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【结 构 式】 
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【分子编号】66671 【品名】 【CA登记号】 |
【 分 子 式 】C27H40F4N3O5PS 【 分 子 量 】625.665 【元素组成】C 51.83% H 6.44% F 12.15% N 6.72% O 12.79% P 4.95% S 5.13% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)
| 【1】 Zlicar M. 2007. Process for the synthesis of rosuvastatin calcium using L-malic acid for the side chain chirality. W0 2007017117(本专利属于Lek Pharmaceuticals D D, Slovenia) |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11058 | (S)-(+)-Hydroxysuccinic acid; (S)-(+)-Malic acid; (S)-(+)-2-Hydroxybutanedioic acid; L-(-)-Apple acid | 97-67-6 | C4H6O5 | 详情 | 详情 |
| (II) | 11806 | dimethyl (2S)-2-hydroxybutanedioate | 617-55-0 | C6H10O5 | 详情 | 详情 |
| (III) | 66669 | (S)-dimethyl 2-((tert-butyldimethylsilyl)oxy)succinate | C12H24O5Si | 详情 | 详情 | |
| (IV) | 66670 | (S)-methyl 3-((tert-butyldimethylsilyl)oxy)-4-oxobutanoate | C11H22O4Si | 详情 | 详情 | |
| (V) | 66671 | C27H40F4N3O5PS | 详情 | 详情 | ||
| (VI) | 66672 | (S,E)-methyl 4-((tert-butyldimethylsilyl)oxy)-6-(4-(4-fluorophenyl)-6- isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)hex-5-enoate | C27H40FN3O5SSi | 详情 | 详情 | |
| (VII) | 66673 | (S,E)66670-tert-butyl 5-((tert-butyldimethylsilyl)oxy)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-oxohept-6-enoate | C32H48FN3O6SSi | 详情 | 详情 | |
| (VIII) | 66674 | (3R,5S,E)-tert-butyl 5-((tert-butyldimethylsilyl)oxy)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxyhept-6-enoate | C32H50FN3O6SSi | 详情 | 详情 | |
| (IX) | 66675 | (3R,5S,E)-tert-butyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate | 355806-00-7 | C26H36FN3O6S | 详情 | 详情 |
Extended Information