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【结 构 式】 
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【分子编号】28414 【品名】4-Amino-1-N-Boc-piperidine; tert-butyl 4-amino-1-piperidinecarboxylate; N-Boc-4-aminopiperidine 【CA登记号】87120-72-7 |
【 分 子 式 】C10H20N2O2 【 分 子 量 】200.28108 【元素组成】C 59.97% H 10.07% N 13.99% O 15.98% |
合成路线1
该中间体在本合成路线中的序号：(XII)In a related procedure, hydroxyacid (IV) was coupled with 1-Boc-4-aminopiperidine (XII) employing EDC and HOBt to give amide (XIII). Acid cleavage of the Boc group of (XIII) yielded amine (XIV), that was finally alkylated with mesylate (IX).
| 【1】 Yamakawa, T.; et al.; Synthesis and structure-activity-relationships of 4-acetamidopiperidines as M3 selective antagonists. 15th European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (Sept 6 1998, Edinburgh) 1998, Abst P.294. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IV) | 31466 | (2R)-2-cyclopentyl-2-hydroxy-2-phenylethanoic acid | C13H16O3 | 详情 | 详情 | |
| (IX) | 41602 | (4S)-4-methylhexyl methanesulfonate | C8H18O3S | 详情 | 详情 | |
| (XII) | 28414 | 4-Amino-1-N-Boc-piperidine; tert-butyl 4-amino-1-piperidinecarboxylate; N-Boc-4-aminopiperidine | 87120-72-7 | C10H20N2O2 | 详情 | 详情 |
| (XIII) | 41605 | tert-butyl 4-[[(2R)-2-cyclopentyl-2-hydroxy-2-phenylethanoyl]amino]-1-piperidinecarboxylate | C23H34N2O4 | 详情 | 详情 | |
| (XIV) | 41606 | (2R)-2-cyclopentyl-2-hydroxy-2-phenyl-N-(4-piperidinyl)ethanamide | C18H26N2O2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(XII)In a related procedure, hydroxyacid (IV) was coupled with 1-Boc-4-aminopiperidine (XII) employing EDC and HOBt to give amide (XIII). Acid cleavage of the Boc group of (XIII) yielded amine (XIV), that was finally alkylated with bromide (IX).
| 【1】 Yamakawa, T.; et al.; Synthesis and structure-activity-relationships of 4-acetamidopiperidines as M3 selective antagonists. 15th European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (Sept 6 1998, Edinburgh) 1998, Abst P.294. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IV) | 31466 | (2R)-2-cyclopentyl-2-hydroxy-2-phenylethanoic acid | C13H16O3 | 详情 | 详情 | |
| (IX) | 31462 | 5-bromo-2-methyl-2-pentene | C6H11Br | 详情 | 详情 | |
| (XII) | 28414 | 4-Amino-1-N-Boc-piperidine; tert-butyl 4-amino-1-piperidinecarboxylate; N-Boc-4-aminopiperidine | 87120-72-7 | C10H20N2O2 | 详情 | 详情 |
| (XIII) | 41605 | tert-butyl 4-[[(2R)-2-cyclopentyl-2-hydroxy-2-phenylethanoyl]amino]-1-piperidinecarboxylate | C23H34N2O4 | 详情 | 详情 | |
| (XIV) | 41606 | (2R)-2-cyclopentyl-2-hydroxy-2-phenyl-N-(4-piperidinyl)ethanamide | C18H26N2O2 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(VII)The condensation of pyruvic aldehyde dimethyl acetal (I) with dimethylformamide dimethyl acetal (II) afforded ketoenamine (III), which was condensed with N-methyl guanidine (IV) to give pyrimidine (V). Acid hydrolysis of the acetal function of (V) yielded pyrimidine carboxaldehyde (VI), which was converted to the imine (VIII) by treatment with 1-Boc-4-aminopiperidine (VII). Isonitrile (XII) was prepared by condensation of 4-fluorobenzaldehyde (IX) with formamide and p-thiocresol (X), followed by dehydration of the resulting formamide (XI) by means of POCl3 and Et3N. Reaction of isonitrile (XII) with imine (VIII) in the presence of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) produced imidazole (XIII). Finally, acid deprotection of the Boc group of (XIII) provided the title compound.
| 【1】 Adams, J.L.; Gallagher, T.F.; Garigipati, R.S.; Boehm, J.C.; Sisko, J.; Peng, Z.-Q.; Lee, J.C.-L. (SmithKline Beecham plc); Certain 1,4,5-tri-substd. imidazole cpds. useful as cytokine. EP 0809499; JP 1998512555; US 5593992; WO 9621452 . |
| 【2】 Garigipati, R.S.; Adams, J.L.; Boehm, J.C. (SmithKline Beecham Corp.); Pyridyl imidazole cpds. and compsns.. US 5670527 . |
| 【3】 Adams, J.L.; Boehm, J.C.; Imidazole cpds., use and process of making. US 5593991 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25433 | 1,1-dimethoxyacetone | 6342-56-9 | C5H10O3 | 详情 | 详情 |
| (II) | 11984 | N-(Dimethoxymethyl)-N,N-dimethylamine;dimethylformamide dimethylacetal;1,1-dimethoxy-N,N-dimethylmethanamine； Dimethoxy-N,N-dimethylmethanamine; N,N-Dimethylformamide dimethyl acetal | 4637-24-5 | C5H13NO2 | 详情 | 详情 |
| (III) | 25434 | (E)-4-(dimethylamino)-1,1-dimethoxy-3-buten-2-one | C8H15NO3 | 详情 | 详情 | |
| (IV) | 28411 | N-Methylguanidine | 598-12-9 | C2H7N3 | 详情 | 详情 |
| (V) | 28412 | 4-(dimethoxymethyl)-N-methyl-2-pyrimidinamine | C8H13N3O2 | 详情 | 详情 | |
| (VI) | 28413 | 2-(methylamino)-4-pyrimidinecarbaldehyde | C6H7N3O | 详情 | 详情 | |
| (VII) | 28414 | 4-Amino-1-N-Boc-piperidine; tert-butyl 4-amino-1-piperidinecarboxylate; N-Boc-4-aminopiperidine | 87120-72-7 | C10H20N2O2 | 详情 | 详情 |
| (VIII) | 28415 | tert-butyl 4-([(Z)-[2-(methylamino)-4-pyrimidinyl]methylidene]amino)-1-piperidinecarboxylate | C16H25N5O2 | 详情 | 详情 | |
| (IX) | 12337 | 4-fluorobenzaldehyde | 459-57-4 | C7H5FO | 详情 | 详情 |
| (X) | 25437 | 4-methylphenylhydrosulfide | 106-45-6 | C7H8S | 详情 | 详情 |
| (XI) | 25438 | (4-fluorophenyl)[(4-methylphenyl)sulfanyl]methylformamide | C15H14FNOS | 详情 | 详情 | |
| (XII) | 28416 | 4-Fluoro-alpha-(4-methylphenylsulfanyl)benzyl isocyanide | C15H12FNS | 详情 | 详情 | |
| (XIII) | 28417 | tert-butyl 4-[4-(4-fluorophenyl)-5-[2-(methylamino)-4-pyrimidinyl]-1H-imidazol-1-yl]-1-piperidinecarboxylate | C24H29FN6O2 | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(VI)Condensation between p-fluorobenzaldehyde (I), p-toluenesulfinic acid (II) and formamide in the presence of camphorsulfonic acid afforded 4-fluorophenyltosylmethyl formamide (III). Subsequent dehydration of (III) by means of POCl3 and Et3N produced isonitrile (IV). Imine (VII) was prepared by condensation of pyridine-4-carboxaldehyde (V) with 1-Boc-4-aminopiperidine (VI) using MgSO4 as the dehydrating reagent. Dipolar cycloaddition of this imine with the anion of tosyl isonitrile (IV) generated the trisubstituted imidazole (VIII). Finally, acid cleavage of the Boc protecting group furnished the title compound.
| 【1】 Adams, J.L.; Gallagher, T.F.; Garigipati, R.S.; Boehm, J.C.; Sisko, J.; Peng, Z.-Q.; Lee, J.C.-L. (SmithKline Beecham plc); Certain 1,4,5-tri-substd. imidazole cpds. useful as cytokine. EP 0809499; JP 1998512555; US 5593992; WO 9621452 . |
| 【2】 Garigipati, R.S.; Adams, J.L.; Boehm, J.C. (SmithKline Beecham Corp.); Pyridyl imidazole cpds. and compsns.. US 5670527 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 16598 | Formamide | 75-12-7 | CH3NO | 详情 | 详情 | |
| (I) | 12337 | 4-fluorobenzaldehyde | 459-57-4 | C7H5FO | 详情 | 详情 |
| (II) | 25593 | 4-methylbenzenesulfinic acid | C7H8O2S | 详情 | 详情 | |
| (III) | 25594 | (4-fluorophenyl)[(4-methylphenyl)sulfonyl]methylformamide | C15H14FNO3S | 详情 | 详情 | |
| (IV) | 25595 | 4-Fluoro-alpha-(4-methylphenylsulfonyl)benzyl isocyanide | C15H12FNO2S | 详情 | 详情 | |
| (V) | 17203 | 4-Pyridinecarboxaldehyde; isonicotinaldehyde | 872-85-5 | C6H5NO | 详情 | 详情 |
| (VI) | 28414 | 4-Amino-1-N-Boc-piperidine; tert-butyl 4-amino-1-piperidinecarboxylate; N-Boc-4-aminopiperidine | 87120-72-7 | C10H20N2O2 | 详情 | 详情 |
| (VII) | 34886 | tert-butyl 4-[[(Z)-4-pyridinylmethylidene]amino]-1-piperidinecarboxylate | C16H23N3O2 | 详情 | 详情 | |
| (VIII) | 34887 | tert-butyl 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-1-yl]-1-piperidinecarboxylate | C24H27FN4O2 | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：(II)Coupling between 2,7-dichloroxanthene-9-carboxylic acid (I) and 4-amino-1-tert-butoxycarbonylpiperidine (II) in the presence of EDC and HOBt afforded amide (III). After acidic cleavage of the Boc protecting group of (III), the resulting amine (IV) was reductively condensed with 1-cyclooctene carbaldehyde (V) by means of NaBH(OAc)3 to yield the cyclooctenylmethyl amine (VI). Subsequent alkylation of the tertiary amine (VI) with iodoethane gave rise to the target ammonium salt. Separation of the geometric isomers was carried out by column chromatography.
| 【1】 Naya, A.; et al.; Design, synthesis, and discovery of a novel CCR1 antagonist. J Med Chem 2001, 44, 9, 1429. |
| 【2】 Naya, A.; Owada, Y.; Saeki, T.; Ohwaki, K.; Iwasawa, Y. (Banyu Pharmaceutical Co., Ltd.); Chemokine receptor antagonists. EP 0916668; WO 9804554 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 37972 | 2,7-dichloro-9H-xanthene-9-carboxylic acid | C14H8Cl2O3 | 详情 | 详情 | |
| (II) | 28414 | 4-Amino-1-N-Boc-piperidine; tert-butyl 4-amino-1-piperidinecarboxylate; N-Boc-4-aminopiperidine | 87120-72-7 | C10H20N2O2 | 详情 | 详情 |
| (III) | 37973 | tert-butyl 4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-piperidinecarboxylate | C24H26Cl2N2O4 | 详情 | 详情 | |
| (IV) | 37974 | 2,7-dichloro-N-(4-piperidinyl)-9H-xanthene-9-carboxamide | C19H18Cl2N2O2 | 详情 | 详情 | |
| (V) | 37975 | 1-cyclooctene-1-carbaldehyde | C9H14O | 详情 | 详情 | |
| (VI) | 37976 | 2,7-dichloro-N-[1-(1-cycloocten-1-ylmethyl)-4-piperidinyl]-9H-xanthene-9-carboxamide | C28H32Cl2N2O2 | 详情 | 详情 |
合成路线6
该中间体在本合成路线中的序号：(II)The condensation of 3-cyanophenyl isocyanate (I) with N-Boc-4-aminopiperidine (II) produced the corresponding urea (III). The diazepinone system (V) was then obtained by dialkylation of the urea (III) functionality with 1,4-dibromobutane (IV) in the presence of NaH. After acid cleavage of the Boc protecting group of (V), the resulting piperidine (VI) was acylated with 2-thiophenesulfonyl chloride (VII) to give sulfonamide (VIII). Addition of methanol to the cyano group of (VIII) in the presence of anhydrous HCl in MeOAc furnished imidate (IX). This was then converted to the corresponding amidine by treatment with either methanolic ammonia or (NH4)2CO3, followed by conversion to the title hydrochloride salt.
| 【1】 Rossi, K.A.; Wells, B.L.; Galemmo, R.A. Jr.; et al.; The de novo design and synthesis of cyclic urea inhibitors of factor Xa: Optimization of the S4 ligand. Bioorg Med Chem Lett 2000, 10, 3, 301. |
| 【2】 Maduskuie, T.P. Jr.; Galemmo, R.A. Jr.; Dominguez, C.; Quan, M.L.; Rossi, K.A.; Stouten, P.F.W.; Sun, J.H.; Wells, B.L. (DuPont Pharmaceuticals Co.); N-(Amidinophenyl)-N'-(substd.)-3H-2, 4-benzodiazepin-3-one derivs. as factor Xa inhibitors. EP 0960104; US 5925635; WO 9738984 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 40756 | 3-isocyanatobenzonitrile | 16413-26-6 | C8H4N2O | 详情 | 详情 |
| (II) | 28414 | 4-Amino-1-N-Boc-piperidine; tert-butyl 4-amino-1-piperidinecarboxylate; N-Boc-4-aminopiperidine | 87120-72-7 | C10H20N2O2 | 详情 | 详情 |
| (III) | 40757 | tert-butyl 4-[[(3-cyanoanilino)carbonyl]amino]-1-piperidinecarboxylate | C18H24N4O3 | 详情 | 详情 | |
| (IV) | 11883 | 1,4-Dibromobutane; 1,4-Butylene bromide | 110-52-1 | C4H8Br2 | 详情 | 详情 |
| (V) | 40758 | tert-butyl 4-[3-(3-cyanophenyl)-2-oxo-1,3-diazepan-1-yl]-1-piperidinecarboxylate | C22H30N4O3 | 详情 | 详情 | |
| (VI) | 40759 | 3-[2-oxo-3-(4-piperidinyl)-1,3-diazepan-1-yl]benzonitrile | C17H22N4O | 详情 | 详情 | |
| (VII) | 40760 | 2-thiophenesulfonyl chloride | 16629-19-9 | C4H3ClO2S2 | 详情 | 详情 |
| (VIII) | 40761 | 3-[2-oxo-3-[1-(2-thienylsulfonyl)-4-piperidinyl]-1,3-diazepan-1-yl]benzonitrile | C21H24N4O3S2 | 详情 | 详情 | |
| (IX) | 40762 | methyl 3-[2-oxo-3-[1-(2-thienylsulfonyl)-4-piperidinyl]-1,3-diazepan-1-yl]benzenecarboximidoate | C22H28N4O4S2 | 详情 | 详情 |
合成路线7
该中间体在本合成路线中的序号：(IV)2-Chloronicotinic acid (I) was reduced to alcohol (II) employing borane, generated from NaBH4 and BF3.Et2O. Subsequent oxidation of (II) with N-bromosuccinimide produced aldehyde (III), which was condensed with N-Boc-4-aminopiperidine (IV), yielding imine (V). Addition to (V) of (4-fluorophenyl)-toluenesulfonylmethyl isocyanide (VI) gave rise to imidazole (VII). Then, displacement of the 2-chloro of (VII) by means of aniline (VIII) in the presence of NaH furnished the 2-anilinopyridine derivative (IX). The Boc protecting group of (IX) was finally removed by treatment with trifluoroacetic acid.
| 【1】 Adams, J.L.; Gallagher, T.F.; Sisko, J.; Peng, Z.-Q.; Osifo, I.K.; Boehm, J.C. (SmithKline Beecham plc); Imidazole cpds.. EP 0831830; JP 1999513017; US 5658903; WO 9640143 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 40032 | 2-chloroisonicotinic acid | 6313-54-8 | C6H4ClNO2 | 详情 | 详情 |
| (II) | 40033 | (2-chloro-4-pyridinyl)methanol | 100704-10-7 | C6H6ClNO | 详情 | 详情 |
| (III) | 29234 | 2-chloroisonicotinaldehyde | C6H4ClNO | 详情 | 详情 | |
| (IV) | 28414 | 4-Amino-1-N-Boc-piperidine; tert-butyl 4-amino-1-piperidinecarboxylate; N-Boc-4-aminopiperidine | 87120-72-7 | C10H20N2O2 | 详情 | 详情 |
| (V) | 40034 | tert-butyl 4-[[(E)-(2-chloro-4-pyridinyl)methylidene]amino]-1-piperidinecarboxylate | C16H22ClN3O2 | 详情 | 详情 | |
| (VI) | 40035 | 2-(4-fluorophenyl)-2-[(4-methylphenyl)sulfonyl]acetonitrile | C15H12FNO2S | 详情 | 详情 | |
| (VII) | 40036 | tert-butyl 4-[5-(2-chloro-4-pyridinyl)-4-(4-fluorophenyl)-1H-imidazol-1-yl]-1-piperidinecarboxylate | C24H26ClFN4O2 | 详情 | 详情 | |
| (VIII) | 12294 | Aniline; Phenylamine | 62-53-3 | C6H7N | 详情 | 详情 |
| (IX) | 40037 | tert-butyl 4-[5-(2-anilino-4-pyridinyl)-4-(4-fluorophenyl)-1H-imidazol-1-yl]-1-piperidinecarboxylate | C30H32FN5O2 | 详情 | 详情 |
合成路线8
该中间体在本合成路线中的序号：(VII)Reductive amination of N-Boc-4-piperidone (I) with allyl amine (II) in the presence of sodium triacetoxyborohydride gave aminopiperidine (III), which was condensed with 4-nitrobenzyl chloroformate (IV) to afford carbamate (V). The Boc group of (V) was then cleaved by treatment with methanolic HCl to produce intermediate piperidine (VI). Alternatively, the condensation of 1-Boc-piperidine-4-amine (VII) with chloroformate (IV) gives carbamate (VIII), which is allylated with allyl chloride (IX) and NaH in THF, yielding the already reported carbamate (V).
| 【1】 Chen, P.; Dorn, C.P. Jr.; Caldwell, C.G.; et al.; Synthesis and evaluation of CCR5 antagonists having potent in vitro antiviral activity. 220th ACS Natl Meet (Aug 20 2000, Washington DC) 2000, Abst MEDI 85. |
| 【2】 Finke, P.E.; Mills, S.G.; Caldwell, C.G.; MacCoss, M.; Wang, L.; Kothandaraman, S.; Kim, D.; Oates, B. (Merck & Co., Inc.); Cyclic amine modulators of chemokine receptor activity. EP 1052992; US 6140349; WO 9938514 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18620 | tert-butyl 4-oxo-1-piperidinecarboxylate;BOC-Piperidone;N-(tert-Butoxycarbonyl)-4-piperidone; N-Boc-4-piperidone | 79099-07-3 | C10H17NO3 | 详情 | 详情 |
| (II) | 13672 | Allylamine; 2-Propen-1-amine | 107-11-9 | C3H7N | 详情 | 详情 |
| (III) | 43903 | tert-butyl 4-(allylamino)-1-piperidinecarboxylate | C13H24N2O2 | 详情 | 详情 | |
| (IV) | 33055 | 1-[[(chlorocarbonyl)oxy]methyl]-4-nitrobenzene | 4457-32-3 | C8H6ClNO4 | 详情 | 详情 |
| (V) | 43904 | tert-butyl 4-(allyl[[(4-nitrobenzyl)oxy]carbonyl]amino)-1-piperidinecarboxylate | C21H29N3O6 | 详情 | 详情 | |
| (VI) | 43905 | 4-nitrobenzyl allyl(4-piperidinyl)carbamate | C16H21N3O4 | 详情 | 详情 | |
| (VII) | 28414 | 4-Amino-1-N-Boc-piperidine; tert-butyl 4-amino-1-piperidinecarboxylate; N-Boc-4-aminopiperidine | 87120-72-7 | C10H20N2O2 | 详情 | 详情 |
| (VIII) | 43906 | tert-butyl 4-([[(4-nitrobenzyl)oxy]carbonyl]amino)-1-piperidinecarboxylate | C18H25N3O6 | 详情 | 详情 | |
| (IX) | 13235 | Allyl chloride; 3-Chloro-1-propene | 107-05-1 | C3H5Cl | 详情 | 详情 |