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【结 构 式】 
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【分子编号】41606 【品名】(2R)-2-cyclopentyl-2-hydroxy-2-phenyl-N-(4-piperidinyl)ethanamide 【CA登记号】 |
【 分 子 式 】C18H26N2O2 【 分 子 量 】302.41672 【元素组成】C 71.49% H 8.67% N 9.26% O 10.58% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(XIV)In a related procedure, hydroxyacid (IV) was coupled with 1-Boc-4-aminopiperidine (XII) employing EDC and HOBt to give amide (XIII). Acid cleavage of the Boc group of (XIII) yielded amine (XIV), that was finally alkylated with mesylate (IX).
| 【1】 Yamakawa, T.; et al.; Synthesis and structure-activity-relationships of 4-acetamidopiperidines as M3 selective antagonists. 15th European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (Sept 6 1998, Edinburgh) 1998, Abst P.294. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IV) | 31466 | (2R)-2-cyclopentyl-2-hydroxy-2-phenylethanoic acid | C13H16O3 | 详情 | 详情 | |
| (IX) | 41602 | (4S)-4-methylhexyl methanesulfonate | C8H18O3S | 详情 | 详情 | |
| (XII) | 28414 | 4-Amino-1-N-Boc-piperidine; tert-butyl 4-amino-1-piperidinecarboxylate; N-Boc-4-aminopiperidine | 87120-72-7 | C10H20N2O2 | 详情 | 详情 |
| (XIII) | 41605 | tert-butyl 4-[[(2R)-2-cyclopentyl-2-hydroxy-2-phenylethanoyl]amino]-1-piperidinecarboxylate | C23H34N2O4 | 详情 | 详情 | |
| (XIV) | 41606 | (2R)-2-cyclopentyl-2-hydroxy-2-phenyl-N-(4-piperidinyl)ethanamide | C18H26N2O2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(XIV)In a related procedure, hydroxyacid (IV) was coupled with 1-Boc-4-aminopiperidine (XII) employing EDC and HOBt to give amide (XIII). Acid cleavage of the Boc group of (XIII) yielded amine (XIV), that was finally alkylated with bromide (IX).
| 【1】 Yamakawa, T.; et al.; Synthesis and structure-activity-relationships of 4-acetamidopiperidines as M3 selective antagonists. 15th European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (Sept 6 1998, Edinburgh) 1998, Abst P.294. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IV) | 31466 | (2R)-2-cyclopentyl-2-hydroxy-2-phenylethanoic acid | C13H16O3 | 详情 | 详情 | |
| (IX) | 31462 | 5-bromo-2-methyl-2-pentene | C6H11Br | 详情 | 详情 | |
| (XII) | 28414 | 4-Amino-1-N-Boc-piperidine; tert-butyl 4-amino-1-piperidinecarboxylate; N-Boc-4-aminopiperidine | 87120-72-7 | C10H20N2O2 | 详情 | 详情 |
| (XIII) | 41605 | tert-butyl 4-[[(2R)-2-cyclopentyl-2-hydroxy-2-phenylethanoyl]amino]-1-piperidinecarboxylate | C23H34N2O4 | 详情 | 详情 | |
| (XIV) | 41606 | (2R)-2-cyclopentyl-2-hydroxy-2-phenyl-N-(4-piperidinyl)ethanamide | C18H26N2O2 | 详情 | 详情 |
Extended Information