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【结 构 式】 
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【药物名称】VP-32947 【化学名称】N-Propyl-N-[2-(5H-1,2,4-triazino[5,6-b]indol-3-ylsulfanyl)ethyl]-1-propanamine 【CA登记号】212246-37-2, 189325-62-0 (HCl) 【 分 子 式 】C17H23N5S 【 分 子 量 】329.47036 |
【开发单位】ViroPharma (Originator) 【药理作用】Anti-Hepatitis C Virus Drugs, Anti-Hepatitis Virus Drugs, ANTIINFECTIVE THERAPY, Antiviral Drugs, RNA-Directed RNA Polymerase (NS5B) Inhibitors |
合成路线1
Triazinoindole thione (III) was obtained by condensation of isatin (I) with thiosemicarbazide (II). Subsequent S-alkylation of (III) with dipropylaminoethyl chloride (IV) furnished the title thioether derivative.
| 【1】 Pevear, D.C.; Nitz, T.J.; Seipel, M. (ViroPharma, Inc.); Methods for preventing and treating pestivirus infection and associated diseases. WO 9836752 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14098 | 2,3-Indolinedione; 1H-Indole-2,3-dione; Isatin | 91-56-5 | C8H5NO2 | 详情 | 详情 |
| (II) | 12954 | 1-Hydrazinecarbothioamide; Thiosemicarbazide | 79-19-6 | CH5N3S | 详情 | 详情 |
| (III) | 43357 | 2,5-dihydro-3H-[1,2,4]triazino[5,6-b]indole-3-thione | C9H6N4S | 详情 | 详情 | |
| (IV) | 20351 | N-(2-chloroethyl)-N-propyl-1-propanamine; N-(2-chloroethyl)-N,N-dipropylamine | C8H18ClN | 详情 | 详情 |
Extended Information