Dasatinib, BMS-354825, Sprvcel, -Drug Synthesis Database

【结构式】

【药物名称】Dasatinib, BMS-354825, Sprvcel

【化学名称】N-(2-Chloro-6-methylphenyl)-2-[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-ylamino]thiazole-5-carboxamide

【CA登记号】302962-49-8

【分子式】C₂₂H₂₆ClN₇O₂S

【分子量】488.0065

【开发单位】Bristol-Myers Squibb Co. (US).

【药理作用】Treatment of Leukemia, Treatment of Solid Tumors, Bcr-Abl and Src Kinase Inhibitor

【1】 Chen B-C, Droghini R, et al.2006. Process for preparing 2-aminothiazole-5-cadboxamides from thioureas and acrylamides and their use as anticancer drugs.US 2006004067

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	32323	4,6-dichloro-2-methylpyrimidine	1780-26-3	C₅H₄Cl₂N₂	详情	详情
(II)	21893	2-(1-piperazinyl)-1-ethanol; 1-piperazineethanol; 1-(2-Hydroxyethyl)piperazine	103-76-4	C₆H₁₄N₂O	详情	详情
(III)	66253	2-(4-(6-chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol;4-(6-chloro-2-methyl-4-pyrimidinyl)-1-Piperazineethanol	127116-19-2	C₁₁H₁₇ClN₄O	详情	详情
(IV)	66244	2-amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide	302964-24-5	C₁₁H₁₀ClN₃OS	详情	详情

【1】 Chen B-C,DroghiniR,et aL 2006.Process for preparing 2-aminothiazole-5-carboxamides from thioureas and acrylamides and their use as anticancer drugs. US 2006004067

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
（V)	32323	4,6-dichloro-2-methylpyrimidine	1780-26-3	C₅H₄Cl₂N₂	详情	详情
(I)	29789	2-chloro-6-methylphenylamine; 2-chloro-6-methylaniline	87-63-8	C₇H₈ClN	详情	详情
(II)	20616	(E)-3-ethoxy-2-propenoyl chloride	99471-66-6	C₅H₇ClO₂	详情	详情
(III)	66243	(E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide	863127-76-8	C₁₂H₁₄ClNO₂	详情	详情
(IV)	66244	2-amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide	302964-24-5	C₁₁H₁₀ClN₃OS	详情	详情
(VI)	66245	2-((6-chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazolidine-5-carboxamide		C₁₆H₁₇Cl₂N₅OS	详情	详情
(VII)	21893	2-(1-piperazinyl)-1-ethanol; 1-piperazineethanol; 1-(2-Hydroxyethyl)piperazine	103-76-4	C₆H₁₄N₂O	详情	详情

【1】 Chen B-C,Drohini,et al 2006.Process for preparing 2-aminothiazole-S-carboxamides:from thioureas and acrylamides and tbeir use as anticancer drugs. US 2006004067

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	66246	4-Amino-6-chloro-2-methylpyrimidine;6-Chloro-2-methylpyrimidin-4-amine	1749-68-4	C₅H₆ClN₃	详情	详情
(II)	66247			C₉H₁₁ClN₄O₂S	详情	详情
(III)	66248	1-(6-chloro-2-methylpyrimidin-4-yl)thiourea		C₆H₇ClN₄S	详情	详情
(IV)	66243	(E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide	863127-76-8	C₁₂H₁₄ClNO₂	详情	详情
(V)	66245	2-((6-chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazolidine-5-carboxamide		C₁₆H₁₇Cl₂N₅OS	详情	详情

【1】 Das J,Chen Pt et al.2006. 2-aminothiazole as a novel kinase inhibitor template. Structre-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[ [6-[4-(2-hydroxyethyl)-l- piperazinyl)]-2-methyl-4-pyrimidinyl] amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor.J Med Chem, 49: 6819~6832

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	28906	2-chloro-1,3-thiazole；2-Chlorothiazole	3034-52-4	C₃H₂ClNS	详情	详情
(II)	66249	1-chloro-2-isocyanato-3-methylbenzene;2-Chloro-6-methylphenyl isocyanate	40398-01-4	C₈H₆ClNO	详情	详情
(III)	66250	2-chloro-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide		C₁₁H₈Cl₂N₂OS	详情	详情
(IV)	66251	2-chloro-N-(2-chloro-6-methylphenyl)-N-(4-methoxybenzyl)thiazole-5-carboxamide		C₁₉H₁₆Cl₂N₂O₂S	详情	详情
(V)	66246	4-Amino-6-chloro-2-methylpyrimidine;6-Chloro-2-methylpyrimidin-4-amine	1749-68-4	C₅H₆ClN₃	详情	详情
(VI)	66252	2-((6-chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)-N-(4-methoxybenzyl)thiazole-5-carboxamide		C₂₄H₂₁Cl₂N₅O₂S	详情	详情
(VII)	66245	2-((6-chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazolidine-5-carboxamide		C₁₆H₁₇Cl₂N₅OS	详情	详情

Extended Information