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【结 构 式】

【分子编号】21927

【品名】methyl 5-amino-2-methoxybenzoate

【CA登记号】

【 分 子 式 】C9H11NO3

【 分 子 量 】181.19128

【元素组成】C 59.66% H 6.12% N 7.73% O 26.49%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VII)

2) An alternative method starting from aniline (VII) employed the Meerwein arylation of methyl acrylate (IX) with the intermediate diazonium salt (VIII) in the presence of cuprous oxide. The resulting bromoester (X) was cyclized with thiourea (XI) in Et2O, followed by hydrolysis with HCl in sulfolane to afford (XIII). Finally, acid (XIII) was coupled to benzylamine (V) in the presence of (EtO)2POCN and Et3N.

1 Nomura, M.; et al.; (3-Substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents. Bioorg Med Chem Lett 1999, 9, 4, 533.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
42235 Diethyl phosphorocyanidate; Diethyl cyanophosphonate; Cyanophosphonic acid diethyl ester; Diethyl phosphoryl cyanide; DEPC 2942-58-7 C5H10NO3P 详情 详情
(V) 21925 [4-(trifluoromethyl)phenyl]methanamine; 4-(trifluoromethyl)benzylamine 3300-51-4 C8H8F3N 详情 详情
(VII) 21927 methyl 5-amino-2-methoxybenzoate C9H11NO3 详情 详情
(VIII) 21928 methyl 5-(1lambda(5)-diazynyl)-2-methoxybenzoate C9H10N2O3 详情 详情
(IX) 14156 methyl acrylate 96-33-3 C4H6O2 详情 详情
(X) 21930 methyl 5-(2-bromo-3-methoxy-3-oxopropyl)-2-methoxybenzoate C13H15BrO5 详情 详情
(XI) 10180 Thiourea 62-56-6 CH4N2S 详情 详情
(XII) 21932 methyl 5-[(2-imino-4-oxo-1,3-thiazolidin-5-yl)methyl]-2-methoxybenzoate C13H14N2O4S 详情 详情
(XIII) 21933 5-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]-2-methoxybenzoic acid C12H11NO5S 详情 详情
Extended Information