Detalliptinium, Datelliptium chloride, SR-95156B(monoHCl), NSC-311152, DTL, -Drug Synthesis Database

【结构式】

【药物名称】Detalliptinium, Datelliptium chloride, SR-95156B(monoHCl), NSC-311152, DTL

【化学名称】2-[2-(Diethylamino)ethyl]-9-hydroxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazolium chloride
　　　　　　2-[2-(Diethylamino)ethyl]-9-hydroxyellipticinium chloride

【CA登记号】105118-14-7, 81531-58-0 (acetate), 81531-57-9 (free cation)

【分子式】C₂₃H₂₈ClN₃O

【分子量】397.95211

【开发单位】ANVAR (Originator), CNRS (Originator), Sanofi-synthélabo (Originator), Sanofi-Synthelabo (Licensee)

【药理作用】Alkaloids

合成路线1

By reaction of 9-hydroxyellipticine (I) with 2-(diethylamino)ethyl chloride (II) in DMF at 100 C.

参考文献中间体

【1】 Gros, P.; Crisafulli, E. (CNRS (Centre National de la Recherche Scientifique); Sanofi-Synthélabo); Hydrochlorides of 2-aminoalkyl-9-hydroxyellipticinium chloride derivs. and pharmaceutical compsns. containing them. EP 0209511; FR 2584409; JP 1987010084; US 4897398 .
【2】 Eastland, G. Jr.; Prous, J.; Castaner, J.; DATELLIPTIUM CHLORIDE < Rec INN >. Drugs Fut 1989, 14, 2, 109.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	20350	5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol		C₁₇H₁₄N₂O	详情	详情
(II)	20351	N-(2-chloroethyl)-N-propyl-1-propanamine; N-(2-chloroethyl)-N,N-dipropylamine		C₈H₁₈ClN	详情	详情

Extended Information