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【结 构 式】 
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【药物名称】 【化学名称】N-[2-(Dimethylamino)ethyl]-6,10-dimethyl-10H-indolo[3,2-b]quinoline-4-carboxamide 【CA登记号】 【 分 子 式 】C22H24N4O 【 分 子 量 】360.46278 |
【开发单位】La Trobe University (Originator), University of Auckland (Originator) 【药理作用】ONCOLYTIC DRUGS |
合成路线1
Methylation of 6-methyl-10H-quindoline-4-carboxylic acid (I) with iodomethane in the presence of KOH in DMSO takes place at both the indole N and the carboxylate group, producing (II). Subsequent aminolysis of ester (II) with N,N-dimethylethanediamine (III) in refluxing dioxan furnishes the target amide.
| 【1】 Chen, J.; Deady, L.W.; Kaye, A.J.; Finlay, G.J.; Baguley, B.C.; Denny, W.A.; Synthesis and cytotoxic activity of N-(2-diethylamino)ethylcarboxamide and other derivatives of 10H-quindoline. Bioorg Med Chem 2002, 10, 7, 2381. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 65090 | 6-methyl-10H-indolo[3,2-b]quinoline-4-carboxylic acid | C17H12N2O2 | 详情 | 详情 | |
| (II) | 65091 | methyl 6,10-dimethyl-10H-indolo[3,2-b]quinoline-4-carboxylate | C19H16N2O2 | 详情 | 详情 | |
| (III) | 14881 | N-(2-aminoethyl)-N,N-dimethylamine; N(1),N(1)-dimethyl-1,2-ethanediamine; 2-Dimethylaminoethylamine | 108-00-9 | C4H12N2 | 详情 | 详情 |
Extended Information