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【结 构 式】 
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【药物名称】Dinimide hydrochloride, PD-113322, NCS D355263, KU 87 【化学名称】2-(2-Dimethylaminoethyl)-5,8-dinitro-1H-benz[de] isoquinoline-1,3(2H)-dione monohydrochloride 【CA登记号】94985-13-4 【 分 子 式 】C16H15ClN4O6 【 分 子 量 】394.77415 |
【开发单位】Pfizer (Originator), University of Kansas Medical Center (Originator) 【药理作用】ONCOLYTIC DRUGS |
合成路线1
Nitration of 1,8-naphthalic anhydride (I) in sulfuric acid at 60 C for 1 h gives 3,6-dinitro-1,8-naphthalic anhydride (II) in 80% yield (m.p. 209-211 C from toluene; NMR: in CDCl3 a 9.22, 9.27, 2 singlet aromatic H), which, on treatment with unsym-N,N-dimethylethylenediamine at room temperature for 30 min, followed by azeotropical removal of water at 140 C for 2 h in refluxing toluene solution and salt conversion with HCl, yields the monohydrochloride salt of dinimide in 62% yield.
| 【1】 Cheng, C.C.; Zee-Cheng, R.K.-Y. (Pfizer Inc.); 3,6-Disubstd.-1,8-naphthalimides and methods for their production and use. EP 0125439; JP 1985001166; US 4499266 . |
| 【2】 Zee-Cheng R.K.-Y.; Cheng, C.C.; Dinimide hydrochloride. Drugs Fut 1986, 11, 9, 737. |
| 【3】 Zee-Cheng, R.K.Y.; Cheng, C.C.; N-(Aminoalkyl)imide antineoplastic agents. Synthesis and biological activity. J Med Chem 1985, 28, 9, 1216-22. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 14881 | N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine | 108-00-9 | C4H12N2 | 详情 | 详情 | |
| (I) | 16982 | 1H,3H-benzo[de]isochromene-1,3-dione; 1,8-Naphthalic Anhydride | 81-84-5 | C12H6O3 | 详情 | 详情 |
| (II) | 24268 | 5,8-dinitro-1H,3H-benzo[de]isochromene-1,3-dione | C12H4N2O7 | 详情 | 详情 | |
| (III) | 24269 | 8-([[2-(dimethylamino)ethyl]amino]carbonyl)-3,6-dinitro-1-naphthoic acid | C16H16N4O7 | 详情 | 详情 |