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【结 构 式】 
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【分子编号】20351 【品名】N-(2-chloroethyl)-N-propyl-1-propanamine; N-(2-chloroethyl)-N,N-dipropylamine 【CA登记号】 |
【 分 子 式 】C8H18ClN 【 分 子 量 】163.69036 【元素组成】C 58.7% H 11.08% Cl 21.66% N 8.56% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(II)By reaction of 9-hydroxyellipticine (I) with 2-(diethylamino)ethyl chloride (II) in DMF at 100 C.
| 【1】 Gros, P.; Crisafulli, E. (CNRS (Centre National de la Recherche Scientifique); Sanofi-Synthélabo); Hydrochlorides of 2-aminoalkyl-9-hydroxyellipticinium chloride derivs. and pharmaceutical compsns. containing them. EP 0209511; FR 2584409; JP 1987010084; US 4897398 . |
| 【2】 Eastland, G. Jr.; Prous, J.; Castaner, J.; DATELLIPTIUM CHLORIDE < Rec INN >. Drugs Fut 1989, 14, 2, 109. |
合成路线2
该中间体在本合成路线中的序号：(IV)Triazinoindole thione (III) was obtained by condensation of isatin (I) with thiosemicarbazide (II). Subsequent S-alkylation of (III) with dipropylaminoethyl chloride (IV) furnished the title thioether derivative.
| 【1】 Pevear, D.C.; Nitz, T.J.; Seipel, M. (ViroPharma, Inc.); Methods for preventing and treating pestivirus infection and associated diseases. WO 9836752 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14098 | 2,3-Indolinedione; 1H-Indole-2,3-dione; Isatin | 91-56-5 | C8H5NO2 | 详情 | 详情 |
| (II) | 12954 | 1-Hydrazinecarbothioamide; Thiosemicarbazide | 79-19-6 | CH5N3S | 详情 | 详情 |
| (III) | 43357 | 2,5-dihydro-3H-[1,2,4]triazino[5,6-b]indole-3-thione | C9H6N4S | 详情 | 详情 | |
| (IV) | 20351 | N-(2-chloroethyl)-N-propyl-1-propanamine; N-(2-chloroethyl)-N,N-dipropylamine | C8H18ClN | 详情 | 详情 |
Extended Information