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【结 构 式】 
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【分子编号】66246 【品名】4-Amino-6-chloro-2-methylpyrimidine;6-Chloro-2-methylpyrimidin-4-amine 【CA登记号】1749-68-4 |
【 分 子 式 】C5H6ClN3 【 分 子 量 】143.576 【元素组成】C 41.83% H 4.21% Cl 24.69% N 29.27% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(I)
| 【1】 Chen B-C,Drohini,et al 2006.Process for preparing 2-aminothiazole-S-carboxamides:from thioureas and acrylamides and tbeir use as anticancer drugs. US 2006004067 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 66246 | 4-Amino-6-chloro-2-methylpyrimidine;6-Chloro-2-methylpyrimidin-4-amine | 1749-68-4 | C5H6ClN3 | 详情 | 详情 |
| (II) | 66247 | C9H11ClN4O2S | 详情 | 详情 | ||
| (III) | 66248 | 1-(6-chloro-2-methylpyrimidin-4-yl)thiourea | C6H7ClN4S | 详情 | 详情 | |
| (IV) | 66243 | (E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide | 863127-76-8 | C12H14ClNO2 | 详情 | 详情 |
| (V) | 66245 | 2-((6-chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazolidine-5-carboxamide | C16H17Cl2N5OS | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(V)
| 【1】 Das J,Chen Pt et al.2006. 2-aminothiazole as a novel kinase inhibitor template. Structre-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[ [6-[4-(2-hydroxyethyl)-l- piperazinyl)]-2-methyl-4-pyrimidinyl] amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor.J Med Chem, 49: 6819~6832 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 28906 | 2-chloro-1,3-thiazole；2-Chlorothiazole | 3034-52-4 | C3H2ClNS | 详情 | 详情 |
| (II) | 66249 | 1-chloro-2-isocyanato-3-methylbenzene;2-Chloro-6-methylphenyl isocyanate | 40398-01-4 | C8H6ClNO | 详情 | 详情 |
| (III) | 66250 | 2-chloro-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide | C11H8Cl2N2OS | 详情 | 详情 | |
| (IV) | 66251 | 2-chloro-N-(2-chloro-6-methylphenyl)-N-(4-methoxybenzyl)thiazole-5-carboxamide | C19H16Cl2N2O2S | 详情 | 详情 | |
| (V) | 66246 | 4-Amino-6-chloro-2-methylpyrimidine;6-Chloro-2-methylpyrimidin-4-amine | 1749-68-4 | C5H6ClN3 | 详情 | 详情 |
| (VI) | 66252 | 2-((6-chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)-N-(4-methoxybenzyl)thiazole-5-carboxamide | C24H21Cl2N5O2S | 详情 | 详情 | |
| (VII) | 66245 | 2-((6-chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazolidine-5-carboxamide | C16H17Cl2N5OS | 详情 | 详情 |
Extended Information