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【结 构 式】 
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【分子编号】40763 【品名】diethyl 2-[(2-fluoroanilino)methylene]malonate 【CA登记号】 |
【 分 子 式 】C14H16FNO4 【 分 子 量 】281.2837832 【元素组成】C 59.78% H 5.73% F 6.75% N 4.98% O 22.75% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The condensation of 2-fluoroaniline (I) with diethyl ethoxymethylene malonate (II) at 130 C afforded enamine (III), which was further cyclized to ethyl 8-fluoro-4-hydroxy-3-quinolinecarboxylate (IV) upon heating at 250 C. Condensation of (III) with neat 4-chlorobenzylamine (V) then provided the desired carboxamide.
| 【1】 Cudahy, M.M.; Clayton, T.L.; Vailancourt, V.A.; et al.; 4-Hydroxyquinoline-3-carboxamides as inhibitors of herpes virus DNA polymerases. 219th ACS Natl Meet (March 26 2000, San Francisco) 2000, Abst MEDI 135. |
| 【2】 Schnute, M.E.; Turner, S.R.; Cudahy, M.M.; Vaillancourt, V.A.; Thaisrivongs, S.; Strohbach, J.W.; Romines, K.R.; Tucker, J.A. (Pharmacia Corp.); 4-Hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents. EP 1042295; US 6093732; WO 9932450 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 22296 | 2-fluorophenylamine; 2-fluoroaniline | 348-54-9 | C6H6FN | 详情 | 详情 |
| (II) | 14088 | Diethyl ethoxymethylenemalonate; Diethyl 2-(ethoxymethylene)malonate | 87-13-8 | C10H16O5 | 详情 | 详情 |
| (III) | 40763 | diethyl 2-[(2-fluoroanilino)methylene]malonate | C14H16FNO4 | 详情 | 详情 | |
| (IV) | 40764 | ethyl 8-fluoro-4-hydroxy-3-quinolinecarboxylate | C12H10FNO3 | 详情 | 详情 | |
| (V) | 23378 | (4-chlorophenyl)methanamine; 4-chlorobenzylamine | 104-86-9 | C7H8ClN | 详情 | 详情 |
Extended Information