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【结 构 式】 
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【药物名称】 【化学名称】3-[2-Oxo-3-[1-(2-thienylsulfonyl)piperidin-4-yl]perhydro-1,3-diazepin-1-yl]benzamidine hydrochloride 【CA登记号】198824-33-8 (free base) 【 分 子 式 】C21H28ClN5O3S2 【 分 子 量 】498.07001 |
【开发单位】Bristol-Myers Squibb (Originator) 【药理作用】Anticoagulants, Coagulation Disorders Therapy, HEMATOLOGIC DRUGS, Coagulation Factor Xa Inhibitors |
合成路线1
The condensation of 3-cyanophenyl isocyanate (I) with N-Boc-4-aminopiperidine (II) produced the corresponding urea (III). The diazepinone system (V) was then obtained by dialkylation of the urea (III) functionality with 1,4-dibromobutane (IV) in the presence of NaH. After acid cleavage of the Boc protecting group of (V), the resulting piperidine (VI) was acylated with 2-thiophenesulfonyl chloride (VII) to give sulfonamide (VIII). Addition of methanol to the cyano group of (VIII) in the presence of anhydrous HCl in MeOAc furnished imidate (IX). This was then converted to the corresponding amidine by treatment with either methanolic ammonia or (NH4)2CO3, followed by conversion to the title hydrochloride salt.
| 【1】 Rossi, K.A.; Wells, B.L.; Galemmo, R.A. Jr.; et al.; The de novo design and synthesis of cyclic urea inhibitors of factor Xa: Optimization of the S4 ligand. Bioorg Med Chem Lett 2000, 10, 3, 301. |
| 【2】 Maduskuie, T.P. Jr.; Galemmo, R.A. Jr.; Dominguez, C.; Quan, M.L.; Rossi, K.A.; Stouten, P.F.W.; Sun, J.H.; Wells, B.L. (DuPont Pharmaceuticals Co.); N-(Amidinophenyl)-N'-(substd.)-3H-2, 4-benzodiazepin-3-one derivs. as factor Xa inhibitors. EP 0960104; US 5925635; WO 9738984 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 40756 | 3-isocyanatobenzonitrile | 16413-26-6 | C8H4N2O | 详情 | 详情 |
| (II) | 28414 | 4-Amino-1-N-Boc-piperidine; tert-butyl 4-amino-1-piperidinecarboxylate; N-Boc-4-aminopiperidine | 87120-72-7 | C10H20N2O2 | 详情 | 详情 |
| (III) | 40757 | tert-butyl 4-[[(3-cyanoanilino)carbonyl]amino]-1-piperidinecarboxylate | C18H24N4O3 | 详情 | 详情 | |
| (IV) | 11883 | 1,4-Dibromobutane; 1,4-Butylene bromide | 110-52-1 | C4H8Br2 | 详情 | 详情 |
| (V) | 40758 | tert-butyl 4-[3-(3-cyanophenyl)-2-oxo-1,3-diazepan-1-yl]-1-piperidinecarboxylate | C22H30N4O3 | 详情 | 详情 | |
| (VI) | 40759 | 3-[2-oxo-3-(4-piperidinyl)-1,3-diazepan-1-yl]benzonitrile | C17H22N4O | 详情 | 详情 | |
| (VII) | 40760 | 2-thiophenesulfonyl chloride | 16629-19-9 | C4H3ClO2S2 | 详情 | 详情 |
| (VIII) | 40761 | 3-[2-oxo-3-[1-(2-thienylsulfonyl)-4-piperidinyl]-1,3-diazepan-1-yl]benzonitrile | C21H24N4O3S2 | 详情 | 详情 | |
| (IX) | 40762 | methyl 3-[2-oxo-3-[1-(2-thienylsulfonyl)-4-piperidinyl]-1,3-diazepan-1-yl]benzenecarboximidoate | C22H28N4O4S2 | 详情 | 详情 |