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【结 构 式】

【分子编号】66680

【品名】tert-butyl 2-((4R,6S)-6-((dimethoxyphosphoryl)methyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

【CA登记号】 

【 分 子 式 】C15H29O7P

【 分 子 量 】352.365

【元素组成】C 51.13% H 8.29% O 31.78% P 8.79%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

 

1 Wang SQ, Wu B,Xu SX. 2006. Process for preparation of rosuvastatin calcium as HMG-CoA reductase inhibitor.发明专利申请公开说明书,CN 1821242(本专利属于Yabang Chenucal Group Co, Ltd, Peop Rep China; Changzhou Yabang Pharmaceutical Research Institute Co, Ltd)
2 Joshi N, Bhirud SB, Chandrasekhar B, et aL. 2005. An impmved process for preparation of rosuvastatin derivatives, useful as HMG-CoA inhibitor. US 2005124639
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 66681 tert-butyl 2-((4R,6S)-6-(bromomethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate   C13H23BrO4 详情 详情
(II) 66680 tert-butyl 2-((4R,6S)-6-((dimethoxyphosphoryl)methyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate   C15H29O7P 详情 详情
(III) 23882 N-[4-(4-fluorophenyl)-5-formyl-6-isopropyl-2-pyrimidinyl]-N-methylmethanesulfonamide 147118-37-4 C16H18FN3O3S 详情 详情
(IV) 66682 tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate   C29H40FN3O6S 详情 详情
(V) 66675 (3R,5S,E)-tert-butyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate 355806-00-7 C26H36FN3O6S 详情 详情
(VI) 66679 (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid   C22H28FN3O6S 详情 详情
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