XIV) with LiAlH4 followed by reductive methylation of the resulting amine with formic acetic anhydride and LiAlH4 provides the methyl-amino derivative (XV).
| 【1】 Lin, H.; Snider, B.B.; Biomimeric total syntheses of (-)-TAN1251A, (+)-TAN1251B, (+)-TAN1251C, and (+)-TAN1251D. Org Lett 2000, 2, 5, 643. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 36917 | methyl (2S)-2-amino-3-[4-(benzyloxy)phenyl]propanoate | C17H19NO3 | 详情 | 详情 | |
| (II) | 27251 | 4-methoxybenzaldehyde; Anisicaldehyde; p-anisaldehyde | 123-11-5 | C8H8O2 | 详情 | 详情 |
| (III) | 36918 | methyl (2S)-3-[4-(benzyloxy)phenyl]-2-[[(E)-(4-methoxyphenyl)methylidene]amino]propanoate | C25H25NO4 | 详情 | 详情 | |
| (IV) | 36919 | methyl (2S)-3-[4-(benzyloxy)phenyl]-2-[3-(4-methoxyphenyl)-1,2-oxaziridin-2-yl]propanoate | C25H25NO5 | 详情 | 详情 | |
| (V) | 36920 | methyl (2S)-3-[4-(benzyloxy)phenyl]-2-(hydroxyamino)propanoate | C17H19NO4 | 详情 | 详情 | |
| (VI) | 36921 | 7,12-dioxaspiro[5.6]dodecan-3-one | C10H16O3 | 详情 | 详情 | |
| (VII) | 36922 | [(1S)-1-[4-(benzyloxy)benzyl]-2-methoxy-2-oxoethyl](7,12-dioxaspiro[5.6]dodec-3-ylidene)ammoniumolate | C27H33NO6 | 详情 | 详情 | |
| (VIII) | 10164 | ethyl acrylate | 140-88-5 | C5H8O2 | 详情 | 详情 |
| (IX) | 36923 | ethyl (3R)-1-[(1S)-1-[4-(benzyloxy)benzyl]-2-methoxy-2-oxoethyl]-2,9,14-trioxa-1-azadispiro[4.2.6.2]hexadecane-3-carboxylate | C32H41NO8 | 详情 | 详情 | |
| (X) | 36924 | methyl (2S)-2-[(3R)-3-hydroxy-2-oxo-9,14-dioxa-1-azadispiro[4.2.6.2]hexadec-1-yl]-3-(4-hydroxyphenyl)propanoate | C23H31NO7 | 详情 | 详情 | |
| (XI) | 12989 | 4-Bromo-2-methyl-2-butene; 1-Bromo-3-methyl-2-butene | 870-63-3 | C5H9Br | 详情 | 详情 |
| (XII) | 36925 | methyl (2S)-2-[(3R)-3-hydroxy-2-oxo-9,14-dioxa-1-azadispiro[4.2.6.2]hexadec-1-yl]-3-[4-[(3-methyl-2-butenyl)oxy]phenyl]propanoate | C28H39NO7 | 详情 | 详情 | |
| (XIII) | 36926 | methyl (2S)-3-[4-[(3-methyl-2-butenyl)oxy]phenyl]-2-((3R)-3-[[(4-methylphenyl)sulfonyl]oxy]-2-oxo-9,14-dioxa-1-azadispiro[4.2.6.2]hexadec-1-yl)propanoate | C35H45NO9S | 详情 | 详情 | |
| (XIV) | 36927 | methyl (2S)-2-[(3S)-3-azido-2-oxo-9,14-dioxa-1-azadispiro[4.2.6.2]hexadec-1-yl]-3-[4-[(3-methyl-2-butenyl)oxy]phenyl]propanoate | C28H38N4O6 | 详情 | 详情 | |
| (XV) | 36928 | methyl (2S)-2-[(3S)-3-(methylamino)-9,14-dioxa-1-azadispiro[4.2.6.2]hexadec-1-yl]-3-[4-[(3-methyl-2-butenyl)oxy]phenyl]propanoate | C29H44N2O5 | 详情 | 详情 |
合成路线12
该中间体在本合成路线中的序号：(II)The condensation of 4-O-benzyl-L-tyrosine methyl ester (I) with 4-methoxybenzaldehyde (II) in methanol gives the imine (III), which is oxidized with MCPBA yielding the oxaziridine (IV). The reaction of (IV) with NH2OH affords the 4-O-benzyl-N-hydroxy-L-tyrosine methyl ester (V), which is condensed with cyclohexane-1,4-dione monobutyleneketal (VI) in ethanol giving the imine oxide (VII). The cyclization of (VII) with ethyl acrylate (VIII) in refluxing toluene yields the spiranic isoxazolidine (IX). The hydrogenolysis of the O-N bond of (IX) with H2 over Pd/C, followed by lactam formation by means of AcOH affords the spiranic hydroxypyrrolidinone (X), which is alkylated at the phenolic OH with 3-methyl-2-butenyl bromide (XI) and Cs2CO3 in hot acetone providing the phenolic ether (XII). The reaction of (XII) with tosyl chloride, TEA and DMAP gives the tosylate (XIII), which is treated with sodium azide in DMF to affords the azide (XIV). The reduction of (XIV) with LiAlH4 followed by reductive methylation of the resulting amine with formic acetic anhydride and LiAlH4 provides the methylamino derivative.
| 【1】 Lin, H.; Snider, B.B.; Biomimeric total syntheses of (-)-TAN1251A, (+)-TAN1251B, (+)-TAN1251C, and (+)-TAN1251D. Org Lett 2000, 2, 5, 643. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 36917 | methyl (2S)-2-amino-3-[4-(benzyloxy)phenyl]propanoate | C17H19NO3 | 详情 | 详情 | |
| (II) | 27251 | 4-methoxybenzaldehyde; Anisicaldehyde; p-anisaldehyde | 123-11-5 | C8H8O2 | 详情 | 详情 |
| (III) | 36918 | methyl (2S)-3-[4-(benzyloxy)phenyl]-2-[[(E)-(4-methoxyphenyl)methylidene]amino]propanoate | C25H25NO4 | 详情 | 详情 | |
| (IV) | 36919 | methyl (2S)-3-[4-(benzyloxy)phenyl]-2-[3-(4-methoxyphenyl)-1,2-oxaziridin-2-yl]propanoate | C25H25NO5 | 详情 | 详情 | |
| (V) | 36920 | methyl (2S)-3-[4-(benzyloxy)phenyl]-2-(hydroxyamino)propanoate | C17H19NO4 | 详情 | 详情 | |
| (VI) | 36921 | 7,12-dioxaspiro[5.6]dodecan-3-one | C10H16O3 | 详情 | 详情 | |
| (VII) | 36922 | [(1S)-1-[4-(benzyloxy)benzyl]-2-methoxy-2-oxoethyl](7,12-dioxaspiro[5.6]dodec-3-ylidene)ammoniumolate | C27H33NO6 | 详情 | 详情 | |
| (VIII) | 10164 | ethyl acrylate | 140-88-5 | C5H8O2 | 详情 | 详情 |
| (IX) | 36923 | ethyl (3R)-1-[(1S)-1-[4-(benzyloxy)benzyl]-2-methoxy-2-oxoethyl]-2,9,14-trioxa-1-azadispiro[4.2.6.2]hexadecane-3-carboxylate | C32H41NO8 | 详情 | 详情 | |
| (X) | 36924 | methyl (2S)-2-[(3R)-3-hydroxy-2-oxo-9,14-dioxa-1-azadispiro[4.2.6.2]hexadec-1-yl]-3-(4-hydroxyphenyl)propanoate | C23H31NO7 | 详情 | 详情 | |
| (XI) | 12989 | 4-Bromo-2-methyl-2-butene; 1-Bromo-3-methyl-2-butene | 870-63-3 | C5H9Br | 详情 | 详情 |
| (XII) | 36925 | methyl (2S)-2-[(3R)-3-hydroxy-2-oxo-9,14-dioxa-1-azadispiro[4.2.6.2]hexadec-1-yl]-3-[4-[(3-methyl-2-butenyl)oxy]phenyl]propanoate | C28H39NO7 | 详情 | 详情 | |
| (XIII) | 36926 | methyl (2S)-3-[4-[(3-methyl-2-butenyl)oxy]phenyl]-2-((3R)-3-[[(4-methylphenyl)sulfonyl]oxy]-2-oxo-9,14-dioxa-1-azadispiro[4.2.6.2]hexadec-1-yl)propanoate | C35H45NO9S | 详情 | 详情 | |
| (XIV) | 36927 | methyl (2S)-2-[(3S)-3-azido-2-oxo-9,14-dioxa-1-azadispiro[4.2.6.2]hexadec-1-yl]-3-[4-[(3-methyl-2-butenyl)oxy]phenyl]propanoate | C28H38N4O6 | 详情 | 详情 | |
| (XV) | 36928 | methyl (2S)-2-[(3S)-3-(methylamino)-9,14-dioxa-1-azadispiro[4.2.6.2]hexadec-1-yl]-3-[4-[(3-methyl-2-butenyl)oxy]phenyl]propanoate | C29H44N2O5 | 详情 | 详情 |
合成路线13
该中间体在本合成路线中的序号：(XXV)Reaction of chloroacetic acid (XXII) with sodium ethoxide (XXIII) in ethanol gives 2-ethoxyacetic acid ethyl ester (XXIV), which is condensed with 4-methoxybenz-aldehyde (XXV) by means of t-BuOK in THF to yield 2-ethoxy-3-(4-methoxyphenyl)-2-propenoic acid ethyl ester (XXVI). Hydrolysis of ester (XXVI) with NaOH in hot ethanol/water affords the propenoic acid derivative (XXVII), which is reduced with H2 over Pd/C in ethanol to provide racemic 2-ethoxy-3-(4-methoxyphenyl)propionic acid (XXVIII). Optical resolution of mixture (XXVIII) is performed by salt formation with 1(S)-(1-naphthyl)ethylamine (XXIX) followed by crystallization to give the diastereomeric salt (XXX), which is treated with NaOH, followed by acidification with HCl to yield 2(S)-ethoxy-3-(4-methoxyphenyl)propionic acid (XXXI). Demethylation of compound (XXXI) by reaction with NaOH and octanethiol in NMP affords 2(S)-ethoxy-3-(4-hydroxyphenyl)propionic acid (XXXII), which is esterified with ethanol/HCl to provide the corresponding ethyl ester (XXXIII). Condensation of ester (XXXIII) with the bismesylate (II) by means of either K2CO3 in 2-butanone or Na2CO3 in acetone provides 2(S)-ethoxy-3-[4-[2-[4-(methanesulfonyloxy)-phenyl]ethoxy]phenyl]propionic acid ethyl ester (XXI), which is finally hydrolyzed with NaOH or LiOH in acetone/water.
| 【1】 McIntyre, J.A.; Castaner, J.; Bayes, M.; Tesaglitazar. Drugs Fut 2003, 28, 10, 959. |
| 【2】 Ioannidis, P.; Ehrl, R.; MacKintosh, W. (AstraZeneca AB); Process for the preparation 3-aryl-2-hydroxypropionic acid deriv.. WO 0296865 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (II) | 50403 | 4-[2-[(methylsulfonyl)oxy]ethyl]phenyl methanesulfonate | C10H14O6S2 | 详情 | 详情 | |
| (XX) | 50418 | ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate | C13H18O4 | 详情 | 详情 | |
| (XXI) | 50419 | ethyl (2S)-2-ethoxy-3-[4-([4-[(methylsulfonyl)oxy]phenethyl]oxy)phenyl]propanoate | C22H28O7S | 详情 | 详情 | |
| (XXII) | 11847 | 2-Chloroacetic acid; Chloroacetic Acid | 79-11-8 | C2H3ClO2 | 详情 | 详情 |
| (XXIII) | 63048 | sodium 1-ethanolate | C2H5NaO | 详情 | 详情 | |
| (XXIV) | 63049 | ethyl 2-ethoxyacetate | C6H12O3 | 详情 | 详情 | |
| (XXV) | 27251 | 4-methoxybenzaldehyde; Anisicaldehyde; p-anisaldehyde | 123-11-5 | C8H8O2 | 详情 | 详情 |
| (XXVI) | 63050 | ethyl (E)-2-ethoxy-3-(4-methoxyphenyl)-2-propenoate | C14H18O4 | 详情 | 详情 | |
| (XXVII) | 63051 | (E)-2-ethoxy-3-(4-methoxyphenyl)-2-propenoic acid | C12H14O4 | 详情 | 详情 | |
| (XXVIII) | 63052 | 2-ethoxy-3-(4-methoxyphenyl)propanoic acid | C12H16O4 | 详情 | 详情 | |
| (XXIX) | 17443 | (1R)-1-(1-naphthyl)ethylamine; (1R)-1-(1-naphthyl)-1-ethanamine | 3886-70-2 | C12H13N | 详情 | 详情 |
| (XXX) | 63053 | (1S)-1-(1-naphthyl)-1-ethanaminium (2S)-2-ethoxy-3-(4-methoxyphenyl)propanoate | C24H29NO4 | 详情 | 详情 | |
| (XXXI) | 63054 | (2S)-2-ethoxy-3-(4-methoxyphenyl)propanoic acid | C12H16O4 | 详情 | 详情 | |
| (XXXII) | 63055 | (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoic acid | C11H14O4 | 详情 | 详情 |
合成路线14
该中间体在本合成路线中的序号：(II)Condensation of glucosamine (I) with anisaldehyde (II) gave imine (III). Subsequent acetylation of (III) with Ac2O in pyridine produced the tetra O-acetate (IV). The imine group of (IV) was then hydrolyzed with HCl in aqueous acetone to afford, after basic work-up, glucosamine tetraacetate (V), which was coupled with N-acetyl penicillamine using 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate to yield amide (VII). Finally, nitrosation of the mercapto group of (VII) with NaNO2 and HCl furnished the title compound.
| 【1】 Butler, A.R.; Megson, I.L.; Greig, I.R. (University of St. Andrews); Nitric oxide donor drugs. WO 9820015 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 24036 | (3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)tetrahydro-2H-pyran-2,4,5-triol; Glucosamine | 3416-24-8 | C6H13NO5 | 详情 | 详情 |
| (II) | 27251 | 4-methoxybenzaldehyde; Anisicaldehyde; p-anisaldehyde | 123-11-5 | C8H8O2 | 详情 | 详情 |
| (III) | 27252 | (3R,4R,5S,6R)-6-(hydroxymethyl)-3-[[(E)-(4-methoxyphenyl)methylidene]amino]tetrahydro-2H-pyran-2,4,5-triol | C14H19NO6 | 详情 | 详情 | |
| (IV) | 27253 | (2R,3R,4R,5R,6S)-4,6-bis(acetoxy)-2-[(acetoxy)methyl]-5-[[(E)-(4-methoxyphenyl)methylidene]amino]tetrahydro-2H-pyran-3-yl acetate | C22H27NO10 | 详情 | 详情 | |
| (V) | 27254 | (2R,3R,4R,5R,6S)-4,6-bis(acetoxy)-2-[(acetoxy)methyl]-5-aminotetrahydro-2H-pyran-3-yl acetate | C14H21NO9 | 详情 | 详情 | |
| (VI) | 27255 | (2S)-2-(acetamido)-3-methyl-3-sulfanylbutyric acid | 59-53-0 | C7H13NO3S | 详情 | 详情 |
| (VII) | 27256 | (2R,3R,4R,5R,6S)-5-[[(2S)-2-(acetamido)-3-methyl-3-sulfanylbutanoyl]amino]-4,6-bis(acetoxy)-2-[(acetoxy)methyl]tetrahydro-2H-pyran-3-yl acetate | C21H32N2O11S | 详情 | 详情 |
合成路线15
该中间体在本合成路线中的序号：(II)The reaction of the chiral epoxide (I) with 4-methoxybenzaldehyde (II) by means of NaAl(OMe)3H in THF gives the 1,3-dioxane (III), which is opened by reduction with DIBAL in dichloromethane to yield the chiral benzyl ether (IV). The oxidation of the primary alcohol of (IV) with DMP in dichloromethane affords the corresponding aldehyde (V), which is condensed with the boronate (VI) and S,S-diisopropyl tartrate in toluene to provide the unsaturated alcohol (VII).The protection of (VII) with Tbdps-Cl and imidazole yields the fully protected triol (VIII), which is oxidized at the terminal double bond with 9-BBN in THF to give the primary alcohol (IX). The oxidation of (IX) with DMP in dichloromethane affords the aldehyde (X), which is condensed with methylenetriphenylphosphorane (XI) in THF to provide the terminal olefin (XII). Elimination of the Pmb protecting group of (XII) with DDQ in dichloromethane gives the alcohol (XIII), which is esterified with 2-allyl-6-methoxybenzoic acid (XIV)(obtained by allylation of 2-methoxybenzoic acid (XV) with allyl bromide (XVI), BuLi and MgBr2) by means of DEAD and PPh3 yielding the ester (XVII). The cyclization of (XVII) by means of a metathesis reaction catalyzed by a ruthenium catalyst in refluxing dichloromethane affords the bicyclic lactone (XVIII), which is treated with BBr3 in dichloromethane to provide the dihydroxylated lactone (XIX).
| 【1】 Labrecque, D.; et al.; Enantioselective total synthesis of salicylihalamides A and B. Tetrahedron Lett 2001, 42, 14, 2645. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 47480 | [(2R,3R)-3-[3-(benzyloxy)propyl]oxiranyl]methanol | C13H18O3 | 详情 | 详情 | |
| (II) | 27251 | 4-methoxybenzaldehyde; Anisicaldehyde; p-anisaldehyde | 123-11-5 | C8H8O2 | 详情 | 详情 |
| (III) | 47481 | (4R)-4-[3-(benzyloxy)propyl]-2-(4-methoxyphenyl)-1,3-dioxane; benzyl 3-[(4R)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]propyl ether | C21H26O4 | 详情 | 详情 | |
| (IV) | 47482 | (3R)-6-(benzyloxy)-3-[(4-methoxybenzyl)oxy]-1-hexanol | C21H28O4 | 详情 | 详情 | |
| (V) | 47483 | (3R)-6-(benzyloxy)-3-[(4-methoxybenzyl)oxy]hexanal | C21H26O4 | 详情 | 详情 | |
| (VI) | 47484 | dimethyl (E)-2-butenylboronate | C6H13BO2 | 详情 | 详情 | |
| (VII) | 47485 | (3S,4R,6R)-9-(benzyloxy)-6-[(4-methoxybenzyl)oxy]-3-methyl-1-nonen-4-ol | C25H34O4 | 详情 | 详情 | |
| (VIII) | 47486 | [((1R,2S)-1-[(2R)-5-(benzyloxy)-2-[(4-methoxybenzyl)oxy]pentyl]-2-methyl-3-butenyl)oxy](tert-butyl)diphenylsilane; benzyl (4R,6R,7S)-6-[[tert-butyl(diphenyl)silyl]oxy]-4-[(4-methoxybenzyl)oxy]-7-methyl-8-nonenyl ether | C41H52O4Si | 详情 | 详情 | |
| (IX) | 47487 | (3S,4R,6R)-9-(benzyloxy)-4-[[tert-butyl(diphenyl)silyl]oxy]-6-[(4-methoxybenzyl)oxy]-3-methyl-1-nonanol | C41H54O5Si | 详情 | 详情 | |
| (X) | 47488 | (3S,4R,6R)-9-(benzyloxy)-4-[[tert-butyl(diphenyl)silyl]oxy]-6-[(4-methoxybenzyl)oxy]-3-methylnonanal | C41H52O5Si | 详情 | 详情 | |
| (XI) | 27301 | methylene(triphenyl)phosphorane | C19H17P | 详情 | 详情 | |
| (XII) | 47489 | [((1R,2S)-1-[(2R)-5-(benzyloxy)-2-[(4-methoxybenzyl)oxy]pentyl]-2-methyl-4-pentenyl)oxy](tert-butyl)diphenylsilane; benzyl (4R,6R,7S)-6-[[tert-butyl(diphenyl)silyl]oxy]-4-[(4-methoxybenzyl)oxy]-7-methyl-9-decenyl ether | C42H54O4Si | 详情 | 详情 | |
| (XIII) | 47490 | (4R,6R,7S)-1-(benzyloxy)-6-[[tert-butyl(diphenyl)silyl]oxy]-7-methyl-9-decen-4-ol | C34H46O3Si | 详情 | 详情 | |
| (XIV) | 13926 | 2-Methoxybenzoic acid; o-Methoxybenzoic Acid | 579-75-9 | C8H8O3 | 详情 | 详情 |
| (XV) | 11463 | 3-Bromo-1-propene; 3-Bromopropene；allyl bromide | 106-95-6 | C3H5Br | 详情 | 详情 |
| (XVI) | 47491 | 2-allyl-6-methoxybenzoic acid | C11H12O3 | 详情 | 详情 | |
| (XVII) | 47492 | (1S,3R,4S)-1-[3-(benzyloxy)propyl]-3-[[tert-butyl(diphenyl)silyl]oxy]-4-methyl-6-heptenyl 2-allyl-6-methoxybenzoate | C45H56O5Si | 详情 | 详情 | |
| (XVIII) | 47493 | (3S,5R,6S)-3-[3-(benzyloxy)propyl]-5-[[tert-butyl(diphenyl)silyl]oxy]-14-methoxy-6-methyl-3,4,5,6,7,10-hexahydro-1H-2-benzoxacyclododecin-1-one | C43H52O5Si | 详情 | 详情 | |
| (XIX) | 47494 | (3S,5R,6S)-5-[[tert-butyl(diphenyl)silyl]oxy]-14-hydroxy-3-(3-hydroxypropyl)-6-methyl-3,4,5,6,7,10-hexahydro-1H-2-benzoxacyclododecin-1-one | C35H44O5Si | 详情 | 详情 |
合成路线16
该中间体在本合成路线中的序号：(II)The reaction of the chiral epoxide (I) with 4-methoxybenzaldehyde (II) by means of NaAl(OMe)3H in THF gives the 1,3-dioxane (III), which is opened by reduction with DIBAL in dichloromethane to yield the chiral benzyl ether (IV). The oxidation of the primary alcohol of (IV) with DMP in dichloromethane affords the corresponding aldehyde (V), which is condensed with the boronate (VI) and S,S-diisopropyl tartrate in toluene to provide the unsaturated alcohol (VII).The protection of (VII) with Tbdps-Cl and imidazole yields the fully protected triol (VIII), which is oxidized at the terminal double bond with 9-BBN in THF to give the primary alcohol (IX). The oxidation of (IX) with DMP in dichloromethane affords the aldehyde (X), which is condensed with methylenetriphenylphosphorane (XI) in THF to provide the terminal olefin (XII). Elimination of the Pmb protecting group of (XII) with DDQ in dichloromethane gives the alcohol (XIII), which is esterified with 2-allyl-6-methoxybenzoic acid (XIV)(obtained by allylation of 2-methoxybenzoic acid (XV) with allyl bromide (XVI), BuLi and MgBr2) by means of DEAD and PPh3 yielding the ester (XVII). The cyclization of (XVII) by means of a metathesis reaction catalyzed by a ruthenium catalyst in refluxing dichloromethane affords the bicyclic lactone (XVIII), which is treated with BBr3 in dichloromethane to provide the dihydroxylated lactone (XIX).
| 【1】 Labrecque, D.; et al.; Enantioselective total synthesis of salicylihalamides A and B. Tetrahedron Lett 2001, 42, 14, 2645. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 47480 | [(2R,3R)-3-[3-(benzyloxy)propyl]oxiranyl]methanol | C13H18O3 | 详情 | 详情 | |
| (II) | 27251 | 4-methoxybenzaldehyde; Anisicaldehyde; p-anisaldehyde | 123-11-5 | C8H8O2 | 详情 | 详情 |
| (III) | 47481 | (4R)-4-[3-(benzyloxy)propyl]-2-(4-methoxyphenyl)-1,3-dioxane; benzyl 3-[(4R)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]propyl ether | C21H26O4 | 详情 | 详情 | |
| (IV) | 47482 | (3R)-6-(benzyloxy)-3-[(4-methoxybenzyl)oxy]-1-hexanol | C21H28O4 | 详情 | 详情 | |
| (V) | 47483 | (3R)-6-(benzyloxy)-3-[(4-methoxybenzyl)oxy]hexanal | C21H26O4 | 详情 | 详情 | |
| (VI) | 47484 | dimethyl (E)-2-butenylboronate | C6H13BO2 | 详情 | 详情 | |
| (VII) | 47485 | (3S,4R,6R)-9-(benzyloxy)-6-[(4-methoxybenzyl)oxy]-3-methyl-1-nonen-4-ol | C25H34O4 | 详情 | 详情 | |
| (VIII) | 47486 | [((1R,2S)-1-[(2R)-5-(benzyloxy)-2-[(4-methoxybenzyl)oxy]pentyl]-2-methyl-3-butenyl)oxy](tert-butyl)diphenylsilane; benzyl (4R,6R,7S)-6-[[tert-butyl(diphenyl)silyl]oxy]-4-[(4-methoxybenzyl)oxy]-7-methyl-8-nonenyl ether | C41H52O4Si | 详情 | 详情 | |
| (IX) | 47487 | (3S,4R,6R)-9-(benzyloxy)-4-[[tert-butyl(diphenyl)silyl]oxy]-6-[(4-methoxybenzyl)oxy]-3-methyl-1-nonanol | C41H54O5Si | 详情 | 详情 | |
| (X) | 47488 | (3S,4R,6R)-9-(benzyloxy)-4-[[tert-butyl(diphenyl)silyl]oxy]-6-[(4-methoxybenzyl)oxy]-3-methylnonanal | C41H52O5Si | 详情 | 详情 | |
| (XI) | 27301 | methylene(triphenyl)phosphorane | C19H17P | 详情 | 详情 | |
| (XII) | 47489 | [((1R,2S)-1-[(2R)-5-(benzyloxy)-2-[(4-methoxybenzyl)oxy]pentyl]-2-methyl-4-pentenyl)oxy](tert-butyl)diphenylsilane; benzyl (4R,6R,7S)-6-[[tert-butyl(diphenyl)silyl]oxy]-4-[(4-methoxybenzyl)oxy]-7-methyl-9-decenyl ether | C42H54O4Si | 详情 | 详情 | |
| (XIII) | 47490 | (4R,6R,7S)-1-(benzyloxy)-6-[[tert-butyl(diphenyl)silyl]oxy]-7-methyl-9-decen-4-ol | C34H46O3Si | 详情 | 详情 | |
| (XIV) | 13926 | 2-Methoxybenzoic acid; o-Methoxybenzoic Acid | 579-75-9 | C8H8O3 | 详情 | 详情 |
| (XV) | 11463 | 3-Bromo-1-propene; 3-Bromopropene；allyl bromide | 106-95-6 | C3H5Br | 详情 | 详情 |
| (XVI) | 47491 | 2-allyl-6-methoxybenzoic acid | C11H12O3 | 详情 | 详情 | |
| (XVII) | 47492 | (1S,3R,4S)-1-[3-(benzyloxy)propyl]-3-[[tert-butyl(diphenyl)silyl]oxy]-4-methyl-6-heptenyl 2-allyl-6-methoxybenzoate | C45H56O5Si | 详情 | 详情 | |
| (XVIII) | 47493 | (3S,5R,6S)-3-[3-(benzyloxy)propyl]-5-[[tert-butyl(diphenyl)silyl]oxy]-14-methoxy-6-methyl-3,4,5,6,7,10-hexahydro-1H-2-benzoxacyclododecin-1-one | C43H52O5Si | 详情 | 详情 | |
| (XIX) | 47494 | (3S,5R,6S)-5-[[tert-butyl(diphenyl)silyl]oxy]-14-hydroxy-3-(3-hydroxypropyl)-6-methyl-3,4,5,6,7,10-hexahydro-1H-2-benzoxacyclododecin-1-one | C35H44O5Si | 详情 | 详情 |
合成路线17
该中间体在本合成路线中的序号：(III)The hydrolysis of 2-(dimethylamino)-6-methoxybenzo[b]thiophene (I) with HCl in refluxing THF gives 6-methoxybenzo[b]thiophen-2(3H)-one (II), which is condensed with 4-methoxybenzaldehyde (III) by means of piperidine in methanol yielding the 3-benzylidene derivative (IV). The rearrangement of (IV) with the same catalyst and solvent affords trans-6-methoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzo[b]thiophene-3-carboxylic acid methyl ester (V), which is hydrolyzed with NaOH in methanol to the corresponding acid (VI). The reaction of (VI) with SOCl2 in dichloromethane gives the acyl chloride (VII), which is condensed with N,O-dimethylhydroxylamine by means of triethylamine in dichloromethane providing the N-methoxy-N-methylamide (VIII). The condensation of (VIII) with the Grignard reagent (IX) in THF affords the dimethyl ether of the target compound (X), which is finally demethylated with AlCl3 and propanethiol in dichloromethane. The intermediate Grignard reagent (IX) has been obtained by condensation of 4-bromophenol (XI) with 1-(2-chloroethyl)piperidine (XII) by means of K2CO3 in hot DMF to give 1-[2-(4-bromophenoxy)ethyl]piperidine (XIII), which is then treated with magnesium in THF to afford (IX).
| 【1】 Stephenson, G.A.; Glasebrook, A.L.; Schmid, C.R.; Misner, J.W.; Synthesis and biological activity of trans-2,3-dihydroraloxifene. Bioorg Med Chem Lett 1999, 9, 8, 1137. |
| 【2】 Glasebrook, A.L.; Schmid, C.R.; Stephenson, G.A.; Misner, J.W.; Synthesis and biological activity of dihydroraloxifene. 217th ACS Natl Meet (March 21 1999, Anaheim) 1999, Abst MEDI 072. |
| 【3】 Misner, J.W.; Schmid, C.R. (Eli Lilly and Company); Intermediates and processes for preparing benzo[b]thiophenes. EP 0979076; WO 9848793 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 30906 | N-(6-methoxy-1-benzothiophen-2-yl)-N,N-dimethylamine; 6-methoxy-N,N-dimethyl-1-benzothiophen-2-amine | C11H13NOS | 详情 | 详情 | |
| (II) | 30907 | 6-methoxy-1-benzothiophen-2(3H)-one | C9H8O2S | 详情 | 详情 | |
| (III) | 27251 | 4-methoxybenzaldehyde; Anisicaldehyde; p-anisaldehyde | 123-11-5 | C8H8O2 | 详情 | 详情 |
| (IV) | 30908 | 6-methoxy-3-[(Z)-(4-methoxyphenyl)methylidene]-1-benzothiophen-2-one | C17H14O3S | 详情 | 详情 | |
| (V) | 30909 | methyl (2R,3S)-6-methoxy-2-(4-methoxyphenyl)-2,3-dihydro-1-benzothiophene-3-carboxylate | C18H18O4S | 详情 | 详情 | |
| (VI) | 30910 | (2R,3S)-6-methoxy-2-(4-methoxyphenyl)-2,3-dihydro-1-benzothiophene-3-carboxylic acid | C17H16O4S | 详情 | 详情 | |
| (VII) | 30911 | (2R,3R)-6-methoxy-2-(4-methoxyphenyl)-2,3-dihydro-1-benzothiophene-3-carbonyl chloride | C17H15ClO3S | 详情 | 详情 | |
| (VIII) | 30912 | (2R,3S)-N,6-dimethoxy-2-(4-methoxyphenyl)-N-methyl-2,3-dihydro-1-benzothiophene-3-carboxamide | C19H21NO4S | 详情 | 详情 | |
| (IX) | 30913 | bromo[4-[2-(1-piperidinyl)ethoxy]phenyl]magnesium | C13H18BrMgNO | 详情 | 详情 | |
| (X) | 30914 | [(2R,3S)-6-methoxy-2-(4-methoxyphenyl)-2,3-dihydro-1-benzothiophen-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone | C30H33NO4S | 详情 | 详情 | |
| (XI) | 25313 | 4-bromophenol | 106-41-2 | C6H5BrO | 详情 | 详情 |
| (XII) | 10117 | 1-(2-Chloroethyl)piperidine; N-(2-Chloroethyl)piperidine | 1932-03-2 | C7H14ClN | 详情 | 详情 |
| (XIII) | 30915 | 4-bromophenyl 2-(1-piperidinyl)ethyl ether; 1-[2-(4-bromophenoxy)ethyl]piperidine | C13H18BrNO | 详情 | 详情 |
合成路线18
该中间体在本合成路线中的序号：(I)Condensation of 4-methoxybenzaldehyde (I) with gamma-butyrolactone (II) by means of NaOMe yields furanone derivative (III), which is then reduced in ether with LiAlH4 to afford diol (IV). Mesylation of (IV) by means of MsCl and Et3N in benzene provides dimesylate (V), which is finally condensed with amine (VI) with simultaneous cyclization in refluxing benzene.
| 【1】 Batra, S.; et al.; A new class of potential chloroquine-resistance reversal agents for plasmodia: Syntheses and biological evaluation of 1-(3'-diethylaminopropyl)-3-(substituted phenylmethylene)pyrrolidines. J Med Chem 2000, 43, 18, 3428. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 27251 | 4-methoxybenzaldehyde; Anisicaldehyde; p-anisaldehyde | 123-11-5 | C8H8O2 | 详情 | 详情 |
| (II) | 44219 | 1,2-dioxolan-3-one | C3H4O3 | 详情 | 详情 | |
| (III) | 44220 | 4-[(E)-(4-methoxyphenyl)methylidene]-1,2-dioxolan-3-one | C11H10O4 | 详情 | 详情 | |
| (IV) | 44221 | 2-[(E)-(4-methoxyphenyl)methylidene]-1,4-butanediol | C12H16O3 | 详情 | 详情 | |
| (V) | 44222 | 5-[(E)-(4-methoxyphenyl)methylidene]-2,9-dimethyl-2,9-dimethylene-3,8-dioxa-2lambda(6),9lambda(6)-dithia-1,9-decadiene; methyl 4-[(E)-4-[[methyl(dimethylene)-lambda(6)-sulfanyl]oxy]-2-([[methyl(dimethylene)-lambda(6)-sulfanyl]oxy]methyl)-1-butenyl]phenyl ether | C18H28O3S2 | 详情 | 详情 | |
| (VI) | 29977 | N-(3-aminopropyl)-N,N-diethylamine; N(1),N(1)-diethyl-1,3-propanediamine | 104-78-9 | C7H18N2 | 详情 | 详情 |