N-isopropyl-N-(3-[[(Z)-(4-methoxyphenyl)methylidene]amino]propyl)amine; N(1)-isopropyl-N(3)-[(Z)-(4-methoxyphenyl)methylidene]-1,3-propanediamine -Drug Synthesis Database

【结构式】

【分子编号】29954

【品名】N-isopropyl-N-(3-[[(Z)-(4-methoxyphenyl)methylidene]amino]propyl)amine; N(1)-isopropyl-N(3)-[(Z)-(4-methoxyphenyl)methylidene]-1,3-propanediamine

【CA登记号】

【分子式】C₁₄H₂₂N₂O

【分子量】234.34156

【元素组成】C 71.76% H 9.46% N 11.95% O 6.83%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The reaction of p-anisaldehyde (I) with N-isopropyl-1,3-diaminopropane (II) in refluxing toluene gives N-anisylidene-N'-isopropyl-1,3-diaminopropane (III), which is then condensed with 2,6-dimethylphenylisocyanate (IV) in refluxing dichloromethane.

参考文献中间体

合成目标

【1】 Sulkowski, T.S.; Bergey, J.L.; Mascitti, A.A. (American Home Products Corp.); Urea derivatives, processes for preparing them and compositions containing them. EP 0007184; GB 2025406; JP 80500480; US 4224242 .
【2】 Serradell, M.N.; Castaner, J.; Badia, A.; WY-42362. Drugs Fut 1984, 9, 1, 38.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	27251	4-methoxybenzaldehyde; Anisicaldehyde; p-anisaldehyde	123-11-5	C₈H₈O₂	详情	详情
(II)	29953	N-(3-aminopropyl)-N-isopropylamine; N(1)-isopropyl-1,3-propanediamine	3360-16-5	C₆H₁₆N₂	详情	详情
(III)	29954	N-isopropyl-N-(3-[[(Z)-(4-methoxyphenyl)methylidene]amino]propyl)amine; N(1)-isopropyl-N(3)-[(Z)-(4-methoxyphenyl)methylidene]-1,3-propanediamine		C₁₄H₂₂N₂O	详情	详情
(IV)	29955	2,6-Dimethylphenyl isocyanate; 2-Isocyanato-1,3-dimethylbenzene	28556-81-2	C₉H₉NO	详情	详情

Extended Information