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【结 构 式】 
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【分子编号】28906 【品名】2-chloro-1,3-thiazole；2-Chlorothiazole 【CA登记号】3034-52-4 |
【 分 子 式 】C3H2ClNS 【 分 子 量 】119.57432 【元素组成】C 30.13% H 1.69% Cl 29.65% N 11.71% S 26.82% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(VII)The condensation of 2-chlorothiazole (VII) with isopropyl 2-(4-hydroxyphenyl)propionate (VIII) by means of K2CO3 in DMF at 150 C gives (VI), previously obtained.
| 【1】 Maeda, R.; Hirose, K. (Shionogi & Co. Ltd.); Thiazole derivatives and the production thereof. CA 1051906; FR 2248835; GB 1481465 . |
| 【2】 Castaner, J.; Serradell, M.N.; Arrigoni-Martelli, E.; 480156-S. Drugs Fut 1985, 10, 1, 37. |
合成路线2
该中间体在本合成路线中的序号：(I)
| 【1】 Das J,Chen Pt et al.2006. 2-aminothiazole as a novel kinase inhibitor template. Structre-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[ [6-[4-(2-hydroxyethyl)-l- piperazinyl)]-2-methyl-4-pyrimidinyl] amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor.J Med Chem, 49: 6819~6832 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 28906 | 2-chloro-1,3-thiazole；2-Chlorothiazole | 3034-52-4 | C3H2ClNS | 详情 | 详情 |
| (II) | 66249 | 1-chloro-2-isocyanato-3-methylbenzene;2-Chloro-6-methylphenyl isocyanate | 40398-01-4 | C8H6ClNO | 详情 | 详情 |
| (III) | 66250 | 2-chloro-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide | C11H8Cl2N2OS | 详情 | 详情 | |
| (IV) | 66251 | 2-chloro-N-(2-chloro-6-methylphenyl)-N-(4-methoxybenzyl)thiazole-5-carboxamide | C19H16Cl2N2O2S | 详情 | 详情 | |
| (V) | 66246 | 4-Amino-6-chloro-2-methylpyrimidine;6-Chloro-2-methylpyrimidin-4-amine | 1749-68-4 | C5H6ClN3 | 详情 | 详情 |
| (VI) | 66252 | 2-((6-chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)-N-(4-methoxybenzyl)thiazole-5-carboxamide | C24H21Cl2N5O2S | 详情 | 详情 | |
| (VII) | 66245 | 2-((6-chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazolidine-5-carboxamide | C16H17Cl2N5OS | 详情 | 详情 |
Extended Information