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【结 构 式】

【分子编号】14881

【品名】N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine

【CA登记号】108-00-9

【 分 子 式 】C4H12N2

【 分 子 量 】88.15276

【元素组成】C 54.5% H 13.72% N 31.78%
与该中间体有关的原料药合成路线共 20 条
合成路线1合成路线2合成路线3合成路线4合成路线5合成路线6合成路线7合成路线8合成路线9合成路线10合成路线11合成路线12合成路线13合成路线14合成路线15合成路线16合成路线17合成路线18合成路线19合成路线20

合成路线1

该中间体在本合成路线中的序号：

Nitration of 1,8-naphthalic anhydride (I) in sulfuric acid at 60 C for 1 h gives 3,6-dinitro-1,8-naphthalic anhydride (II) in 80% yield (m.p. 209-211 C from toluene; NMR: in CDCl3 a 9.22, 9.27, 2 singlet aromatic H), which, on treatment with unsym-N,N-dimethylethylenediamine at room temperature for 30 min, followed by azeotropical removal of water at 140 C for 2 h in refluxing toluene solution and salt conversion with HCl, yields the monohydrochloride salt of dinimide in 62% yield.

参考文献 中间体
合成目标
【1】 Cheng, C.C.; Zee-Cheng, R.K.-Y. (Pfizer Inc.); 3,6-Disubstd.-1,8-naphthalimides and methods for their production and use. EP 0125439; JP 1985001166; US 4499266 .
【2】 Zee-Cheng R.K.-Y.; Cheng, C.C.; Dinimide hydrochloride. Drugs Fut 1986, 11, 9, 737.
【3】 Zee-Cheng, R.K.Y.; Cheng, C.C.; N-(Aminoalkyl)imide antineoplastic agents. Synthesis and biological activity. J Med Chem 1985, 28, 9, 1216-22.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
14881 N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine 108-00-9 C4H12N2 详情 详情
(I) 16982 1H,3H-benzo[de]isochromene-1,3-dione; 1,8-Naphthalic Anhydride 81-84-5 C12H6O3 详情 详情
(II) 24268 5,8-dinitro-1H,3H-benzo[de]isochromene-1,3-dione C12H4N2O7 详情 详情
(III) 24269 8-([[2-(dimethylamino)ethyl]amino]carbonyl)-3,6-dinitro-1-naphthoic acid C16H16N4O7 详情 详情

合成路线2

该中间体在本合成路线中的序号：(I)

SR 27417 (N-(2-dimethylaminoethyl)-N-(3-pyridinylmethyl)[4-(2,4,6-triisopropylphenyl)thiazol-2-yl]amine difumarate) was prepared via a convergent route. Reductive amination of N,N-dimethylaminoethanamine (I) and pyridyl-3-carboxaldehyde (II) by sodium borohydride gave the amine (III). Eaction of pivaloyl chloride (IV) and potassium thiocyanate in anhydrous acetone provided the pivaloyl isothiocyanate (V), which was condensed in situ with the amine (III) to afford the protected thiourea (VI). Chlorhydric hydrolysis of (IV) gave the thiourea (VII) with the bromoketene (IX) in refluxing ethanol led to SR 27417.

参考文献 中间体
合成目标
【1】 Herbert, J.M.; Valette, G.; Bernat, A.; Savi, P.; Maffrand, J.P.; Le Fur, G.; SR 27417, a highly potent, selective and long-acting antagonist of the PAF receptor. Drugs Fut 1992, 17, 11, 1011.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 14881 N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine 108-00-9 C4H12N2 详情 详情
(II) 12849 Nicotinaldehyde; 3-Pyridinecarboxaldehyde 500-22-1 C6H5NO 详情 详情
(III) 14883 N-[2-(dimethylamino)ethyl]-N-(3-pyridinylmethyl)amine; N(1),N(1)-dimethyl-N(2)-(3-pyridinylmethyl)-1,2-ethanediamine C10H17N3 详情 详情
(IV) 13597 2,2-Dimethylpropanoyl chloride; Pivaloyl chloride 3282-30-2 C5H9ClO 详情 详情
(V) 14885 2,2-dimethylpropanoyl isothiocyanate C6H9NOS 详情 详情
(VI) 14886 N-[2-(dimethylamino)ethyl]-N'-(2,2-dimethylpropanoyl)-N-(3-pyridinylmethyl)thiourea C16H26N4OS 详情 详情
(VII) 14887 N-[2-(dimethylamino)ethyl]-N-(3-pyridinylmethyl)thiourea C11H18N4S 详情 详情
(VIII) 14888 1,3,5-triisopropylbenzene 717-74-8 C15H24 详情 详情
(IX) 14889 2-bromo-1-(2,4,6-triisopropylphenyl)-1-ethanone C17H25BrO 详情 详情

合成路线3

该中间体在本合成路线中的序号：(IV)

This compound has been obtained by two different methods: The reduction of 1,4-diamino-5,8-dihydroxyanthraquinone (I) or 1,5-diamino-4,8-dihydroxyanthraquinone (II) with Na2S2O4 and NaOH in water gives the leuco derivative (III), which is condensed with N,N-dimethylethylene-1,2-diamine (IV) in refluxing ethanol and reoxidized by air to yield 1,4-bis[2-(dimethylamino)ethylamino]-5,8-dihydroxyanthraquinone (V). Finally, this compound is treated with MCPBA in dichloromethane to afford the target bis-N-oxide. Alternatively, the reduction of tetrachlorophthalic anhydride (VI) with Zn and NaOH in water at 50-60 C gives 3,4,6-trichlorophthalic anhydride (VII), which is further reduced with Zn and NaOH in refluxing water to yield 3,6-dichlorophthalic anhydride (VIII). The reaction of (VIII) with KF and NaF at 260-27 ?C affords 3,6-difluorophthalic anhydride (IX), which is cyclized with hydroquinone (X) by means of AlCl3 and NaCl at 200 +/- 5 C to provide 1,4-difluoro-5,8-dihydroxyanthraquinone (XI). Finally, this compound is condensed with N,N-dimethylethylene-1,2-diamine (IV) in pyridine to afford the already reported 1,4-bis[2-(dimethylamino)ethylamino]-5,8-dihydroxyanthraquinone (V), which is oxidized with MCPBA as before.

参考文献 中间体
合成目标
【1】 Chang, P.; Chang, C.C.; An improved practical synthesis of leuco-1,4,5,8-tetrahydroxyanthraquinone. Synth. Commun. 1995, 25, 3, 1893.
【2】 Denny, W.A.; Lee, H.H.; A large-scale synthesis of the bioreductive drug 1,4-bis[[2-(dimethylamino)ethyl]amino]-5,8-dihydroxyanthracene-9,10-dione bis-N-oxide (AQ4N). J Chem Soc - Perkins Trans I 1999, 19, 2755.
【3】 Patterson, L.H. (National Research Development Corp.); Anti-cancer cpds.. US 5132327; WO 9105824 .
【4】 Denny, W.A.; Lee, H.H. (BTG International Ltd.); Process for the preparation of 1,4-bis[[2-(dimethylamino)ethyl]amino]-5,8-dihydroxyanthracene-9,10-dione. WO 0005194 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 55217 1,4-diamino-5,8-dihydroxyanthra-9,10-quinone C14H10N2O4 详情 详情
(II) 55218 1,5-diamino-4,8-dihydroxyanthra-9,10-quinone C14H10N2O4 详情 详情
(III) 55219 1,4,5,8-tetrahydroxy-2,3-dihydro-9,10-anthracenedione C14H10O6 详情 详情
(IV) 14881 N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine 108-00-9 C4H12N2 详情 详情
(V) 55220 1,4-bis{[2-(dimethylamino)ethyl]amino}-5,8-dihydroxyanthra-9,10-quinone C22H28N4O4 详情 详情
(VI) 51351 Tetrachlorophthalic anhydride; 4,5,6,7-Tetrachloro-1,3-isobenzofurandione 117-08-8 C8Cl4O3 详情 详情
(VII) 55221 4,5,7-trichloro-2-benzofuran-1,3-dione C8HCl3O3 详情 详情
(VIII) 55222 3,6-Dichlorophthalic anhydride C8H2Cl2O3 详情 详情
(IX) 55223 3,6-Difluorophthalic anhydride C8H2F2O3 详情 详情
(X) 13163 p-Dihydrobenzene; Hydroquinone 123-31-9 C6H6O2 详情 详情
(XI) 55224 1,4-difluoro-5,8-dihydroxyanthra-9,10-quinone C14H6F2O4 详情 详情

合成路线4

该中间体在本合成路线中的序号：(IV)

The cyclization of 9-fluoro-6-(tosyloxy)-5,10-dihydrobenzo[g]isoquinoline-5,10-dione (I) with 2-(dimethylamino)ethylhydrazine (II) gives 2-[2-(dimethylamino)ethyl]-5-(tosyloxy)indazolo[4,3-gh]isoquinolin-6(2H)-one (III), which is finally condensed with N,N-dimethylethylene-1,2-diamine (IV) to afford the title compound.

参考文献 中间体
合成目标
【1】 Gallagher, C.E.; Maresch, M.J.; Krapcho, A.P.; et al.; 6,9-Disubstituted benz[g]isoquinoline-5,10-diones, key intermediates for the synthesis of antitumor 2,5-disubstituted-indazolo[4,3-gh]isoquinoline-6(2H)-ones (9-aza-anthrapyrazoles). 25th Natl Med Chem Symp (June 18, Univ. Michigan, Ann Arbor) 1996, Abst. 15.
【2】 Menta, E.; et al.; Synthesis and antitumor evalution of 2, 5-disubstituted-indazolo[4, 3-gh]isoquinoline-6(2H)-ones (9-aza-anthrapyrazoles). 211th ACS Natl Meet (March 24-28, New Orleans) 1996, Abst MEDI 076.
【3】 Krapcho, A.P.; Menta, E.; Antitumor aza-anthrapyrazoles. Drugs Fut 1997, 22, 6, 641.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 41185 9-fluoro-5,10-dioxo-5,10-dihydrobenzo[g]isoquinolin-6-yl 4-methylbenzenesulfonate C20H12FNO5S 详情 详情
(II) 41186 N-(2-hydrazinoethyl)-N,N-dimethylamine; 2-hydrazino-N,N-dimethyl-1-ethanamine C4H13N3 详情 详情
(III) 41187 2-[2-(dimethylamino)ethyl]-6-oxo-2,6-dihydroindazolo[4,3-gh]isoquinolin-5-yl 4-methylbenzenesulfonate C24H22N4O4S 详情 详情
(IV) 14881 N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine 108-00-9 C4H12N2 详情 详情

合成路线5

该中间体在本合成路线中的序号：(XI)

Tetrahydropyridine (II), obtained by NaBH4 reduction of the 1-benzylpyridinium salt (I), was condensed with 5-methoxyindole (III) in refluxing 50% AcOH to produce, through a biomimetic sequence, the aminoethyl carbazole compound (IV). Catalytic debenzylation of (IV) led to the primary amine (V), which was converted to the oxalic acid mono-amide (VI) upon heating with diethyl oxalate. Cyclization of amide (VI) in the presence of POCl3 under Vilsmeier conditions furnished the pyridocarbazole tetracyclic system (VII). Dehydrogenation of (VII) over Pd/C in boiling diphenyl ether led to a mixture of the desired aromatized compound (VIII) and the decarbethoxylated byproduct (IX), which were separated by column chromatography. N-Methylation of the pyrrole ring of (VIII) to give (X) was performed by using dimethyl carbonate in DMF in the presence of K2CO3 and crown ether. Reaction of ester (X) with 2-(dimethylamino)ethylamine (XI) at 115 C gave amide (XII). Finally, the desired 9-hydroxy derivative was obtained by methyl ether cleavage in (XII) employing boron tribromide. Alternatively, the title compound was obtained by demethylation of ether (X) and subsequent reaction with 2-(dimethylamino)ethylamine (XI).

参考文献 中间体
合成目标
【1】 Jasztold-Howorko, R.; Landras, C.; Pierré, A.; Atassi, G.; Guilbaud, N.; Kraus-Berthier, L.; Leonce, S.; Rolland, Y.; Prost, J.F.; Bisagni, E.; Synthesis and evaluation of 9-hydroxy-5-methyl-(and 5,6-dimethyl)-6H-pyrido[4, 3-b]carbazole-1-N-[(dialkylamino)alkyl]carboxamides, a new promising series of antitumor olivacine derivatives. J Med Chem 1994, 37, 15, 2445.
【2】 Bisagni, E.; Jasztold-Howorko, R.; Atassi, G.; Pierre, A. (ADIR et Cie.); Ellipticine derivs. with antitumor activity. EP 0591058; FR 2696465; JP 1994211852; US 5498611 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 59757 1-Benzyl-4-(2-methyl-1,3-dioxolan-2-yl)pyridinium C16H18NO2 详情 详情
(II) 59758 1-benzyl-4-(2-methyl-1,3-dioxolan-2-yl)-1,2,3,6-tetrahydropyridine C16H21NO2 详情 详情
(III) 25902 1H-Indol-5-yl methyl ether; 5-Methoxy-1H-indole; 5-Methoxyindole 1006-94-6 C9H9NO 详情 详情
(IV) 59759 N-benzyl-2-(6-methoxy-1-methyl-9H-carbazol-2-yl)-1-ethanamine; N-benzyl-N-[2-(6-methoxy-1-methyl-9H-carbazol-2-yl)ethyl]amine C23H24N2O 详情 详情
(V) 59760 2-(6-methoxy-1-methyl-9H-carbazol-2-yl)-1-ethanamine; 2-(6-methoxy-1-methyl-9H-carbazol-2-yl)ethylamine C16H18N2O 详情 详情
(VI) 59761 ethyl 2-{[2-(6-methoxy-1-methyl-9H-carbazol-2-yl)ethyl]amino}-2-oxoacetate C20H22N2O4 详情 详情
(VII) 59762 ethyl 9-methoxy-5-methyl-4,6-dihydro-3H-pyrido[4,3-b]carbazole-1-carboxylate C20H20N2O3 详情 详情
(VIII) 59764 ethyl 9-methoxy-5-methyl-6H-pyrido[4,3-b]carbazole-1-carboxylate C20H18N2O3 详情 详情
(IX) 59763 methyl 5-methyl-6H-pyrido[4,3-b]carbazol-9-yl ether; 9-methoxy-5-methyl-6H-pyrido[4,3-b]carbazole C17H14N2O 详情 详情
(X) 59765 ethyl 9-methoxy-5,6-dimethyl-6H-pyrido[4,3-b]carbazole-1-carboxylate C21H20N2O3 详情 详情
(XI) 14881 N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine 108-00-9 C4H12N2 详情 详情
(XII) 59766 N-[2-(dimethylamino)ethyl]-9-methoxy-5,6-dimethyl-6H-pyrido[4,3-b]carbazole-1-carboxamide C23H26N4O2 详情 详情

合成路线6

该中间体在本合成路线中的序号：(IV)

The synthesis of BBR-3409 has been described: The cyclization of 6-chloro-9-fluorobenz[g]isoquinoline-5,10-quinone (I) with 2-hydroxyethylhydrazine (II) in hot pyridine gives 2-(2-hydroxyethyl)-5-chloroindazolo[4,3-gh]isoquinolin-6(2H)-one (III), which is condensed with N-(2-aminoethyl)-N,N-dimethylamine (IV) in hot pyridine yielding the corresponding compound (V). The mesylation of the OH group of (V) with mesyl chloride and triethylamine in dichloromethane affords the mesylate (VI), which is condensed with hot ethanolamine (VII) to give BBR-3409.

参考文献 中间体
合成目标
【1】 Krapcho, A.P.; Menta, E.; Oliva, A.; Di Domenico, R.; Fiocchi, L.; Maresch, M.E.; Gallagher, C.E.; Hacker, M.P.; Beggiolin, G.; Giuliani, F.C.; Pezzoni, G.; Spinelli, S.; Synthesis and antitumor evaluation of 2,5-disubstituted-indazolo[4,3-gh]isoquinolin-6(2H)-ones (9-aza-anthrapyrazoles). J Med Chem 1998, 41, 27, 5429.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 24950 6-chloro-9-fluorobenzo[g]isoquinoline-5,10-dione C13H5ClFNO2 详情 详情
(II) 24951 2-hydrazino-1-ethanol 109-84-2 C2H8N2O 详情 详情
(III) 24952 5-chloro-2-(2-hydroxyethyl)indazolo[4,3-gh]isoquinolin-6(2H)-one C15H10ClN3O2 详情 详情
(IV) 14881 N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine 108-00-9 C4H12N2 详情 详情
(V) 26315 5-[[2-(dimethylamino)ethyl]amino]-2-(2-hydroxyethyl)indazolo[4,3-gh]isoquinolin-6(2H)-one C19H21N5O2 详情 详情
(VI) 26316 2-[5-[[2-(dimethylamino)ethyl]amino]-6-oxoindazolo[4,3-gh]isoquinolin-2(6H)-yl]ethyl methanesulfonate C20H23N5O4S 详情 详情
(VII) 10259 Ethanol amine;Ethanolamine;2-Aminoethanol; 2-Amino-1-ethanol；2-Aminoethyl alcohol 141-43-5 C2H7NO 详情 详情

合成路线7

该中间体在本合成路线中的序号：(VI)

The condensation of 1,3-dioxoindane-2-carboxylic acid ethyl ester (I) with m-anisidine (II) in refluxing toluene gives the corresponding amide (III), which is cyclized with polyphosphoric acid (PPA) at 120 C yielding 3-methoxy-6,7-dihydro-5H-indeno[2,1-c]quinoline-6,7-dione (IV). The reaction of (IV) with refluxing POCl3 affords the chloroketone (V), which is condensed with 2-(dimethylamino)ethylamine (VI) in pyridine at 100 C giving the aminoketone (VII). Finally, this compound is demethylated with concentrated HBr in refluxing acetic acid.

参考文献 中间体
合成目标
【1】 Castañer, J.; Hoshi, A.; TAS-103. Drugs Fut 1998, 23, 5, 513.
【2】 Ishida, K.; Wakida, M.; Utsugi, T.; Okazaki, S.; Yamada, Y.; Asano, T.; Synthesis of novel indeno[2,1-c]quinolin-7-one derivatives and their topoisomerase inhibitory and antitumor activities. 17th Symp Med Chem/6th Annu Meet Div Med Chem/2nd Conf Drug Discov (Nov 19-21, Tsukuba) 1997, Abst 2-P-05..
【3】 Okazaki, S.; Asao, T.; Wakida, M.; Ishida, K.; Washinosu, M.; Utsugi, T.; Yamada, Y. (Taiho Pharmaceutical Co., Ltd.); Novel fused indan deriv. and pharmaceutically acceptable salt. EP 0713870; US 5710162; US 5733918; WO 9532187 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 17166 ethyl 1,3-dioxo-2-indanecarboxylate C12H10O4 详情 详情
(II) 13704 3-Methoxyphenylamine; 3-Methoxyaniline; m-Anisidine 536-90-3 C7H9NO 详情 详情
(III) 17168 N-(3-methoxyphenyl)-1,3-dioxo-2-indanecarboxamide C17H13NO4 详情 详情
(IV) 17169 3-methoxy-5H-indeno[2,1-c]quinoline-6,7-dione C17H11NO3 详情 详情
(V) 17170 6-chloro-3-methoxy-7H-indeno[2,1-c]quinolin-7-one C17H10ClNO2 详情 详情
(VI) 14881 N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine 108-00-9 C4H12N2 详情 详情
(VII) 17172 6-[[2-(dimethylamino)ethyl]amino]-3-methoxy-7H-indeno[2,1-c]quinolin-7-one C21H21N3O2 详情 详情

合成路线8

该中间体在本合成路线中的序号：(V)

Mitsunobu coupling between boronic acid (I) and 3-bromo-2,5-dichlorothiophene (II) affords the thienyl isophthalate (III). Partial hydrolysis of diester (III) using methanolic KOH gives rise to mono-acid (IV), which is further condensed with N,N-dimethyl ethylenediamine (V) to provide the amide-ester (VI). Displacement of the methyl ester function of (VI) by guanidine (VII) then produces the target acyl guanidine, which is finally converted into the corresponding dihydrochloride salt.

参考文献 中间体
合成目标
【1】 Kuno, A.; Mizuno, H.; Yamasaki, K.; Inoue, Y. (Fujisawa Pharmaceutical Co., Ltd.); Benzoylguanidine derivs. as medicaments. JP 1998503770; WO 9604241 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 58211 3,5-bis(methoxycarbonyl)phenylboronic acid C10H11BO6 详情 详情
(II) 58212 3-bromo-2,5-dichlorothiophene 60404-18-4 C4HBrCl2S 详情 详情
(III) 58213 dimethyl 5-(2,5-dichloro-3-thienyl)isophthalate C14H10Cl2O4S 详情 详情
(IV) 58214 3-(2,5-dichloro-3-thienyl)-5-(methoxycarbonyl)benzoic acid C13H8Cl2O4S 详情 详情
(V) 14881 N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine 108-00-9 C4H12N2 详情 详情
(VI) 58215 methyl 3-(2,5-dichloro-3-thienyl)-5-({[2-(dimethylamino)ethyl]amino}carbonyl)benzoate C17H18Cl2N2O3S 详情 详情
(VII) 14790 Guanidine 113-00-8 CH5N3 详情 详情

合成路线9

该中间体在本合成路线中的序号：(IV)

Condensation of 2-amino-4-iodobenzoic acid (I) with 2-chloronicotinic acid (II) in refluxing EtOH in the presence of HCl yields pyridoquinazoline acid derivative (III), which is then condensed with N,N-dimethylethylenediamine (IV) in CH2Cl2 using BOP as coupling reagent to provide (V). Reaction of 2-bromopyridine (VI) in Et2O with n-BuLi and trimethylborate, followed by treatment with EtOH and HOAc, gives 3-pyridinyl boronic acid (VII), which is finally coupled to (V) in an Na2CO3 solution via a Suzuki coupling catalyzed by Pd(PPh3)4.

参考文献 中间体
合成目标
【1】 Kitchen, D.B.; Schow, S.R.; Casscles, W.T. Jr.; Discafani, C.; Trova, M.P.; Lassota, P.; Zhang, N.; Powell, D.W.; Hetero biarylpyridoquinazolinone derivatives as anticancer agents. 219th ACS Natl Meet (March 26 2000, San Francisco) 2000, Abst MEDI 59.
【2】 Trova, M.P.; Zhang, N. (American Cyanamid Co.); Hetero-biaryl-pyridoquinazolinone derivs. as anti-cancer agents. EP 0944628; WO 9823617 .
【3】 Trova, M.P.; Zhang, N. (American Cyanamid Co.); Hetero-biaryl-pyridoquinazolinone derivs. as anti-cancer agents. US 5908840 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 19964 5-Iodoanthranilic acid; 2-amino-5-iodobenzoic acid 5326-47-6 C7H6INO2 详情 详情
(II) 28824 2-Chloropyridine-3-carboxylic acid; 2-Chloronicotinic acid 2942-59-8 C6H4ClNO2 详情 详情
(III) 42991 2-iodo-11-oxo-5,11-dihydro-10lambda(5)-pyrido[2,1-b]quinazoline-6-carboxylic acid C13H9IN2O3 详情 详情
(IV) 14881 N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine 108-00-9 C4H12N2 详情 详情
(V) 42992 N-[2-(dimethylamino)ethyl]-2-iodo-11-oxo-5,11-dihydro-10lambda(5)-pyrido[2,1-b]quinazoline-6-carboxamide C17H19IN4O2 详情 详情
(VI) 13265 3-Bromopyridine 626-55-1 C5H4BrN 详情 详情
(VII) 38825 3-pyridinylboronic acid 1692-25-7 C5H6BNO2 详情 详情

合成路线10

该中间体在本合成路线中的序号：(VI)

Treatment of 4-bromophthalic anhydride (I) in MeOH with NaOMe affords methyl ester (II), which is then treated with diphenylphosphoryl azide ((PhO)2PON3) in toluene, acetone/H2O to yield a mixture of regioisomers from which derivative (III) is obtained by chromatographic separation. Condensation of (III) with 2-chloronicotinic acid (IV) in refluxing EtOH in the presence of HCl yields pyridoquinazoline acid derivative (V), which is then condensed with N,N-dimethylethylenediamine (VI) in CH2Cl2 using BOP as coupling reagent to provide (VII). Reaction of 2-bromopyridine (VIII) in Et2O with n-BuLi and trimethylborate, followed by treatment with EtOH and HOAc, gives 3-pyridinyl boronic acid (IX), which is finally coupled to (VII) in an Na2CO3 solution via a Suzuki coupling catalyzed by Pd(PPh3)4.

参考文献 中间体
合成目标
【1】 Kitchen, D.B.; Schow, S.R.; Casscles, W.T. Jr.; Discafani, C.; Trova, M.P.; Lassota, P.; Zhang, N.; Powell, D.W.; Hetero biarylpyridoquinazolinone derivatives as anticancer agents. 219th ACS Natl Meet (March 26 2000, San Francisco) 2000, Abst MEDI 59.
【2】 Trova, M.P.; Zhang, N. (American Cyanamid Co.); Hetero-biaryl-pyridoquinazolinone derivs. as anti-cancer agents. EP 0944628; WO 9823617 .
【3】 Trova, M.P.; Zhang, N. (American Cyanamid Co.); Hetero-biaryl-pyridoquinazolinone derivs. as anti-cancer agents. US 5908840 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 43060 5-bromo-2-benzofuran-1,3-dione 86-90-8 C8H3BrO3 详情 详情
(II) 43061 5-bromo-2-(methoxycarbonyl)benzoic acid C9H7BrO4 详情 详情
(III) 43062 methyl 2-amino-4-bromobenzoate 135484-83-2 C8H8BrNO2 详情 详情
(IV) 28824 2-Chloropyridine-3-carboxylic acid; 2-Chloronicotinic acid 2942-59-8 C6H4ClNO2 详情 详情
(V) 43063 3-bromo-11-oxo-5,11-dihydro-10lambda(5)-pyrido[2,1-b]quinazoline-6-carboxylic acid C13H9BrN2O3 详情 详情
(VI) 14881 N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine 108-00-9 C4H12N2 详情 详情
(VII) 43064 3-bromo-N-[2-(dimethylamino)ethyl]-11-oxo-5,11-dihydro-10lambda(5)-pyrido[2,1-b]quinazoline-6-carboxamide C17H19BrN4O2 详情 详情
(VIII) 13265 3-Bromopyridine 626-55-1 C5H4BrN 详情 详情
(IX) 38825 3-pyridinylboronic acid 1692-25-7 C5H6BNO2 详情 详情

合成路线11

该中间体在本合成路线中的序号：(IV)

The cyclization of anthracenedione derivative (I) with formamide in refluxing dimethylacetamide (DMA) in the presence of NH4VO3 affords benzo[e]perimidinone derivative (II), whose benzyl groups are removed with TFA to yield (III). Intermediate (III) is finally heated with 2-(dimethylamino)ethylamine (IV) in N,N,N',N'-tetramethylethylenediamine and a small amount of water. Alternatively, the target product can be obtained as follows: Reduction of the nitro group of anthracenedione derivative (V) by means of hydrazine and Pd/C provides amine (VI), which is then cyclized with formamide in phenol to give (VII). The removal of the benzyl groups of (VII) by treatment with TFA yields intermediate (VIII), which is finally condensed with 2-(dimethylamino)ethylamine (IV) under similar conditions as described for (III).

参考文献 中间体
合成目标
【1】 Stefanska, B.; Bontemps-Gracz, M.M.; Dzieduszycka, M.; Borowski, E.; 8,11-Dihydroxy-6-[8aminoalkyl)amino]-7H-benzo[e]perimidin-7-ones with activity in multidrug-resistant cell lines: Synthesis and antitumor evaluation. J Med Chem 1999, 42, 18, 3494.
【2】 Borowski, E. (Politechnika Gdanska); New derivs. of 6-[(aminoalkyl)amino]-7H-benzo[e]-perimidin-7-one, method of their preparation, and their use as a medicament. WO 9825910 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 42946 1,4-diamino-5,8-bis(benzyloxy)anthra-9,10-quinone C28H22N2O4 详情 详情
(II) 42947 6-amino-8,11-bis(benzyloxy)-7H-benzo[e]perimidin-7-one C29H21N3O3 详情 详情
(III) 42948 6-amino-8,11-dihydroxy-7H-benzo[e]perimidin-7-one C15H9N3O3 详情 详情
(IV) 14881 N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine 108-00-9 C4H12N2 详情 详情
(V) 42949 1,4-bis(benzyloxy)-5-hydroxy-8-nitroanthra-9,10-quinone C28H19NO7 详情 详情
(VI) 42950 1-amino-5,8-bis(benzyloxy)-4-hydroxyanthra-9,10-quinone C28H21NO5 详情 详情
(VII) 42951 8,11-bis(benzyloxy)-6-hydroxy-7H-benzo[e]perimidin-7-one C29H20N2O4 详情 详情
(VIII) 42952 6,8,11-trihydroxy-7H-benzo[e]perimidin-7-one C15H8N2O4 详情 详情

合成路线12

该中间体在本合成路线中的序号：(X)

Esterification of 4-fluoro-3-nitrobenzoic acid (I) with MeOH in the presence of SOCl2 provided the methyl ester (II). Subsequent displacement of the fluoro group with the imidazolyl piperidine (III) gave adduct (IV), which was further protected as the N-trityl derivative (V) using triphenylmethyl chloride and N-methylmorpholine. Catalytic hydrogenation of the nitro group of (V) over Raney-Ni produced aniline (VI), which was acylated with cyclopropanecarbonyl chloride (VII) to furnish amide (VIII). After basic hydrolysis of the methyl ester group of (VIII), the resultant carboxylic acid (IX) was coupled with N,N-dimethyl ethanediamine (X) using PyBOP to yield amide (XI). Finally, acidic treatment of (XI) with HOAc removed the N-trityl protecting group.

参考文献 中间体
合成目标
【1】 Hoornaert, C.; Rouannet, V.; Dellac, G.; Daumas, M.; Adler, M.-A.; Cremer, G. (Sanofi-Synthelabo); 4-[(1H-Imidazol-4-yl)piperidin-1-yl]anilide derivs., their preparation and application in therapy. EP 0991639; WO 9900379 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 46937 4-fluoro-3-nitrobenzoic acid 453-71-4 C7H4FNO4 详情 详情
(II) 46938 methyl 4-fluoro-3-nitrobenzoate C8H6FNO4 详情 详情
(III) 46939 4-(5-methyl-1H-imidazol-4-yl)piperidine C9H15N3 详情 详情
(IV) 46940 methyl 4-[4-(5-methyl-1H-imidazol-4-yl)-1-piperidinyl]-3-nitrobenzoate C17H20N4O4 详情 详情
(V) 46945 methyl 4-[4-(5-methyl-1-trityl-1H-imidazol-4-yl)-1-piperidinyl]-3-nitrobenzoate C36H34N4O4 详情 详情
(VI) 46941 methyl 3-amino-4-[4-(5-methyl-1-trityl-1H-imidazol-4-yl)-1-piperidinyl]benzoate C36H36N4O2 详情 详情
(VII) 14061 Cyclopropanecarbonyl chloride; Cyclopropanecarboxylic acid chloride 4023-34-1 C4H5ClO 详情 详情
(VIII) 46942 methyl 3-[(cyclopropylcarbonyl)amino]-4-[4-(5-methyl-1-trityl-1H-imidazol-4-yl)-1-piperidinyl]benzoate C40H40N4O3 详情 详情
(IX) 46943 3-[(cyclopropylcarbonyl)amino]-4-[4-(5-methyl-1-trityl-1H-imidazol-4-yl)-1-piperidinyl]benzoic acid C39H38N4O3 详情 详情
(X) 14881 N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine 108-00-9 C4H12N2 详情 详情
(XI) 46944 3-[(cyclopropylcarbonyl)amino]-N-[2-(dimethylamino)ethyl]-4-[4-(5-methyl-1-trityl-1H-imidazol-4-yl)-1-piperidinyl]benzamide C43H48N6O2 详情 详情

合成路线13

该中间体在本合成路线中的序号：(IV)

The known pyridocarbazole (I) was methylated to (II) using dimethyl carbonate as the alkylating agent in the presence of K2CO3 and the phase-transfer catalyst adogen-464. For the preparation of the required amide (V), the ester group of (III) was first hydrolyzed with NaOH to the carboxylic acid (III), which was then coupled with 2-(dimethylamino)ethyl amine (IV) by means of (benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) in hot N-methylpyrrolidone yielding (V). Finally, cleavage of the methyl ether of (V) with BBr3 provided the title compound.

参考文献 中间体
合成目标
【1】 Charton, Y.; Guilbaud, N.; Léonce, S.; Pierré, A.; Guillonneau, C.; Michel, A.; Atassi, G.; Kraus-Berthier, L.; Bisagni, E.; Synthesis of 9-O-substituted derivatives of 9-hydroxy-5, 6-dimethyl-6H-pyrido[4,3-b]carbazole-1-carboxylic acid (2-(dimethylamino)ethyl)amide and their 10- and 11-methyl analogues with improved antitumor activity. J Med Chem 1999, 42, 12, 2191.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 36272 ethyl 9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole-1-carboxylate C21H20N2O3 详情 详情
(II) 36273 ethyl 9-methoxy-5,6,11-trimethyl-6H-pyrido[4,3-b]carbazole-1-carboxylate C22H22N2O3 详情 详情
(III) 36274 9-methoxy-5,6,11-trimethyl-6H-pyrido[4,3-b]carbazole-1-carboxylic acid C20H18N2O3 详情 详情
(IV) 14881 N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine 108-00-9 C4H12N2 详情 详情
(V) 36275 N-[2-(dimethylamino)ethyl]-9-methoxy-5,6,11-trimethyl-6H-pyrido[4,3-b]carbazole-1-carboxamide C24H28N4O2 详情 详情

合成路线14

该中间体在本合成路线中的序号：(V)

The reaction of 2-bromo-5-methoxybenzoic acid (I) with ethyl 2-amino-4-chlorobenzoate (II) by means of Cu(OAc)2 and 1-methyl-2-pyrrolidone in DIEA, followed by cyclization by means of polyphosphoric acid ethyl ester in refluxing chloroform gives the acridone (III), which is hydrolyzed with NaOH in refluxing ethanol yielding the carboxylic acid (IV). The condensation of (IV) with N,N-dimethylethylenediamine (V) by means of CDI in DMF affords the corresponding amide (VI), which is cyclized with phosgene in chloroform to provide the pyrimidoacridinetrione (VII). The reaction of (VII) with N,N-dimethyleythylenediamine (V) gives the final intermediate (VIII), which is demethylated with refluxing 48% HBr.

参考文献 中间体
合成目标
【1】 Polucci, P.; Antonini, I.; Kelland, L.R.; Menta, E.; Pescalli, N.; Martelli, S.; 2,3-Dihydro-1H,7H-pyrimido[5,6,1-de]acridine-1,3,7-trione derivatives, a class of cytotoxic agents active on multidrug-resistant cell lines: Synthesis, biological evaluation, and structure-activity relationships. J Med Chem 1999, 42, 14, 2535.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 17189 (3S)-5-oxotetrahydro-1H-pyrrol-3-yl methanesulfonate C5H9NO4S 详情 详情
(II) 31887 ethyl 2-amino-4-chlorobenzoate C9H10ClNO2 详情 详情
(III) 31888 ethyl 1-chloro-7-methoxy-9-oxo-9,10-dihydro-4-acridinecarboxylate C17H14ClNO4 详情 详情
(IV) 31889 1-chloro-7-methoxy-9-oxo-9,10-dihydro-4-acridinecarboxylic acid C15H10ClNO4 详情 详情
(V) 14881 N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine 108-00-9 C4H12N2 详情 详情
(VI) 31890 1-chloro-N-[2-(dimethylamino)ethyl]-7-methoxy-9-oxo-9,10-dihydro-4-acridinecarboxamide C19H20ClN3O3 详情 详情
(VII) 31891 6-chloro-2-[2-(dimethylamino)ethyl]-9-methoxy-1H,7H-pyrimido[5,6,1-de]acridine-1,3,7(2H)-trione C20H18ClN3O4 详情 详情
(VIII) 31892 2-[2-(dimethylamino)ethyl]-6-[[2-(dimethylamino)ethyl]amino]-9-methoxy-1H,7H-pyrimido[5,6,1-de]acridine-1,3,7(2H)-trione C24H29N5O4 详情 详情

合成路线15

该中间体在本合成路线中的序号：(VII)

Nitration of anthraquinone-1-carboxylic acid (I) produced a mixture of 5-nitro (II) and 8-nitro (III) anthraquinones from which the desired 8-nitro isomer (III) was separated by fractional crystallization from ethanol and further purified by washing with toluene. Reduction of the nitro group of (III) with aqueous sodium sulfide gave 8-aminoanthraquinone-1-carboxylic acid (IV). Condensation of (IV) with acetone in the presence of NaOH furnished the dibenzoisoquinolinone system (V). After activation of the carboxylate group of (V) as the imidazolide (VI) upon treatment with carbonyldiimidazole, its coupling with N,N-dimethylethylenediamine (VII) afforded the target amide.

参考文献 中间体
合成目标
【1】 Bu, X.; et al.; Synthesis and cytotoxic activity of 7-oxo-7H-dibenz [f,ij]isoquinoline and 7-oxo-7H-benzo[e]perimidine derivatives. J Med Chem 2001, 44, 12, 2004.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 50964 9,10-dioxo-9,10-dihydro-1-anthracenecarboxylic acid C15H8O4 详情 详情
(II) 50965 5-nitro-9,10-dioxo-9,10-dihydro-1-anthracenecarboxylic acid C15H7NO6 详情 详情
(III) 50966 8-nitro-9,10-dioxo-9,10-dihydro-1-anthracenecarboxylic acid C15H7NO6 详情 详情
(IV) 50967 8-amino-9,10-dioxo-9,10-dihydro-1-anthracenecarboxylic acid C15H9NO4 详情 详情
(V) 50968 2-methyl-7-oxo-7H-naphtho[1,2,3-de]quinoline-11-carboxylic acid C18H11NO3 详情 详情
(VI) 50969 11-(1H-imidazol-1-ylcarbonyl)-2-methyl-7H-naphtho[1,2,3-de]quinolin-7-one C21H13N3O2 详情 详情
(VII) 14881 N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine 108-00-9 C4H12N2 详情 详情

合成路线16

该中间体在本合成路线中的序号：(VI)

The Ullmann condensation between 2-chloro-5-nitrobenzoic acid (I) and 2-amino-4-chlorobenzoic acid (II) afforded the diaryl amine (III). Cyclization of (III) by treatment with POCl3 in refluxing xylene yielded a mixture of the desired acridine (IV) and minor amounts of its regioisomer (V). The isomeric mixture of acids (IV) and (V) was activated as the respective mixed anhydrides with ethyl chloroformate and subsequently condensed with N,N-dimethylethylenediamine (VI) to produce the corresponding amides. The required isomer (VII) was easily isolated from the mixture owing to its insolubility in the reaction solvent. Finally, the title pyrazoloacridine compound was prepared by condensation of (VII) with 2-(dimethylamino)ethyl hydrazine in 2-ethoxyethanol at 120 C.

参考文献 中间体
合成目标
【1】 Antonini, I.; et al.; Synthesis, antitumor cytotoxicity, and DNA-binding of novel N-5,2-Di(omega-aminoalkyl)-2,6-dihydropyrazolo[3,4,5-kl) acridine-5-carboxamides. J Med Chem 2001, 44, 20, 3329.
【2】 Matelli, S.; Polucci, P.; Antonini, I. (Università degli Studi di Camerino); Pyrazolo-acridine derivs. having antitumour activity. WO 9906405 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 10188 2-Chloro-5-nitrobenzoic acid 2516-96-3 C7H4ClNO4 详情 详情
(II) 52504 4-Chloro-2-aminobenzoic acid; 2-Amino-4-chlorobenzoic acid; 2-Carboxy-5-chloroaniline; 3-Amino-4-carboxy-1-chlorobenzene; 4-Chloroanthranilic acid 89-77-0 C7H6ClNO2 详情 详情
(III) 52505 　 C14H9ClN2O6 详情 详情
(IV) 52506 1-chloro-7-nitro-9-oxo-9,10-dihydro-4-acridinecarboxylic acid C14H7ClN2O5 详情 详情
(V) 52507 6-chloro-2-nitro-9-oxo-9,10-dihydro-4-acridinecarboxylic acid C14H7ClN2O5 详情 详情
(VI) 14881 N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine 108-00-9 C4H12N2 详情 详情
(VII) 52508 1-chloro-N-[2-(dimethylamino)ethyl]-7-nitro-9-oxo-9,10-dihydro-4-acridinecarboxamide C18H17ClN4O4 详情 详情
(VIII) 41186 N-(2-hydrazinoethyl)-N,N-dimethylamine; 2-hydrazino-N,N-dimethyl-1-ethanamine C4H13N3 详情 详情

合成路线17

该中间体在本合成路线中的序号：(III)

Methylation of 6-methyl-10H-quindoline-4-carboxylic acid (I) with iodomethane in the presence of KOH in DMSO takes place at both the indole N and the carboxylate group, producing (II). Subsequent aminolysis of ester (II) with N,N-dimethylethanediamine (III) in refluxing dioxan furnishes the target amide.

参考文献 中间体
合成目标
【1】 Chen, J.; Deady, L.W.; Kaye, A.J.; Finlay, G.J.; Baguley, B.C.; Denny, W.A.; Synthesis and cytotoxic activity of N-(2-diethylamino)ethylcarboxamide and other derivatives of 10H-quindoline. Bioorg Med Chem 2002, 10, 7, 2381.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 65090 6-methyl-10H-indolo[3,2-b]quinoline-4-carboxylic acid C17H12N2O2 详情 详情
(II) 65091 methyl 6,10-dimethyl-10H-indolo[3,2-b]quinoline-4-carboxylate C19H16N2O2 详情 详情
(III) 14881 N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine 108-00-9 C4H12N2 详情 详情

合成路线18

该中间体在本合成路线中的序号：(V)

Reaction of ethyl (3-carboxy-8-methylquinolin-2-yl)acetate (I) with POCl3/DMF under Vilsmeier formylation conditions leads to the cyclic anhydride (II). Subsequent treatment of (II) with methylamine gives rise to the benzonaphthyridine derivative (III). After activation of acid (III) as the corresponding acyl chloride (IV) with SOCl2, condensation with N,N-dimethyl ethylenediamine (V) furnishes the title amide.

参考文献 中间体
合成目标
【1】 Deady, L.W.; Rodermann, T.; Zhuang, L.; Baguley, B.C.; Denny, W.A.; Synthesis and cytotoxic activity of carboxamide derivatives of benzo[b][1,6]naphthyridines. J Med Chem 2003, 46, 6, 1049.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 64034 2-[2-(ethyloxy)-2-oxoethyl]-8-methyl-3-quinolinecarboxylic acid C15H15NO4 详情 详情
(II) 64035 4-[(dimethylamino)methylidene]-6-methyl-1H-pyrano[4,3-b]quinoline-1,3(4H)-dione C16H14N2O3 详情 详情
(III) 64036 2,6-dimethyl-1-oxo-1,2-dihydrobenzo[b][1,6]naphthyridine-4-carboxylic acid C15H12N2O3 详情 详情
(IV) 64037 2,6-dimethyl-1-oxo-1,2-dihydrobenzo[b][1,6]naphthyridine-4-carbonyl chloride C15H11ClN2O2 详情 详情
(V) 14881 N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine 108-00-9 C4H12N2 详情 详情

合成路线19

该中间体在本合成路线中的序号：(III)

1-Chloro-4-nitro-9,10-dihydroacridin-9-one (I) is refluxed with POCl3 in the presence of a catalytic amount of DMF and subsequently reacted with ammonium carbonate in hot phenol to provide the amino acridine (II). Displacement of the 4-chloro group of (II) with N,N-dimethylethanediamine (III) in DMF at 100 C leads to amine (IV). Cyclization of (IV) with SOCl2 yields the target thiadiazinoacridine, which is finally isolated as the corresponding maleate salt.

参考文献 中间体
合成目标
【1】 Antonini, I.; Polucci, P.; Magnano, A.; Cacciamani, D.; Konieczny, M.T.; Paradziej-Lukowicz, J.; Martelli, S.; Rational design, synthesis and biological evaluation of thiadiazinoacridines: A new class of antitumor agents. Bioorg Med Chem 2003, 11, 3, 399.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 52276 1-chloro-4-nitro-9(10H)-acridinone C13H7ClN2O3 详情 详情
(II) 63194 1-chloro-4-nitro-9-acridinamine; 1-chloro-4-nitro-9-acridinylamine C13H8ClN3O2 详情 详情
(III) 14881 N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine 108-00-9 C4H12N2 详情 详情
(IV) 63195 N-[2-(dimethylamino)ethyl]-N-(9-imino-4-nitro-9,10-dihydro-1-acridinyl)amine; N~1~-(9-imino-4-nitro-9,10-dihydro-1-acridinyl)-N~2~,N~2~-dimethyl-1,2-ethanediamine C17H19N5O2 详情 详情

合成路线20

该中间体在本合成路线中的序号：(VII)

Treatment of 1,4-di(benzyloxy)-5,8-dichloro-9,10-dihydro-9,10-anthracenedione (I) with CuCN in hot DMA results in the desired monosubstituted derivative (II). Subsequent basic hydrolysis of the nitrile group of (II) leads to carboxylic acid (III). After conversion of (III) into the corresponding acid chloride (IV) by means of PCl5, reaction with 2-(dimethylamino)ethylhydrazine (V) produces the tetracyclic compound (VI). Displacement of the remaining chloride of (VI) with 2-(dimethylamino)ethylamine (VII) in DMA then gives (VIII). The protecting benzyl groups of (VIII) are finally removed with trifluoroacetic acid to furnish the title compound.

参考文献 中间体
合成目标
【1】 Stefanska, B.; Arciemiuk, M.; Bontemps-Gracz, M.M.; Dzieduszycka, M.; Kupiec, A.; Martelli, S.; Borowski, E.; Synthesis and biological evaluation of 2,7-dihydro-3H-dibenzo[de,h]cinnoline-3,7-dione derivatives, a novel group of anticancer agents active on a multidrug resistant cell line. Bioorg Med Chem 2003, 11, 4, 561.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 27774 1,4-bis(benzyloxy)-5,8-dichloroanthra-9,10-quinone C28H18Cl2O4 详情 详情
(II) 63403 5,8-bis(benzyloxy)-4-chloro-9,10-dioxo-9,10-dihydro-1-anthracenecarbonitrile C29H18ClNO4 详情 详情
(III) 63404 5,8-bis(benzyloxy)-4-chloro-9,10-dioxo-9,10-dihydro-1-anthracenecarboxylic acid C29H19ClO6 详情 详情
(IV) 63405 5,8-bis(benzyloxy)-4-chloro-9,10-dioxo-9,10-dihydro-1-anthracenecarbonyl chloride C29H18Cl2O5 详情 详情
(V) 41186 N-(2-hydrazinoethyl)-N,N-dimethylamine; 2-hydrazino-N,N-dimethyl-1-ethanamine C4H13N3 详情 详情
(VI) 63406 8,11-bis(benzyloxy)-6-chloro-2-[2-(dimethylamino)ethyl]-3H-dibenzo[de,h]cinnoline-3,7(2H)-dione C33H28ClN3O4 详情 详情
(VII) 14881 N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine 108-00-9 C4H12N2 详情 详情
(VIII) 63407 8,11-bis(benzyloxy)-2-[2-(dimethylamino)ethyl]-6-{[2-(dimethylamino)ethyl]amino}-3H-dibenzo[de,h]cinnoline-3,7(2H)-dione C37H39N5O4 详情 详情
Extended Information