2,5-dihydro-3H-[1,2,4]triazino[5,6-b]indole-3-thione -Drug Synthesis Database

【结构式】

【分子编号】43357

【品名】2,5-dihydro-3H-[1,2,4]triazino[5,6-b]indole-3-thione

【CA登记号】

【分子式】C₉H₆N₄S

【分子量】202.2396

【元素组成】C 53.45% H 2.99% N 27.7% S 15.86%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Triazinoindole thione (III) was obtained by condensation of isatin (I) with thiosemicarbazide (II). Subsequent S-alkylation of (III) with dipropylaminoethyl chloride (IV) furnished the title thioether derivative.

参考文献中间体

合成目标

【1】 Pevear, D.C.; Nitz, T.J.; Seipel, M. (ViroPharma, Inc.); Methods for preventing and treating pestivirus infection and associated diseases. WO 9836752 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	14098	2,3-Indolinedione; 1H-Indole-2,3-dione; Isatin	91-56-5	C₈H₅NO₂	详情	详情
(II)	12954	1-Hydrazinecarbothioamide; Thiosemicarbazide	79-19-6	CH₅N₃S	详情	详情
(III)	43357	2,5-dihydro-3H-[1,2,4]triazino[5,6-b]indole-3-thione		C₉H₆N₄S	详情	详情
(IV)	20351	N-(2-chloroethyl)-N-propyl-1-propanamine; N-(2-chloroethyl)-N,N-dipropylamine		C₈H₁₈ClN	详情	详情

Extended Information