tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate -Drug Synthesis Database

【结构式】

【分子编号】66682

【品名】tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

【CA登记号】　

【分子式】C₂₉H₄₀FN₃O₆S

【分子量】577.718

【元素组成】C 60.29% H 6.98% F 3.29% N 7.27% O 16.62% S 5.55%

与该中间体有关的原料药合成路线共 2 条

合成路线1 合成路线2

合成路线1

该中间体在本合成路线中的序号：(IV)

参考文献中间体

合成目标

【1】 Wang SQ, Wu B,Xu SX. 2006. Process for preparation of rosuvastatin calcium as HMG-CoA reductase inhibitor.发明专利申请公开说明书，CN 1821242(本专利属于Yabang Chenucal Group Co, Ltd, Peop Rep China; Changzhou Yabang Pharmaceutical Research Institute Co, Ltd)
【2】 Joshi N, Bhirud SB, Chandrasekhar B, et aL. 2005. An impmved process for preparation of rosuvastatin derivatives, useful as HMG-CoA inhibitor. US 2005124639

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	66681	tert-butyl 2-((4R,6S)-6-(bromomethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate		C₁₃H₂₃BrO₄	详情	详情
(II)	66680	tert-butyl 2-((4R,6S)-6-((dimethoxyphosphoryl)methyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate		C₁₅H₂₉O₇P	详情	详情
(III)	23882	N-[4-(4-fluorophenyl)-5-formyl-6-isopropyl-2-pyrimidinyl]-N-methylmethanesulfonamide	147118-37-4	C₁₆H₁₈FN₃O₃S	详情	详情
(IV)	66682	tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate		C₂₉H₄₀FN₃O₆S	详情	详情
(V)	66675	(3R,5S,E)-tert-butyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate	355806-00-7	C₂₆H₃₆FN₃O₆S	详情	详情
(VI)	66679	(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid		C₂₂H₂₈FN₃O₆S	详情	详情

合成路线2

该中间体在本合成路线中的序号：(IV)

参考文献中间体

合成目标

【1】 Mei GY．Cai QF. 2005．Preparation for rosurrastatin and its intermediates. 发明专利申请公开说明书，CN 1687087(本专利属于Zhqiang HiSIm Pharmaceutical Co，Ltd，Peop Rep China)

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	66687	N-(5-(bromomethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide	C₁₆H₁₉BrFN₃O₂S	详情	详情
(II)	66688	((4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)methyl)triphenylphosphonium	C₃₄H₃₄FN₃O₂PS	详情	详情
(III)	66689	tert-butyl 2-((4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl)acetate	C₁₃H₂₂O₅	详情	详情
(IV)	66682	tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate	C₂₉H₄₀FN₃O₆S	详情	详情

Extended Information