(3R,5S,E)-tert-butyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate -Drug Synthesis Database

【结构式】

【分子编号】66675

【品名】(3R,5S,E)-tert-butyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate

【CA登记号】355806-00-7

【分子式】C₂₆H₃₆FN₃O₆S

【分子量】537.653

【元素组成】C 58.08% H 6.75% F 3.53% N 7.81% O 17.85% S 5.96%

与该中间体有关的原料药合成路线共 2 条

该中间体在本合成路线中的序号：(IX)

【1】 Zlicar M. 2007. Process for the synthesis of rosuvastatin calcium using L-malic acid for the side chain chirality. W0 2007017117(本专利属于Lek Pharmaceuticals D D, Slovenia)

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	11058	(S)-(+)-Hydroxysuccinic acid; (S)-(+)-Malic acid; (S)-(+)-2-Hydroxybutanedioic acid; L-(-)-Apple acid	97-67-6	C₄H₆O₅	详情	详情
(II)	11806	dimethyl (2S)-2-hydroxybutanedioate	617-55-0	C₆H₁₀O₅	详情	详情
(III)	66669	(S)-dimethyl 2-((tert-butyldimethylsilyl)oxy)succinate		C₁₂H₂₄O₅Si	详情	详情
(IV)	66670	(S)-methyl 3-((tert-butyldimethylsilyl)oxy)-4-oxobutanoate		C₁₁H₂₂O₄Si	详情	详情
(V)	66671			C₂₇H₄₀F₄N₃O₅PS	详情	详情
(VI)	66672	(S,E)-methyl 4-((tert-butyldimethylsilyl)oxy)-6-(4-(4-fluorophenyl)-6- isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)hex-5-enoate		C₂₇H₄₀FN₃O₅SSi	详情	详情
(VII)	66673	(S,E)66670-tert-butyl 5-((tert-butyldimethylsilyl)oxy)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-oxohept-6-enoate		C₃₂H₄₈FN₃O₆SSi	详情	详情
(VIII)	66674	(3R,5S,E)-tert-butyl 5-((tert-butyldimethylsilyl)oxy)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxyhept-6-enoate		C₃₂H₅₀FN₃O₆SSi	详情	详情
(IX)	66675	(3R,5S,E)-tert-butyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate	355806-00-7	C₂₆H₃₆FN₃O₆S	详情	详情

该中间体在本合成路线中的序号：(V)

【1】 Wang SQ, Wu B,Xu SX. 2006. Process for preparation of rosuvastatin calcium as HMG-CoA reductase inhibitor.发明专利申请公开说明书，CN 1821242(本专利属于Yabang Chenucal Group Co, Ltd, Peop Rep China; Changzhou Yabang Pharmaceutical Research Institute Co, Ltd)
【2】 Joshi N, Bhirud SB, Chandrasekhar B, et aL. 2005. An impmved process for preparation of rosuvastatin derivatives, useful as HMG-CoA inhibitor. US 2005124639

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	66681	tert-butyl 2-((4R,6S)-6-(bromomethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate		C₁₃H₂₃BrO₄	详情	详情
(II)	66680	tert-butyl 2-((4R,6S)-6-((dimethoxyphosphoryl)methyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate		C₁₅H₂₉O₇P	详情	详情
(III)	23882	N-[4-(4-fluorophenyl)-5-formyl-6-isopropyl-2-pyrimidinyl]-N-methylmethanesulfonamide	147118-37-4	C₁₆H₁₈FN₃O₃S	详情	详情
(IV)	66682	tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate		C₂₉H₄₀FN₃O₆S	详情	详情
(V)	66675	(3R,5S,E)-tert-butyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate	355806-00-7	C₂₆H₃₆FN₃O₆S	详情	详情
(VI)	66679	(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid		C₂₂H₂₈FN₃O₆S	详情	详情

Extended Information