2-((6-chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)-N-(4-methoxybenzyl)thiazole-5-carboxamide -Drug Synthesis Database

【结构式】

【分子编号】66252

【品名】2-((6-chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)-N-(4-methoxybenzyl)thiazole-5-carboxamide

【CA登记号】　

【分子式】C₂₄H₂₁Cl₂N₅O₂S

【分子量】514.43464

【元素组成】C 56.04% H 4.11% Cl 13.78% N 13.61% O 6.22% S 6.23%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VI)

【1】 Das J,Chen Pt et al.2006. 2-aminothiazole as a novel kinase inhibitor template. Structre-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[ [6-[4-(2-hydroxyethyl)-l- piperazinyl)]-2-methyl-4-pyrimidinyl] amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor.J Med Chem, 49: 6819~6832

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	28906	2-chloro-1,3-thiazole；2-Chlorothiazole	3034-52-4	C₃H₂ClNS	详情	详情
(II)	66249	1-chloro-2-isocyanato-3-methylbenzene;2-Chloro-6-methylphenyl isocyanate	40398-01-4	C₈H₆ClNO	详情	详情
(III)	66250	2-chloro-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide		C₁₁H₈Cl₂N₂OS	详情	详情
(IV)	66251	2-chloro-N-(2-chloro-6-methylphenyl)-N-(4-methoxybenzyl)thiazole-5-carboxamide		C₁₉H₁₆Cl₂N₂O₂S	详情	详情
(V)	66246	4-Amino-6-chloro-2-methylpyrimidine;6-Chloro-2-methylpyrimidin-4-amine	1749-68-4	C₅H₆ClN₃	详情	详情
(VI)	66252	2-((6-chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)-N-(4-methoxybenzyl)thiazole-5-carboxamide		C₂₄H₂₁Cl₂N₅O₂S	详情	详情
(VII)	66245	2-((6-chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazolidine-5-carboxamide		C₁₆H₁₇Cl₂N₅OS	详情	详情

Extended Information