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【结 构 式】 
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【药物名称】Topixantrone hydrochloride, BBR-3576, BBR-3409(dimaleate) 【化学名称】5-[2-(Dimethylamino)ethylamino]-2-[2-(2-hydroxyethylamino)ethyl]indazolo[4,3-gh]isoquinolin-6(2H)-one dihydrochloride 【CA登记号】156090-18-5 (free base) 【 分 子 式 】C21H28Cl2N6O2 【 分 子 量 】467.40231 |
【开发单位】Novuspharma (Originator) 【药理作用】Gastric Cancer Therapy, Oncolytic Drugs, Prostate Cancer Therapy, Solid Tumors Therapy, DNA-Intercalating Drugs |
合成路线1
The synthesis of BBR-3409 has been described: The cyclization of 6-chloro-9-fluorobenz[g]isoquinoline-5,10-quinone (I) with 2-hydroxyethylhydrazine (II) in hot pyridine gives 2-(2-hydroxyethyl)-5-chloroindazolo[4,3-gh]isoquinolin-6(2H)-one (III), which is condensed with N-(2-aminoethyl)-N,N-dimethylamine (IV) in hot pyridine yielding the corresponding compound (V). The mesylation of the OH group of (V) with mesyl chloride and triethylamine in dichloromethane affords the mesylate (VI), which is condensed with hot ethanolamine (VII) to give BBR-3409.
| 【1】 Krapcho, A.P.; Menta, E.; Oliva, A.; Di Domenico, R.; Fiocchi, L.; Maresch, M.E.; Gallagher, C.E.; Hacker, M.P.; Beggiolin, G.; Giuliani, F.C.; Pezzoni, G.; Spinelli, S.; Synthesis and antitumor evaluation of 2,5-disubstituted-indazolo[4,3-gh]isoquinolin-6(2H)-ones (9-aza-anthrapyrazoles). J Med Chem 1998, 41, 27, 5429. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 24950 | 6-chloro-9-fluorobenzo[g]isoquinoline-5,10-dione | C13H5ClFNO2 | 详情 | 详情 | |
| (II) | 24951 | 2-hydrazino-1-ethanol | 109-84-2 | C2H8N2O | 详情 | 详情 |
| (III) | 24952 | 5-chloro-2-(2-hydroxyethyl)indazolo[4,3-gh]isoquinolin-6(2H)-one | C15H10ClN3O2 | 详情 | 详情 | |
| (IV) | 14881 | N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine | 108-00-9 | C4H12N2 | 详情 | 详情 |
| (V) | 26315 | 5-[[2-(dimethylamino)ethyl]amino]-2-(2-hydroxyethyl)indazolo[4,3-gh]isoquinolin-6(2H)-one | C19H21N5O2 | 详情 | 详情 | |
| (VI) | 26316 | 2-[5-[[2-(dimethylamino)ethyl]amino]-6-oxoindazolo[4,3-gh]isoquinolin-2(6H)-yl]ethyl methanesulfonate | C20H23N5O4S | 详情 | 详情 | |
| (VII) | 10259 | Ethanol amine;Ethanolamine;2-Aminoethanol; 2-Amino-1-ethanol；2-Aminoethyl alcohol | 141-43-5 | C2H7NO | 详情 | 详情 |