2-amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide -Drug Synthesis Database

【结构式】

【分子编号】66244

【品名】2-amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

【CA登记号】302964-24-5

【分子式】C₁₁H₁₀ClN₃OS

【分子量】267.739

【元素组成】C 49.35% H 3.76% Cl 13.24% N 15.69% O 5.97% S 11.98%

与该中间体有关的原料药合成路线共 2 条

该中间体在本合成路线中的序号：(IV)

【1】 Chen B-C,DroghiniR,et aL 2006.Process for preparing 2-aminothiazole-5-carboxamides from thioureas and acrylamides and their use as anticancer drugs. US 2006004067

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
（V)	32323	4,6-dichloro-2-methylpyrimidine	1780-26-3	C₅H₄Cl₂N₂	详情	详情
(I)	29789	2-chloro-6-methylphenylamine; 2-chloro-6-methylaniline	87-63-8	C₇H₈ClN	详情	详情
(II)	20616	(E)-3-ethoxy-2-propenoyl chloride	99471-66-6	C₅H₇ClO₂	详情	详情
(III)	66243	(E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide	863127-76-8	C₁₂H₁₄ClNO₂	详情	详情
(IV)	66244	2-amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide	302964-24-5	C₁₁H₁₀ClN₃OS	详情	详情
(VI)	66245	2-((6-chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazolidine-5-carboxamide		C₁₆H₁₇Cl₂N₅OS	详情	详情
(VII)	21893	2-(1-piperazinyl)-1-ethanol; 1-piperazineethanol; 1-(2-Hydroxyethyl)piperazine	103-76-4	C₆H₁₄N₂O	详情	详情

该中间体在本合成路线中的序号：(IV)

【1】 Chen B-C, Droghini R, et al.2006. Process for preparing 2-aminothiazole-5-cadboxamides from thioureas and acrylamides and their use as anticancer drugs.US 2006004067

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	32323	4,6-dichloro-2-methylpyrimidine	1780-26-3	C₅H₄Cl₂N₂	详情	详情
(II)	21893	2-(1-piperazinyl)-1-ethanol; 1-piperazineethanol; 1-(2-Hydroxyethyl)piperazine	103-76-4	C₆H₁₄N₂O	详情	详情
(III)	66253	2-(4-(6-chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol;4-(6-chloro-2-methyl-4-pyrimidinyl)-1-Piperazineethanol	127116-19-2	C₁₁H₁₇ClN₄O	详情	详情
(IV)	66244	2-amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide	302964-24-5	C₁₁H₁₀ClN₃OS	详情	详情

Extended Information