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【结 构 式】 
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【分子编号】14088 【品名】Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate 【CA登记号】87-13-8 |
【 分 子 式 】C10H16O5 【 分 子 量 】216.23404 【元素组成】C 55.55% H 7.46% O 37% |
合成路线1
该中间体在本合成路线中的序号：(X)The reaction of 2,6-dichloro-3-nitropyridine (I) with N-ethoxycarbonylpiperidine (II) by means of triethylamine in CHCl gives 6-chloro-2-(4-ethoxycarbonyl-1-piperazinyl)-3-nitropyridine (III), which is treated with ethanolic NH3 at 120 C in a sealed tube to afford 6-amino-2-(4-ethoxycarbonyl-1-piperazinyl)-3-nitropyridine (IV). The acetylation of (IV) with acetic anhydride - acetic acid at 90 C yields the corresponding 6-acetamido derivative (V), which is reduced with H2 over Pd/C in acetic acid giving 3-amino-6-acetamido-2-(4-ethoxycarbonyl-1-piperazinyl)pyridine (VI). The diazotation of (VI) with isoamyl nitrite (A) and tetrafluoroboric acid in ethanol affords 6-acetylamino-2-(4-ethoxycarbonylpiperazinyl)-3-pyridine diazonium tetrafluoroborate (VII), which by heat treatment at 120 C in toluene is converted into 6-acetylamino-2-(4-ethoxycarbonylpiperazinyl)-3-fluoropyridine (VIII). The hydrolysis of (VIII) with HCl in methanol yields the corresponding 6-aminopyridine derivative (IX), which is condensed with diethyl ethoxymethylenemalonate (X) by heating at 130 C to afford diethyl N-[2-(4-ethoxycarbonyl-1-piperazinyl)-3-fluoro-6-pyridinyl]aminomethylenemalonate (XI). The cyclization of (XI) by heating at 255 C yields ethyl 7-(4-ethoxycarbonyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate (XII), which is N-alkylated by means of ethyl iodide and K2CO3 in hot DMF to afford ethyl 7-(4-ethoxycarbonyl-1-piperazinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate (XIII). Finally, this compound is hydrolyzed by means of NaOH in refluxing ethanol.
| 【1】 Matsumoto, J.; et al. (Aventis Pharma SA; Dainippon Pharmaceutical Co., Ltd.); Novel naphthyridine derivatives, intermediates thereof, processes for preparation thereof and use thereof. EP 0009425; ES 483629; US 4359578 . |
| 【2】 Blancafort, P.; Serradell, M.N.; Mealy, N.E.; Castaner, J.; Leeson, P.A.; AT-2266. Drugs Fut 1981, 6, 3, 129. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 32169 | 3-Methyl-1-nitrobutane; Isoamyl nitrite | 543-87-3 | C5H11NO2 | 详情 | 详情 |
| (I) | 13574 | 2,6-Dichloro-3-nitropyridine | 16013-85-7 | C5H2Cl2N2O2 | 详情 | 详情 |
| (II) | 24694 | N-ethoxycarbonylpiperidine; Ethyl 1-piperazinecarboxylate; N-Ethoxycarbonyl piperazine; N-Carbethoxy piperazine | 120-43-4 | C7H14N2O2 | 详情 | 详情 |
| (III) | 32165 | 6-Chloro-2-(4-ethoxycarbonyl-1-piperazinyl)-3-nitropyridine; Ethyl 4-(6-chloro-3-nitro-2-pyridinyl)-1-piperazinecarboxylate | C12H15ClN4O4 | 详情 | 详情 | |
| (IV) | 32166 | Ethyl 4-(6-amino-3-nitro-2-pyridinyl)-1-piperazinecarboxylate; 6-Amino-2-(4-ethoxycarbonyl-1-piperazinyl)-3-nitropyridine | C12H17N5O4 | 详情 | 详情 | |
| (V) | 32167 | ethyl 4-[6-(acetamido)-3-nitro-2-pyridinyl]-1-piperazinecarboxylate | C14H19N5O5 | 详情 | 详情 | |
| (VI) | 32168 | Ethyl 4-[6-(acetamido)-3-amino-2-pyridinyl]-1-piperazinecarboxylate; 3-Amino-6-acetamido-2-(4-ethoxycarbonyl-1-piperazinyl)pyridine | C14H21N5O3 | 详情 | 详情 | |
| (VII) | 32170 | 6-acetamido-2-(4-ethoxycarbonylpiperazinyl)-3-pyridine diazonium tetrafluoroborate; 6-Acetamido-2-[4-(ethoxycarbonyl)pipderazin-1-yl]pyridin-3-yldiazonium tetrafluoroborate | C14H19BF4N6O3 | 详情 | 详情 | |
| (VIII) | 32171 | 6-acetamido-2-(4-ethoxycarbonylpiperazinyl)-3-fluoropyridine; Ethyl 4-[6-(acetamido)-3-fluoro-2-pyridinyl]-1-piperazinecarboxylate | C14H19FN4O3 | 详情 | 详情 | |
| (IX) | 32172 | ethyl 4-(6-amino-3-fluoro-2-pyridinyl)-1-piperazinecarboxylate | C12H17FN4O2 | 详情 | 详情 | |
| (X) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (XI) | 32173 | N-[2-(4-EthoxycarbonyI-1-piperazinyl)-3-fluoro-6-pyridinyl]aminomethylenemalonate; Diethyl 2-[([6-[4-(ethoxycarbonyl)-1-piperazinyl]-5-fluoro-2-pyridinyl]amino)methylene]malonate | C20H27FN4O6 | 详情 | 详情 | |
| (XII) | 32174 | Ethyl 7-(4-ethoxycarbonyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate; Ethyl 7-[4-(ethoxycarbonyl)-1-piperazinyl]-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylate | C18H21FN4O5 | 详情 | 详情 | |
| (XIII) | 32175 | Ethyl 7-[4-(ethoxycarbonyl)-1-piperazinyl]-1-ethyl-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylate; Ethyl 7-(4-ethoxycarbonyl-1-piperazinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate | C20H25FN4O5 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(A)3-Chloro-4-fluoroaniline (I), condensed by heating at 125 C with diethyl ethoxymethylenemalonate (A), gives diethyl 3-chloro-4-fluoroanilinomethylenemalonate (II). The thermal cyclization of (II) by reflux in A Dowtherm gives ethyl 6-fluoro-7-chloro-4-hydroxyquinoline-3-carboxylate (III), which, alkylated by ethyliodide in DMF with potassium carbonate, leads to ethyl 1-ethyl-6 fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylate (IV), purified by recrystallization. The ester (IV), after saponification and acidification, provides the corresponding acid (V). 1-Ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (V), heated to 100 C in pyridine with 1-methylpiperazine (B), leads to 1-ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (VI). The salification of (VI) with methanesulfonic acid provides the salt.
| 【1】 Pesson, M.; Montay, G.; Goueffon, Y.; Roquet, F.; Microbiologie: Sur un nouvel antibacterien de synthese:l¡Acide ethyl-2-fluoro-6-(methyl-4-piperazinyl-1)-oxo-4-dihydro-1,4-quinoleine-3-carboxylique (1589 RB). CR Acad Sci Paris 1981, 292. |
| 【2】 Bellon, A.; Pefloxacin mesylate. Drugs Fut 1982, 7, 9, 646. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (B) | 10061 | 1-Methylpiperazine; 1-Methyl piperazine; N-Methylpiperazine | 109-01-3 | C5H12N2 | 详情 | 详情 |
| (A) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (I) | 18688 | 3-Chloro-4-fluorophenylamine; 3-Chloro-4-fluoroaniline | 367-21-5 | C6H5ClFN | 详情 | 详情 |
| (II) | 32073 | Diethyl 2-[[(3-chloro-4-fluorophenyl)imino]methyl]malonate; Diethyl 3-chloro-4-fluoroanilinomethylenemalonate | C14H15ClFNO4 | 详情 | 详情 | |
| (III) | 32074 | Ethyl 7-chloro-6-fluoro-4-hydroxy-1,4-dihydro-3-quinolinecarboxylate | C12H11ClFNO3 | 详情 | 详情 | |
| (IV) | 32075 | ethyl 7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylate | C14H13ClFNO3 | 详情 | 详情 | |
| (V) | 32076 | 7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | 68077-26-9 | C12H9ClFNO3 | 详情 | 详情 |
| (VI) | 32077 | 1-ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | C17H20FN3O3 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(II)The condensation of 1-ethyl-5-aminopyrazole (I) with diethyl ethoxymethylenemalonate (II) by heating at 120 C gives diethyl [((1-ethyl-5-pyrazolyl)amino)methylene]malonate (III), which by heating at 235-5 C in diphenyl ether is converted into ethyl 1-ethyl-4-hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylate (IV). The reaction of (IV) with ethyl iodide (A) and K2CO3 in DMF affords ethyl 1-ethyl-4-ethoxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylate (V), which is condensed with hydrazine in refluxing ethanol with ZnCl2 yielding ethyl 1-ethyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylate (VI). Finally, (VI) is condensed with refluxing acetone (B).
| 【1】 Hoehn, H.; Chasin, M. (Bristol-Myers Squibb Co.); Hydrazines and hydrazones of pyrazolopyridine carboxylic acids and esters. DE 2028869; GB 1317797; NL 165461C; NL 7008768 . |
| 【2】 Chatterjee, S.S.; Etazolate. Drugs Fut 1977, 2, 4, 243. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 10925 | Iodoethane;ethyl iod | 75-03-6 | C2H5I | 详情 | 详情 |
| (B) | 23199 | 2-Propanone; Acetone; beta-ketopropane; chevron acetone;propan-2-one； Dimethyl formaldehyde; Dimethyl ketone; dimethylketal; Ketone propane; Methyl ketone; Propanone; Pyroacetic acid; Pyroacetic ether | 67-64-1 | C3H6O | 详情 | 详情 |
| (I) | 40098 | 1-ethyl-1H-pyrazol-5-amine; 1-ethyl-1H-pyrazol-5-ylamine | 3528-58-3 | C5H9N3 | 详情 | 详情 |
| (II) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (III) | 40099 | diethyl 2-[[(1-ethyl-1H-pyrazol-5-yl)amino]methylene]malonate | C13H19N3O4 | 详情 | 详情 | |
| (IV) | 40100 | ethyl 1-ethyl-4-hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylate | C11H13N3O3 | 详情 | 详情 | |
| (V) | 40101 | ethyl 4-ethoxy-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate | C13H17N3O3 | 详情 | 详情 | |
| (VI) | 40102 | ethyl 1-ethyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylate | C11H15N5O2 | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(II)The condensation of aniline (I) with diethyl ethoxymethylenemalonate (II) by heating at 90 C gives diethyl anilinomethylenemalonate (III), which is cyclized to ethyl 4-hydroxyquinoline-3-carboxylate (IV) by heating at 240 C in diphenyl ether-biphenyl. The reaction of (IV) with hot POCl3 affords ethyl 4-chloro-quinoline-3-carboxylate (V), which is finally cyclized with phenylhydrazine (VI) by heating at 105 C in xylene. (VI) is prepared in the usual way starting from aniline (I) by diazotation with NaNO2-HCl to phenyldiazonium chloride (VII), and reduction with SnCl2-HCl.
| 【1】 Yokoyama, N.; EP 0022078 . |
| 【2】 Yokoyama, N.; US 4312870 . |
| 【3】 Ritter, B.; Yokoyama, N.; Neubert, A.D.; 2-Arylpyrazolo[4,3-c]quinolin-3-ones: A partial novel agonist and antagonist of benzodiazepines. J Med Chem 1982, 25, 4, 337-339. |
| 【4】 Serradell, M.N.; Grau, M.; Castaner, J.; Blancafort, P.; CGS-8216 and CGS-9896. Drugs Fut 1983, 8, 2, 99. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12294 | Aniline; Phenylamine | 62-53-3 | C6H7N | 详情 | 详情 |
| (II) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (III) | 35953 | diethyl 2-(anilinomethylene)malonate | C14H17NO4 | 详情 | 详情 | |
| (IV) | 35954 | ethyl 4-hydroxy-3-quinolinecarboxylate | C12H11NO3 | 详情 | 详情 | |
| (V) | 35955 | ethyl 4-chloro-3-quinolinecarboxylate | C12H10ClNO2 | 详情 | 详情 | |
| (VI) | 11818 | Phenyl hydrazine; 1-Phenylhydrazine | 100-63-0 | C6H8N2 | 详情 | 详情 |
| (VII) | 25897 | benzenediazonium chloride | C6H5ClN2 | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：(II)The condensation of aniline (I) with diethyl ethoxymethylenemalonate (II) by heating at 90 C gives diethyl anilinomethylenemalonate (III), which is cyclized to ethyl 4-hydroxyquinoline-3carboxylate (IV) by heating at 240 C in diphenyl ether-biphenyl. The reaction of (IV) with hot POCl3 affords ethyl-4-chloroquinoline-3-carboxylate (V), which is finally cyclized with 4-chlorophenylhydrazine (VIII) by heating at 105 C in xylene. (VIII) is prepared in the usual way starting from 4-chloroaniline (IX) by diazotation with NaNO2-HCl to 4-chlorophenyldiazonium chloride (X), and reduction with SnCl2-HCl.
| 【1】 Yokoyama, N.; US 4312870 . |
| 【2】 Yokoyama, N.; EP 0022078 . |
| 【3】 Ritter, B.; Yokoyama, N.; Neubert, A.D.; 2-Arylpyrazolo[4,3-c]quinolin-3-ones: A partial novel agonist and antagonist of benzodiazepines. J Med Chem 1982, 25, 4, 337-339. |
| 【4】 Castaner, J.; Blancafort, P.; Grau, M.; Serradell, M.N.; CGS-8216 and CGS-9896. Drugs Fut 1983, 8, 2, 99. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12294 | Aniline; Phenylamine | 62-53-3 | C6H7N | 详情 | 详情 |
| (II) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (III) | 35953 | diethyl 2-(anilinomethylene)malonate | C14H17NO4 | 详情 | 详情 | |
| (IV) | 35954 | ethyl 4-hydroxy-3-quinolinecarboxylate | C12H11NO3 | 详情 | 详情 | |
| (V) | 35955 | ethyl 4-chloro-3-quinolinecarboxylate | C12H10ClNO2 | 详情 | 详情 | |
| (VIII) | 33345 | 1-(4-chlorophenyl)hydrazine; 4-Chlorophenylhydrazine | 1073-70-7 | C6H7ClN2 | 详情 | 详情 |
| (IX) | 12034 | 4-Chlorophenylamine; 4-Chloroaniline; p-Chloroaniline | 106-47-8 | C6H6ClN | 详情 | 详情 |
| (X) | 10197 | 4-Chlorobenzenediazonium chloride | C6H4Cl2N2 | 详情 | 详情 |
合成路线6
该中间体在本合成路线中的序号：(III)The reduction of 4-fluoro-3-nitroaniline (I) with SnCl2.2H20 in concentrated aqueous HCl gives 4 fluoro-m-phenylenediamine (II), which is condensed with diethyl ethoxymethylenemalonate (III) in refluxing ethanol to afford diethyl 4-fluoro-3-aminoanilinomethylenemalonate (IV). The cyclization of (IV) by means of acetic anhydride in diphenyl oxide at 250 C yields ethyl 7-acetamido-4-hydroxy-6-fluoroquinoline-3-carboxylate (V), which is alkyiated with ethyl bromide and NaOH in refluxing ethanol to give 7-amino-6-fluoro-1-ethyl-1,4 dihydro-4-oxoquinoline-3-carboxylic acid (VI). Finally, this compound is condensed with 2,5-dimethoxytetrahydrofuran (VII) in hot acetic acid.
| 【1】 Esteve Soler, J. (Provesan SA); 7-(1-Pyrrolyl) derivs. of 1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids and 1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids and their use as antimicrobial agents. EP 0134165; FR 2548664; FR 2559484; US 4552882 . |
| 【2】 Prous, J.; Castaner, J.; Irloxafin. Drugs Fut 1986, 11, 10, 839. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 24710 | 4-fluoro-3-nitroaniline | 364-76-1 | C6H5FN2O2 | 详情 | 详情 |
| (II) | 24711 | 3-amino-4-fluorophenylamine | C6H7FN2 | 详情 | 详情 | |
| (III) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (IV) | 24713 | diethyl 2-[(3-amino-4-fluoroanilino)methylene]malonate | C14H17FN2O4 | 详情 | 详情 | |
| (V) | 24714 | ethyl 7-(acetamido)-6-fluoro-4-hydroxy-3-quinolinecarboxylate | C14H13FN2O4 | 详情 | 详情 | |
| (VI) | 24715 | 7-amino-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | C12H11FN2O3 | 详情 | 详情 | |
| (VII) | 12132 | 2,5-Dimethoxytetrahydrofuran; 5-Methoxytetrahydro-2-furanyl methyl ether | 696-59-3 | C6H12O3 | 详情 | 详情 |
合成路线7
该中间体在本合成路线中的序号：(VI)The partial hydrolysis ot 2,3,4-trifluoronitrobenzene (I) with KOH in DMSO gives 2,3-difluoro-6-nitrophenol (II), which by condensation with chloroacetone (III) by means of K2CO3 - KI in refluxing acetone yields 2-acetonyloxy-3,4-difluoronitrobenzene (IV). The reductive cyclization of (IV) with H2 over Raney-Ni in ethanol affords 7,8-difluoro-2,3-dihydro-3-methyl-4H-benzoxazine (V), which is condensed with diethyl ethoxymethylenemalonate (VI) by heating at 145 C giving the malonic derivative (VII). The cyclization of (VII) by heating at 145 C with ethyl polyphosphate (PPE) yields ethyl 9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate (VIII), which is hydrolyzed with HCl in refluxing acetic acid affording the corresponding free acid (IX). Finally, this compound is condensed with N-methylpiperazine (X) in DMSO at 110 C.
| 【1】 Hayakawa, I.; Hiramitsu, T.; Tanaka, Y. (Daiichi Pharmaceutical Co., Ltd.); Benzoxazine derivs.. EP 0047005; US 4382892 . |
| 【2】 Serradell, M.N.; Blancafort, P.; Castaner, J.; DL-8280. Drugs Fut 1983, 8, 5, 395. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 30677 | 1,2,3-trifluoro-4-nitrobenzene; 2,3,4-trifluoronitrobenzene | 771-69-7 | C6H2F3NO2 | 详情 | 详情 |
| (II) | 30678 | 2,3-difluoro-6-nitrophenol | 82419-26-9 | C6H3F2NO3 | 详情 | 详情 |
| (III) | 15288 | 1-Chloroacetone; Chloroacetone | 78-95-5 | C3H5ClO | 详情 | 详情 |
| (IV) | 30679 | 1-(2,3-difluoro-6-nitrophenoxy)acetone | C9H7F2NO4 | 详情 | 详情 | |
| (V) | 30680 | 7,8-difluoro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine | C9H9F2NO | 详情 | 详情 | |
| (VI) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (VII) | 30681 | diethyl 2-[(7,8-difluoro-3-methyl-2,3-dihydro-4H-1,4-benzoxazin-4-yl)methylene]malonate | C17H19F2NO5 | 详情 | 详情 | |
| (VIII) | 30682 | ethyl 9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate | C15H13F2NO4 | 详情 | 详情 | |
| (IX) | 12058 | 9,10-Difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid; 8,9-Difluoro-3-me-6-oxo-2,3-dihydro-6h-1-oxa-3a-aza-phenalene-5-carboxylic acid | 82419-35-0 | C13H9F2NO4 | 详情 | 详情 |
| (X) | 10061 | 1-Methylpiperazine; 1-Methyl piperazine; N-Methylpiperazine | 109-01-3 | C5H12N2 | 详情 | 详情 |
合成路线8
该中间体在本合成路线中的序号：(XVI)The condensation of ethoxymethylenemalonic acid diethyl ester (XVI) with 2-methoxyaniline (XVII) in hot toluene gives the aminomethylene derivative (XVIII), which is cyclized with POCl3 and polyphosphoric acid (PPA) at 100 C yielding 8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester (XIX), which is hydrolyzed with NaOH in methanol to the corresponding free acid (XX), and treated with refluxing SOCl2 to afford 4-chloro-8-methoxyquinoline-3-carbonyl chloride (XXI). The reaction of (XXI) with dimethylamine gives the corresponding amide (XXII), which is condensed with o-toluidine (VII) in refluxing dioxane yielding the expected secondary amine (XXIII). Finally, this compound is treated with propylmagnesium chloride (XXIV) to afford the target compound.
| 【1】 Atkins, R.J.; et al.; Synthetic routes to quinoline derivatives: Novel syntheses of 3-butyryl-8-methoxy-4-[(2-methylphenyl)amini]quinoline and 3-butyryl-8-(2-hydroxyethoxy)-4-[(2-methylphenyl)amino]quin. Org Process Res Dev 1997, 1, 3, 185. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 19443 | N-methylmethanamine; N,N-dimethylamine | 124-40-3 | C2H7N | 详情 | 详情 | |
| 40593 | Sulfurous oxychloride; Thionyl chloride | 7719-09-7 | Cl2OS | 详情 | 详情 | |
| (VII) | 15511 | o-toluidine; 2-methylphenylamine;2-Methylaniline；2-Aminotoluene;1-Amino-2-methylbenzene;1-Methyl-2-aminobenzene; ortho-Toluidine | 95-53-4 | C7H9N | 详情 | 详情 |
| (XVI) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (XVII) | 25193 | 2-methoxyphenylamine; 2-methoxyaniline | 517-28-2 | C7H9NO | 详情 | 详情 |
| (XVIII) | 32784 | diethyl 2-[(2-methoxyanilino)methylene]malonate | C15H19NO5 | 详情 | 详情 | |
| (XIX) | 32785 | ethyl 8-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylate | C13H13NO4 | 详情 | 详情 | |
| (XX) | 32786 | 8-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | C11H9NO4 | 详情 | 详情 | |
| (XXI) | 32787 | 4-chloro-8-methoxy-3-quinolinecarbonyl chloride | C11H7Cl2NO2 | 详情 | 详情 | |
| (XXII) | 32788 | 4-chloro-8-methoxy-N,N-dimethyl-3-quinolinecarboxamide | C13H13ClN2O2 | 详情 | 详情 | |
| (XXIII) | 32789 | 8-methoxy-N,N-dimethyl-4-(2-toluidino)-3-quinolinecarboxamide | C20H21N3O2 | 详情 | 详情 | |
| (XXIV) | 32790 | Chloro(propyl)magnesium | 2234-82-4 | C3H7ClMg | 详情 | 详情 |
合成路线9
该中间体在本合成路线中的序号：(XXV)The condensation of ethoxymethylenemalonic acid diethyl ester (XXV) with 2-methoxyaniline (XXVI) in hot toluene gives the aminomethylene derivative (XXVII), which is cyclized with POCl3 and polyphosphoric acid (PPA) at 100 C yielding 8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester (XXVIII), which is hydrolyzed with NaOH in methanol to the corresponding free acid (XXIX), and treated with refluxing SOCl2 to afford 4-chloro-8-methoxyquinoline-3-carbonyl chloride (XXX). The reaction of (XXX) with dimethylamine gives the corresponding amide (XXXI), which is condensed with o-toluidine (VIII) in refluxing dioxane yielding the expected secondary amine (XXXII). Finally, this compound is treated with propylmagnesium chloride (XXXIII) to afford the intermediate (XII).
| 【1】 Atkins, R.J.; et al.; Synthetic routes to quinoline derivatives: Novel syntheses of 3-butyryl-8-methoxy-4-[(2-methylphenyl)amini]quinoline and 3-butyryl-8-(2-hydroxyethoxy)-4-[(2-methylphenyl)amino]quin. Org Process Res Dev 1997, 1, 3, 185. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 19443 | N-methylmethanamine; N,N-dimethylamine | 124-40-3 | C2H7N | 详情 | 详情 | |
| 40593 | Sulfurous oxychloride; Thionyl chloride | 7719-09-7 | Cl2OS | 详情 | 详情 | |
| (VIII) | 15511 | o-toluidine; 2-methylphenylamine;2-Methylaniline；2-Aminotoluene;1-Amino-2-methylbenzene;1-Methyl-2-aminobenzene; ortho-Toluidine | 95-53-4 | C7H9N | 详情 | 详情 |
| (XII) | 32799 | 1-[8-methoxy-4-(2-toluidino)-3-quinolinyl]-1-butanone | C21H22N2O2 | 详情 | 详情 | |
| (XXV) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (XXVI) | 25193 | 2-methoxyphenylamine; 2-methoxyaniline | 517-28-2 | C7H9NO | 详情 | 详情 |
| (XXVII) | 32784 | diethyl 2-[(2-methoxyanilino)methylene]malonate | C15H19NO5 | 详情 | 详情 | |
| (XXVIII) | 32785 | ethyl 8-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylate | C13H13NO4 | 详情 | 详情 | |
| (XXIX) | 32786 | 8-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | C11H9NO4 | 详情 | 详情 | |
| (XXX) | 32787 | 4-chloro-8-methoxy-3-quinolinecarbonyl chloride | C11H7Cl2NO2 | 详情 | 详情 | |
| (XXXI) | 32788 | 4-chloro-8-methoxy-N,N-dimethyl-3-quinolinecarboxamide | C13H13ClN2O2 | 详情 | 详情 | |
| (XXXII) | 32789 | 8-methoxy-N,N-dimethyl-4-(2-toluidino)-3-quinolinecarboxamide | C20H21N3O2 | 详情 | 详情 | |
| (XXXIII) | 32790 | Chloro(propyl)magnesium | 2234-82-4 | C3H7ClMg | 详情 | 详情 |
合成路线10
该中间体在本合成路线中的序号：(II)Reaction of 2-phenoxymethylpyridine (I) with diethyl ethoxymethylenemalonate (II) and n-butyllithium in THF gives ethyl 3-ethoxy-2-(ethoxycarbonyl)-4-phenoxy-4-(2-pyridyl)butyrate (III), which is cyclized to ethyl 4-oxo-1-phenoxy-4H-quinolizine-3-carboxylate (IV) by heating at 250 C in a mixture of diphenyl and diphenyl ether. Ester hydrolysis of (IV) with sodium hydroxide in methanol yields 4-oxo-1-phenoxy-4H-quinolizine-3-carboxylic acid (V), which is converted to 4-oxo-1-phenoxy-N-(1H-tetrazol-5-yl)-4H-quinolizine-3-carboxamide (VII) on treatment with carbonyldiimidazole and 5-amino-1H-tetrazole (VI) in DMF. Finally, the sodium salt of (VII) is formed by means of sodium hydroxide.
| 【1】 Kitaura, Y.; Oku, T.; Hirai, H.; Yamamoto, T.; Hashimoto, M. (Fujisawa Pharmaceutical Co., Ltd.); Quinolizinone cpd., processes for preparation thereof and pharmaceutical compsns. comprising the same. AU 8547341; EP 0157346; ES 8609321; JP 1985222482; JP 1987077385; JP 1988284174; JP 1989193268; JP 1990015029; US 4650804; US 4698349 . |
| 【2】 Kitamura, S.; Okamoto, Y.; Tada, T.; Momonaga, M. (Fujisawa Pharmaceutical Co., Ltd.); Crystalline monohydrate of sodium N-(1H-tetrazol-5-yl)-1-phenoxy-4H-quinolizin-4-one-3-carboxamide. EP 0301465; JP 1989104073 . |
| 【3】 Castaner, J.; Prous, J.; Mealy, N.; Quinotolast Sodium. Drugs Fut 1994, 19, 2, 118. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14087 | Phenyl 2-pyridinylmethyl ether; 2-(Phenoxymethyl)pyridine | C12H11NO | 详情 | 详情 | |
| (II) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (III) | 14089 | diethyl 2-[1-ethoxy-2-phenoxy-2-(2-pyridinyl)ethyl]malonate | C22H27NO6 | 详情 | 详情 | |
| (IV) | 14090 | ethyl 4-oxo-1-phenoxy-4H-quinolizine-3-carboxylate | C18H15NO4 | 详情 | 详情 | |
| (V) | 14091 | 4-Oxo-1-phenoxy-4H-quinolizine-3-carboxylic acid | C16H11NO4 | 详情 | 详情 | |
| (VI) | 14092 | 1H-1,2,3,4-Tetraazol-5-ylamine; 1H-Tetrazol-5-amine; 1H-1,2,3,4-Tetraazol-5-amine; 5-Amino-1H-1,2,3,4-tetrazole | 4418-61-5 | CH3N5 | 详情 | 详情 |
| (VII) | 14093 | 4-Oxo-1-phenoxy-N-(1H-1,2,3,4-tetraazol-5-yl)-4H-quinolizine-3-carboxamide | C17H12N6O3 | 详情 | 详情 |
合成路线11
该中间体在本合成路线中的序号：(IV)Aminothiophene (III) was prepared by condensation of phenylacetone (I) with ethyl cyanoacetate (II), followed by treatment with sulfur and diethylamine. Subsequent condensation of (III) with diethyl ethoxymethylenemalonate (IV) at 120 C provided the enaminomalonate (V). the partial hydrolysis of (V) with KOH in EtOH-dioxan provided monoacid (VI), which was cyclized by means of PPE to the thienopyridine (VII). Alkylation of (VII) with 2,6-difluorobenzyl chloride (VIII) and K2CO3 yielded predominantly the N-benzylated compound (IX), which was selectively nitrated at the phenyl ring to produce (X) (2). Radical bromination of the 3-methyl group of (X) gave bromomethyl compound (XI).
| 【1】 Cho, N.; Harada, M.; Imaeda, T.; Imada, T.; Matsumoto, H.; Hayase, Y.; Sasaki, S,; Furuya, S.; Suzuki, N.; Okubo, S.; Ogi, K.; Endo, S.; Onda, H.; Fujino, M.; Discovery of a novel, potent, and orally active no. J Med Chem 1998, 41, 22, 4190. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 23143 | 1-Phenylacetone; Methyl benzyl ketone; Benzyl methyl ketone; phenylacetone; Phenyl-2-propanone | 103-79-7 | C9H10O | 详情 | 详情 |
| (II) | 11877 | Cyanoacetic acid ethyl ester; Ethyl 2-cyanoacetate; Ethyl cyanoacetate; Ethyl isocyanacetate | 105-56-6 | C5H7NO2 | 详情 | 详情 |
| (III) | 23145 | ethyl 2-amino-4-methyl-5-phenyl-3-thiophenecarboxylate | C14H15NO2S | 详情 | 详情 | |
| (IV) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (V) | 23147 | diethyl 2-([[3-(ethoxycarbonyl)-4-methyl-5-phenyl-2-thienyl]amino]methylene)malonate | C22H25NO6S | 详情 | 详情 | |
| (VI) | 23148 | 2-[[3-ethoxy-2-(ethoxycarbonyl)-3-oxo-1-propenyl]amino]-4-methyl-5-phenyl-3-thiophenecarboxylic acid | C20H21NO6S | 详情 | 详情 | |
| (VII) | 23149 | ethyl 4-hydroxy-3-methyl-2-phenylthieno[2,3-b]pyridine-5-carboxylate | C17H15NO3S | 详情 | 详情 | |
| (VIII) | 23150 | 2-(chloromethyl)-1,3-difluorobenzene | 697-73-4 | C7H5ClF2 | 详情 | 详情 |
| (IX) | 23151 | ethyl 7-(2,6-difluorobenzyl)-3-methyl-4-oxo-2-phenyl-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylate | C24H19F2NO3S | 详情 | 详情 | |
| (X) | 23152 | ethyl 7-(2,6-difluorobenzyl)-3-methyl-2-(4-nitrophenyl)-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylate | C24H18F2N2O5S | 详情 | 详情 | |
| (XI) | 23153 | ethyl 3-(bromomethyl)-7-(2,6-difluorobenzyl)-2-(4-nitrophenyl)-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylate | C24H17BrF2N2O5S | 详情 | 详情 |
合成路线12
该中间体在本合成路线中的序号：(V)3-Methoxybenzonitrile (I) was converted to the corresponding imidate (II) by treatment with ethanolic HCl. Condensation of (II) with aminoacetaldehyde diethyl acetal (III) gave amidine (IV), which was cyclized with diethyl ethoxymethylenemalonate (V) in refluxing ethanol to yield the pyrimidinone (VI). Hydrolysis of the ethyl ester function of (VI) by treatment with LiI in hot pyridine provided acid (VII). This was subjected to a Curtius rearrangement with diphenylphosphoryl azide, and the intermediate isocyanate was condensed with benzyl alcohol to produce the benzyl carbamate (VIII). Acid hydrolysis of the diethyl acetal group of (VIII), followed by oxidation of the resulting aldehyde with sodium chlorite, furnished the carboxylic acid (IX).
| 【1】 Akahoshi, F.; Ashimori, A.; Yoshimura, T.; Eda, M.; Sakashita, H.; Nakajima, M.; Imada, T. (Welfide Corporation); Novel heterocyclic amide cpds. and medicinal uses thereof. EP 0940400; US 6080738; WO 9818794 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 36250 | 3-methoxybenzonitrile | 1527-89-5 | C8H7NO | 详情 | 详情 |
| (II) | 34363 | ethyl 3-methoxybenzenecarboximidoate | C10H13NO2 | 详情 | 详情 | |
| (III) | 10331 | 2,2-Diethoxy-1-ethanamine; 2,2-Diethoxyethylamine; Aminoacetaldehyde diethyl acetal | 645-36-3 | C6H15NO2 | 详情 | 详情 |
| (IV) | 48623 | N-(2,2-diethoxyethyl)-3-methoxybenzenecarboximidamide | C14H22N2O3 | 详情 | 详情 | |
| (V) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (VI) | 48624 | ethyl 1-(2,2-diethoxyethyl)-2-(3-methoxyphenyl)-6-oxo-1,6-dihydro-5-pyrimidinecarboxylate | C20H26N2O6 | 详情 | 详情 | |
| (VII) | 48625 | 1-(2,2-diethoxyethyl)-2-(3-methoxyphenyl)-6-oxo-1,6-dihydro-5-pyrimidinecarboxylic acid | C18H22N2O6 | 详情 | 详情 | |
| (VIII) | 48626 | benzyl 1-(2,2-diethoxyethyl)-2-(3-methoxyphenyl)-6-oxo-1,6-dihydro-5-pyrimidinylcarbamate | C25H29N3O6 | 详情 | 详情 | |
| (IX) | 48627 | 2-[5-[[(benzyloxy)carbonyl]amino]-2-(3-methoxyphenyl)-6-oxo-1(6H)-pyrimidinyl]acetic acid | C21H19N3O6 | 详情 | 详情 |
合成路线13
该中间体在本合成路线中的序号：(IV)Palladium-catalyzed displacement of 2,6-dibromotoluene (I) with cyclopropylamine (II) affords N-cyclopropyl-3-bromo-2-methylaniline (III). Subsequent condensation of aniline (III) with diethyl ethoxymethylenemalonate (IV) produces the enaminomalonate (V), which is further cyclized to the quinolinecarboxylate (VI) in hot PPA.
| 【1】 Hayashi, K.; Yamakawa, T.; Kawafuchi, H.; Kito, T.; Mitsuyama, J.; Kuroda, H. (Toyama Chemical Co., Ltd.); Quinolonecarboxylic acid derivs. or salts thereof. EP 1070713; WO 9951588 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 58232 | 1,3-dibromo-2-methylbenzene; 2,6-Dibromotoluene | 69321-60-4 | C7H6Br2 | 详情 | 详情 |
| (II) | 12263 | Cyclopropylamine; Cyclopropanamine | 765-30-0 | C3H7N | 详情 | 详情 |
| (III) | 58233 | 3-bromo-N-cyclopropyl-2-methylaniline; N-(3-bromo-2-methylphenyl)-N-cyclopropylamine | C10H12BrN | 详情 | 详情 | |
| (IV) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (V) | 58234 | diethyl 2-{[3-bromo(cyclopropyl)-2-methylanilino]methylene}malonate | C18H22BrNO4 | 详情 | 详情 | |
| (VI) | 58235 | ethyl 7-bromo-1-cyclopropyl-8-methyl-4-oxo-1,4-dihydro-3-quinolinecarboxylate | C16H16BrNO3 | 详情 | 详情 |
合成路线14
该中间体在本合成路线中的序号：(II)Pyrimidinone (III) was formed by condensation of benzamidine hydrochloride (I) with diethyl (ethoxymethylene)malonate (II). Subsequent reaction with glycinamide derivative (V) in the presence of p-tosyl chloride and Et3N afforded the aminopyrimidine (VI) (1). Alternatively, aminopyrimidine (VI) was prepared by chlorination of pyrimidinone (III) with POCl3, followed by displacement of the resulting chloropyrimidine (IV) with glycinamide (V) (2). Basic hydrolysis of the ethyl ester group of (VI) furnished pyrimidinecarboxylic acid (VII). This was then subjected to a Curtius rearrangement employing diphenyl phosphoryl azide (DPPA) to produce the 8-oxopurine system (VIII). Finally, N-alkylation of (VIII) with iodomethane gave rise to the title compound.
| 【1】 Masumoto, K.; et al.; SX-5216, highly potent and selective mitochondrial benzodiazepine receptor ligand as a potential anxiolytic agent. 219th ACS Natl Meet (March 26 2000, San Francisco) 2000, Abst MEDI 113. |
| 【2】 Matsumoto, K.; Kondo, K.; Furukawa, K.; Murata, T.; Oka, M. (Dainippon Pharmaceutical Co., Ltd.); 2-Aryl-8-oxodihydropurine derivs., process for producing the same, medicinal compsns. containing the same, and intermediates thereof. EP 1036794; WO 9928320 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 37052 | Benzamidine; benzenecarboximidamide | C7H8N2 | 详情 | 详情 | |
| (II) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (III) | 40809 | ethyl 6-oxo-2-phenyl-1,6-dihydro-5-pyrimidinecarboxylate | C13H12N2O3 | 详情 | 详情 | |
| (IV) | 40810 | ethyl 4-chloro-2-phenyl-5-pyrimidinecarboxylate | C13H11ClN2O2 | 详情 | 详情 | |
| (V) | 40811 | 2-amino-N-benzyl-N-ethylacetamide | C11H16N2O | 详情 | 详情 | |
| (VI) | 40812 | ethyl 4-([2-[benzyl(ethyl)amino]-2-oxoethyl]amino)-2-phenyl-5-pyrimidinecarboxylate | C24H26N4O3 | 详情 | 详情 | |
| (VII) | 40813 | 4-([2-[benzyl(ethyl)amino]-2-oxoethyl]amino)-2-phenyl-5-pyrimidinecarboxylic acid | C22H22N4O3 | 详情 | 详情 | |
| (VIII) | 40814 | N-benzyl-N-ethyl-2-(8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide | C22H21N5O2 | 详情 | 详情 |
合成路线15
该中间体在本合成路线中的序号：(II)The condensation of 2-fluoroaniline (I) with diethyl ethoxymethylene malonate (II) at 130 C afforded enamine (III), which was further cyclized to ethyl 8-fluoro-4-hydroxy-3-quinolinecarboxylate (IV) upon heating at 250 C. Condensation of (III) with neat 4-chlorobenzylamine (V) then provided the desired carboxamide.
| 【1】 Cudahy, M.M.; Clayton, T.L.; Vailancourt, V.A.; et al.; 4-Hydroxyquinoline-3-carboxamides as inhibitors of herpes virus DNA polymerases. 219th ACS Natl Meet (March 26 2000, San Francisco) 2000, Abst MEDI 135. |
| 【2】 Schnute, M.E.; Turner, S.R.; Cudahy, M.M.; Vaillancourt, V.A.; Thaisrivongs, S.; Strohbach, J.W.; Romines, K.R.; Tucker, J.A. (Pharmacia Corp.); 4-Hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents. EP 1042295; US 6093732; WO 9932450 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 22296 | 2-fluorophenylamine; 2-fluoroaniline | 348-54-9 | C6H6FN | 详情 | 详情 |
| (II) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (III) | 40763 | diethyl 2-[(2-fluoroanilino)methylene]malonate | C14H16FNO4 | 详情 | 详情 | |
| (IV) | 40764 | ethyl 8-fluoro-4-hydroxy-3-quinolinecarboxylate | C12H10FNO3 | 详情 | 详情 | |
| (V) | 23378 | (4-chlorophenyl)methanamine; 4-chlorobenzylamine | 104-86-9 | C7H8ClN | 详情 | 详情 |
合成路线16
该中间体在本合成路线中的序号：(II)The condensation between 4-iodoaniline (I) and diethyl ethoxymethylenemalonate (II) at 130 C, followed by cyclization in diphenyl ether at 250 C, furnished ethyl 4-hydroxy-6-iodoquinoline-3-carboxylate (III). Subsequent reaction of ester (III) with 4-chlorobenzylamine (IV) at 180 C produced the corresponding amide (V). Finally, coupling of (V) with propargyl alcohol (VI) in the presence of CuI and palladium catalyst afforded the desired (hydroxypropynyl)quinoline.
| 【1】 Schnute, M.E.; Turner, S.R.; Cudahy, M.M.; Vaillancourt, V.A.; Thaisrivongs, S.; Strohbach, J.W.; Romines, K.R.; Tucker, J.A. (Pharmacia Corp.); 4-Hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents. EP 1042295; US 6093732; WO 9932450 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 26393 | 4-iodoaniline; 4-iodophenylamine | 540-37-4 | C6H6IN | 详情 | 详情 |
| (II) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (III) | 44988 | ethyl 4-hydroxy-6-iodo-3-quinolinecarboxylate | C12H10INO3 | 详情 | 详情 | |
| (IV) | 23378 | (4-chlorophenyl)methanamine; 4-chlorobenzylamine | 104-86-9 | C7H8ClN | 详情 | 详情 |
| (V) | 44989 | N-(4-chlorobenzyl)-4-hydroxy-6-iodo-3-quinolinecarboxamide | C17H12ClIN2O2 | 详情 | 详情 | |
| (VI) | 16664 | Propargyl Alcohol; 2-propyn-1-ol | 107-19-7 | C3H4O | 详情 | 详情 |
合成路线17
该中间体在本合成路线中的序号：(II)The 4-hydroxyquinoline (III) was synthesized via Gould-Jacobs reaction from 4-iodoaniline (I) and diethyl ethoxymethylenemalonate (II). Displacement of the ethyl ester group with 4-chlorobenzylamine (IV) at 180 C furnished the chlorobenzyl amide (V). Subsequent palladium-catalyzed carbonylation of iodide (V) provided the methyl carboxylate (VI), which was further reduced to alcohol (VII) using LiAlH4. Methylation of the hydroxyquinoline (VII) with iodomethane gave rise to the N-methyl quinolone (VIII). After conversion of the alcohol function of (VIII) to the corresponding mesylate (IX), displacement with morpholine (X) yielded the target morpholinomethyl quinolone.
| 【1】 Turner, S.R.; Strohbach, J.W.; Scott, A.; Schnute, M.E.; Vaillancourt, V.A.; Thaisrivongs, S. (Pharmacia Corp.); 4-Oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents. EP 1140851; WO 0040563 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 26393 | 4-iodoaniline; 4-iodophenylamine | 540-37-4 | C6H6IN | 详情 | 详情 |
| (II) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (III) | 44988 | ethyl 4-hydroxy-6-iodo-3-quinolinecarboxylate | C12H10INO3 | 详情 | 详情 | |
| (IV) | 23378 | (4-chlorophenyl)methanamine; 4-chlorobenzylamine | 104-86-9 | C7H8ClN | 详情 | 详情 |
| (V) | 44989 | N-(4-chlorobenzyl)-4-hydroxy-6-iodo-3-quinolinecarboxamide | C17H12ClIN2O2 | 详情 | 详情 | |
| (VI) | 49889 | methyl 3-[[(4-chlorobenzyl)amino]carbonyl]-4-hydroxy-6-quinolinecarboxylate | C19H15ClN2O4 | 详情 | 详情 | |
| (VII) | 49890 | N-(4-chlorobenzyl)-4-hydroxy-6-(hydroxymethyl)-3-quinolinecarboxamide | C18H15ClN2O3 | 详情 | 详情 | |
| (VIII) | 49891 | N-(4-chlorobenzyl)-6-(hydroxymethyl)-1-methyl-4-oxo-1,4-dihydro-3-quinolinecarboxamide | C19H17ClN2O3 | 详情 | 详情 | |
| (IX) | 49892 | (3-[[(4-chlorobenzyl)amino]carbonyl]-1-methyl-4-oxo-1,4-dihydro-6-quinolinyl)methyl methanesulfonate | C20H19ClN2O5S | 详情 | 详情 | |
| (X) | 10338 | 1-[(4S,5S)-5-([[tert-Butyl(dimethyl)silyl]oxy]methyl)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-(trityloxy)-1-ethanone | C33H42O5Si | 详情 | 详情 |
合成路线18
该中间体在本合成路线中的序号：(II)The cyclization of 3aminopyridine (I) with diethyl ethoxymethylenemalonate (II) in refluxing Dowtherm gives 4-hydroxy-1,5-naphthyridine-3-carboxylic acid ethyl ester (III), which is hydrolyzed with NaOH in refluxing water to yield the corresponding hydroxyacid (IV). The decarboxylation of (IV) by heating at 320 C in mineral oil affords 4-hydroxy-1,5-naphthyridine (V), which is acylated with trifluoromethanesulfonic anhydride to provide the triflate (VI). The reaction of (VI) with propylamine in pyridine affords 4-amino-1,5-naphthyridine (VII), which is condensed with 2-methylbenzoxazole-6-ylcarbonyl azide (VIII) (obtained by reaction of the corresponding acid (IX) with DPPA) in refluxing toluene to provide the target urea.
| 【1】 Porter, R.A.; et al.; 1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor. Bioorg Med Chem Lett 2001, 11, 14, 1907. |
| 【2】 Adams, J.T.; et al.; Synthesis of antimalarials. VI. Synthesis of certain 1,5- and 1,8-naphthyridine derivatives. J Am Chem Soc 1946, 68, 1317. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 33327 | 3-Pyridinylamine; 3-Aminopyridine; 3-Pyridinamine | 462-08-8 | C5H6N2 | 详情 | 详情 |
| (II) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (III) | 53616 | ethyl 4-hydroxy[1,5]naphthyridine-3-carboxylate | 13801-51-9 | C11H10N2O3 | 详情 | 详情 |
| (IV) | 43932 | 4-hydroxy[1,5]naphthyridine-3-carboxylic acid | C9H6N2O3 | 详情 | 详情 | |
| (V) | 43933 | [1,5]naphthyridin-4-ol | C8H6N2O | 详情 | 详情 | |
| (VI) | 53617 | [1,5]naphthyridin-4-yl trifluoromethanesulfonate | n/a | C9H5F3N2O3S | 详情 | 详情 |
| (VII) | 43935 | [1,5]naphthyridin-4-amine; [1,5]naphthyridin-4-ylamine | C8H7N3 | 详情 | 详情 | |
| (VIII) | 53618 | 2-methyl-1,3-benzoxazole-6-carbonyl azide | n/a | C9H6N4O2 | 详情 | 详情 |
| (IX) | 43936 | 2-methyl-1,3-benzoxazole-6-carboxylic acid | C9H7NO3 | 详情 | 详情 |
合成路线19
该中间体在本合成路线中的序号：(I)The condensation between diethyl ethoxymethylenemalonate (I) and 5-amino-1-ethylpyrazole (II) afforded the enamino malonate (III). Cyclization of (III) upon heating at 255 C in diphenyl ether produced the pyrazolopyridine (IV). This was subsequently chlorinated to (V) in refluxing phosphoryl chloride. Alternatively, enamino malonate (III) was directly converted to the chloro pyrazolopyridine (V) by treatment with POCl3. Nitrile (VI) was prepared by displacement of the chloro group of (V) with cyanide in the presence of a phase-transfer catalyst. Cyclization of the cyano ester (VI) with hydrazine led to the pyrazolopyridopyridiazine tricyclic system (VII). Diazotization of amine (VII) generated the dioxo derivative (VIII), which was chlorinated with POCl3 to yield the dichloro derivative (IX). Selective displacement of the 6-chloro group of (IX) with the imidazole carboxamide (X) produced the imidazolyl derivative (XI).
| 【1】 Kim, S.; Wang, Y.; Yu, G.; Macor, J.; Chung, H.-J.; Humora, M.; Katipally, K. (Bristol-Myers Squibb Co.); Fused pyridopyridazine inhibitors of cGMP phosphodiesterase. EP 1165521; JP 2002540102; US 6316438; WO 0056719 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (II) | 40098 | 1-ethyl-1H-pyrazol-5-amine; 1-ethyl-1H-pyrazol-5-ylamine | 3528-58-3 | C5H9N3 | 详情 | 详情 |
| (III) | 40099 | diethyl 2-[[(1-ethyl-1H-pyrazol-5-yl)amino]methylene]malonate | C13H19N3O4 | 详情 | 详情 | |
| (IV) | 40100 | ethyl 1-ethyl-4-hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylate | C11H13N3O3 | 详情 | 详情 | |
| (V) | 58542 | ethyl 4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate | C11H12ClN3O2 | 详情 | 详情 | |
| (VI) | 58543 | ethyl 4-cyano-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate | C12H12N4O2 | 详情 | 详情 | |
| (VII) | 58544 | 9-amino-3-ethyl-3,7-dihydro-6H-pyrazolo[4',3':5,6]pyrido[3,4-d]pyridazin-6-one | C10H10N6O | 详情 | 详情 | |
| (VIII) | 58545 | 3-ethyl-7,8-dihydro-3H-pyrazolo[4',3':5,6]pyrido[3,4-d]pyridazine-6,9-dione | C10H9N5O2 | 详情 | 详情 | |
| (IX) | 58546 | 6,9-dichloro-3-ethyl-3H-pyrazolo[4',3':5,6]pyrido[3,4-d]pyridazine | C10H7Cl2N5 | 详情 | 详情 | |
| (X) | 58547 | N-methyl-1H-imidazole-4-carboxamide | C5H7N3O | 详情 | 详情 | |
| (XI) | 58548 | 1-(9-chloro-3-ethyl-3H-pyrazolo[4',3':5,6]pyrido[3,4-d]pyridazin-6-yl)-N-methyl-1H-imidazole-4-carboxamide | C15H13ClN8O | 详情 | 详情 |
合成路线20
该中间体在本合成路线中的序号：(V)The intermediate pyrimidineacetic acid (X) was prepared as follows. 4-Fluorobenzonitrile (I) was converted to the corresponding imidate (II) by treatment with ethanolic HCl. Reaction of imidate (II) with aminoacetaldehyde diethyl acetal (III) produced amidine (IV), which was condensed with diethyl ethoxymethylenemalonate (V) in boiling EtOH to furnish pyrimidinone (VI). Hydrolysis of the ethyl ester function of (VI) was carried out by treatment with LiI in hot pyridine. The resulting carboxylic acid (VII) was then subjected to a Curtius rearrangement with diphenylphosphoryl azide, and the intermediate isocyanate was subsequently condensed with benzyl alcohol, producing the benzyl carbamate (VIII). Acid hydrolysis of the diethyl acetal group of (VIII) gave aldehyde (IX), which was then oxidized to carboxylic acid (X) by using sodium chlorite.
| 【1】 Akahoshi, F.; Yoshimura, T.; Eda, M.; Ashimori, A.; Fukuyama, H.; Nakajima, M.; Imada, T.; Okunishi, H.; Miyazaki, M. (Welfide Corporation); Heterocyclic amide cpds. and medicinal use of the same. EP 0826671; US 5948785; WO 9633974 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14144 | 4-Fluorobenzonitrile | 1194-02-1 | C7H4FN | 详情 | 详情 |
| (II) | 49074 | ethyl 4-fluorobenzenecarboximidoate | C9H10FNO | 详情 | 详情 | |
| (III) | 10331 | 2,2-Diethoxy-1-ethanamine; 2,2-Diethoxyethylamine; Aminoacetaldehyde diethyl acetal | 645-36-3 | C6H15NO2 | 详情 | 详情 |
| (IV) | 49075 | N-(2,2-diethoxyethyl)-4-fluorobenzenecarboximidamide | C13H19FN2O2 | 详情 | 详情 | |
| (V) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (VI) | 49076 | ethyl 1-(2,2-diethoxyethyl)-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-5-pyrimidinecarboxylate | C19H23FN2O5 | 详情 | 详情 | |
| (VII) | 49077 | 1-(2,2-diethoxyethyl)-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-5-pyrimidinecarboxylic acid | C17H19FN2O5 | 详情 | 详情 | |
| (VIII) | 49078 | benzyl 1-(2,2-diethoxyethyl)-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-5-pyrimidinylcarbamate | C24H26FN3O5 | 详情 | 详情 | |
| (IX) | 49079 | benzyl 2-(4-fluorophenyl)-6-oxo-1-(2-oxoethyl)-1,6-dihydro-5-pyrimidinylcarbamate | C20H16FN3O4 | 详情 | 详情 | |
| (X) | 49080 | 2-[5-[[(benzyloxy)carbonyl]amino]-2-(4-fluorophenyl)-6-oxo-1(6H)-pyrimidinyl]acetic acid | C20H16FN3O5 | 详情 | 详情 |
合成路线21
该中间体在本合成路线中的序号：(XIV)The reaction of 3-chlorobenzonitrile (X) with HCl and ethanol gives the ethyl 3-chlorobenzimidate (XI), which is condensed with 2-aminoacetaldehyde diethylacetal (XII) in ethanol to yield 3-chloro-N-(2,2-diethoxyethyl)benzamidine (XIII). The cyclization of (XIII) with diethyl ethoxymethylenemalonate (XIV) in refluxing ethanol affords the pyrimidinone (XV), the ester group of which is hydrolyzed with LiI and NaHCO3 in pyridine to provide the corresponding carboxylic acid (XVI). The reaction of the carboxylic group of (XVI) with DPPA and TEA in refluxing dioxane gives the N-benzyloxycarbonylamino-pyrimidinone (XVII). The hydrolysis of he diethylacetal group of (XVII) with hot 1M HCl yields the acetaldehyde derivative (XVIII), which is oxidized with NaClO2 in water to afford the acetic acid derivative (XIX). The condensation of (XIX) with the already reported intermediate (IX) by means of HOBt and WSC provides the amide (XX), which is finally deprotected by means of trifluromethanesulfonic acid and anisole in dichloromethane to yield the target diamide derivative.
| 【1】 Kobayashi, F.; Naito, K.; Yoshikawa, T.; Kuwahara, S.; Imada, T.; Komorita, N. (Mitsubishi Pharma Corp.); IgE antibody production inhibitors and autoimmune diseases inhibitors. EP 1062949; US 6528514; WO 9945928 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IX) | 57839 | 4-amino-N-benzyl-2,2-difluoro-5-phenylpentanamide | C18H20F2N2O | 详情 | 详情 | |
| (X) | 33570 | 3-chlorobenzonitrile | 766-84-7 | C7H4ClN | 详情 | 详情 |
| (XI) | 57840 | ethyl 3-chlorobenzenecarboximidoate | C9H10ClNO | 详情 | 详情 | |
| (XII) | 10331 | 2,2-Diethoxy-1-ethanamine; 2,2-Diethoxyethylamine; Aminoacetaldehyde diethyl acetal | 645-36-3 | C6H15NO2 | 详情 | 详情 |
| (XIII) | 57841 | 3-chloro-N-(2,2-diethoxyethyl)benzenecarboximidamide | C13H19ClN2O2 | 详情 | 详情 | |
| (XIV) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (XV) | 57842 | methyl 2-(3-chlorophenyl)-1-(2,2-diethoxyethyl)-6-oxo-1,6-dihydro-5-pyrimidinecarboxylate | C18H21ClN2O5 | 详情 | 详情 | |
| (XVI) | 57843 | 2-(3-chlorophenyl)-1-(2,2-diethoxyethyl)-6-oxo-1,6-dihydro-5-pyrimidinecarboxylic acid | C17H19ClN2O5 | 详情 | 详情 | |
| (XVII) | 57844 | benzyl 2-(3-chlorophenyl)-1-(2,2-diethoxyethyl)-6-oxo-1,6-dihydro-5-pyrimidinylcarbamate | C24H26ClN3O5 | 详情 | 详情 | |
| (XVIII) | 57845 | benzyl 2-(3-chlorophenyl)-6-oxo-1-(2-oxoethyl)-1,6-dihydro-5-pyrimidinylcarbamate | C20H16ClN3O4 | 详情 | 详情 | |
| (XIX) | 57846 | 2-[5-{[(benzyloxy)carbonyl]amino}-2-(3-chlorophenyl)-6-oxo-1(6H)-pyrimidinyl]acetic acid | C20H16ClN3O5 | 详情 | 详情 | |
| (XX) | 57847 | benzyl 1-(2-{[1-benzyl-4-(benzylamino)-3,3-difluoro-4-oxobutyl]amino}-2-oxoethyl)-2-(3-chlorophenyl)-6-oxo-1,6-dihydro-5-pyrimidinylcarbamate | C38H34ClF2N5O5 | 详情 | 详情 |
合成路线22
该中间体在本合成路线中的序号：(II)1) Condensation of 2-trifluoromethylaniline (I) with ethyl ethoxymethylenemalonate (II) at 125 C to give ethyl-alpha-carbethoxy-beta-(2-trifluoromethylanilino)acrylate (III), m.p. 94 C; this product is cyclized by refluxing with diphenyl ether affording 3-carbethoxy-4-hydroxy-8-trifluoromethylquinoline (IV), m.p. 216 C, which in turn, is hydrolyzed with refluxing aqueous NaOH to the corresponding acid (V), m.p. 290-2 C; this acid is decarboxylated by refluxing in diphenyl ether to 4-hydroxy-8-trifluoromethylquinoline (VI), m.p. 180 C; this product by refluxing with POCl3 is converted into chloro-8-trifluoromethylquinoline (VII), m.p. 78 C; the condensation of quinoline (VII) with methyl anthranilate (A) by means of aqueous 2N HCl affords 4-(2-methoxycarbonylphenylamino)-8-trifluoromethylquinoline (VIII), m.p. 176 C (1,2). The transesterification of methyl ester (VIII) with glycerol affords the final product. (1) 2) Transesterification of methylester (VIII) with 2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane (B) to give the acetoneketal of floctafenine (IX), mp 108 C which is finally hydrolized with HCl. (2) 3) Condensation of the chloroquinoline (VII) with the 2,2-dimethyl-4-hydroxymethyl-2,3-dioxolane ester of anthranilic acid by means aqueous HCl to give the already obtained acetoneketal (IX), which is finally hydrolized as before. (2)
| 【1】 (Roussel-Uclaf.); DE 1815467 . |
| 【2】 Castaner, J.; Arrigoni, Martelli, E.; Floctafenine. Drugs Fut 1976, 1, 2, 59. |
| 【3】 Allais, A.; et al.; NMR structure of tissue inhibitor of metalloproteinases-1 implicates localized induced fit in recognition of matrix metalloproteinases. Chim Ther 1973, 8, 2, 154. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 11161 | methyl 2-aminobenzoate; Methyl anthranilate | 134-20-3 | C8H9NO2 | 详情 | 详情 |
| (B) | 16476 | 2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane; (2,2-dimethyl-1,3-dioxolan-4-yl)methanol; 2,3-o-Isopropylideneglycerol | 100-79-8 | C6H12O3 | 详情 | 详情 |
| (I) | 25812 | 2-(trifluoromethyl)phenylamine; 2-(trifluoromethyl)aniline | 88-17-5 | C7H6F3N | 详情 | 详情 |
| (II) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (III) | 60720 | diethyl 2-{[2-(trifluoromethyl)anilino]methylene}malonate | C15H16F3NO4 | 详情 | 详情 | |
| (IV) | 60721 | ethyl 4-hydroxy-8-(trifluoromethyl)-3-quinolinecarboxylate | C13H10F3NO3 | 详情 | 详情 | |
| (V) | 60722 | 4-hydroxy-8-(trifluoromethyl)-3-quinolinecarboxylic acid | C11H6F3NO3 | 详情 | 详情 | |
| (VI) | 60723 | 8-(trifluoromethyl)-4-quinolinol | C10H6F3NO | 详情 | 详情 | |
| (VII) | 60724 | 4-chloro-8-(trifluoromethyl)quinoline | C10H5ClF3N | 详情 | 详情 | |
| (VIII) | 60727 | methyl 2-{[8-(trifluoromethyl)-4-quinolinyl]amino}benzoate | C18H13F3N2O2 | 详情 | 详情 | |
| (IX) | 60726 | (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 2-{[8-(trifluoromethyl)-4-quinolinyl]amino}benzoate | C23H21F3N2O4 | 详情 | 详情 | |
| (C) | 60725 | (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 2-aminobenzoate | C13H17NO4 | 详情 | 详情 |
合成路线23
该中间体在本合成路线中的序号：(IV)The cyclization of phenylacetone (I) with ethyl cyanoacetate (II) by means of HOAc and AcONH4 in refluxing benzene, followed by a treatment with sulfur in hot ethanol gives 2-amino-4-methyl-5-phenylthiophene-3-carboxylic acid ethyl ester (III). The condensation of (III) with diethyl ethoxymethylene malonate (IV) by heating at 120 C yields the adduct (V), which is submitted to a selective hydrolysis with KOH in hot ethanol to afford the carboxylic acid (VI). The cyclization of (VI) by means of PPE at 120 C provides the thienopyridine (VII), which is nitrated with NaNO3 and H2SO4 to give the 4-nitrophenyl derivative (VIII). The alkylation of the hydroxy-thienopyridine (VIII) with 2,6-difluorobenzyl chloride (IX) by means of NaH in DMF yields the benzylated thienopyridinone (X), which is brominated with NBS and AIBN in refluxing CCl4 to afford the bromomethyl derivative (XI). The condensation of (XI) with N-benzyl-N-methylamine (XII) by means of TEA in DMF provides the tertiary amine (XIII). The reduction of the nitro group of (XIII) by means of Fe and HCl in ethanol gives the 4-aminophenyl derivative (XIV), which is acylated with trifluoroacetic anhydride and TEA to yield the acetamide (XV). The reaction of (XV) with N,O-dimethylhydroxylamine (XVI) and TEA in CH2Cl2 affords the methoxyamide (XVII).
| 【1】 Imada, T.; Fujino, M.; Suzuki, N.; Harada, M.; Kasai, S.; Sasaki, S.; Endo, S.; Hayase, Y.; Furuya, S.; Cho, N.; Discovery of the thieno[2,3-b]pyridin-4-one derivative TAK-810: Highly potent and orally active nonpeptide LHRH (GnRH) antagonist (I). 224th ACS Natl Meet (Aug 18 2002, Boston) 2002, Abst MEDI 353. |
| 【2】 Suzuki, N.; Furuya, S.; Choh, N.; Imada, T. (Takeda Chemical Industries, Ltd.); Thienopyridine cpds., their production and use. EP 1090010; JP 2000219690; JP 2000219691; US 6262267; US 6329388; WO 0000493 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 23143 | 1-Phenylacetone; Methyl benzyl ketone; Benzyl methyl ketone; phenylacetone; Phenyl-2-propanone | 103-79-7 | C9H10O | 详情 | 详情 |
| (II) | 11877 | Cyanoacetic acid ethyl ester; Ethyl 2-cyanoacetate; Ethyl cyanoacetate; Ethyl isocyanacetate | 105-56-6 | C5H7NO2 | 详情 | 详情 |
| (III) | 23145 | ethyl 2-amino-4-methyl-5-phenyl-3-thiophenecarboxylate | C14H15NO2S | 详情 | 详情 | |
| (IV) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (V) | 23147 | diethyl 2-([[3-(ethoxycarbonyl)-4-methyl-5-phenyl-2-thienyl]amino]methylene)malonate | C22H25NO6S | 详情 | 详情 | |
| (VI) | 23148 | 2-[[3-ethoxy-2-(ethoxycarbonyl)-3-oxo-1-propenyl]amino]-4-methyl-5-phenyl-3-thiophenecarboxylic acid | C20H21NO6S | 详情 | 详情 | |
| (VII) | 23149 | ethyl 4-hydroxy-3-methyl-2-phenylthieno[2,3-b]pyridine-5-carboxylate | C17H15NO3S | 详情 | 详情 | |
| (VIII) | 58691 | ethyl 4-hydroxy-3-methyl-2-(4-nitrophenyl)thieno[2,3-b]pyridine-5-carboxylate | C17H14N2O5S | 详情 | 详情 | |
| (IX) | 23150 | 2-(chloromethyl)-1,3-difluorobenzene | 697-73-4 | C7H5ClF2 | 详情 | 详情 |
| (X) | 23152 | ethyl 7-(2,6-difluorobenzyl)-3-methyl-2-(4-nitrophenyl)-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylate | C24H18F2N2O5S | 详情 | 详情 | |
| (XI) | 23153 | ethyl 3-(bromomethyl)-7-(2,6-difluorobenzyl)-2-(4-nitrophenyl)-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylate | C24H17BrF2N2O5S | 详情 | 详情 | |
| (XII) | 11969 | N-Methyl(phenyl)methanamine; N-Benzyl-N-methylamine; N-Methylbenzylamine | 103-67-3 | C8H11N | 详情 | 详情 |
| (XIII) | 23155 | ethyl 3-[[benzyl(methyl)amino]methyl]-7-(2,6-difluorobenzyl)-2-(4-nitrophenyl)-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylate | C32H27F2N3O5S | 详情 | 详情 | |
| (XIV) | 23156 | ethyl 2-(4-aminophenyl)-3-[[benzyl(methyl)amino]methyl]-7-(2,6-difluorobenzyl)-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylate | C32H29F2N3O3S | 详情 | 详情 | |
| (XV) | 58692 | ethyl 3-{[benzyl(methyl)amino]methyl}-7-(2,6-difluorobenzyl)-4-oxo-2-{4-[(2,2,2-trifluoroacetyl)amino]phenyl}-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylate | C34H28F5N3O4S | 详情 | 详情 | |
| (XVI) | 13361 | (Methoxyamino)methane; N,O-Dimethylhydroxylamine | 1117-97-1 | C2H7NO | 详情 | 详情 |
| (XVII) | 58693 | 3-{[benzyl(methyl)amino]methyl}-7-(2,6-difluorobenzyl)-N-methoxy-N-methyl-4-oxo-2-{4-[(2,2,2-trifluoroacetyl)amino]phenyl}-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide | C34H29F5N4O4S | 详情 | 详情 |
合成路线24
该中间体在本合成路线中的序号：(VIII)O-Protection of 2,4-di-tert-butylphenol (I) with methyl chloroformate (II) in the presence of Et3N and DMAP in CH2Cl2 gives 2,4-ditert-butylphenyl methyl carbonate (III), which by nitration with HNO3 and H2SO4 provides a mixture of the 5- and 6-nitrophenyl carbonates (IVa) and (IVb), respectively. Hydrolysis of the mixture of carbonates (IVa) and (IVb) by means of KOH in MeOH followed by chromatographic separation of the resulting mixture of nitrophenols affords 2,4-di-tert-butyl-5-nitrophenol (V), which is reduced by transfer hydrogenation with HCOONH4 in the presence of Pd/C in refluxing EtOH to the amine (VI). Finally, amine (VI) is condensed with 4-oxo-1,4-dihydroquinoline-3-carboxylic acid (VII) by means of HBTU and Et3N in DMF or CH2Cl2 .
4-Oxo-1,4-dihydroquinoline-3-carboxylic acid (VII) is prepared by coupling of diethyl 2-(ethoxymethylene)malonate (VIII) with aniline (IX) by heating at 140-150 °C to afford diethyl 2-(anilinomethylene) malonate (X), which by cyclization by means of PPA and POCl3 at 70 °C yields ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate (XI). Finally, ethyl ester derivative (XI) is saponified with NaOH at reflux, followed by acidification with HCl .
| 【1】 Hadida Ruah, S.S., Hazlewood, A.R., Grootenhuis, P.D.J., Van Goor, F.F., Singh, A.K., Zhou, J., McCartney, J. (Vertex Pharmaceuticals, Inc.).Modulators of ATP-binding cassette transporters. CN 10193301, EP 1773816, JP 2008504291, US 2006074075, US 7495013, US 8101767, WO 2006002421. |
| 【2】 Hurter, P. (Vertex Pharmaceuticals, Inc.). Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide. EP 1993360, JP 200952278, US 011064811, WO 2007079139. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IVa) | 68207 | 2,4-di-tert-butyl-5-nitrophenyl methyl carbonate | 873055-55-1 | C16H23NO5 | 详情 | 详情 |
| (IVb) | 68208 | 2,4-di-tert-butyl-6-nitrophenyl methyl carbonate | 详情 | 详情 | ||
| (I) | 68205 | 2,4-di-tert-butylphenol;2,4-Bis(1,1-dimethylethyl)-phenol | 96-76-4 | C14H22O | 详情 | 详情 |
| (II) | 16993 | methyl chlorocarbonate;Carbonochloridic acid methyl ester；[(chlorocarbonyl)oxy]methane；methyl chloroformate | 79-22-1 | C2H3ClO2 | 详情 | 详情 |
| (III) | 68206 | 2,4-ditert-butylphenyl methyl carbonate | C16H24O3 | 详情 | 详情 | |
| (V) | 68209 | 2,4-di-tert-butyl-5-nitrophenol | C14H21NO3 | 详情 | 详情 | |
| (VI) | 68210 | 5-amino-2,4-di-tert-butylphenol | C14H23NO | 详情 | 详情 | |
| (VII) | 68211 | 4-oxo-1,4-dihydroquinoline-3-carboxylic acid | 13721-01-2 | C10H7NO3 | 详情 | 详情 |
| (VIII) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (IX) | 12294 | Aniline; Phenylamine | 62-53-3 | C6H7N | 详情 | 详情 |
| (X) | 35953 | diethyl 2-(anilinomethylene)malonate | C14H17NO4 | 详情 | 详情 | |
| (XI) | 68212 | ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate | C12H11NO3 | 详情 | 详情 |