5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol -Drug Synthesis Database

【结构式】

【分子编号】20350

【品名】5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol

【CA登记号】

【分子式】C₁₇H₁₄N₂O

【分子量】262.31104

【元素组成】C 77.84% H 5.38% N 10.68% O 6.1%

与该中间体有关的原料药合成路线共 2 条

合成路线1 合成路线2

合成路线1

该中间体在本合成路线中的序号：(II)

The iodide is formed as follows: 9-Methoxy-ellipticine (I) (extracted from Ochrosia maculata) is demethylated by refluxing with pyridine hydrochloride to give 9-hydroxy-ellipticine (II), which is then treated with methyl iodide in DMF at room temperature.

参考文献中间体

合成目标

【1】 Le Pecq, J.B.; et al. (ANVAR (Agence Natl. Valor. Rech.)); Derivatives of 9-hydroxy-ellipticine and a process fo their preparation. CH 616937; DE 2618223; FR 2308365; GB 1508388 .
【2】 Woodman, R.J.; NSC-264137. Drugs Fut 1979, 4, 4, 267.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	33272	9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole; 5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-yl methyl ether		C₁₈H₁₆N₂O	详情	详情
(II)	20350	5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol		C₁₇H₁₄N₂O	详情	详情

合成路线2

该中间体在本合成路线中的序号：(I)

By reaction of 9-hydroxyellipticine (I) with 2-(diethylamino)ethyl chloride (II) in DMF at 100 C.

参考文献中间体

合成目标

【1】 Gros, P.; Crisafulli, E. (CNRS (Centre National de la Recherche Scientifique); Sanofi-Synthélabo); Hydrochlorides of 2-aminoalkyl-9-hydroxyellipticinium chloride derivs. and pharmaceutical compsns. containing them. EP 0209511; FR 2584409; JP 1987010084; US 4897398 .
【2】 Eastland, G. Jr.; Prous, J.; Castaner, J.; DATELLIPTIUM CHLORIDE < Rec INN >. Drugs Fut 1989, 14, 2, 109.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	20350	5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol		C₁₇H₁₄N₂O	详情	详情
(II)	20351	N-(2-chloroethyl)-N-propyl-1-propanamine; N-(2-chloroethyl)-N,N-dipropylamine		C₈H₁₈ClN	详情	详情

Extended Information