(E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide -Drug Synthesis Database

【结构式】

【分子编号】66243

【品名】(E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide

【CA登记号】863127-76-8

【分子式】C₁₂H₁₄ClNO₂

【分子量】239.7014

【元素组成】C 60.13% H 5.89% Cl 14.79% N 5.84% O 13.35%

与该中间体有关的原料药合成路线共 2 条

该中间体在本合成路线中的序号：(III)

【1】 Chen B-C,DroghiniR,et aL 2006.Process for preparing 2-aminothiazole-5-carboxamides from thioureas and acrylamides and their use as anticancer drugs. US 2006004067

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
（V)	32323	4,6-dichloro-2-methylpyrimidine	1780-26-3	C₅H₄Cl₂N₂	详情	详情
(I)	29789	2-chloro-6-methylphenylamine; 2-chloro-6-methylaniline	87-63-8	C₇H₈ClN	详情	详情
(II)	20616	(E)-3-ethoxy-2-propenoyl chloride	99471-66-6	C₅H₇ClO₂	详情	详情
(III)	66243	(E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide	863127-76-8	C₁₂H₁₄ClNO₂	详情	详情
(IV)	66244	2-amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide	302964-24-5	C₁₁H₁₀ClN₃OS	详情	详情
(VI)	66245	2-((6-chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazolidine-5-carboxamide		C₁₆H₁₇Cl₂N₅OS	详情	详情
(VII)	21893	2-(1-piperazinyl)-1-ethanol; 1-piperazineethanol; 1-(2-Hydroxyethyl)piperazine	103-76-4	C₆H₁₄N₂O	详情	详情

该中间体在本合成路线中的序号：(IV)

【1】 Chen B-C,Drohini,et al 2006.Process for preparing 2-aminothiazole-S-carboxamides:from thioureas and acrylamides and tbeir use as anticancer drugs. US 2006004067

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	66246	4-Amino-6-chloro-2-methylpyrimidine;6-Chloro-2-methylpyrimidin-4-amine	1749-68-4	C₅H₆ClN₃	详情	详情
(II)	66247			C₉H₁₁ClN₄O₂S	详情	详情
(III)	66248	1-(6-chloro-2-methylpyrimidin-4-yl)thiourea		C₆H₇ClN₄S	详情	详情
(IV)	66243	(E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide	863127-76-8	C₁₂H₁₄ClNO₂	详情	详情
(V)	66245	2-((6-chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazolidine-5-carboxamide		C₁₆H₁₇Cl₂N₅OS	详情	详情

Extended Information