(3R,5S,E)-tert-butyl 5-((tert-butyldimethylsilyl)oxy)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxyhept-6-enoate -Drug Synthesis Database

【结构式】

【分子编号】66674

【品名】(3R,5S,E)-tert-butyl 5-((tert-butyldimethylsilyl)oxy)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxyhept-6-enoate

【CA登记号】　

【分子式】C₃₂H₅₀FN₃O₆SSi

【分子量】651.916

【元素组成】C 58.96% H 7.73% F 2.91% N 6.44% O 14.72% S 4.92% Si 4.31%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VIII)

参考文献中间体

合成目标

【1】 Zlicar M. 2007. Process for the synthesis of rosuvastatin calcium using L-malic acid for the side chain chirality. W0 2007017117(本专利属于Lek Pharmaceuticals D D, Slovenia)

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	11058	(S)-(+)-Hydroxysuccinic acid; (S)-(+)-Malic acid; (S)-(+)-2-Hydroxybutanedioic acid; L-(-)-Apple acid	97-67-6	C₄H₆O₅	详情	详情
(II)	11806	dimethyl (2S)-2-hydroxybutanedioate	617-55-0	C₆H₁₀O₅	详情	详情
(III)	66669	(S)-dimethyl 2-((tert-butyldimethylsilyl)oxy)succinate		C₁₂H₂₄O₅Si	详情	详情
(IV)	66670	(S)-methyl 3-((tert-butyldimethylsilyl)oxy)-4-oxobutanoate		C₁₁H₂₂O₄Si	详情	详情
(V)	66671			C₂₇H₄₀F₄N₃O₅PS	详情	详情
(VI)	66672	(S,E)-methyl 4-((tert-butyldimethylsilyl)oxy)-6-(4-(4-fluorophenyl)-6- isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)hex-5-enoate		C₂₇H₄₀FN₃O₅SSi	详情	详情
(VII)	66673	(S,E)66670-tert-butyl 5-((tert-butyldimethylsilyl)oxy)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-oxohept-6-enoate		C₃₂H₄₈FN₃O₆SSi	详情	详情
(VIII)	66674	(3R,5S,E)-tert-butyl 5-((tert-butyldimethylsilyl)oxy)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxyhept-6-enoate		C₃₂H₅₀FN₃O₆SSi	详情	详情
(IX)	66675	(3R,5S,E)-tert-butyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate	355806-00-7	C₂₆H₃₆FN₃O₆S	详情	详情

Extended Information