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【结 构 式】 
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【分子编号】42235 【品名】Diethyl phosphorocyanidate; Diethyl cyanophosphonate; Cyanophosphonic acid diethyl ester; Diethyl phosphoryl cyanide; DEPC 【CA登记号】2942-58-7 |
【 分 子 式 】C5H10NO3P 【 分 子 量 】163.113102 【元素组成】C 36.82% H 6.18% N 8.59% O 29.43% P 18.99% |
合成路线1
该中间体在本合成路线中的序号：A new synthesis of ES-6864 has been reported: The condensation of 3-(morpholinocarbonyl)-2(R)-(1-naphthylmethyl)propionic acid (I) with N-[N-(tert-butoxycarbonyl)-3-(4-thiazolyl)-L-alanyl]cyclosatine 2-morpholinoethylamide (II) by means of a previous hydrolysis with HCl followed by the condensation step with diethylphosphoryl cyanide gives ES-6864.
| 【1】 Nishi, T.; Nagahori, H.; Saito, F.; et al.; Syntheses and biological activities of renin inhibitors containing statine analogues. Chem Pharm Bull 1990, 38, 1, 103-9. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 42235 | Diethyl phosphorocyanidate; Diethyl cyanophosphonate; Cyanophosphonic acid diethyl ester; Diethyl phosphoryl cyanide; DEPC | 2942-58-7 | C5H10NO3P | 详情 | 详情 | |
| (I) | 12864 | (2R)-4-(4-Morpholinyl)-2-(1-naphthylmethyl)-4-oxobutyric acid | C19H21NO4 | 详情 | 详情 | |
| (II) | 12865 | tert-butyl (1S)-2-[((1S,2S)-1-(cyclohexylmethyl)-2-hydroxy-4-[[2-(4-morpholinyl)ethyl]amino]-4-oxobutyl)amino]-2-oxo-1-(1,3-thiazol-4-ylmethyl)ethylcarbamate | C28H47N5O6S | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：The starting product (II) is obtained as follows: The condensation of N-(tert-butoxycarbonyl)-L-phenylalanine (XI) with magnesium diethylmalonate (XII) by means of N,N'-carbonyldiimidazole in THF - DMSO gives 4(S)-(tert-butoxycarbonylamino)-3-oxo-4-phenylpentanoic acid ethyl ester (XIII), which by an asymetric hydrogenation with H2 and (R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl-Ruthenium complex in ethanol is converted into 4(S)-(tert-butoxycarbonylamino)-4(S)-hydroxy-5-phenylpentanoic acid ethyl ester (XIV). The hydrolysis of (XIV) with KOH in water - dioxane gives the corresponding free acid (XV), which is hydrogenated with H2 over Rh/Al2O3 in ethanol to yield N-(tert-butoxycarbonyl)cyclostatine (XVI).The condensation of (XVI) with 2-morpholinoethylamine (XVII) by means of triethylamine and diethylphosphoryl cyanide in THF affords the corresponding amide (XVIII), which is finally condensed with N-(tert-butoxycarbonyl)-3-(4-thiazolyl)-L-alanine (XIX) by means of a previous hydrolysis with HCl, followed by the condensation step with diethylphosphoryl cyanide in THF, to give the cyclostatine derivative (II).
| 【1】 Nishi, T.; Nagahori, H.; Saito, F.; et al.; Syntheses and biological activities of renin inhibitors containing statine analogues. Chem Pharm Bull 1990, 38, 1, 103-9. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 42235 | Diethyl phosphorocyanidate; Diethyl cyanophosphonate; Cyanophosphonic acid diethyl ester; Diethyl phosphoryl cyanide; DEPC | 2942-58-7 | C5H10NO3P | 详情 | 详情 | |
| (II) | 12865 | tert-butyl (1S)-2-[((1S,2S)-1-(cyclohexylmethyl)-2-hydroxy-4-[[2-(4-morpholinyl)ethyl]amino]-4-oxobutyl)amino]-2-oxo-1-(1,3-thiazol-4-ylmethyl)ethylcarbamate | C28H47N5O6S | 详情 | 详情 | |
| (XI) | 12874 | (2R)-2-[(tert-Butoxycarbonyl)amino]-3-phenylpropionic acid; N-alpha-t-BOC-L-Phenylalanine | 13734-34-4 | C14H19NO4 | 详情 | 详情 |
| (XII) | 12875 | Bromo[2-ethoxy-1-(ethoxycarbonyl)-2-oxoethyl]magnesium | C7H11BrMgO4 | 详情 | 详情 | |
| (XIII) | 12876 | ethyl (4S)-4-[(tert-butoxycarbonyl)amino]-3-oxo-5-phenylpentanoate | C18H25NO5 | 详情 | 详情 | |
| (XIV) | 12877 | ethyl (3S,4S)-4-[(tert-butoxycarbonyl)amino]-3-hydroxy-5-phenylpentanoate | C18H27NO5 | 详情 | 详情 | |
| (XV) | 12878 | (3S,4S)-4-[(tert-Butoxycarbonyl)amino]-3-hydroxy-5-phenylpentanoic acid | 72155-46-5 | C16H23NO5 | 详情 | 详情 |
| (XVI) | 12879 | (3S,4S)-4-[(tert-Butoxycarbonyl)amino]-5-cyclohexyl-3-hydroxypentanoic acid | C16H29NO5 | 详情 | 详情 | |
| (XVII) | 12880 | 4-(2-Aminoethyl)morpholine; 2-(4-Morpholinyl)ethylamine; 2-(4-Morpholinyl)-1-ethanamine; N-(2-Aminoethyl)morpholine; N-Morpholine ethanamide | 2038-03-1 | C6H14N2O | 详情 | 详情 |
| (XVIII) | 12881 | tert-butyl (1S,2S)-1-(cyclohexylmethyl)-2-hydroxy-4-[[2-(4-morpholinyl)ethyl]amino]-4-oxobutylcarbamate | C22H41N3O5 | 详情 | 详情 | |
| (XIX) | 12882 | (2S)-2-[(tert-Butoxycarbonyl)amino]-3-(1,3-thiazol-4-yl)propionic acid | C11H16N2O4S | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：The condensation of N-tert-butoxycarbonyl-cyclostatin (I) with 2-morpholinoethylamine (II) by means of diethyl cyanophosphonate in THF gives the corresponding amide (III), which is deprotected with HCl in dioxane yielding cyclostatin 2-morpholinoethylamide (IV). The condensation of (IV) with N-tert-butoxycarbonyl-3-(4-thiazolyl)-L-alanine (V) by means of diethyl cyanophosphonate as before affords the protected dipeptide (VI), which is treated with HCl in dioxane to obtain the free dipeptide 3-(4-thiazolyl)-L-alanyl-cyclostatin 2-morpholinoethylamide (VII). Finally, this compound is condensed with 3-(morpholinocarbonyl)-2(R)-(4-thiazolyl)propionic acid (VIII) by means of diethyl cyanophosphonate as before.
| 【1】 Kataoko, M.; Yabe, Y.; Iijima, Y.; Takahagi, H.; Koike, H.; Kokubu, T.; Hiwada, K.; Morisawa, Y. (Sankyo Co., Ltd.); New renin-inhibitory oligopeptides, their preparation and their use. EP 0274259; JP 1989063559; US 5378690 . |
| 【2】 Prous, J.; Castaner, J.; ES-6864. Drugs Fut 1989, 14, 9, 852. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 42235 | Diethyl phosphorocyanidate; Diethyl cyanophosphonate; Cyanophosphonic acid diethyl ester; Diethyl phosphoryl cyanide; DEPC | 2942-58-7 | C5H10NO3P | 详情 | 详情 | |
| (I) | 21275 | 4-[(tert-butoxycarbonyl)amino]-5-cyclohexyl-3-hydroxypentanoic acid | C16H29NO5 | 详情 | 详情 | |
| (II) | 12880 | 4-(2-Aminoethyl)morpholine; 2-(4-Morpholinyl)ethylamine; 2-(4-Morpholinyl)-1-ethanamine; N-(2-Aminoethyl)morpholine; N-Morpholine ethanamide | 2038-03-1 | C6H14N2O | 详情 | 详情 |
| (III) | 21277 | tert-butyl 1-(cyclohexylmethyl)-2-hydroxy-4-[[2-(4-morpholinyl)ethyl]amino]-4-oxobutylcarbamate | C22H41N3O5 | 详情 | 详情 | |
| (IV) | 21278 | 4-amino-5-cyclohexyl-3-hydroxy-N-[2-(4-morpholinyl)ethyl]pentanamide | C17H33N3O3 | 详情 | 详情 | |
| (V) | 12882 | (2S)-2-[(tert-Butoxycarbonyl)amino]-3-(1,3-thiazol-4-yl)propionic acid | C11H16N2O4S | 详情 | 详情 | |
| (VI) | 12865 | tert-butyl (1S)-2-[((1S,2S)-1-(cyclohexylmethyl)-2-hydroxy-4-[[2-(4-morpholinyl)ethyl]amino]-4-oxobutyl)amino]-2-oxo-1-(1,3-thiazol-4-ylmethyl)ethylcarbamate | C28H47N5O6S | 详情 | 详情 | |
| (VII) | 21281 | 4-[[(2S)-2-amino-3-(1,3-thiazol-4-yl)propanoyl]amino]-5-cyclohexyl-3-hydroxy-N-[2-(4-morpholinyl)ethyl]pentanamide | C23H39N5O4S | 详情 | 详情 | |
| (VIII) | 12864 | (2R)-4-(4-Morpholinyl)-2-(1-naphthylmethyl)-4-oxobutyric acid | C19H21NO4 | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：1) The Knoevenagel condensation of aldehyde (I) with rhodanine (II) using NH4OAc and AcOH afforded benzylidene- thiazolidine (III). The methyl ester group of (III) was hydrolyzed with HCl in AcOH, and the resulting carboxylic acid (IV) was coupled to 4-(trifluoromethyl)benzylamine (V) in the presence of diethyl phosphorocyanidate and Et3N to produce amide (VI). Subsequent hydrogenation of the olefinic double bond of (VI) over Pd/C provided the target benzylthiazolidine.
| 【1】 Nomura, M.; et al.; (3-Substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents. Bioorg Med Chem Lett 1999, 9, 4, 533. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 42235 | Diethyl phosphorocyanidate; Diethyl cyanophosphonate; Cyanophosphonic acid diethyl ester; Diethyl phosphoryl cyanide; DEPC | 2942-58-7 | C5H10NO3P | 详情 | 详情 | |
| (I) | 21921 | methyl 5-formyl-2-methoxybenzoate | C10H10O4 | 详情 | 详情 | |
| (II) | 10883 | 1,3-Thiazolane-2,4-dione; 2,4-Thiazolidinedione | 2295-31-0 | C3H3NO2S | 详情 | 详情 |
| (III) | 21923 | methyl 5-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-methoxybenzoate | C13H11NO5S | 详情 | 详情 | |
| (IV) | 21924 | 5-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-methoxybenzoic acid | C12H9NO5S | 详情 | 详情 | |
| (V) | 21925 | [4-(trifluoromethyl)phenyl]methanamine; 4-(trifluoromethyl)benzylamine | 3300-51-4 | C8H8F3N | 详情 | 详情 |
| (VI) | 21926 | 5-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-methoxy-N-[4-(trifluoromethyl)benzyl]benzamide | C20H15F3N2O4S | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：2) An alternative method starting from aniline (VII) employed the Meerwein arylation of methyl acrylate (IX) with the intermediate diazonium salt (VIII) in the presence of cuprous oxide. The resulting bromoester (X) was cyclized with thiourea (XI) in Et2O, followed by hydrolysis with HCl in sulfolane to afford (XIII). Finally, acid (XIII) was coupled to benzylamine (V) in the presence of (EtO)2POCN and Et3N.
| 【1】 Nomura, M.; et al.; (3-Substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents. Bioorg Med Chem Lett 1999, 9, 4, 533. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 42235 | Diethyl phosphorocyanidate; Diethyl cyanophosphonate; Cyanophosphonic acid diethyl ester; Diethyl phosphoryl cyanide; DEPC | 2942-58-7 | C5H10NO3P | 详情 | 详情 | |
| (V) | 21925 | [4-(trifluoromethyl)phenyl]methanamine; 4-(trifluoromethyl)benzylamine | 3300-51-4 | C8H8F3N | 详情 | 详情 |
| (VII) | 21927 | methyl 5-amino-2-methoxybenzoate | C9H11NO3 | 详情 | 详情 | |
| (VIII) | 21928 | methyl 5-(1lambda(5)-diazynyl)-2-methoxybenzoate | C9H10N2O3 | 详情 | 详情 | |
| (IX) | 14156 | methyl acrylate | 96-33-3 | C4H6O2 | 详情 | 详情 |
| (X) | 21930 | methyl 5-(2-bromo-3-methoxy-3-oxopropyl)-2-methoxybenzoate | C13H15BrO5 | 详情 | 详情 | |
| (XI) | 10180 | Thiourea | 62-56-6 | CH4N2S | 详情 | 详情 |
| (XII) | 21932 | methyl 5-[(2-imino-4-oxo-1,3-thiazolidin-5-yl)methyl]-2-methoxybenzoate | C13H14N2O4S | 详情 | 详情 | |
| (XIII) | 21933 | 5-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]-2-methoxybenzoic acid | C12H11NO5S | 详情 | 详情 |
合成路线6
该中间体在本合成路线中的序号：The alkylation of 4(S)-benzyl-3-nonanoyloxazolidin-2-one (I) with allyl bromide (II) by means of lithium diisopropylamide (LDA), followed by hydrolysis with LiOOH gives the chiral pentenoic acid (III), which is treated with dimethylamine and cyanophosphonic acid diethyl ester yielding the dimethylamide (IV). The iodination of (IV) with I2/dimethoxyethane (DME) with simultaneous cyclization yields 3(R)-heptyl-5(S)-(iodomethyl)tetrahydrofuran-2-one (V). The condensation of (V) with thioacetic acid by means of NaH, followed by a reductive cleavage and tritylation with triphenylmethanol and trifluoroacetic acid (TFA) affords 3(R)-heptyl-5(S)-(tritylsulfanylmethyl)tetrahydrofuran-2-one (VI). The ring opening of (VI) with NaOH, follwed by silylation with tert-butyldimethylsilyl chloride gives 4(S)-(tert-butyldimethyl-silyloxy)-2(R)-heptyl-5-(tritylsulfanyl)pentanoic acid (VII), which is condensed with 2(S)-amino-N,3,3-trimethylbutyramide (VIII) by means of cyanophosphonic acid diethyl ester and desilylated with tetrabutylammonium fluoride to yield 2(S)-[2(R)-heptyl-4-(S)-hydroxy-5-(tritylsulfanyl)pentanamido]-N,3,3-trimethylbutyramide (IX). Finally, this compound is detritylated with trifluoroacetic acid (TFA) to afford the target compound (X).
| 【1】 Levin, J.I.; DiJoseph, J.F.; Killar, L.M.; Sharr, M.A.; Skotnicki, J.S.; Patel, D.V.; Xiao, X.-Y.; Shi, L.; Navre, M.; Campbell, D.A.; The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases. Bioorg Med Chem Lett 1998, 8, 10, 1163. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 42235 | Diethyl phosphorocyanidate; Diethyl cyanophosphonate; Cyanophosphonic acid diethyl ester; Diethyl phosphoryl cyanide; DEPC | 2942-58-7 | C5H10NO3P | 详情 | 详情 | |
| (I) | 27010 | (4S)-4-benzyl-3-nonanoyl-1,3-oxazolidin-2-one | C19H27NO3 | 详情 | 详情 | |
| (II) | 11463 | 3-Bromo-1-propene; 3-Bromopropene；allyl bromide | 106-95-6 | C3H5Br | 详情 | 详情 |
| (III) | 27011 | (2R)-2-hexyl-4-pentenoic acid | C11H20O2 | 详情 | 详情 | |
| (IV) | 27012 | (2R)-2-hexyl-N,N-dimethyl-4-pentenamide | C13H25NO | 详情 | 详情 | |
| (V) | 27013 | (3R,5S)-3-heptyl-5-(iodomethyl)dihydro-2(3H)-furanone | C12H21IO2 | 详情 | 详情 | |
| (VI) | 27014 | (3R,5S)-3-heptyl-5-[(tritylsulfanyl)methyl]dihydro-2(3H)-furanone | C31H36O2S | 详情 | 详情 | |
| (VII) | 27015 | (2R)-2-[(2S)-2-[[tert-butyl(dimethyl)silyl]oxy]-3-(tritylsulfanyl)propyl]nonanoic acid | C37H52O3SSi | 详情 | 详情 | |
| (VIII) | 18843 | (2S)-2-amino-N,3,3-trimethylbutanamide | 89226-12-0 | C7H16N2O | 详情 | 详情 |
| (IX) | 27016 | (2R)-2-[(2S)-2-[[tert-butyl(dimethyl)silyl]oxy]-3-(tritylsulfanyl)propyl]-N-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]nonanamide | C44H66N2O3SSi | 详情 | 详情 |
合成路线7
该中间体在本合成路线中的序号：The alkylation of 4(S)-benzyl-3-(4-methylpentanoyl)oxazolidin-2-one (I) with allyl bromide (II) by means of lithium diisopro-pylamide (LDA), followed by hydrolysis with LiOOH gives the chiral pentenoic acid (III), which is iodinated with I2, KI, KHCO3 with simultaneous cyclization yielding (R,R)-5-(iodomethyl)-3-isobutyltetrahydrofuran-2-one (IV). The condensation of (IV) with thioacetic acid by means of NaH, followed by a reductive cleavage and tritylation with triphenylmethanol and trifluoroacetic acid gives (R,R)-3-isobutyl-5-(tritylsulfanylmethyl)tetrahydrofuran-2-one (V). The ring opening of (V) with NaOH, follwed by silylation with tert-butyldimethylsilyl chloride gives (R,R)-4-(tert-butyldimethylsilyloxy)-2-isobutyl-5-(tritylsulfanyl)pentanoic acid (VI), which is condensed with 2(S)-amino-N,3,3-trimethylbutyramide (VII) by means of cyanophosphonic acid diethyl ester and desilylated with tetrabutylammonium fluoride to yield 2(S)-[2(R)-isobutyl-4-(R)-hydroxy-5-(triphenylmethylsulfanyl)pen-tanamido]-N,3,3-trimethylbutyramide (VIII). Finally, this compound is detritylated with trifluoroacetic acid (TFA) to afford the target compound.
| 【1】 Levin, J.I.; DiJoseph, J.F.; Killar, L.M.; Sharr, M.A.; Skotnicki, J.S.; Patel, D.V.; Xiao, X.-Y.; Shi, L.; Navre, M.; Campbell, D.A.; The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases. Bioorg Med Chem Lett 1998, 8, 10, 1163. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 42235 | Diethyl phosphorocyanidate; Diethyl cyanophosphonate; Cyanophosphonic acid diethyl ester; Diethyl phosphoryl cyanide; DEPC | 2942-58-7 | C5H10NO3P | 详情 | 详情 | |
| (I) | 25391 | (4S)-4-benzyl-3-(4-methylpentanoyl)-1,3-oxazolidin-2-one | C16H21NO3 | 详情 | 详情 | |
| (II) | 11463 | 3-Bromo-1-propene; 3-Bromopropene；allyl bromide | 106-95-6 | C3H5Br | 详情 | 详情 |
| (III) | 26985 | (2R)-2-isobutyl-4-pentenoic acid | C9H16O2 | 详情 | 详情 | |
| (IV) | 27021 | (3R,5R)-5-(iodomethyl)-3-isobutyldihydro-2(3H)-furanone | C9H15IO2 | 详情 | 详情 | |
| (V) | 27022 | (3R,5R)-3-isobutyl-5-[(tritylsulfanyl)methyl]dihydro-2(3H)-furanone | C28H30O2S | 详情 | 详情 | |
| (VI) | 27023 | (2R,4R)-4-[[tert-butyl(dimethyl)silyl]oxy]-2-isobutyl-5-(tritylsulfanyl)pentanoic acid | C34H46O3SSi | 详情 | 详情 | |
| (VII) | 18843 | (2S)-2-amino-N,3,3-trimethylbutanamide | 89226-12-0 | C7H16N2O | 详情 | 详情 |
| (VIII) | 27024 | (2R,4R)-N-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-4-hydroxy-2-isobutyl-5-(tritylsulfanyl)pentanamide | C35H46N2O3S | 详情 | 详情 |
合成路线8
该中间体在本合成路线中的序号：The alkylation of 4(S)-benzyl-3-(4-methylpentanoyl)oxazolidin-2-one (I) with allyl bromide (II) by means of lithium diisopro-pylamide (LDA), followed by hydrolysis with LiOOH gives the chiral pentenoic acid (III), which is treated with dimethylamine and cyanophosphonic acid diethyl ester yielding the dimethylamide (IV). The iodination of (IV) with I2/dimethoxyethane (DME) with simultaneous cyclization yields 5(S)-(iodomethyl)-3(R)-isobutyltetrahydrofuran-2-one (V). The condensation of (V) with thioacetic acid by means of NaH, followed by a reductive cleavage and tritylation with triphenylmethanol and TFA affords 3(R)-isobutyl-5(S)-(triphenylmethylsulfanylmethyl)tetrahydrofuran-2-one (VI). The ring opening of (VI) with NaOH, follwed by silylation with tert-butyldimethylsilyl chloride gives 4(S)-(tert-butyldimethylsilyloxy)-2(R)-isobutyl-5-(tritylsulfanyl)pentanoic acid (VII), which is condensed with 2(S)-amino-N,3,3-trimethylbutyramide (VIII) by means of cyanophosphonic acid diethyl ester and desilylated with tetrabutylammonium fluoride to yield 2(S)-[2(R)-isobutyl-4-(S)-hydroxy-5-(tritylsulfanyl)pentanamido]-N,3,3-trimethylbutyramide (IX). Finally, this compound is detritylated with trifluoroacetic acid (TFA) to afford the target campound (X).
| 【1】 Levin, J.I.; DiJoseph, J.F.; Killar, L.M.; Sharr, M.A.; Skotnicki, J.S.; Patel, D.V.; Xiao, X.-Y.; Shi, L.; Navre, M.; Campbell, D.A.; The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases. Bioorg Med Chem Lett 1998, 8, 10, 1163. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 42235 | Diethyl phosphorocyanidate; Diethyl cyanophosphonate; Cyanophosphonic acid diethyl ester; Diethyl phosphoryl cyanide; DEPC | 2942-58-7 | C5H10NO3P | 详情 | 详情 | |
| (I) | 25391 | (4S)-4-benzyl-3-(4-methylpentanoyl)-1,3-oxazolidin-2-one | C16H21NO3 | 详情 | 详情 | |
| (II) | 11463 | 3-Bromo-1-propene; 3-Bromopropene；allyl bromide | 106-95-6 | C3H5Br | 详情 | 详情 |
| (III) | 26985 | (2R)-2-isobutyl-4-pentenoic acid | C9H16O2 | 详情 | 详情 | |
| (IV) | 26986 | (2R)-2-isobutyl-N,N-dimethyl-4-pentenamide | C11H21NO | 详情 | 详情 | |
| (V) | 26987 | (3R,5S)-5-(iodomethyl)-3-isobutyldihydro-2(3H)-furanone | C9H15IO2 | 详情 | 详情 | |
| (VI) | 26988 | (3R,5S)-3-isobutyl-5-[(tritylsulfanyl)methyl]dihydro-2(3H)-furanone | C28H30O2S | 详情 | 详情 | |
| (VII) | 26989 | (2R,4S)-4-[[tert-butyl(dimethyl)silyl]oxy]-2-isobutyl-5-(tritylsulfanyl)pentanoic acid | C34H46O3SSi | 详情 | 详情 | |
| (VIII) | 18843 | (2S)-2-amino-N,3,3-trimethylbutanamide | 89226-12-0 | C7H16N2O | 详情 | 详情 |
| (IX) | 26990 | (2R,4S)-N-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-4-hydroxy-2-isobutyl-5-(tritylsulfanyl)pentanamide | C35H46N2O3S | 详情 | 详情 |
合成路线9
该中间体在本合成路线中的序号：The alkylation of 4(S)-benzyl-3-nonanoyloxazolidin-2-one (I) with allyl bromide (II) by means of lithium diisopropylamide (LDA), followed by hydrolysis with LiOOH gives the chiral pentenoic acid (III), which is iodinated with I2, KI, KHCO3 with simultaneous cyclization yielding (R,R)-3-heptyl-5-(iodomethyl)tetrahydrofuran-2-one (IV). The condensation of (IV) with thioacetic acid by means of NaH, followed by a reductive cleavage and tritylation with triphenylmethanol and trifluoroacetic acid (TFA) affords (R,R)-3-heptyl-5-(triphenylmethyl-sulfanylmethyl)tetrahydrofuran-2-one (V). The ring opening of (V) with NaOH, follwed by silylation with tert-butyldimethylsilyl chloride gives (R,R)-4-(tert-butyldimethylsilyloxy)-2-heptyl-5-(tritylsulfanyl)pentanoic acid (VI), which is condensed with 2(S)-amino-N,3,3-trimethylbutyramide (VII) by means of cyanophosphonic acid diethyl ester and desilylated with tetrabutylammonium fluoride to yield 2(S)-[2(R)-heptyl-4(R)-hydroxy-5-(tritylsulfanyl)pentanamido]-N,3,3-trimethylbutyramide (VIII). Finally, compound (VIII) is oxidized with TFA, pyridine, DMSO and EDC, and detritylated with TFA to give the target compound.
| 【1】 Levin, J.I.; DiJoseph, J.F.; Killar, L.M.; Sharr, M.A.; Skotnicki, J.S.; Patel, D.V.; Xiao, X.-Y.; Shi, L.; Navre, M.; Campbell, D.A.; The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases. Bioorg Med Chem Lett 1998, 8, 10, 1163. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 42235 | Diethyl phosphorocyanidate; Diethyl cyanophosphonate; Cyanophosphonic acid diethyl ester; Diethyl phosphoryl cyanide; DEPC | 2942-58-7 | C5H10NO3P | 详情 | 详情 | |
| (I) | 27010 | (4S)-4-benzyl-3-nonanoyl-1,3-oxazolidin-2-one | C19H27NO3 | 详情 | 详情 | |
| (II) | 11463 | 3-Bromo-1-propene; 3-Bromopropene；allyl bromide | 106-95-6 | C3H5Br | 详情 | 详情 |
| (III) | 27011 | (2R)-2-hexyl-4-pentenoic acid | C11H20O2 | 详情 | 详情 | |
| (IV) | 27017 | (3R,5R)-3-heptyl-5-(iodomethyl)dihydro-2(3H)-furanone | C12H21IO2 | 详情 | 详情 | |
| (V) | 27018 | (3R,5R)-3-heptyl-5-[(tritylsulfanyl)methyl]dihydro-2(3H)-furanone | C31H36O2S | 详情 | 详情 | |
| (VI) | 27019 | (2R)-2-[(2R)-2-[[tert-butyl(dimethyl)silyl]oxy]-3-(tritylsulfanyl)propyl]nonanoic acid | C37H52O3SSi | 详情 | 详情 | |
| (VII) | 18843 | (2S)-2-amino-N,3,3-trimethylbutanamide | 89226-12-0 | C7H16N2O | 详情 | 详情 |
| (VIII) | 27020 | (2R)-N-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-2-[(2R)-2-hydroxy-3-(tritylsulfanyl)propyl]nonanamide | C38H52N2O3S | 详情 | 详情 |
合成路线10
该中间体在本合成路线中的序号：The alkylation of 4(S)-benzyl-3-(4-methylpentanoyl)oxazolidin-2-one (I) with allyl bromide (II) by means of lithium diisopro-pylamide (LDA), followed by hydrolysis with LiOOH gives the chiral pentenoic acid (III), which is iodinated with I2, KI, KHCO3 with simultaneous cyclization yielding (R,R)-5-(iodomethyl)-3-isobutyltetrahydrofuran-2-one (IV). The condensation of (IV) with thioacetic acid by means of NaH, followed by a reductive cleavage and tritylation with triphenylmethanol and trifluoroacetic acid gives (R,R)-3-isobutyl-5-(tritylsulfanylmethyl)tetrahydrofuran-2-one (V). The ring opening of (V) with NaOH, follwed by silylation with tert-butyldimethylsilyl chloride gives (R,R)-4-(tert-butyldimethylsilyloxy)-2-isobutyl-5-(tritylsulfanyl)pentanoic acid (VI), which is condensed with 2(S)-amino-N,3,3-trimethylbutyramide (VII) by means of cyanophosphonic acid diethyl ester and desilylated with tetrabutylammonium fluoride to yield 2(S)-[2(R)-isobutyl-4-(R)-hydroxy-5-(triphenylmethylsulfanyl)pen-tanamido]-N,3,3-trimethylbutyramide (VIII). Finally, compound (VIII) is oxidized with TFA, pyridine, DMSO and EDC, and detritylated with TFA to give the target compound.
| 【1】 Levin, J.I.; DiJoseph, J.F.; Killar, L.M.; Sharr, M.A.; Skotnicki, J.S.; Patel, D.V.; Xiao, X.-Y.; Shi, L.; Navre, M.; Campbell, D.A.; The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases. Bioorg Med Chem Lett 1998, 8, 10, 1163. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 42235 | Diethyl phosphorocyanidate; Diethyl cyanophosphonate; Cyanophosphonic acid diethyl ester; Diethyl phosphoryl cyanide; DEPC | 2942-58-7 | C5H10NO3P | 详情 | 详情 | |
| (I) | 25391 | (4S)-4-benzyl-3-(4-methylpentanoyl)-1,3-oxazolidin-2-one | C16H21NO3 | 详情 | 详情 | |
| (II) | 11463 | 3-Bromo-1-propene; 3-Bromopropene；allyl bromide | 106-95-6 | C3H5Br | 详情 | 详情 |
| (III) | 26985 | (2R)-2-isobutyl-4-pentenoic acid | C9H16O2 | 详情 | 详情 | |
| (IV) | 27021 | (3R,5R)-5-(iodomethyl)-3-isobutyldihydro-2(3H)-furanone | C9H15IO2 | 详情 | 详情 | |
| (V) | 27022 | (3R,5R)-3-isobutyl-5-[(tritylsulfanyl)methyl]dihydro-2(3H)-furanone | C28H30O2S | 详情 | 详情 | |
| (VI) | 27023 | (2R,4R)-4-[[tert-butyl(dimethyl)silyl]oxy]-2-isobutyl-5-(tritylsulfanyl)pentanoic acid | C34H46O3SSi | 详情 | 详情 | |
| (VII) | 18843 | (2S)-2-amino-N,3,3-trimethylbutanamide | 89226-12-0 | C7H16N2O | 详情 | 详情 |
| (VIII) | 27024 | (2R,4R)-N-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-4-hydroxy-2-isobutyl-5-(tritylsulfanyl)pentanamide | C35H46N2O3S | 详情 | 详情 |
合成路线11
该中间体在本合成路线中的序号：Horner-Emmons condensation of benzazepinone (I) with triethyl phosphonoacetate gave unsaturated ester (II). Subsequent reductive treatment of (II) with Mg in MeOH produced the saturated ester (III) with concomitant cleavage of the tosyl group. 2-Chloro-4-(1-pyrrolidinyl)benzoyl chloride (V) (prepared by reaction of the corresponding carboxylic acid (IV) with SOCl2) was then condensed with benzazepine (III) to produce benzamide (VI). Hydrolysis of the methyl ester function of (VI) yielded the racemic carboxylic acid (VII), which was resolved by means of esterification with (R)-2-heptanol, followed by chromatographic separation of the diastereomeric mixture. After saponification of the required diastereoisomeric ester (VIII), the resulting (R)-carboxylic acid was finally coupled with isopropylamine using diethylcyanophosphate as the condensing reagent.
| 【1】 Kondo, K.; et al.; Characterization of orally active nonpeptide vasopressin V2 receptor agonist. Synthesis and biological evaluation of both the (5R)- and (5S)-enantioisomers of 2-[1-(2-chloro-4-pyrrolidin-1yl-benzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-yl]-N-isopropylace. J Med Chem 2002, 45, 17, 3805. |
| 【2】 Ogawa, H.; Kondo, K.; Shinohara, T.; Kan, K.; Tanada, Y.; Kurimura, M.; Morita, S.; Uchida, M.; Mori, T.; Tominaga, M.; Yabuuchi, Y. (Otsuka Pharmaceutical Co., Ltd.); Benzazepine derivs. with vasopressin agonistic activity. EP 0877736; JP 1998081668; US 6096736; WO 9722591 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 10019 | Ethyl 2-(diethoxyphosphoryl)acetate; Triethyl phosphonoacetate | 867-13-0 | C8H17O5P | 详情 | 详情 | |
| 42235 | Diethyl phosphorocyanidate; Diethyl cyanophosphonate; Cyanophosphonic acid diethyl ester; Diethyl phosphoryl cyanide; DEPC | 2942-58-7 | C5H10NO3P | 详情 | 详情 | |
| (I) | 14763 | 1-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one | C17H17NO3S | 详情 | 详情 | |
| (II) | 27544 | ethyl 2-[1-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene]acetate | C21H23NO4S | 详情 | 详情 | |
| (III) | 27545 | methyl 2-(2,3,4,5-tetrahydro-1H-1-benzazepin-5-yl)acetate | C13H17NO2 | 详情 | 详情 | |
| (IV) | 27546 | 2-chloro-4-(1-pyrrolidinyl)benzoic acid | C11H12ClNO2 | 详情 | 详情 | |
| (V) | 27547 | 2-chloro-4-(1-pyrrolidinyl)benzoyl chloride | C11H11Cl2NO | 详情 | 详情 | |
| (VI) | 27548 | methyl 2-[1-[2-chloro-4-(1-pyrrolidinyl)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-5-yl]acetate | C24H27ClN2O3 | 详情 | 详情 | |
| (VII) | 27549 | 2-[1-[2-chloro-4-(1-pyrrolidinyl)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-5-yl]acetic acid | C23H25ClN2O3 | 详情 | 详情 | |
| (VIII) | 27550 | (1R)-1-methylhexyl 2-[(5R)-1-[2-chloro-4-(1-pyrrolidinyl)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-5-yl]acetate | C30H39ClN2O3 | 详情 | 详情 |
合成路线12
该中间体在本合成路线中的序号：This alcohol is oxidized to aldehyde with NMMO and tetrapropylammonium perruthenate (TPAP), and further oxidized to carboxylic acid (XVIII) with KMnO4 and tetrabutylammonium bromide (TBAB). Coupling of (XVIII) with aminoamide (XIX) by means of diethyl cyanophosphonate and TEA gives (XX). Finally, acid hydrolysis of the oxazolidine ring and Boc protecting groups of (XX) furnishes the corresponding amino alcohol, which is finally converted to the hemifumarate salt.
| 【1】 Mealy, N.E.; Castañer, R.M.; Silvestre, J.S.; Castañer, J.; Aliskiren Fumarate. Drugs Fut 2001, 26, 12, 1139. |
| 【2】 Rigollier, P.; Stutz, S.; Goeschke, R.; Yamaguchi, Y.; Maibaum, J.; Wood, J.; Structural modification of the P2' position of 2,7-dialkyl substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octane-carboxamides: Discovery of a potent non-peptide renin inhibitor active after once daily dosing in marmosets. 15th European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (Sept 6 1998, Edinburgh) 1998, Abst P.230. |
| 【3】 Göschke, R.; Maibaum, J.K.; Schilling, W.; Stutz, S.; Rigollier, P.; Yamaguchi, Y.; Cohen, N.C.; Herold, P. (Novartis AG); Delta-amino-gamma-hydroxy-omega-aryl alkanoic acid amides with enzyme especially renin inhibiting activities. EP 0678500; EP 0678503; JP 1996053434; JP 1996081430; US 5559111; US 5627182; US 5646143 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 42235 | Diethyl phosphorocyanidate; Diethyl cyanophosphonate; Cyanophosphonic acid diethyl ester; Diethyl phosphoryl cyanide; DEPC | 2942-58-7 | C5H10NO3P | 详情 | 详情 | |
| (XVIII) | 28128 | (2S)-2-[((4S,5S)-3-(tert-butoxycarbonyl)-4-[(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl]-2,2-dimethyl-1,3-oxazolidin-5-yl)methyl]-3-methylbutyric acid | C33H55NO8 | 详情 | 详情 | |
| (XIX) | 28129 | 3-amino-2,2-dimethylpropanamide | 324763-51-1 | C5H12N2O | 详情 | 详情 |
| (XX) | 28130 | tert-butyl (4S,5S)-5-((2S)-2-[[(3-amino-2,2-dimethyl-3-oxopropyl)amino]carbonyl]-3-methylbutyl)-4-[(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate | C38H65N3O8 | 详情 | 详情 |
合成路线13
该中间体在本合成路线中的序号：Cyclization of amino acid (I) using 3-ethyl-1-(3-dimethylaminopropyl)carbodiimide (EDC) at a pH of 5.6 produced the azaphosphorinane (II) as a mixture of diastereoisomers. Subsequent reaction of (II) with diphenyldiazomethane yielded the bis(benzhydryl) ester (III) as a mixture of isomers, which were separable by column chromatography. Further refluxing of either isomer in EtOH removed selectively the phosphinic ester to give (IV) as an isomeric mixture. Coupling of (IV) with benzhydryl mercaptan by means of diethyl cyanophosphonate produced a mixture of cis (V) and trans (VI) phosphinothioic esters, which were separated by fractional crystallization from EtOAc. Finally, deprotection of both benzhydryl groups from the cis isomer (V) by means of trifluoroacetic acid yielded the title diacid.
| 【1】 Manthey, M.K.; Huang, D.T.C.; Bubb, W.A.; Christopherson, R.I.; Synthesis and enzymic evaluation of 4-mercapto-6-oxo-1,4-azaphosphinane-2-carboxylic acid 4-oxide as an inhibitor of mammalian dihydroorotase. J Med Chem 1998, 41, 23, 4550. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 42235 | Diethyl phosphorocyanidate; Diethyl cyanophosphonate; Cyanophosphonic acid diethyl ester; Diethyl phosphoryl cyanide; DEPC | 2942-58-7 | C5H10NO3P | 详情 | 详情 | |
| (I) | 29228 | 3-[(carboxymethyl)(hydroxy)phosphoryl]alanine | C5H10NO6P | 详情 | 详情 | |
| (II) | 29229 | 4-hydroxy-4,6-dioxo-1,4lambda(5)-azaphosphinane-2-carboxylic acid | C5H8NO5P | 详情 | 详情 | |
| (III) | 29230 | benzhydryl 4-(benzhydryloxy)-4,6-dioxo-1,4lambda(5)-azaphosphinane-2-carboxylate | C31H28NO5P | 详情 | 详情 | |
| (IV) | 29231 | benzhydryl 4-hydroxy-4,6-dioxo-1,4lambda(5)-azaphosphinane-2-carboxylate | C18H18NO5P | 详情 | 详情 | |
| (V) | 29232 | benzhydryl (2R)-4-(benzhydrylsulfanyl)-4,6-dioxo-1,4lambda(5)-azaphosphinane-2-carboxylate | C31H28NO4PS | 详情 | 详情 | |
| (VI) | 29233 | benzhydryl (2R)-4-(benzhydrylsulfanyl)-4,6-dioxo-1,4lambda(5)-azaphosphinane-2-carboxylate | C31H28NO4PS | 详情 | 详情 |