2-allyl-6-methoxybenzoic acid -Drug Synthesis Database

【结构式】

【分子编号】47491

【品名】2-allyl-6-methoxybenzoic acid

【CA登记号】

【分子式】C₁₁H₁₂O₃

【分子量】192.21448

【元素组成】C 68.74% H 6.29% O 24.97%

与该中间体有关的原料药合成路线共 4 条

合成路线1 合成路线2 合成路线3 合成路线4

合成路线1

该中间体在本合成路线中的序号：(XVI)

The reaction of the chiral epoxide (I) with 4-methoxybenzaldehyde (II) by means of NaAl(OMe)3H in THF gives the 1,3-dioxane (III), which is opened by reduction with DIBAL in dichloromethane to yield the chiral benzyl ether (IV). The oxidation of the primary alcohol of (IV) with DMP in dichloromethane affords the corresponding aldehyde (V), which is condensed with the boronate (VI) and S,S-diisopropyl tartrate in toluene to provide the unsaturated alcohol (VII).The protection of (VII) with Tbdps-Cl and imidazole yields the fully protected triol (VIII), which is oxidized at the terminal double bond with 9-BBN in THF to give the primary alcohol (IX). The oxidation of (IX) with DMP in dichloromethane affords the aldehyde (X), which is condensed with methylenetriphenylphosphorane (XI) in THF to provide the terminal olefin (XII). Elimination of the Pmb protecting group of (XII) with DDQ in dichloromethane gives the alcohol (XIII), which is esterified with 2-allyl-6-methoxybenzoic acid (XIV)(obtained by allylation of 2-methoxybenzoic acid (XV) with allyl bromide (XVI), BuLi and MgBr2) by means of DEAD and PPh3 yielding the ester (XVII). The cyclization of (XVII) by means of a metathesis reaction catalyzed by a ruthenium catalyst in refluxing dichloromethane affords the bicyclic lactone (XVIII), which is treated with BBr3 in dichloromethane to provide the dihydroxylated lactone (XIX).

参考文献中间体

合成目标

【1】 Labrecque, D.; et al.; Enantioselective total synthesis of salicylihalamides A and B. Tetrahedron Lett 2001, 42, 14, 2645.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	47480	[(2R,3R)-3-[3-(benzyloxy)propyl]oxiranyl]methanol		C₁₃H₁₈O₃	详情	详情
(II)	27251	4-methoxybenzaldehyde; Anisicaldehyde; p-anisaldehyde	123-11-5	C₈H₈O₂	详情	详情
(III)	47481	(4R)-4-[3-(benzyloxy)propyl]-2-(4-methoxyphenyl)-1,3-dioxane; benzyl 3-[(4R)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]propyl ether		C₂₁H₂₆O₄	详情	详情
(IV)	47482	(3R)-6-(benzyloxy)-3-[(4-methoxybenzyl)oxy]-1-hexanol		C₂₁H₂₈O₄	详情	详情
(V)	47483	(3R)-6-(benzyloxy)-3-[(4-methoxybenzyl)oxy]hexanal		C₂₁H₂₆O₄	详情	详情
(VI)	47484	dimethyl (E)-2-butenylboronate		C₆H₁₃BO₂	详情	详情
(VII)	47485	(3S,4R,6R)-9-(benzyloxy)-6-[(4-methoxybenzyl)oxy]-3-methyl-1-nonen-4-ol		C₂₅H₃₄O₄	详情	详情
(VIII)	47486	[((1R,2S)-1-[(2R)-5-(benzyloxy)-2-[(4-methoxybenzyl)oxy]pentyl]-2-methyl-3-butenyl)oxy](tert-butyl)diphenylsilane; benzyl (4R,6R,7S)-6-[[tert-butyl(diphenyl)silyl]oxy]-4-[(4-methoxybenzyl)oxy]-7-methyl-8-nonenyl ether		C₄₁H₅₂O₄Si	详情	详情
(IX)	47487	(3S,4R,6R)-9-(benzyloxy)-4-[[tert-butyl(diphenyl)silyl]oxy]-6-[(4-methoxybenzyl)oxy]-3-methyl-1-nonanol		C₄₁H₅₄O₅Si	详情	详情
(X)	47488	(3S,4R,6R)-9-(benzyloxy)-4-[[tert-butyl(diphenyl)silyl]oxy]-6-[(4-methoxybenzyl)oxy]-3-methylnonanal		C₄₁H₅₂O₅Si	详情	详情
(XI)	27301	methylene(triphenyl)phosphorane		C₁₉H₁₇P	详情	详情
(XII)	47489	[((1R,2S)-1-[(2R)-5-(benzyloxy)-2-[(4-methoxybenzyl)oxy]pentyl]-2-methyl-4-pentenyl)oxy](tert-butyl)diphenylsilane; benzyl (4R,6R,7S)-6-[[tert-butyl(diphenyl)silyl]oxy]-4-[(4-methoxybenzyl)oxy]-7-methyl-9-decenyl ether		C₄₂H₅₄O₄Si	详情	详情
(XIII)	47490	(4R,6R,7S)-1-(benzyloxy)-6-[[tert-butyl(diphenyl)silyl]oxy]-7-methyl-9-decen-4-ol		C₃₄H₄₆O₃Si	详情	详情
(XIV)	13926	2-Methoxybenzoic acid; o-Methoxybenzoic Acid	579-75-9	C₈H₈O₃	详情	详情
(XV)	11463	3-Bromo-1-propene; 3-Bromopropene；allyl bromide	106-95-6	C₃H₅Br	详情	详情
(XVI)	47491	2-allyl-6-methoxybenzoic acid		C₁₁H₁₂O₃	详情	详情
(XVII)	47492	(1S,3R,4S)-1-[3-(benzyloxy)propyl]-3-[[tert-butyl(diphenyl)silyl]oxy]-4-methyl-6-heptenyl 2-allyl-6-methoxybenzoate		C₄₅H₅₆O₅Si	详情	详情
(XVIII)	47493	(3S,5R,6S)-3-[3-(benzyloxy)propyl]-5-[[tert-butyl(diphenyl)silyl]oxy]-14-methoxy-6-methyl-3,4,5,6,7,10-hexahydro-1H-2-benzoxacyclododecin-1-one		C₄₃H₅₂O₅Si	详情	详情
(XIX)	47494	(3S,5R,6S)-5-[[tert-butyl(diphenyl)silyl]oxy]-14-hydroxy-3-(3-hydroxypropyl)-6-methyl-3,4,5,6,7,10-hexahydro-1H-2-benzoxacyclododecin-1-one		C₃₅H₄₄O₅Si	详情	详情

合成路线2

该中间体在本合成路线中的序号：(XIII)

The stereoselective allylation of aldehyde (I) by means of allylmagnesium bromide (II) catalyzed by (-)-Ipc2BOMe gives the alcohol (III), which is protected with Tbdms-Cl and imidazole to yield the silyl ether (IV). The oxidation of the terminal double bond of (IV) by means of OsO4, NMO and NaIO4 affords the carbaldehyde (V), which is diastereoselectively condensed with the chiral bornanesultam (VI) by means of TiCl4 and DIEA in dichloromethane to provide the adduct (VII). The protection of the OH group of (VII) with Mom-Cl, NaI and DIEA in refluxing DME gives the Mom-ether (VIII). The reductive cleavage of the chiral auxiliary by means of LiEt3BH in THF yields the carbinol (IX), which is treated with Ts-Cl, TEA and DMAP in dichloromethane to afford the tosylate (X). The reductive cleavage of the tosyl group of (X) by means of LiEt3BH in THF provides the chiral methylated compound (XI), which is desilylated by means of TBAF in THF to give the corresponding alcohol (XII). The reaction of (XII) with benzoic acid (XIII) by means of DEAD and PPh3 in refluxing ethyl ether yields the benzoate ester (XIV), which is submitted to a ring closing metathesis (RCA) reaction by means of a Ru catalyst to afford the macrolactone (XV). The selective monodeprotection of (XV) by means of DDQ in dichloromethane/water provides the ethanol derivative (XVI), which is oxidized by means of DMP in dichloromethane to give the carbaldehyde (XVII). The homologation of (XVII) by means of a Horner-Wadsworth-Emmons reaction with phosphonate (XVIII) by means of NaH in THF yields the unsaturated allyl ester (XIX), which is treated with BBr3 in dichloromethane to eliminate the methoxy and methoxymethoxy protecting group, yielding the dihydroxy compound (XX).

参考文献中间体

合成目标

【1】 Xie, X.-S.; De Brabander, J.K.; Wang, R.; Liao, X.; Wu, Y.; Total synthesis and initial structure-function analysis of the potent V-ATPase inhibitors salicylihalamide A and related compounds. J Am Chem Soc 2002, 124, 13, 3245.
【2】 Smith, A.B. III; et al.; Total synthesis of (+)-phorboxazole A exploiting the Petasis-Ferrier rearrangement. J Am Chem Soc 2001, 123, 44, 10942.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	42455	3-[(4-methoxybenzyl)oxy]propanal	C₁₁H₁₄O₃	详情	详情
(II)	10336	(3aR,4S,6R,6aR)-2,2-Dimethyl-6-[(trityloxy)methyl]tetrahydrofuro[3,4-d][1,3]dioxol-4-ol	C₂₇H₂₈O₅	详情	详情
(III)	58187	(3S)-1-[(4-methoxybenzyl)oxy]-5-hexen-3-ol	C₁₄H₂₀O₃	详情	详情
(IV)	58188	tert-butyl(dimethyl)silyl (1S)-1-{2-[(4-methoxybenzyl)oxy]ethyl}-3-butenyl ether; tert-butyl[((1S)-1-{2-[(4-methoxybenzyl)oxy]ethyl}-3-butenyl)oxy]dimethylsilane	C₂₀H₃₄O₃Si	详情	详情
(V)	58189	(3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-[(4-methoxybenzyl)oxy]pentanal	C₁₉H₃₂O₄Si	详情	详情
(VI)	58190	(1R)-10,10-dimethyl-4-(4-pentenoyl)-3lambda~6~-thia-4-azatricyclo[5.2.1.0~1,5~]decane-3,3-dione	C₁₅H₂₃NO₃S	详情	详情
(VII)	58191	(1R)-4-((2S)-2-{(1R,3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-1-hydroxy-5-[(4-methoxybenzyl)oxy]pentyl}-4-pentenoyl)-10,10-dimethyl-3lambda~6~-thia-4-azatricyclo[5.2.1.0~1,5~]decane-3,3-dione	C₃₄H₅₅NO₇SSi	详情	详情
(VIII)	58192	(1R)-4-{(2S)-2-[(1R,3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-[(4-methoxybenzyl)oxy]-1-(methoxymethoxy)pentyl]-4-pentenoyl}-10,10-dimethyl-3lambda~6~-thia-4-azatricyclo[5.2.1.0~1,5~]decane-3,3-dione	C₃₆H₅₉NO₈SSi	详情	详情
(IX)	58193	(2R)-2-[(1R,3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-[(4-methoxybenzyl)oxy]-1-(methoxymethoxy)pentyl]-4-penten-1-ol	C₂₆H₄₆O₆Si	详情	详情
(X)	58194	(2R)-2-[(1R,3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-[(4-methoxybenzyl)oxy]-1-(methoxymethoxy)pentyl]-4-pentenyl 4-methylbenzenesulfonate	C₃₃H₅₂O₈SSi	详情	详情
(XI)	58195	(5R,7R)-7-{2-[(4-methoxybenzyl)oxy]ethyl}-9,9,10,10-tetramethyl-5-[(1S)-1-methyl-3-butenyl]-2,4,8-trioxa-9-silaundecane; tert-butyl(dimethyl)silyl (1R,3R,4S)-1-{2-[(4-methoxybenzyl)oxy]ethyl}-3-(methoxymethoxy)-4-methyl-6-heptenyl ether	C₂₆H₄₆O₅Si	详情	详情
(XII)	58196	(3R,5R,6S)-1-[(4-methoxybenzyl)oxy]-5-(methoxymethoxy)-6-methyl-8-nonen-3-ol	C₂₀H₃₂O₅	详情	详情
(XIII)	47491	2-allyl-6-methoxybenzoic acid	C₁₁H₁₂O₃	详情	详情
(XIV)	58197	(1S,3R,4S)-1-{2-[(4-methoxybenzyl)oxy]ethyl}-3-(methoxymethoxy)-4-methyl-6-heptenyl 2-allyl-6-methoxybenzoate	C₃₁H₄₂O₇	详情	详情
(XV)	58198		C₂₉H₃₆O₇	详情	详情
(XVI)	58199		C₂₁H₂₈O₆	详情	详情
(XVII)	58200		C₂₁H₂₆O₆	详情	详情
(XVIII)	58201	allyl 2-(diethoxyphosphoryl)acetate; Allyl p,p-diethylphosphonoacetate; Phosphonoacetic acid p,p-diethyl allyl ester	C₉H₁₇O₅P	详情	详情
(XIX)	58202		C₂₆H₃₂O₇	详情	详情
(XX)	58203		C₂₃H₂₆O₆	详情	详情

合成路线3

该中间体在本合成路线中的序号：(XVII)

The condensation of aldehyde (I) with boronate (II) in toluene gives the chiral alcohol (III), which is treated with Tbdms-OTf and TEA to yield the silyl ether (IV). The hydroxylation of the terminal double bond of (IV) by means of 9-BBN in refluxing THF affords the primary alcohol (V), which is oxidized by means of the Swern oxidant to provide the aldehyde (VI). The homologation of (VI) with methyltriphenylphosphonium iodide (VII) and NaHMDS gives the unsaturated compound (VIII), which is deprotected at the ketonide group by means of TFA in dichloromethane to afford the diol (IX). The dehydration of (IX) by means of tosylimidazole (X) and NaH in THF provides the epoxide (XI), which is condensed with the Grignard reagent (XIII) (obtained by reaction of the tributyltin derivative (XII) with MgBr2) to give the secondary alcohol (XIV). The reaction of 2-allyl-6-methoxybenzamide (XV) with I2 in THF/water gives the lactone (XVI), which is treated with Zn and AcOH to yield 2-allyl-6-methoxybenzoic acid (XVII). The esterification of acid (XVII) with alcohol (XIV) by means of DEAD and PPH3 affords the corresponding ester (XVIII), which is submitted to a ring closing metathesis reaction by means of a Ru catalyst to provide the macrolactone (XIX). The cleavage of the Pmb protecting group of (XIX) by means of DDQ gives the primary alcohol (XX), which is oxidized to the aldehyde (XXI) by means of DMP oxidant.

参考文献中间体

合成目标

【1】 Smith, A.B.; Zheng, J.Y.; Total synthesis of (-)-salicylihalamide A and related congeners. Tetrahedron 2002, 58, 33, 6455.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	61703	2-[(4S)-2,2-diethyl-1,3-dioxolan-4-yl]acetaldehyde		C₉H₁₆O₃	详情	详情
(II)	61704	diisopropyl (4S,5S)-2-[(E)-2-butenyl]-1,3,2-dioxaborolane-4,5-dicarboxylate		C₁₄H₂₃BO₆	详情	详情
(III)	61705	(2R,3S)-1-[(4S)-2,2-diethyl-1,3-dioxolan-4-yl]-3-methyl-4-penten-2-ol		C₁₃H₂₄O₃	详情	详情
(IV)	61706	tert-butyl(dimethyl)silyl (1R,2S)-1-{[(4S)-2,2-diethyl-1,3-dioxolan-4-yl]methyl}-2-methyl-3-butenyl ether; tert-butyl[((1R,2S)-1-{[(4S)-2,2-diethyl-1,3-dioxolan-4-yl]methyl}-2-methyl-3-butenyl)oxy]dimethylsilane		C₁₉H₃₈O₃Si	详情	详情
(V)	61707	(3S,4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-5-[(4S)-2,2-diethyl-1,3-dioxolan-4-yl]-3-methyl-1-pentanol		C₁₉H₄₀O₄Si	详情	详情
(VI)	61708	(3S,4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-5-[(4S)-2,2-diethyl-1,3-dioxolan-4-yl]-3-methylpentanal		C₁₉H₃₈O₄Si	详情	详情
(VII)	13484	Methyl(triphenyl)phosphonium iodide; Methyltriphenylphosphonium iodide	2065-66-9	C₁₉H₁₈IP	详情	详情
(VIII)	61709	tert-butyl(dimethyl)silyl (1R,2S)-1-{[(4S)-2,2-diethyl-1,3-dioxolan-4-yl]methyl}-2-methyl-4-pentenyl ether; tert-butyl[((1R,2S)-1-{[(4S)-2,2-diethyl-1,3-dioxolan-4-yl]methyl}-2-methyl-4-pentenyl)oxy]dimethylsilane		C₂₀H₄₀O₃Si	详情	详情
(IX)	61710	(2S,4R,5S)-4-{[tert-butyl(dimethyl)silyl]oxy}-5-methyl-7-octene-1,2-diol		C₁₅H₃₂O₃Si	详情	详情
(X)	47846	1-[(4-methylphenyl)sulfonyl]-1H-imidazole	2232-08-8	C₁₀H₁₀N₂O₂S	详情	详情
(XI)	61711	tert-butyl(dimethyl)({(1R,2S)-2-methyl-1-[(2S)oxiranylmethyl]-4-pentenyl}oxy)silane; tert-butyl(dimethyl)silyl (1R,2S)-2-methyl-1-[(2S)oxiranylmethyl]-4-pentenyl ether		C₁₅H₃₀O₂Si	详情	详情
(XII)	61712	tributyl{(E)-3-[(4-methoxybenzyl)oxy]-1-propenyl}stannane; 4-methoxybenzyl (E)-3-(tributylstannyl)-2-propenyl ether		C₂₃H₄₀O₂Sn	详情	详情
(XIII)	61713	bromo{(E)-3-[(4-methoxybenzyl)oxy]-1-propenyl}magnesium		C₁₁H₁₃BrMgO₂	详情	详情
(XIV)	61716	(2E,5R,7R,8S)-7-{[tert-butyl(dimethyl)silyl]oxy}-1-[(4-methoxybenzyl)oxy]-8-methyl-2,10-undecadien-5-ol		C₂₆H₄₄O₄Si	详情	详情
(XV)	61714	2-allyl-6-methoxy-N,N-dipropylbenzamide		C₁₇H₂₅NO₂	详情	详情
(XVI)	61715	3-(iodomethyl)-8-methoxy-3,4-dihydro-1H-isochromen-1-one		C₁₁H₁₁IO₃	详情	详情
(XVII)	47491	2-allyl-6-methoxybenzoic acid		C₁₁H₁₂O₃	详情	详情
(XVIII)	61717	(1S,3R,4S)-3-{[tert-butyl(dimethyl)silyl]oxy}-1-{(E)-4-[(4-methoxybenzyl)oxy]-2-butenyl}-4-methyl-6-heptenyl 2-allyl-6-methoxybenzoate		C₃₇H₅₄O₆Si	详情	详情
(XIX)	61718	(3S,5R,6S)-5-{[tert-butyl(dimethyl)silyl]oxy}-14-methoxy-3-{(E)-4-[(4-methoxybenzyl)oxy]-2-butenyl}-6-methyl-3,4,5,6,7,10-hexahydro-1H-2-benzoxacyclododecin-1-one		C₃₅H₅₀O₆Si	详情	详情
(XX)	61719	(3S,5R,6S)-5-{[tert-butyl(dimethyl)silyl]oxy}-3-[(E)-4-hydroxy-2-butenyl]-14-methoxy-6-methyl-3,4,5,6,7,10-hexahydro-1H-2-benzoxacyclododecin-1-one		C₂₇H₄₂O₅Si	详情	详情
(XXI)	61720	(E)-4-((3S,5R,6S)-5-{[tert-butyl(dimethyl)silyl]oxy}-14-methoxy-6-methyl-1-oxo-3,4,5,6,7,10-hexahydro-1H-2-benzoxacyclododecin-3-yl)-2-butenal		C₂₇H₄₀O₅Si	详情	详情

合成路线4

该中间体在本合成路线中的序号：(XVI)

参考文献中间体

合成目标

【1】 Labrecque, D.; et al.; Enantioselective total synthesis of salicylihalamides A and B. Tetrahedron Lett 2001, 42, 14, 2645.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	47480	[(2R,3R)-3-[3-(benzyloxy)propyl]oxiranyl]methanol		C₁₃H₁₈O₃	详情	详情
(II)	27251	4-methoxybenzaldehyde; Anisicaldehyde; p-anisaldehyde	123-11-5	C₈H₈O₂	详情	详情
(III)	47481	(4R)-4-[3-(benzyloxy)propyl]-2-(4-methoxyphenyl)-1,3-dioxane; benzyl 3-[(4R)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]propyl ether		C₂₁H₂₆O₄	详情	详情
(IV)	47482	(3R)-6-(benzyloxy)-3-[(4-methoxybenzyl)oxy]-1-hexanol		C₂₁H₂₈O₄	详情	详情
(V)	47483	(3R)-6-(benzyloxy)-3-[(4-methoxybenzyl)oxy]hexanal		C₂₁H₂₆O₄	详情	详情
(VI)	47484	dimethyl (E)-2-butenylboronate		C₆H₁₃BO₂	详情	详情
(VII)	47485	(3S,4R,6R)-9-(benzyloxy)-6-[(4-methoxybenzyl)oxy]-3-methyl-1-nonen-4-ol		C₂₅H₃₄O₄	详情	详情
(VIII)	47486	[((1R,2S)-1-[(2R)-5-(benzyloxy)-2-[(4-methoxybenzyl)oxy]pentyl]-2-methyl-3-butenyl)oxy](tert-butyl)diphenylsilane; benzyl (4R,6R,7S)-6-[[tert-butyl(diphenyl)silyl]oxy]-4-[(4-methoxybenzyl)oxy]-7-methyl-8-nonenyl ether		C₄₁H₅₂O₄Si	详情	详情
(IX)	47487	(3S,4R,6R)-9-(benzyloxy)-4-[[tert-butyl(diphenyl)silyl]oxy]-6-[(4-methoxybenzyl)oxy]-3-methyl-1-nonanol		C₄₁H₅₄O₅Si	详情	详情
(X)	47488	(3S,4R,6R)-9-(benzyloxy)-4-[[tert-butyl(diphenyl)silyl]oxy]-6-[(4-methoxybenzyl)oxy]-3-methylnonanal		C₄₁H₅₂O₅Si	详情	详情
(XI)	27301	methylene(triphenyl)phosphorane		C₁₉H₁₇P	详情	详情
(XII)	47489	[((1R,2S)-1-[(2R)-5-(benzyloxy)-2-[(4-methoxybenzyl)oxy]pentyl]-2-methyl-4-pentenyl)oxy](tert-butyl)diphenylsilane; benzyl (4R,6R,7S)-6-[[tert-butyl(diphenyl)silyl]oxy]-4-[(4-methoxybenzyl)oxy]-7-methyl-9-decenyl ether		C₄₂H₅₄O₄Si	详情	详情
(XIII)	47490	(4R,6R,7S)-1-(benzyloxy)-6-[[tert-butyl(diphenyl)silyl]oxy]-7-methyl-9-decen-4-ol		C₃₄H₄₆O₃Si	详情	详情
(XIV)	13926	2-Methoxybenzoic acid; o-Methoxybenzoic Acid	579-75-9	C₈H₈O₃	详情	详情
(XV)	11463	3-Bromo-1-propene; 3-Bromopropene；allyl bromide	106-95-6	C₃H₅Br	详情	详情
(XVI)	47491	2-allyl-6-methoxybenzoic acid		C₁₁H₁₂O₃	详情	详情
(XVII)	47492	(1S,3R,4S)-1-[3-(benzyloxy)propyl]-3-[[tert-butyl(diphenyl)silyl]oxy]-4-methyl-6-heptenyl 2-allyl-6-methoxybenzoate		C₄₅H₅₆O₅Si	详情	详情
(XVIII)	47493	(3S,5R,6S)-3-[3-(benzyloxy)propyl]-5-[[tert-butyl(diphenyl)silyl]oxy]-14-methoxy-6-methyl-3,4,5,6,7,10-hexahydro-1H-2-benzoxacyclododecin-1-one		C₄₃H₅₂O₅Si	详情	详情
(XIX)	47494	(3S,5R,6S)-5-[[tert-butyl(diphenyl)silyl]oxy]-14-hydroxy-3-(3-hydroxypropyl)-6-methyl-3,4,5,6,7,10-hexahydro-1H-2-benzoxacyclododecin-1-one		C₃₅H₄₄O₅Si	详情	详情

Extended Information