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【结 构 式】 
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【分子编号】44220 【品名】4-[(E)-(4-methoxyphenyl)methylidene]-1,2-dioxolan-3-one 【CA登记号】 |
【 分 子 式 】C11H10O4 【 分 子 量 】206.198 【元素组成】C 64.07% H 4.89% O 31.04% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Condensation of 4-methoxybenzaldehyde (I) with gamma-butyrolactone (II) by means of NaOMe yields furanone derivative (III), which is then reduced in ether with LiAlH4 to afford diol (IV). Mesylation of (IV) by means of MsCl and Et3N in benzene provides dimesylate (V), which is finally condensed with amine (VI) with simultaneous cyclization in refluxing benzene.
| 【1】 Batra, S.; et al.; A new class of potential chloroquine-resistance reversal agents for plasmodia: Syntheses and biological evaluation of 1-(3'-diethylaminopropyl)-3-(substituted phenylmethylene)pyrrolidines. J Med Chem 2000, 43, 18, 3428. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 27251 | 4-methoxybenzaldehyde; Anisicaldehyde; p-anisaldehyde | 123-11-5 | C8H8O2 | 详情 | 详情 |
| (II) | 44219 | 1,2-dioxolan-3-one | C3H4O3 | 详情 | 详情 | |
| (III) | 44220 | 4-[(E)-(4-methoxyphenyl)methylidene]-1,2-dioxolan-3-one | C11H10O4 | 详情 | 详情 | |
| (IV) | 44221 | 2-[(E)-(4-methoxyphenyl)methylidene]-1,4-butanediol | C12H16O3 | 详情 | 详情 | |
| (V) | 44222 | 5-[(E)-(4-methoxyphenyl)methylidene]-2,9-dimethyl-2,9-dimethylene-3,8-dioxa-2lambda(6),9lambda(6)-dithia-1,9-decadiene; methyl 4-[(E)-4-[[methyl(dimethylene)-lambda(6)-sulfanyl]oxy]-2-([[methyl(dimethylene)-lambda(6)-sulfanyl]oxy]methyl)-1-butenyl]phenyl ether | C18H28O3S2 | 详情 | 详情 | |
| (VI) | 29977 | N-(3-aminopropyl)-N,N-diethylamine; N(1),N(1)-diethyl-1,3-propanediamine | 104-78-9 | C7H18N2 | 详情 | 详情 |
Extended Information