【结 构 式】 |
【分子编号】24268 【品名】5,8-dinitro-1H,3H-benzo[de]isochromene-1,3-dione 【CA登记号】 |
【 分 子 式 】C12H4N2O7 【 分 子 量 】288.17304 【元素组成】C 50.02% H 1.4% N 9.72% O 38.86% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(II)Nitration of 1,8-naphthalic anhydride (I) in sulfuric acid at 60 C for 1 h gives 3,6-dinitro-1,8-naphthalic anhydride (II) in 80% yield (m.p. 209-211 C from toluene; NMR: in CDCl3 a 9.22, 9.27, 2 singlet aromatic H), which, on treatment with unsym-N,N-dimethylethylenediamine at room temperature for 30 min, followed by azeotropical removal of water at 140 C for 2 h in refluxing toluene solution and salt conversion with HCl, yields the monohydrochloride salt of dinimide in 62% yield.
【1】 Cheng, C.C.; Zee-Cheng, R.K.-Y. (Pfizer Inc.); 3,6-Disubstd.-1,8-naphthalimides and methods for their production and use. EP 0125439; JP 1985001166; US 4499266 . |
【2】 Zee-Cheng R.K.-Y.; Cheng, C.C.; Dinimide hydrochloride. Drugs Fut 1986, 11, 9, 737. |
【3】 Zee-Cheng, R.K.Y.; Cheng, C.C.; N-(Aminoalkyl)imide antineoplastic agents. Synthesis and biological activity. J Med Chem 1985, 28, 9, 1216-22. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
14881 | N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine | 108-00-9 | C4H12N2 | 详情 | 详情 | |
(I) | 16982 | 1H,3H-benzo[de]isochromene-1,3-dione; 1,8-Naphthalic Anhydride | 81-84-5 | C12H6O3 | 详情 | 详情 |
(II) | 24268 | 5,8-dinitro-1H,3H-benzo[de]isochromene-1,3-dione | C12H4N2O7 | 详情 | 详情 | |
(III) | 24269 | 8-([[2-(dimethylamino)ethyl]amino]carbonyl)-3,6-dinitro-1-naphthoic acid | C16H16N4O7 | 详情 | 详情 |
Extended Information